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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Metabolic Diseases (17):
- Lipid Metabolism Disorders
- Acid-Base Imbalance
- Glucose Metabolism Disorders
- Brain Diseases, Metabolic
- Metabolism, Inborn Errors
- DNA Repair-Deficiency Disorders
- Amyloidosis
- Porphyrias
- Wasting Syndrome
- Skin Diseases, Metabolic
- Metabolic Syndrome X
- Iron Metabolism Disorders
- Calcium Metabolism Disorders
- Phosphorus Metabolism Disorders
- Malabsorption Syndromes
- Water-Electrolyte Imbalance
- Mitochondrial Diseases
Recent article
Metabolic Diseases
Chemmedchem (6)6 2011
Abstract
We report the design and discovery of a novel APJ antagonist. By using a bivalent ligand approach, we have designed compounds with two 'affinity' motifs and a short series of linker groups with different conformational and non-bonded interaction properties. One of these, cyclo(1-6)CRPRLC-KH-cyclo(9-...
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PMID: 21560248
PDF is available here.
PDF is available here.
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New England Journal of Medicine (364)23 2011
Abstract
Abstract
Research efforts spanning the past two decades have established a clear link between nuclear receptor function, regulation of the circadian clock and lipid homeostasis. As such, this family of receptors represents an important area of research. Recent advances in the field have ident...
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PMID: 21526899
PDF is available here.
PDF is available here.
Birth Defects Research (93)1 2011
Abstract
Considerable epidemiological, experimental and clinical data have amassed showing that the risk of developing disease in later life is dependent on early life conditions, mainly operating within the normative range of developmental exposures. This relationship reflects plastic respon...
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PMID: 21425438
PDF is available here.
PDF is available here.
Abstract
We developed a model to examine cardiometabolic plasticity (i.e., changes in Si and plasma lipids) in MA compared to NHW adults in response to a diet-exercise intervention.
Sedentary subjects (20 NHW: 11F, 9M, 23.0 y, 25.5 kg/m(2); 17 MA: 13F, 4M, 22.7 y, 25.4 kg/m(2)) consumed their...
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PMID: 21364957
PDF is available here.
PDF is available here.
Abstract
Metabolic syndrome (MetS), cardiovascular diseases (CVD) and cancers such as colon cancer (CCa), prostate cancer (PCa) and breast cancer (BCa) have been recognized as obesity-initiated diseases. The development of obesity can cause changes in metabolic and hormonal conditions, which...
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PMID: 21392470
PDF is available here.
PDF is available here.
Clinical Nephrology (75)1 2011
Abstract
Adiponectin is a protein secreted by adipose tissue. Unlike other adipocytokines produced by adipose tissue, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Although secreted solely by adipose tissue, plasma levels of adiponectin are generally negativel...
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PMID: 21176748
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)47 2010
Abstract
We present a case with a ten-year-old girl with trimethylaminuria (TMAU). Primary TMAU is caused by a deficiency of flavin monooxygenase 3 (FMO3) due to mutations in the FMO3-gene. Patients suffering from TMAU show an impaired enzymatic oxidation of fish-smelling trimethylamine, and their excretion...
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PMID: 21092725
PDF is available here.
PDF is available here.
Abstract
To identify the association between medical or psychiatric comorbidities, clinical characteristics, or course of illness/recovery in pediatric bipolar disorder (BD).
Data from the South Carolina Medicaid program covering all medical services and medication prescriptions between January 1996 and Dece...
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PMID: 20584522
PDF is available here.
PDF is available here.
Abstract
Abstract
Intestinal epithelium, mucosal immune system, and bacterial flora represent a morpho-functional system on dynamic balance responsible for the intestinal metabolic and trophic functions, and the regulation of mucosal and systemic host's immunity. Obesity is a pathological condition af...
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PMID: 20865475
PDF is available here.
PDF is available here.
Abstract
I 0-30/Delta G 0-30 and Delta I 0-180/Delta G 0-180), insulin sensitivity [Matsuda index, homeostasis model assessment of insulin resistance (HOMA-IR)], and disposition index (Delta 0-30/Delta 0-30 G ÷ HOMA-I), markers of increased risk of T2DM. In addition, those with ≥ 155 mg/dL were older, m...
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PMID: 20854093
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
We provide an overview of the alterations on energetic metabolism occurring in AD. First, we resume the evidences that link the 'metabolic syndrome' with increased risk for developing AD and revisit the major changes occurring on both extra-mitochondrial and mitochondrial metabolic pathways, as reve...
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PMID: 20840064
PDF is available here.
PDF is available here.
Abstract
Abstract
Most second-generation antipsychotics (SGAs) induce metabolic disturbances, but large differences exist in the degree to which individual patients develop these. Little is known about genetic factors associated with differential liability. Cross-sectional studies suggested an association between pol...
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PMID: 20523222
PDF is available here.
PDF is available here.
Abstract
We investigated the potential utility of combination therapy with vildagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor and nateglinide, a rapid-onset/short-duration insulinotropic agent, for the treatment of postprandial metabolic derangements in Zucker Fatty (ZF) rats, an animal model of obes...
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PMID: 20625970
PDF is available here.
PDF is available here.
Circulation Journal (74)8 2010
Abstract
The present study was designed to examine whether serum uric acid (SUA) levels were associated with cardiometabolic risk factors and to determine optimal cut-offs for SUA to identify multiple risk factors among Japanese junior high school students.
A total of 958 students (518 boys and 440 girls, ag...
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PMID: 20534946
PDF is available here.
PDF is available here.
Bulletin du cancer (97)8 2010
Abstract
We propose here some guidelines that might be of help in daily practice, in order to manage properly these side effects....
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PMID: 20529767
PDF is available here.
PDF is available here.
Abstract
Abstract
We have described how an understanding of patterns of disease may be used to develop new strategies for reducing the prevalence and risk of major immune-based illnesses and diseases influenced by environmental stimuli.
Examples of recently defined patterns of diseases that begin in childhood include...
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PMID: 20483701
PDF is available here.
PDF is available here.
Abstract
Human Mutation (31)7 2010
Abstract
We report a resequencing array that allows the simultaneous resequencing of up to 92 genes associated with IMDs. To validate the array, DNA samples from 51 patients with 52 different known variants (including point variants, small insertion, and deletions [indels]) in seven genes (C14ORF133, GAA, NP...
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PMID: 20578233
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: The purpose of this review is to describe the epidemiologic, etiopathogenetic, clinical, and imaging characteristics of various nonalcoholic, nonbiliary pancreatitis syndromes. CONCLUSION: The spectrum of nonalcoholic, nonbiliary pancreatitis includes autoimmune pancreatitis, groove pancr...
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PMID: 20566798
PDF is available here.
PDF is available here.
Pediatric Annals (39)7 2010
Abstract
Abstract
We examined the relationship between capacity of IFN-alpha production and metabolic parameters including fasting plasma glucose (FPG), lipids, uric acid, body mass index (BMI), and blood pressure in 575 healthy subjects. Linear regression analysis showed that log(IFN-alpha production) was positively...
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PMID: 20235627
PDF is available here.
PDF is available here.
Neurobiology of Aging (31)6 2010
Abstract
We examined the relationship between the ACE Insertion Deletion (ACE ID) variant and dementia with consideration for metabolic phenotypes, age and APOEepsilon4 using a population-based, cross-sectional sample of 891 Swedish women and men aged 70-92 years, of whom 61 people were demented. The odds of...
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PMID: 18838196
PDF is available here.
PDF is available here.
Abstract
In the sample of 199 patients, multiple logistic regression showed that WBC (log transformed) strongly predicted the condition of metabolic syndrome after potential confounding variables including age, gender, race, age of illness onset, family history of diabetes, smoking status and antipsychotic a...
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PMID: 20189773
PDF is available here.
PDF is available here.
Abstract
Topiramate could prevent olanzapine induced weight gain and adverse metabolic effects. It also results in a greater clinical improvement when used with olanzapine in schizophrenia.
Copyright (c) 2010 Elsevier B.V. All rights reserved....
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PMID: 20207521
PDF is available here.
PDF is available here.
Abstract
We review the clinical data of MIF and discuss its potential as a biomarker for different disease applications....
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PMID: 20520854
PDF is available here.
PDF is available here.
Clinica Chimica Acta (411)9-10 2010
Abstract
The use of underivatized techniques may also result in the inability to differentiate isobaric acylcarnitines. Laboratories should establish their own protocols by focusing on the decisions that identify test results requiring additional follow-up testing versus those that do not.
Published by Elsev...
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PMID: 20122909
PDF is available here.
PDF is available here.
Neuropharmacology (58)6 2010
Abstract
Over the last decade, the potential for therapeutic use of stem cell transplantation for cell replacement or as cellular vectors for gene delivery for neurometabolic and neurodegenerative diseases has received a great deal of interest. There has been substantial progress in our understanding of stem...
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PMID: 20036262
PDF is available here.
PDF is available here.
Abstract
Bariatric surgery is the most durable intervention for severe obesity. Appropriate candidates for surgery include those with a body mass index over 40 kg/m(2), or those with a BMI over 35 kg/m(2) who also have weight-related comorbidities. Bariatric procedures are categorized as restrictive, where f...
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PMID: 20350267
PDF is available here.
PDF is available here.
Abstract
Humans and other mammals have three main adipose tissue depots: visceral white adipose tissue, subcutaneous white adipose tissue and brown adipose tissue, each of which possesses unique cell-autonomous properties. In contrast to visceral adipose tissue, which can induce detrimental m...
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PMID: 20195269
PDF is available here.
PDF is available here.
Abstract
We performed a Medline/Pubmed search to find published studies on the role of SHP in the regulation of metabolism in the liver, pancreatic islets, blood vessel, and kidney and on the feasibility of using SHP as a therapeutic target in metabolic disease. WHAT THE READER WILL GAIN: In this review, we...
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PMID: 20230197
PDF is available here.
PDF is available here.
Abstract
Traditional risk factors for CVD are prevalent in this setting leading to intermediate 10-year risk of CVD. Modification of these risk factors through education and intervention programs are needed to reduce CVD....
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PMID: 20563442
PDF is available here.
PDF is available here.
Abstract
We report the clinical, myopathological and MRI findings in the first German patient suffering from a myosin storage myopathy due to a heterozygous R 1845W missense mutation....
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PMID: 20376763
PDF is available here.
PDF is available here.
Abstract
In 2009 lung transplantation is a valuable therapeutic option for a number of patients suffering from end-stage pulmonary diseases. Lung transplantation frequently offers a major improvement in quality of life; however, long-term survival is often limited by the development of the bronchiolitis obli...
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PMID: 20403546
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the impacts of HFD on obesity, metabolic and stress hormones, learning performance, and hippocampal synaptic plasticity. Both male and female C57BL/6J mice fed with HFD (3 weeks to 9-12 months) gained significantly more weights than the sex-specific control groups. Compared with the...
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PMID: 19730425
PDF is available here.
PDF is available here.
Abstract
We retrospectively reviewed charts of 54 children with metabolic disorders evaluated from 1989-2005 for presenting symptoms, transplantation timing and indications, survival, metabolic parameters, growth, and development. Thirty-three patients underwent liver transplantation (12 received combined li...
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PMID: 19671092
PDF is available here.
PDF is available here.
Collegium Antropologicum (34)1 2010
Abstract
Chronic inflammation has arised as a major underlying cause of atherosclerosis, obesity and diabetes. It is mediated by cells of innate immune system like macrophages but also by their antecedents, circulating monocytes. Roles of monocyte subsets and different markers of monocyte activation in the c...
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PMID: 20432766
PDF is available here.
PDF is available here.
Abstract
We examine studies on food and nutrition among shift workers [ie, dietary assessment (designs, methods, variables) and the factors that might influence eating habits and metabolic parameters]. The discussion focuses on the quality of existing dietary assessment data, nutritional status parameters (p...
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PMID: 20143038
PDF is available here.
PDF is available here.
Abstract
Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: increased energy harvesting from the diet, regulation of appetite through gut peptide, secretion, regulation of tissue-free fatty acid composition and uptake, storage and oxidation, modulation of in...
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PMID: 19915460
PDF is available here.
PDF is available here.
Abstract
Abstract
We review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders....
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PMID: 20166967
PDF is available here.
PDF is available here.
Abstract
The present paper introduces the clinical practice of professor Lü Da-gu on treatment of hyper lipemia, fatty liver, obesity, metabolic syndrome and other chronic metabolic diseases by using "the method of coordinating spleen and stomach". This needling method has a strong effectiveness of regulati...
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PMID: 20214074
PDF is available here.
PDF is available here.
Abstract
Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation.
Abstract
Identifying persons at risk for sudden cardiac death (SCD) is challenging. A comprehensive evaluation may reveal clues about the clinical, anatomical, genetic, and metabolic risk factors for SCD.
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PMID: 20102864
PDF is available here.
PDF is available here.
Abstract
We discuss various miRNAs that are differentially expressed in human chronic inflammatory diseases, neurodegenerative diseases, cancer and the further prospective development of miRNA based diagnostics and therapeutics....
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PMID: 20515844
PDF is available here.
PDF is available here.
Abstract
We describe a rapid HPLC/MS/MS method for these measurements using a normal phase HILIC column after analyte derivatization....
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PMID: 20077070
PDF is available here.
PDF is available here.
Journal of Reproduction and Development (56 Suppl) 2010
Abstract
This paper reviews the importance of energy metabolism in transition dairy cows, its associations with disease and reproduction, and strategies for monitoring cows under field conditions during this critical time. Essentially all dairy cattle experience a period of insulin resistance, reduced feed i...
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PMID: 20629214
PDF is available here.
PDF is available here.
Abstract
The surfaces of lipid droplets (LDs) constitute major sites of regulated accumulation and degradation of lipid in cells, and hence play important roles in lipid homeostasis of the whole body. CGI-58 (also called alpha/beta hydrolase domain-containing protein 5 (ABHD5)) is a member of the alpha/beta-...
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PMID: 20190389
PDF is available here.
PDF is available here.
Clinical Therapeutics (32 Suppl 1) 2010
Abstract
The available evidence supports the efficacy and tolerability of aripiprazole in the maintenance treatment of bipolar disorder. The placebo-subtracted differences in body composition and metabolic parameters suggest utility for aripiprazole in the long-term treatment of bipolar disorder.
2010 Excerp...
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PMID: 20152551
PDF is available here.
PDF is available here.
Abstract
A large body of epidemiological data suggests that adverse early environments, including obesity during pregnancy or early postnatal life, are linked to an elevated prevalence of metabolic disease in adult offspring. The mechanisms underlying these effects are still poorly understood...
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PMID: 20139672
PDF is available here.
PDF is available here.
Abstract
There is a complex interplay between sleep, metabolism and the function of the endocrine system. A number of endocrine systems are modulated by either the homeostatic drive to sleep, or by the function of the circadian system. As a result, changes in sleep duration and quality have reciprocal effect...
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PMID: 20526243
PDF is available here.
PDF is available here.
Abstract
We review the effects of oxidative stress on intracellular Ca²+ homeostasis and the role of antioxidants in the prevention and treatment of disorders associated to abnormal Ca²+ mobilization induced by ROS....
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PMID: 20953160
PDF is available here.
PDF is available here.
Hypertension (55)1 2010
Abstract
We assessed adverse metabolic effects of atenolol and hydrochlorothiazide among hypertensive patients with and without abdominal obesity using data from a randomized, open-label study of hypertensive patients without evidence of cardiovascular disease or diabetes mellitus. Intervention included rand...
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PMID: 19917874
PDF is available here.
PDF is available here.
Lakartidningen (107)36 2010
Abstract
Lakartidningen (107)36 2010
Abstract
Klinicheskaia meditsina (88)2 2010
Abstract
Combination of arterial hypertension (AH) and metabolic disorders accelerates development of organic lesions in target organs. As shown in recent prospective studies, myocardial hypertrophy rate closely correlated with severity of metabolic disturbance. The thickness of interventricular septum and p...
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PMID: 21105463
PDF is available here.
PDF is available here.