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Aldehydes (11):
Recent article
Aldehydes
Organic Letters (13)6 2011
Abstract
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5' has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorpo...
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PMID: 21338077
PDF is available here.
PDF is available here.
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Abstract
Abstract
We developed a sensitive and automated method to simultaneously analyze eight T&O compounds (boiling points ranging from 38°C to 239°C) by using Purge-and-Trap (P&T) coupled with GC/MS. Maximum particulate dimethyl trisulfide (DMTS, 69.6 ng/L) exceeded its odor threshold concentrations (OTC, 10 ng...
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PMID: 21056900
PDF is available here.
PDF is available here.
Abstract
An unexpected discovery of new trans-4-acetyl-1,9-dimethyl-4,4a-dihydro-3H-fluoren-3-ones from one pot reactions of benzaldehydes and acetylacetone is described. The synthetic mechanism and stereochemistry were discussed. These new derivatives exhibit good fluorescent properties in solutions.
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PMID: 20820667
PDF is available here.
PDF is available here.
Abstract
epi-Jasmonic acid (epi-JA) and tuberonic acid (TA) were synthesized from the key aldehyde, all cis-2-(2-hydroxy-5-vinylcyclopentyl)acetaldehyde (14), which was in turn prepared stereoselectively from the (1R)-acetate of 4-cyclopentene-1,3-diol (10) through S(N)2-type allylic substitution with CH(2)[...
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PMID: 20844792
PDF is available here.
PDF is available here.
Abstract
We oxidized n-pentanal, n-octanal, n-undecanal and n-tridecanal with OH radicals at high NO(x). The C(n-1) aldehyde molar yields after the peroxyl radical + NO reaction were 69 ± 15, 36 ± 10, 16 ± 5 and 4 ± 1%, respectively. Complementary structure-activity relationship calculations of important...
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PMID: 20856967
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
A diastereoselective Henry reaction of chiral aldehydes with nitroalkanes was developed using a chiral sulfonyldiamine (L1)-CuCl complex. The reaction of (R)-2-phenylpropanal and nitromethane was smoothly catalyzed by the (S,S,S)-L1-CuCl complex to give the adduct with 99/1 syn/anti selectivity in 9...
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PMID: 20862429
PDF is available here.
PDF is available here.
Abstract
A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(II) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction...
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PMID: 20734011
PDF is available here.
PDF is available here.
Abstract
A new fluorescent probe (5-[(4-diethylamino-2-hydroxy-benzylidene)-amino]-1H-pyrimidine-2, 4-dione) (Receptor 1) has been synthesized by the Schiff base condensation of 5-aminouracil with 4-(diethylamino)salicylaldehyde. The receptor 1 exhibits high selectively for Al(3+) in DMSO as well as in aqueo...
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PMID: 20820652
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that 4-HHE induces the antioxidative enzyme heme oxygenase-1 (HO-1) through activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulatory transcriptional factor, and prevents oxidative stress-induced cytotoxicity in vascular endothelial cells. This me...
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PMID: 20920477
PDF is available here.
PDF is available here.
Biodegradation (21)6 2010
Abstract
These results demonstrate that indigenous Fe(III)-reducing microorganisms in RDX-contaminated environments utilize extracellular electron shuttles to enhance RDX mineralization. Electron shuttle-mediated RDX mineralization may become an effective in situ option for contaminated environments....
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PMID: 20424887
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.
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PMID: 20835425
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
A highly efficient organocatalytic sequential reaction involving Michael addition of bis(phenylsulfonyl)ethylene, in situ condensation and intramolecular nitrone [3+2] cycloaddition with a variety of aldehydes and hydroxyamines to afford a single diastereomer of indanes with four stereogenic centers...
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PMID: 20838691
PDF is available here.
PDF is available here.
Current Eye Research (35)11 2010
Abstract
Our results clearly showed that NAC inhibited indicators of oxidative stress and the activation of NF-κB induced by laser injury, and, consequently, suppressed macrophage and neutrophil infiltration and the development of CNV. This suggests novel preventative and interventional therapeutic strategi...
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PMID: 20958190
PDF is available here.
PDF is available here.
Abstract
A new, heterogeneous, 4 A molecular sieve-supported copper(ii) catalyst was developed and was used successfully in the A(3) coupling of alkynes, aldehydes and amines under simple reaction conditions.
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PMID: 20740243
PDF is available here.
PDF is available here.
Abstract
Condensation of an aldehyde with an α-amino-ester, followed by a tandem process involving cyclization to a seven-membered ring, deprotonation to an intermediate azomethine ylide and intramolecular dipolar cycloaddition gave tricyclic products related to stenine and neostenine.
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PMID: 20737084
PDF is available here.
PDF is available here.
Abstract
The first highly efficient Michael addition of challenging α,α-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon centers in high yields (up to 99%) with excellen...
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PMID: 20730207
PDF is available here.
PDF is available here.
Abstract
The current syntheses of imines from benzylamines are often performed in organic solvents or under harsh reaction conditions. Clean oxidation of primary benzylamines to imines has been successfully achieved using H(2)O(2) in water at room temperature catalyzed by V(2)O(5). Among the 10 imine product...
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PMID: 20714661
PDF is available here.
PDF is available here.
Abstract
We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and h...
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PMID: 20625608
PDF is available here.
PDF is available here.
Abstract
We review recent developments and applications of aldolase-type organocatalytic direct transformations in aqueous media without addition of organic solvent.
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PMID: 20617260
PDF is available here.
PDF is available here.
Abstract
Benzoyl radicals are generated directly from (hetero)aromatic aldehydes upon tetrabutylammonium decatungstate ((n-Bu(4)N)(4)W(10)O(32)), TBADT) photocatalysis under mild conditions. In the presence of alpha,beta-unsaturated esters, ketones and nitriles radical conjugate addition ensues and gives the...
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PMID: 20661511
PDF is available here.
PDF is available here.
Chemical Communications (46)34 2010
Abstract
Selective oxidation of alcohol in water using molecular oxygen as the terminal oxidant is mediated by rhodium porphyrin complexes. Addition of methanol to an aqueous solution of (TSPP)Rh(III) resulted in observation of the key intermediate porphyrin rhodium(III) methoxide species. The activation par...
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PMID: 20714542
PDF is available here.
PDF is available here.
Chemical Communications (46)34 2010
Abstract
A highly efficient silver triflate and N-heterocyclic carbene co-catalyzed three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, methanol with alpha,beta-unsaturated aldehyde is described, which gives rise to the 2-amino-1,2-dihydroisoquinolines in good yield.
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PMID: 20697636
PDF is available here.
PDF is available here.
Abstract
Abstract
Twenty new Schiff bases were synthesized by reacting 5-fluoro-salicylaldehyde and primary amine as potent inhibitors of FabH. These compounds were assayed for antibacterial activity against Escherichia coli, Pseudomonas fluorescence, Bacillus subtilis and Staphylococcus aureus. Compounds with potent...
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PMID: 20557983
PDF is available here.
PDF is available here.
Abstract
We hypothesized that abnormal redox control may lead to impaired cytokine production by keratinocytes, thus causing noncytotoxic defects in melanocyte proliferation and melanogenesis. We found significantly suppressed mRNA and protein expression of glutathione-S-transferase (GST) M1 isoform, and hig...
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PMID: 20070240
PDF is available here.
PDF is available here.
Abstract
We find that an L-system generated sequence can be inserted into the OR1D2 subfamily-specific star model and novel full-length olfactory receptors can be generated. This remarkable mathematical principle could be utilized for making new subfamily olfactory receptor members from any olfactory recepto...
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PMID: 20826948
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
A new fluorogenic fluorescein derivative containing an alpha,beta-unsaturated aldehyde moiety produces a selective fluorescent signal enhancement in the presence of cysteine or peptides containing N-terminal cysteine residues. The mechanism is based on synergistic covalent and supramolecular interac...
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PMID: 20617237
PDF is available here.
PDF is available here.
Abstract
We therefore examined whether IsoKs induced mitochondrial dysfunction. Incubation of mitochondria with synthetic IsoKs in the presence or absence of Ca(2+) was associated with alterations in mitochondrial respiration, membrane potential (DeltaPsi), and pyridine nucleotide redox state. IsoKs dose dep...
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PMID: 20472054
PDF is available here.
PDF is available here.
Abstract
We describe the discovery of an alkane biosynthesis pathway from cyanobacteria. The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together convert intermediates of fatty acid metabolism to alkanes and alkenes. The aldehyde decarbonylase is related to...
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PMID: 20671186
PDF is available here.
PDF is available here.
Perceptual and Motor Skills (111)1 2010
Abstract
Hexanal is a suspected irritant in indoor air. Free-number magnitude estimation was used to measure intensity of odor and sensory irritation of two test concentrations (64 or 178 ppb) as a function of five concentrations and four interpresentation intervals. 9 of 12 participants (6 men, 6 women, age...
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PMID: 21058601
PDF is available here.
PDF is available here.
Abstract
Al-containing helical mesoporous silicas have been synthesized and characterised by different techniques, showing outstanding activities (comparable to those obtained with sulfuric acid) in the oxathioacetalization of cyclohexane.
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PMID: 20526517
PDF is available here.
PDF is available here.
Abstract
The aim of this work is to construct a safe and effective drug candidate against Streptococcus suis infection. A panel of chitosan-based polymer conjugates with branched galabiose (Galalpha1-4Gal) side chains was synthesized as inhibitors of S. suis adhesion. The synthesis was achieved by using an a...
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PMID: 20540558
PDF is available here.
PDF is available here.
Abstract
Oxidative stress during aging of Saccharomyces cerevisiae in stationary culture was documented by demonstration of progressive increase in the formation of superoxide, decrease in the content of acid-soluble thiols and of acid-soluble antioxidant capacity of cell extracts, and accumulation of aldehy...
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PMID: 20337598
PDF is available here.
PDF is available here.
Abstract
Two cytosolic NADPH-dependent carbonyl reductases from Gluconobacter oxydans 621H, Gox0644 and Gox1615, were heterologously produced in Escherichia coli. The recombinant proteins were purified to homogeneity and characterized. Gox0644 and Gox1615 were dimers with native molecular masses of 66.1 and...
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PMID: 20414648
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Abstract
Syntheses of four new ruthenium(II) complexes of the [RuCl(2)(P)(2)(N)(2)] type using 2-(diphenylphosphino)ethyl methyl ether (P-O) as ether-phosphine and triphenylphosphine (PPh(3)) as monodentate phosphine ligands in the presence of [3-(2-aminoethyl)aminopropyl]trimethoxysilane as diamine co-ligan...
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PMID: 20657383
PDF is available here.
PDF is available here.
Abstract
We explore the idea that these dysautonomias results, in part, from a defect in synaptic transmission. To test this idea, we investigated cultured sympathetic neurons and show that hyperglycemia inactivates nAChRs through a mechanism involving an elevation in reactive oxygen species and an interacti...
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PMID: 20620869
PDF is available here.
PDF is available here.
Inflammation Research (59)6 2010
Abstract
EDSS exerted protective effects on SAP rats and remarkably alleviated the severity of experimental SAP. Mechanisms that might account for the beneficial effects include protecting the intestinal barrier, inhibiting over-inflammatory reaction and abating oxidative stress. The combined strategy proved...
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PMID: 20043232
PDF is available here.
PDF is available here.
Neurobiology of Aging (31)6 2010
Abstract
We show that oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors. Oxidative stress-induced beta-secretase activity and sAPPbeta levels were suppressed by gamma-secretase inhibitors. Levels of...
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PMID: 18687504
PDF is available here.
PDF is available here.
Hypertension Research (33)6 2010
Abstract
We have reported previously that intermittent hypoxia related to sleep apnea induces cardiovascular remodeling secondary to the oxidative stress. The aim of this study was to examine the effect of pitavastatin as an antioxidant to prevent intermittent hypoxia-induced left ventricular (LV) remodeling...
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PMID: 20300107
PDF is available here.
PDF is available here.
Abstract
We quantify over 40 end-products (amines, acids, alcohols, aldehydes, or ketones) produced by malignant neuroblastoma under accelerated glycolysis (+glucose (GLU) supply 1-10 mM) +/- mitochondrial toxin; 1-methyl-4-phenylpyridinium (MPP(+)) to abate aerobic respiration to delineate differences betwe...
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PMID: 19784859
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine the effects of eplerenone on hepatic fibrosis induced by bile duct ligation (BDL) in rat. Low- (1.0 mg/kg body weight, BW) and high- (4.0 mg/kg BW) dose eplerenone was administered orally for 21 days immediately following BDL. Fibrosis was assessed by measuring t...
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PMID: 20428791
PDF is available here.
PDF is available here.
Abstract
Mango ginger (Curcuma amada Roxb.) rhizome is used in the manufacture of pickles and other food preparations due to its unique raw mango flavour. The chloroform extract of mango ginger rhizome was subjected to antibacterial activity-guided purification by repeated silica gel column chromatography to...
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PMID: 20689179
PDF is available here.
PDF is available here.
Abstract
We developed a novel method to monitor fatty aldehyde dehydrogenase activity by quantification of the product pyrenedecanoic acid together with the substrate pyrenedecanal and possible side products, such as aldehyde adducts. As shown with recombinant enzymes, pyrenedecanal showed a high preference...
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PMID: 19965611
PDF is available here.
PDF is available here.
Abstract
We add to the large corpus of anomalous and paradoxical data collected for this reaction by measuring a normal (> 1) 2 degrees kinetic isotope effect (KIE) for the reduction of benzaldehyde. Because the relevant equilibrium effect is inverse (< 1), this KIE eludes the traditional interpretation of 2...
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PMID: 20457944
PDF is available here.
PDF is available here.
Chemical Communications (46)18 2010
Abstract
Dynamic mixtures generated by reversible aminal formation of fragrance aldehydes with N,N-dibenzyl alkyldiamines in aqueous systems were found to be suitable delivery systems for the controlled release of bioactive volatiles.
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PMID: 20386798
PDF is available here.
PDF is available here.
Abstract
A strategy for catalyst-controlled regioselectivity in aldehyde-alkyne reductive couplings has been developed. This strategy is the first where either regiochemical outcome may be selected for a broad range of couplings, without relying on substrate biases or directing effects. The complementary use...
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PMID: 20394367
PDF is available here.
PDF is available here.
Abstract
We reported that 4-hydroxyacids are catabolized through two parallel pathways. In this report we detail two isotopic tools that have allowed the dissection of this catabolic process and illustrate how these tools can be used to quantify the relative flux down each pathway. We found that 4-hydroxynon...
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PMID: 20408520
PDF is available here.
PDF is available here.
Abstract
A new chiral bicyclic guanidine-catalyzed direct catalytic aldol reaction of 5H-oxazol-4-ones with aldehydes has been developed. The present aldol reaction proceeds smoothly with high enantioselectivity using bicyclic guanidines bearing a hydroxy group at the appropriate position, and various combin...
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PMID: 20408533
PDF is available here.
PDF is available here.
Abstract
Enantioenriched homoallylic ethers containing a alpha,beta-unsaturated ester (syn-vinylogous aldol products) were directly accessed by Lewis acid catalyzed crotylation utilizing chiral silane 2. The reagents were prepared by enantioselective Si-H insertion to an alpha-diazovinylacetates using Davies...
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PMID: 20387893
PDF is available here.
PDF is available here.
Abstract
N-heterocyclic carbene catalyzed oxidative amidations of various aldehydes to the corresponding hexafluoroisopropylesters by using the readily available organic oxidant A are described. The hexafluoroisopropylesters prepared in situ are shown to be highly useful active esters for amide bond formatio...
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PMID: 20359171
PDF is available here.
PDF is available here.
Abstract
An in situ generated catalyst from readily available RuH(2)(PPh(3))(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and a...
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PMID: 20369820
PDF is available here.
PDF is available here.
Abstract
An efficient synthesis of C-1 derivatives of 7-deoxypancratistatin is reported. The key steps include the following: selective opening of an epoxide with aluminum acetylide in the presence of an aziridine; solid-state silica-gel-catalyzed opening of an aziridine; and oxidative cleavage of a phenanth...
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PMID: 20373760
PDF is available here.
PDF is available here.
Abstract
Novel reaction of tetranitromethane (TNM) with electrophilic alkenes in the presence of triethylamine yielding substituted 3-nitroisoxazoles was found and studied. Triethylamine increases the reactivity of TNM toward electrophilic alkenes promoting their heterocyclization, and the reactions proceed...
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PMID: 20384287
PDF is available here.
PDF is available here.
Abstract
We have developed a simple and straightforward procedure for the enantioselective preparation of densely substituted bicyclic and tricyclic nitrogen heterocycles using conveniently substituted enantiopure pyrrolidines as common synthetic intermediates, which are easily accessible by our recently dev...
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PMID: 20401401
PDF is available here.
PDF is available here.