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RNA, Viral (0):
Recent article
RNA, Viral
Abstract
We experienced a case of a peritoneal dialysis patient with chronic hepatitis C who was successfully treated with PEG-IFN monotherapy. A 50-year old man was undergoing peritoneal dialysis because of diabetic nephropathy. Considering that his HCV genotype was 2, we decided to treat him with PEG-IFN a...
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PMID: 21873827
PDF is available here.
PDF is available here.
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Abstract
We developed a nuclear magnetic resonance approach that enabled direct detection of structural elements within the intact leader (712-nucleotide dimer) that are critical for genome packaging. Residues spanning the gag start codon (AUG) form a hairpin in the monomeric leader and base pair with residu...
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PMID: 21998393
PDF is available here.
PDF is available here.
Abstract
We recently characterized the interaction between the intraviral domains of envelope glycoproteins (Gn and Gc) and ribonucleoprotein (RNP) of Puumala and Tula hantaviruses (genus Hantavirus, family Bunyaviridae). Herein we report a direct interaction between spike-forming glycoprotein and nucleic ac...
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PMID: 21807393
PDF is available here.
PDF is available here.
Abstract
Recent epidemiological and immunological studies provide evidence for an association between Epstein-Barr virus infection and multiple sclerosis, suggesting a role of Epstein-Barr virus infection in disease induction and pathogenesis. A key question in this context is whether Epstein-Barr virus-infec...
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PMID: 21846731
PDF is available here.
PDF is available here.
Avian Diseases (55)3 2011
Abstract
The very virulent form of infectious bursal disease virus (vvIBDV) causes an immunosuppressive disease that is further characterized by the rapid onset of morbidity and high mortality in susceptible chickens. In 2009, vvIBDV was first reported in California, U. S. A., and since that...
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PMID: 22017037
PDF is available here.
PDF is available here.
Abstract
We show here a study on the pathogenesis and the physiopathology of ROCV disease in the central nervous system of a Balb/C young adult mice experimental model. The animals were intraperitoneally infected by ROCV and followed from 0 to 9 days after infection, when all of them died. Nervous tissue sam...
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PMID: 21813860
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)25 2011
Abstract
We assigned 1088 patients with HCV genotype 1 infection who had not received previous treatment for the infection to one of three groups: a group receiving telaprevir combined with peginterferon alfa-2a and ribavirin for 12 weeks (T12PR group), followed by peginterferon-ribavirin alone for 12 weeks...
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PMID: 21696307
PDF is available here.
PDF is available here.
Abstract
We describe the development and validation of a rapid, sensitive and specific real-time reverse transcription quantitative PCR assay (RT-qPCR) that amplifies sequence from representative isolates of all VHSV genotypes (I, II, III and IV). The pan-specific VHSV RT-qPCR assay reliably detects 100 copi...
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PMID: 21848118
PDF is available here.
PDF is available here.
Abstract
Abstract
We retrospectively reviewed the medical records of 82 patients with chronic hepatitis C who received a combination therapy with peginterferon and ribavirin. The patients were categorized into 3 subgroups on the basis of medication adherence. Group 1 comprised patients who received ≥80% of the reco...
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PMID: 21623138
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe the adaptation of a modified replicon system for a high-throughput screening (HTS) in anti-HCV drug discovery. In this system, the antiviral activity and cytotoxicity of any experimental compound are measured from a single well. This duplex measurement greatly increases the efficiency of...
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PMID: 19009266
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We recently showed that isolated replication complexes are able to synthesize two species of nascent viral RNA, one double stranded and the other single stranded. NS5B nucleoside inhibitors block synthesis of both species, whereas nonnucleoside inhibitors inhibit mostly single- tranded RNA synthesis...
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PMID: 19009261
PDF is available here.
PDF is available here.
Abstract
Abstract
We retrospectively investigated the impact of treatment in a large cohort of children with chronic hepatitis C over the past 20 years.
376 hepatitis C virus RNA positive children were recruited consecutively in five Italian centres since 1990 and followed for 1-17 years....
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PMID: 21111693
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)13 2011
Abstract
We conducted a double-blind study in which previously untreated adults with HCV genotype 1 infection were randomly assigned to one of three groups. In all three groups, peginterferon alfa-2b and ribavirin were administered for 4 weeks (the lead-in period). Subsequently, group 1 (the control group) r...
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PMID: 21449783
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)13 2011
Abstract
We randomly assigned patients (in a 1:2:2 ratio) to one of three groups. In all three groups, peginterferon alfa-2b and ribavirin were administered for 4 weeks (the lead-in period). Subsequently, group 1 (control group) received placebo plus peginterferon-ribavirin for 44 weeks; group 2 received boc...
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PMID: 21449784
PDF is available here.
PDF is available here.
Abstract
We designed and tested an integrated nucleic acid extraction and amplification device employing a loop-mediated isothermal amplification (LAMP) or reverse transcriptase-LAMP assay. Our system provides a screening tool with polymerase-chain-reaction-level sensitivity and specificity for outbreak dete...
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PMID: 21342806
PDF is available here.
PDF is available here.
Abstract
We determined the methylation status of all 110 CpG sites within the viral epigenome in advanced stage III/IV HPV-16-associated head and neck cancers. We found that the viral genome was hypomethylated in the majority of head and neck cancers, in particular within the viral regulatory region, long co...
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PMID: 21292634
PDF is available here.
PDF is available here.
Abstract
Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. This combination therapy has drastically improved the rate of sustained virological response, specifically in difficult-to-treat patien...
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PMID: 21274371
PDF is available here.
PDF is available here.
Abstract
To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy.
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PMID: 21274379
PDF is available here.
PDF is available here.
Epidemiology and Infection (139)2 2011
Abstract
We study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 an...
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PMID: 20334728
PDF is available here.
PDF is available here.
Abstract
We generated a recombinant IHNV, rIHNV-NV-ΔEGDL in which the (32)EGDL(35) was deleted from the NV. rIHNVs with wild-type NV (rIHNV-NV) or with the NV gene replaced with GFP (rIHNV-ΔNV-GFP) were used as controls. RTG-2 cells infected with rIHNV-ΔNV-GFP and rIHNV-NV-ΔEGDL yielded 12- and 5-fold le...
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PMID: 21814578
PDF is available here.
PDF is available here.
Abstract
We decided to investigate blood donors for evidence of XMRV/pMLV.
Testing of cDNA prepared from the whole blood of 80 random blood donors, generated gag PCR signals from two samples (7C and 9C). These had previously tested negative for XMRV by two other PCR based techniques. To test...
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PMID: 21647447
PDF is available here.
PDF is available here.
Abstract
We were able to identify viral RNA molecules which specifically associated with RIG-I during infection. We showed that in Sendai virus infected cells, RIG-I specifically and preferentially associated with the copy-back defective interfering (DI) particle RNA and not with the full-length Sendai virus...
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PMID: 21422808
PDF is available here.
PDF is available here.
Abstract
We analyze all available RBD, ED, and full-length NS1 structures, including four novel crystal structures obtained using EDs from divergent human and avian viruses, as well as two forms of a monomeric ED mutant. The data reveal the helix-helix interface as the only strictly conserved ED homodimeric...
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PMID: 21464929
PDF is available here.
PDF is available here.
Retrovirology (8)1 2011
Abstract
We introduce a novel method to explore the proteome associated with the nuclear HIV-1 RNAs. At the core of the method is the generation of cell lines harboring an integrated provirus carrying RNA binding sites for the MS2 bacteriophage protein. Flag-tagged MS2 is then used for affinity purification...
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PMID: 21771346
PDF is available here.
PDF is available here.
Virology Journal (8)1 2011
Abstract
Current standard therapy commonly followed for chronic Hepatitis C Virus (HCV) in Pakistan is interferon alpha plus ribavirin combination therapy (IFN α/ribavirin) and pegylated interferon plus ribavirin (PegIFN/ribavirin). PegIFN/ribavirin has increased rate of sustained virologica...
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PMID: 21575275
PDF is available here.
PDF is available here.
Annals of Hepatology (10)4 2011
Abstract
We studied 102 patients, 60% were men, and 40% of them were rs8099917 TT and 18% rs12979860 CC. Mean baseline serum HCV RNA was 1.673.092 IU/mL and mean F score was: 2.10 ± 1.18 (21% cirrhotic). SVR rate was higher in rs8099917 TT genotypes (55%) when compared to GT/GG (25%) (p = 0.002) and in rs15...
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PMID: 21911885
PDF is available here.
PDF is available here.
Abstract
A two-part challenge study was done in marmoset monkeys to confirm the efficacy of an inactivated hepatitis A vaccine. In part 1 (preexposure), 7 marmosets received a single low dose of vaccine (360 ELISA units [EL.U.]) and were challenged orally with wild type hepatitis A virus (HAV) either 1 or 6...
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PMID: 7876647
PDF is available here.
PDF is available here.
Clinical Nephrology (75)1 2011
Abstract
Among patients after renal transplantation (NTx), hepatitis C virus (HCV) infection is a risk factor for graft loss and patient death caused by hepatic decompensation. Also, HCV has been implicated in the pathogenesis of glomerular diseases in native and transplanted kidneys. Therefore, the aim of t...
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PMID: 21176747
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
We reported that EBV can infect rabbits by intravenous, intranasal and/or peroral inoculation, which caused primary EBV infection in rabbits with heterogeneous host reactions. Some rabbits showed chronic and lifelong EBV infection with hemophagocytosis. In this study, to reveal detailed mechanisms i...
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PMID: 20689312
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
Our results provide evidence that the mAb D32.10 recognizes E1E2 envelope complexes expressed in the cell cytoplasm and on the surface of HCV RNA-containing particles released from short-term cultures of in vivo infected hepatocytes.
Copyright © 2010 S. Karger AG, Basel....
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PMID: 20689310
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
There is a large number of immigrant workers from Cambodia and Myanmar in Thailand. The aim of our study was to determine seroprevalence and genotypes of hepatitis C virus (HCV) in this group.
Immigrants aged between 15 and 60 years (1,431 Cambodians and 1,594 Myanmarese) were recruited into this st...
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PMID: 20689311
PDF is available here.
PDF is available here.
Abstract
We have expanded upon previous methods to develop a flow cytometry-based method to efficiently clone monoclonal antibodies (mAbs) from humans with expansions of RF-like, immunoglobulin heavy chain variable region (IgVH) 1-69 gene segment-containing B cells. The cloned variable regions are expressed...
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PMID: 20875420
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We obtained new results, which led us to propose a novel model for the initiation of viral RNA (vRNA) replication. In our study, we analyzed the initiation mechanisms of influenza virus vRNA and complementary RNA (cRNA) synthesis in vitro, using purified RNA polymerase (RdRp) and 84-nt model RNA tem...
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PMID: 20858902
PDF is available here.
PDF is available here.
Abstract
Abstract
Chronic hepatitis C virus (HCV) infection is an important, global pathognomonic causal factor for development of liver cirrhosis and hepatocellular carcinoma. After parenteral transmission of the virus the majority of cases develop a chronic infection. Nowadays, the diagnosis of HCV-infection is mad...
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PMID: 21140330
PDF is available here.
PDF is available here.
Abstract
Despite recent success after the introduction of combination therapy with interferon (IFN)-α and ribavirin, approximately 60% of patients with hepatitis C virus (HCV) genotype 4 fail to respond. Resistance to antiviral therapy remains a serious problem in the management of chronic hepatitis C. In m...
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PMID: 20811275
PDF is available here.
PDF is available here.
Abstract
Influenza surveillance was implemented in Kolkata, eastern India in 2005 to identify the circulating subtypes and characterize their genetic diversity. Throat and nasal swabs were collected from outpatients with influenza-like illness (ILI). Of 2844 ILI cases identified at two referr...
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PMID: 20678590
PDF is available here.
PDF is available here.
Abstract
We report a single-molecule study that monitors the dynamics of individual initiation complexes, comprised of vRNA, tRNA and HIV reverse transcriptase (RT). RT transitions between two opposite binding orientations on tRNA-vRNA complexes, and the prominent pausing events are related to RT binding in...
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PMID: 21102446
PDF is available here.
PDF is available here.
Abstract
The role of nitric oxide (NO) in infectious diseases is gaining attention because of its antiviral effects. Aim: To evaluate whether serum and hepatic NO levels are predictors of the outcome of treatment in patients with chronic hepatitis C genotype 4.
Fifty six patie...
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PMID: 21188329
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)12 2010
Abstract
Few reports exist regarding the association between onychomadesis and an enterovirus infection presenting clinically as hand, foot, and mouth disease (HFMD). In February 2009, an outbreak of HFMD occurred in a Spanish nursery school, followed by onychomadesis 36-69 days later. Twelve of 17 children...
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PMID: 20854714
PDF is available here.
PDF is available here.
Clinical Nephrology (74)6 2010
Abstract
Our results showed various histological patterns of HCV-related kidney disease and the specificity of CG, and revealed that a minority of HCV patients (n = 7) presented typical CG, while IgAN, MN, and diabetic nephropathy were more frequent....
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PMID: 21084048
PDF is available here.
PDF is available here.
Virus/Uirusu (60)2 2010
Abstract
I discuss the pathogenesis by EBV and KSHV with special reference to recent progress in this field....
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PMID: 21488336
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We present a fully automated system with pseudo-multiplexing capability for rapid infectious disease diagnosis. The all-in-one system was comprised of a polymer cartridge, a miniaturized thermal cycler, 1-color, 3-chamber fluorescence detectors for real-time reverse transcription polymerase chain re...
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PMID: 20865195
PDF is available here.
PDF is available here.
Abstract
We show that a West Nile virus (WNV) mutant (E218A) that lacks 2'-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling. 2'-O methylation of viral RNA did not affect IFN induction in WNV-infected fibroblasts but in...
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PMID: 21085181
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We describe the isolation of the hTLR8 promoter and the characterization of the molecular mechanisms involved in its regulation. Reporter gene analysis and ChIP assays demonstrated that the hTLR8 regulation of the basal transcription is regulated via three C/EBP cis-acting elements that required C/E...
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PMID: 20829351
PDF is available here.
PDF is available here.
Abstract
These results demonstrate the potential utility of HDX to probe conformational and dynamical changes within non-covalently bound protein-ligand complexes which are of widespread importance in many biomolecular systems....
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PMID: 20877857
PDF is available here.
PDF is available here.
Abstract
We solved the crystal structure of a Rev dimer at 2.5-Å resolution. The dimer arrangement organizes arginine-rich helices at the ends of a V-shaped assembly to bind adjacent RNA sites and structurally couple dimerization and RNA recognition. A second protein-protein interface arranges higher-order...
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PMID: 20953181
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (16)11 2010
Abstract
Hepatitis C virus (HCV) infection is a major public health problem in the Middle East. A database of 400 patients with chronic HCV in Qatar was retrospectively analysed: 242 patients underwent antiviral treatment, of whom 212 (87.6%) were naïve to treatment. The response to treatment and the predic...
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PMID: 21218734
PDF is available here.
PDF is available here.
Abstract
We therefore aimed to determine the impact of chronic hepatitis C and its treatment on circulating lipids in a large European cohort of HCV genotype 1 patients.
The serum lipid profile of 575 HCV genotype 1-infected patients was characterized before, during and after treatment with pegylated interfe...
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PMID: 20729742
PDF is available here.
PDF is available here.
Abstract
Results of treatments for chronic hepatitis C virus are only estimated and disclosed from pivotal trials.
To report the 'true life' results of pegylated interferon and ribavirin in treatment-naive patients.
A prospective, multicenter observatory in 22 general hospitals.
Five-hundred and one patients...
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PMID: 20964260
PDF is available here.
PDF is available here.
Abstract
We aimed to identify risk factors for more pronounced anaemia and to evaluate endogenous erythropoietic response during antiviral therapy.
One hundred and forty-five naive chronic hepatitis C patients on pegylated-interferon-ribavirin treatment were evaluated for haemoglobin, haematocrit, serum riba...
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PMID: 20729740
PDF is available here.
PDF is available here.
Abstract
These results illustrate the great progress that has been made in the HCV field and how this knowledge can be used to devise innovative strategies to counteract this pathogen.
© Thieme Medical Publishers....
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PMID: 20960374
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
Tethered hydroxyl-radical probing has been used to determine the orientation of binding of polypyrimidine tract-binding protein (PTB) to the poliovirus type 1 (Mahoney) (PV-1(M)) internal ribosome entry site/segment (IRES)-the question of which RNA-binding domain (RBD) binds to which sites on the IR...
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PMID: 20859255
PDF is available here.
PDF is available here.
Abstract
Hepatitis C infection has evolved in the past quarter century from a newly recognized entity without a known pathogen (non-A, non-B hepatitis) to one of the world's most prevalent causes of liver disease, an important source for hepatocellular carcinoma, and the major indication for liver transplant...
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PMID: 20960375
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We describe a combined structural and functional analysis of genotype 1 HCV-NS5b of strains H77 (subtype 1a), for which no structure has been previously reported, and J4 (subtype 1b). Our results highlight the linker as directly involved in lifting the first boundary to processive RNA synthesis, the...
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PMID: 20729191
PDF is available here.
PDF is available here.
Abstract
These results suggest that the isolates are a novel IBV genotype in Japan (designated JP-IV)....
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PMID: 20460833
PDF is available here.
PDF is available here.
Abstract
Infectious myonecrosis virus (IMNV) has been causing a progressive disease in farm-reared shrimps in Brazil and Indonesia. Immunodiagnostic methods for IMNV detection, although reliable, are not employed currently because monoclonal antibodies (MAbs) against this virus are not available. In this stu...
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PMID: 20678523
PDF is available here.
PDF is available here.
Abstract
The control measures prescribed by the World Organization for Animal Health (OIE) for international trade in extended semen implicate repeated free testing of the donor's blood for bluetongue virus (BTV). The aim of this study was to validate a real-time RT-PCR for the direct testing of semen for ar...
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PMID: 20674609
PDF is available here.
PDF is available here.