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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Oligonucleotides (7):
Recent article
Oligonucleotides
Abstract
We present six design rules that can be used to deliberately prepare nine distinct colloidal crystal structures, with control over lattice parameters on the 25- to 150-nanometer length scale. These design rules outline a strategy to independently adjust each of the relevant crystallographic paramete...
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PMID: 21998382
PDF is available here.
PDF is available here.
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Brain research (1411) 2011
Abstract
We show MMP-9 overexpression conferred a poor prognosis in 163 GBM patients. Furthermore, MMP-9 specific miRNA expression profile (14 positively and 31 negatively correlated miRNAs with MMP-9) was established via miRNA microarrays in 60 GBM samples. Among them, two miRNAs: miR-885-5p and miR-491-5p,...
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PMID: 21831363
PDF is available here.
PDF is available here.
Abstract
We describe the potential of estimating melting temperature (T(m)) for nonstandard oligonucleotides by using the correlation of the experimental T(m) with the calculated duplex binding energy (BE) for oligonucleotides of a given length. This method has been automated into a standardized molecular dy...
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PMID: 21702481
PDF is available here.
PDF is available here.
Current Biology (21)5 2011
Abstract
We carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulation of a target that is not subject to Ago2-mediated catalytic cleavage. By quantitating the number of molecules of the miRNA and its target in steady state and in the course of its decay,...
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PMID: 21353554
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)5 2011
Abstract
The re-biopsy of lung cancer patients with acquired resistance is feasible and provides sufficient material for mutation analysis in most patients. Using high sensitivity methods, the T790M is detected in up to 68% of these patients....
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PMID: 21248300
PDF is available here.
PDF is available here.
Bioengineered Bugs (2)3 2011
Abstract
Close to 90% of human genes are transcribed into pre-mRNA that undergoes alternative splicing, producing multiple mRNAs and proteins from single genes. This process is largely responsible for human proteome diversity, and about half of genetic disease-causing mutations affect splicin...
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PMID: 21637003
PDF is available here.
PDF is available here.
Oligonucleotides (21)2 2011
Abstract
We focused on the function of special AT-rich sequence binding protein 1 (SATB1) as a target molecule for the treatment of TN breast cancers. By recruiting chromatin remodeling enzymes and transcriptional factors, SATB1 regulates the expression of >1,000 genes related to cell growth and translocatio...
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PMID: 21500976
PDF is available here.
PDF is available here.
Oligonucleotides (21)2 2011
Abstract
Oligonucleotide- and polynucleotide-based gene modification strategies were developed as an alternative to transgene-based and classical gene targeting-based gene therapy approaches for treatment of genetic disorders. Unlike the transgene-based strategies, oligo/polynucleotide gene t...
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PMID: 21417933
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)53 2010
Abstract
These results suggest an alternative pathway in which Pif1 removes Okazaki fragments initiated by fold-back flaps in vivo....
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PMID: 20959454
PDF is available here.
PDF is available here.
Abstract
The conformations of the benzo[a]pyrene-7,8-quinone (BPQ) modified oligonucleotide were investigated using molecular dynamic simulation. In the initial structures, the central guanine base was modified with BPQ resulting in the formation of four structurally distinguishable 10-(N2-deoxyguanosyl)-9,1...
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PMID: 20919757
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2 (ALK2) receptor-dependent mechanism. In lesions from individuals with fibrodysplasia ossificans progressiva (FOP), a disease in which heterotopic ossification occurs as a result of acti...
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PMID: 21102460
PDF is available here.
PDF is available here.
Abstract
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
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PMID: 20862439
PDF is available here.
PDF is available here.
Abstract
We report an efficient synthesis of LNA thymine and LNA 5-methylcytosine 5'-phosphoramidites, allowing incorporation of LNA thymine and LNA 5-methylcytosine into oligonucleotides synthesized in the 5'→3' direction. Key steps include regioselective enzymatic benzoylation of the 5'-hydroxy group of...
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PMID: 20820663
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
Photo-induced artificial RNA editing was demonstrated using photo-reactive oligonucleotides containing 3-cyanovinylcarbazole nucleoside. This non-enzymatic and sequence-specific methodology will make a major contribution to the elucidation of RNA functions including non-coding RNAs and to the develo...
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PMID: 20848024
PDF is available here.
PDF is available here.
Nature Nanotechnology (5)11 2010
Abstract
We report using reconfigurable nucleic acid catalyst-based units to build a multipurpose reprogrammable molecular automaton that goes beyond single-purpose 'hard-wired' molecular automata. The automaton covers all possible responses to two consecutive sets of four inputs (such as four first and four...
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PMID: 20972436
PDF is available here.
PDF is available here.
Abstract
An efficient enzymatic synthesis of 6-chloropurine-2'-deoxyriboside from the reaction of 6-chloropurine with 2'-deoxycytidine catalyzed by nucleoside-2'-deoxyribosyltransferase (E.C. 2.4.2.6) followed by chemical conversion into the 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropyl...
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PMID: 21128170
PDF is available here.
PDF is available here.
Oligonucleotides (20)5 2010
Abstract
A forced degradation study of a proprietary short interfering RNA (siRNA) molecule most of whose constituent nucleotides have been modified at the 2' position was conducted to assess degradation pathways and stability liabilities. The siRNA was subjected to various conditions as a so...
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PMID: 20977375
PDF is available here.
PDF is available here.
Abstract
Liposomes applications in health care include meanly their ability to carry drugs and genes inside the human body for therapeutic purposes. Nevertheless their applicability can extend far beyond and could be used as analytical tools in order to perform rapid, low-cost, sensitive and...
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PMID: 21133073
PDF is available here.
PDF is available here.
Abstract
This review deals with 2-azapurine (imidazo[4,5-d] [1,2,3]triazine) nucleosides and closely related analogs. Different routes are described to yield the desired target compounds, including a sequence of ring-opening and ring-closure reactions performed on purine nucleosides or dire...
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PMID: 20860023
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
The first nucleic acid-directed catalytic photochemical reaction that is induced by nontoxic red light was developed. This reaction is fast, high yielding, sequence specific, and enables one to functionalize an oligonucleotide.
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PMID: 20574574
PDF is available here.
PDF is available here.
Abstract
PRO-051 (GSK-2402968), being developed by GlaxoSmithKline plc, under license from Leiden University Medical Center and Prosensa Therapeutics BV, is a 2'-O-methyl phosphorothioate antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy (DMD). The PRO-051 oligonucleotide s...
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PMID: 20677099
PDF is available here.
PDF is available here.
Abstract
I enzyme, with fish sperm double stranded deoxyribonucleic acid (dsDNA) and synthetic short oligonucleotides were studied electrochemically based on the oxidation signals of guanine and CPT-11 by using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) at pencil graphite electrode (PGE...
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PMID: 20426745
PDF is available here.
PDF is available here.
Abstract
We report that this hydrogen bonding pattern can be replaced by metal-ligation between specific metal ions and the natural bases. To demonstrate the feasibility of this principle, two linear oligonucleotides and silver ions were examined as models for DNA hybridization assay and adenosine triphospha...
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PMID: 20597497
PDF is available here.
PDF is available here.
Cancer Research (70)14 2010
Abstract
We describe the development of a therapeutic formulation using chemically synthesized miR-34a and a lipid-based delivery vehicle that blocks tumor growth in mouse models of non-small-cell lung cancer. This formulation is effective when administered locally or systemically. The antioncogenic effects...
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PMID: 20570894
PDF is available here.
PDF is available here.
Abstract
We have generated an allele of Noxa1 suitable for conditional inactivation. Moreover, by crossing Noxa1 conditional allele carriers to B6.129S4-Meox2(tm1(Cre)Sor)/J mice, we have generated first, Noxa1-null heterozygotes, and ultimately, Noxa1-null homozygotes. Through the thoughtful use of tissue-s...
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PMID: 20645308
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)7 2010
Abstract
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that has been identified as a marker of cancer-initiating cells. EpCAM is highly expressed on most carcinomas, and transient silencing of EpCAM expression leads to reduced oncogenic potential. To silence the EpCAM gene in a per...
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PMID: 20593890
PDF is available here.
PDF is available here.
Abstract
We characterized the zebrafish ortholog nphp3 by morpholino oligo (MO)-mediated knockdown. When nphp3 function was suppressed by either of the two MOs blocking the translation of the protein or the splicing of mRNA, zebrafish embryos displayed hydrocephalus and pronephric cysts. Knockdown of nphp3 a...
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PMID: 20462968
PDF is available here.
PDF is available here.
Abstract
We report a rare case of oligo-secretory myeloma coexistent with ankylosing spondylitis....
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PMID: 19582458
PDF is available here.
PDF is available here.
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Abstract
We validated a procedure for precise quantification of the JAK2V617F allele burden. We used DNA samples from patients suspected to suffer from MPN and dilutions of HEL cells, carrying the mutation, to compare the LNA-qPCR assay to two previously published methods. All assays detected the same 36 JAK...
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PMID: 20431031
PDF is available here.
PDF is available here.
Abstract
The left-handed Z-DNA form of the short unmodified alternating guanine-cytosine oligonucleotides, 5'-(dGdC)(24) and 5'-(dGdC)(18), was selectively detected under physiological ionic strength and pH conditions using the anionic nickel(II) porphyrin, NiTPPS. No spectroscopic signal was observed for Ni...
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PMID: 20510880
PDF is available here.
PDF is available here.
Abstract
We describe examples of influenza A virus-derived small viral RNAs (svRNAs). svRNAs are 22-27 nt in length and correspond to the 5' end of each of the viral genomic RNA (vRNA) segments. Expression of svRNA correlates with the accumulation of vRNA and a bias in RNA-dependent RNA polymerase (RdRp) act...
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PMID: 20534471
PDF is available here.
PDF is available here.
Abstract
We evaluated the in vitro transdermal delivery of fluorescein isothiocyanate (FITC)-NF-kappaB decoy ODN using a pulse depolarization (PDP) iontophoresis. In vitro iontophoretic experiments were performed on isolated C57BL/6 mice skin using a horizontal diffusion cell. The apparent flux values of FIT...
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PMID: 20417264
PDF is available here.
PDF is available here.
Abstract
We propose inhalation local delivery of anticancer drugs in combination with suppressors of pump and nonpump cellular resistance. To test this approach, nanoscale-based delivery systems containing doxorubicin as a cell death inducer, antisense oligonucleotides targeted to MRP1 mRNA as a suppressor o...
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PMID: 20498076
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigate a proposed origins of life scenario involving the clay montmorillonite and its catalytic role in forming oligonucleotides from activated mononucleotides. Clay and mineral surfaces are important for concentrating the reactants and for promoting nucleotide polymerization reactions. Usin...
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PMID: 20213159
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We have examined the ability of several commonly used DNA methylation profiling methods to distinguish between 5mC and 5hmC. We show that techniques based on sodium bisulfite treatment of DNA are incapable of distinguishing between the two modified bases. In contrast, techniques based on immunopreci...
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PMID: 20371518
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We find that the sms formation rate varies as the oligonucleotide concentration and increases at high temperature. Competitively with the tetramer involved in sms elongation, C(n)XC(m) oligonucleotides form i-motif dimers that compete with sms elongation. The dimer stability is strongly reduced when...
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PMID: 20185569
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We investigated how the D1 domain and two peptides encompassing the D1 basic clusters chaperoned the annealing of complementary canonical nucleic acids that correspond to the DNA sequences of the HIV-1 transactivation response element TAR and its complementary cTAR. The core peptides were found to a...
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PMID: 20167640
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
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PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
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PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
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PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We propose a set of statistical quality metrics analogous to those in expression microarrays with application to tiling array data. We also develop a method to estimate the significance level of an observed quality measurement using randomization tests. These methods have been applied to multiple re...
|
PMID: 19645697
PDF is available here.
PDF is available here.