Abstract
We take a personal look back on some past as well as some recent results....
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PMID: 21137677
PDF is available here.
Abstract
This experiment was preformed on an animal model of CCl4 hepatitis using 320 Wistar rats. The animals underwent combined effect of saprogel and a magnetic field during different seasons. It was shown that non-medicamentous treatment of experimental CCl4 hepatitis had the most pronounced beneficial e...
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PMID: 20364684
PDF is available here.
Abstract
We find that removal of the anionic C-terminal domain (CTD) of HTLV-1 NC results in a protein with chaperone properties comparable with that of other retroviral NCs. Increasing the ionic strength of the solution also improves the chaperone activity of full-length HTLV-1 NC. To determine how the CTD...
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PMID: 19887455
PDF is available here.
Abstract
These results provide further insight into the essential properties of the C2-L1Tc protein as a NAC....
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PMID: 19751212
PDF is available here.
Abstract
We have discussed briefly about mitochondrial DNA and related diseases, various barriers encountered in the delivery of DNA, internalization processes, delivery strategies and methods for targeted delivery of DNA to the mitochondria....
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PMID: 20021331
PDF is available here.
Abstract
Zinc plays many basic metabolic functions in human organism as a co-enzymatic or activator about 80 enzymes. It participates in metabolic changes of lipids, proteins and carbohydrates. Zinc easily binds with nucleic acids with beneficial effect on active transport, protein biosynthesis, transcriptio...
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PMID: 19999809
PDF is available here.
Abstract
The Food and Drug Administration (FDA) is announcing the classification of the respiratory viral panel multiplex nucleic acid assay into class II (special controls). The special controls that will apply to the device are three guidance documents entitled: "Class II Special Controls Guidance Document...
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PMID: 19877377
PDF is available here.
Abstract
These results suggest a new strategy for label-free nucleic acid-based biosensing applications....
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PMID: 19722507
PDF is available here.
Abstract
We provide an overview of these recent advances in the APOBEC field with a special emphasis on AID and APOBEC3G....
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PMID: 19911124
PDF is available here.
Abstract
About 25 years after the publication of the first report on gene transfer in vitro in cultured cells by the means of electric pulses delivery, reversible cell electroporation for gene transfer and gene therapy (DNA electrotransfer) is at a cross in its development. Present knowledge on the effects o...
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PMID: 19562526
PDF is available here.
Abstract
We will discuss the optical properties of pyrene excimer and summarize recent progresses on pyrene excimer signaling nucleic acid probes for the signaling of biomolecules and their interactions in complex biological samples....
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PMID: 20201423
PDF is available here.
Abstract
We aim to personalize and deliver cost-effective healthcare, we must consider the need to fully integrate genomics into decision-making. We must be able to accurately and cost effectively obtain a complete genome sequence for disease diagnosis, interrogate a molecular signature from blood for therap...
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PMID: 19817551
PDF is available here.
Abstract
We have explored the region around the splice sites of the human intron and exons from the exon-intron database (EID) and located a number of short 6-nucleotide and 7-nucleotide sequences that are relatively common in the regions. These short sequences, we expect play an important role in the select...
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PMID: 20027863
PDF is available here.
Abstract
We demonstrate that IMAC beads possess a strong adsorption of nucleic acids, especially single-stranded or single-stranded-region-containing nucleic acids, leading to approximately 50% loss of phosphopeptides during the process of IMAC enrichment. Therefore, nucleic acids must be removed from protei...
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PMID: 19412670
PDF is available here.
Abstract
We have recently identified deoxyribonuclease I (DNase I) and endonuclease G (EndoG) as the major degradative enzymes in the mouse kidney proximal tubule epithelial (TKPTS) cells. In this study, we used immortalized mouse TKPTS cells and primary tubular epithelial cells isolated from DNase I or Endo...
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PMID: 19558214
PDF is available here.
Abstract
We obtain good agreement between experiment and the Boltzmann weighted theoretical photoemission spectra, which allows a quantitative determination of the ratio of oxo to hydroxy tautomer populations. For the photoabsorption spectra, good agreement is found for the C 1s and O 1s spectra but only fai...
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PMID: 19634878
PDF is available here.
Abstract
Twenty hydrogen-bonded complexes composed of nucleic acid base and amino acid side chain have been analyzed using ab initio quantum chemistry methods with the aim of gaining insights into the nature of molecular interactions in these systems. The intermolecular interaction energies were estimated us...
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PMID: 19637846
PDF is available here.
Abstract
Threshold collision-induced dissociation techniques are employed to determine the activation energies (AEs) and bond dissociation energies (BDEs) of metal cation-triethyl phosphate complexes, M(+)(TEP), where M(+) = Mg(+), Al(+), Cu(+), and Zn(+). Activated dissociation resulting in loss of ethene,...
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PMID: 19618931
PDF is available here.
Abstract
We describe various heterologous nucleic acid tethering systems that can be used to examine transcription factors that function via P-TEFb....
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PMID: 19398004
PDF is available here.
Abstract
We have used a cross-linking polymer to overcome this problem. Pendant thiol moieties have been incorporated into a PAA (polyamidoamine) homopolymer and a PEG [poly(ethylene glycol)]-PAA-PEG copolymer reported previously as a self-assembling system. When mixed with DNA, small monodisperse sterically...
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PMID: 19614581
PDF is available here.
Abstract
Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specif...
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PMID: 19627190
PDF is available here.
Abstract
We have demonstrated great potential for virus capture and inactivation via continual ion and reactive species bombardment when conditions in the ESP are enforced to generate a corona discharge....
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PMID: 19731701
PDF is available here.
Abstract
We examine restraints on sequence, which arise from selectively advantageous roles for structure and function and which lead to the conservation of local sequences and structures in families and superfamilies. We analyse structurally aligned members of protein families and superfamilies in order to...
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PMID: 19614584
PDF is available here.