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2-Acetylaminofluorene (2):
Recent article
2-Acetylaminofluorene
Abstract
Hepatocellular carcinoma (HCC) is characterized by a multi-cause, multi-stage and multi-focus process of tumor progression. Its prognosis is poor and early diagnosis is of utmost importance. This study was undertaken to investigate the dynamic expression of oncofetal antigen glypican...
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PMID: 21669573
PDF is available here.
PDF is available here.
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Abstract
Hepatocytes showed vacuole-like degeneration during the early stages, then had a hyperplastic nodal appearance during the middle stages, and finally progressed to tubercles of cancerous nests with high differentiation. The NF-kappaB-positive material was buff-colored, fine particles localized in the...
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PMID: 19822494
PDF is available here.
PDF is available here.
Abstract
The above observations support the hypothesis that the overexpression of HIF-1alpha and its gene are closely associated with the malignant transformation of hepatocytes and play an important role at the stage of hepatocarcinogenesis....
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PMID: 19666411
PDF is available here.
PDF is available here.
Journal of Hepatology (51)1 2009
Abstract
Six cancer cell lines were established from our model of hepatocholangiocarcinoma. HGF modulated LCSC resistance to apoptosis, while G-CSF acted on LCSCs as a proliferative and chemotactic agent....
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PMID: 19446912
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (17)4 2009
[The effect of thalidomine-induced NF-kappa B activation on malignant transformation of hepatocytes]
Abstract
Abstract
The positive rate of GFP and CFDA-SE labeled HOC was 10% and 90%, respectively, with no significant change in cell viabilities. The survival rate was higher in HOC transplantation group than in control group, especially 48 (9/15 vs 6/15) and 72 h (9/15 vs 4/15) after HOC transplantation. The serum A...
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PMID: 19322926
PDF is available here.
PDF is available here.
Abstract
Abstract
A variety of precursor minifoci were noted to be selectively bound to bile ducts and ductules in rat liver, which may be of physiologic significance in excretion of carcinogens during initiation....
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PMID: 18708648
PDF is available here.
PDF is available here.
Saudi medical journal (29)9 2008
Abstract
Notably, there were no appreciable differences in CYP1A2 level among control, olive oil, and DMSO-treated animals. The CYP1A2 level was significantly decreased in 2-AAF, DEN+2-AAF, DEN, DEN+2-AAF+DMV, DEN+2-AAF+1-alpha-hydroxy-DMV, 1-alpha-hydroxy-DMV, and DMV-treated animals as compared to the cont...
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PMID: 18813404
PDF is available here.
PDF is available here.
Abstract
These results showed that NO(2)F=O was the mutagen derived from AAF in the presence of the chemical model and was formed via oxidation of N-OH-AAF, NO(2)F, and NO(2)F-OH. These results may lead to a new metabolic pathway of AAF....
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PMID: 18586499
PDF is available here.
PDF is available here.
Toxicological Sciences (104)1 2008
Abstract
Our results suggest that CAPE modifies the enzymatic activity of CYP isoforms involved in the activation of DEN, such as CYP1A1/2 and CYP2B1/2. These findings describe an alternative mechanism for understanding the ability of CAPE to protect against chemical hepatocarcinogenesis....
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PMID: 18397917
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (118)1 2008
Abstract
Pretreatment with defatted methanolic fruit extract (100 and 200mg/kg b.w.) of Emblica officinalis showed significant partial recovery of pathological manifestations as compared to DEN and 2-AAF-treated group animals (p<0.001) and suppressed the tumor forming potential of 2-AAF (p<0.05) at both the...
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PMID: 18467048
PDF is available here.
PDF is available here.
Mutagenesis (23)3 2008
Abstract
Although the rodent comet assay is gaining acceptance as a standard technique for evaluating DNA damage in vivo, there is no internationally accepted guideline for its conduct and several aspects of its experimental design have not been optimized. For example, no standard positive control is used, t...
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PMID: 18326531
PDF is available here.
PDF is available here.
Abstract
All the examined indicators were not significantly different between the rats treated with 2-acetaminofluorene and normal saline, which was not the case with rats treated with retrorsine. A dynamic distribution of L02 hepatocytes in the rat liver was detected from wk 1 to mo 6 after transplantation...
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PMID: 18416458
PDF is available here.
PDF is available here.
Abstract
We evaluated the anti-tumor effect of PEG-IFN using a rat hepatocarcinogenesis model. Male Fisher Rats were treated using the Solt and Faber model to induce liver cancer. IFN and PEG-IFN were administered from chemical initiation, and pre-neoplastic foci and neoplastic hepatocellular carcinoma (HCC)...
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PMID: 18292937
PDF is available here.
PDF is available here.
Carcinogenesis (29)3 2008
Abstract
We investigated whether or not the mechanism of 2-AAF-induced hepatocarcinogenesis consists of both genotoxic (genetic) and non-genotoxic (epigenetic) alterations. Male and female Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 6, 12, 18 or 24 weeks. The levels of DNA adducts...
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PMID: 18204080
PDF is available here.
PDF is available here.
Abstract
Genotoxicity screening sensors that measure DNA damage from metabolism of arylamines were developed and evaluated. The sensors feature ultrathin films containing DNA and N-acetyltransferase (NAT) on pyrolytic graphite (PG) electrodes. NAT in the film catalyzed the conversion of the arylamine 2-amino...
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PMID: 18189370
PDF is available here.
PDF is available here.
Abstract
We observed that 71.3% pPNL and 25.4% rPNL (P < 0.05) presented p53 staining in the cytoplasm. Similarly, 67.7% pPNL and 23.1 % rPNL (P < 0.05) presented increased Bcl-2 staining. Thirty-two percent pPNL and 15.6% rPNL (P < 0.05) presented p65 staining. Compared to normal rats, increase (P < 0.05) o...
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PMID: 17546582
PDF is available here.
PDF is available here.
Hepatology (47)2 2008
Abstract
We found that EpCAM(+) and Thy-1(+) cells represent two different populations of cells in the oval cell niche. EpCAM(+) cells express the classical oval cell markers (alpha-fetoprotein, cytokeratin-19, OV-1 antigen, a6 integrin, and connexin 43), cell surface markers recently identified by us (CD44,...
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PMID: 18023068
PDF is available here.
PDF is available here.
BioFactors (34)4 2008
Abstract
Huqi San can obviously increase these activities of G-6-Pase, SDH and ATPase, and at the same time significantly decrease the expression of gamma-GT and AFP. Therefore, it can obstruct or inhibit the rat's liver preneolastic lesion induced by DEN....
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PMID: 19850985
PDF is available here.
PDF is available here.
Abstract
The results indicated that rat FLT3 cDNA has high homology with mouse and human FLT3 cDNA. It was also found that FLT3 is expressed in most of the rat tissues and during liver regeneration. In addition, its intracellular localization is altered during the late stages of liver regeneration. CONCLUSIO...
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PMID: 18031378
PDF is available here.
PDF is available here.
Abstract
Acetaminophen, a monocyclic phenolic compound and analgesic, when fed at 8900 p.p.m. in the diet, was reported to inhibit the hepatocarcinogenicity in rats of the aromatic amine proximate carcinogen N-hydroxy-N-acetyl-2-aminofluorene. To elucidate the mechanism(s) of this anticarcinogenicity, the pr...
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PMID: 18090125
PDF is available here.
PDF is available here.
Abstract
We found a small hepatocyte-specific protein, annexin A3 (AnxA3), in fractionated adult rat hepatocytes. Here we describe the results of an in vivo demonstration of AnxA3-expressing cellular phenotypes in the liver with 2-acetylaminofluoren (2-AAF)/carbon tetrachloride (CCl(4))-injury. In associatio...
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PMID: 18071240
PDF is available here.
PDF is available here.
Biochemistry (Washington) (46)46 2007
Abstract
We studied NarI-based fully paired [(5'-CTCG1G2CG3*CNATC-3')(5'-GATNCGGCCGAG-3'), N = dC or dT] and -2 deletion [(5'-CTCG1G2CG3*CNATC-3')(5'-GATNGCCGAG-3'), N = dC or dT] duplexes, in which G* was either AF [N-(2'-deoxyguanosin-8-yl)-2-aminofluorene] or the 19F probe FAF [N-(2'-deoxyguanosin-8-yl)-7...
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PMID: 17960913
PDF is available here.
PDF is available here.
Biochemistry (Washington) (46)40 2007
Abstract
We prepared and characterized eight 12-mer DNA duplexes (-AG*N- series, d[CTTCTAG*NCCTC]; -CG*N- series, d[CTTCTCG*NCCTC]), in which the central guanines (G*) were site-specifically modified with FAF with varying flanking bases (N = G, A, C, T). S/B heterogeneity was examined by CD, UV, and dynamic...
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PMID: 17877372
PDF is available here.
PDF is available here.
Toxicological Sciences (99)2 2007
Abstract
Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known t...
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PMID: 17636249
PDF is available here.
PDF is available here.
Abstract
We found 7.6% of the hepatocyte foci were positive for an oval cell marker cytokeratin 19 (CK-19). These foci were positive for alpha-fetoprotein, less positive for carbamoylphosphate synthetase 1, and more positive for laminin in the basement membrane lining. Rarely present transitional foci had we...
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PMID: 17661067
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (46)9 2007
Abstract
DRH rats are a hepatocarcinogenesis-resistant strain isolated from hepatocarcinogenesis-sensitive Donryu rats, and the liver of DRH shows less histological damage and fewer/smaller neoplastic hepatic lesions by the treatment with hepatocarcinogens. To investigate the mechanism of the resistance, the...
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PMID: 17546627
PDF is available here.
PDF is available here.
Cell and Tissue Research (329)3 2007
Abstract
Thy-1, a glycophosphatidylinositol-linked glycoprotein of the outer membrane leaflet, has been described in myofibroblasts of several organs. Previous studies have shown that, in fetal liver, Thy-1 is expressed in a subpopulation of ductular/progenitor cells. The aim of this study has been to invest...
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PMID: 17576600
PDF is available here.
PDF is available here.
Abstract
Monocyclic phenolics (MPs) occur widely in foods, both naturally and as synthetic antioxidant additives. Several have been shown to inhibit the carcinogenicity of a variety of genotoxic carcinogens in various tissues. Hydroquinone (HQ), one of the simplest of the MPs, which occurs naturally as the g...
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PMID: 17433518
PDF is available here.
PDF is available here.
Gastroenterology (133)2 2007
Abstract
We assessed the involvement of G-CSF during oval cell activation....
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PMID: 17681181
PDF is available here.
PDF is available here.
Archives of Toxicology (81)8 2007
Abstract
We decided to evaluate the role of the GST/GSH system in isolated hepatocytes from preneoplastic rat livers (IP) in the presence of EA and determine the cytotoxicity of the drug. Our results showed a resistance to the toxic effects of EA since viability and cellular integrity values were significant...
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PMID: 17340122
PDF is available here.
PDF is available here.
Carcinogenesis (28)8 2007
Abstract
Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcript...
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PMID: 17317680
PDF is available here.
PDF is available here.
European Journal of Cancer (43)11 2007
Abstract
We evaluated the preventive effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the induction of early carcinogenic events. We monitored pre-neoplastic foci induced by a two-stage initiation/promotion model of hepatocarcinogenesis in rats, using diethylnitrosamine...
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PMID: 17582756
PDF is available here.
PDF is available here.
Journal of Hepatology (46)6 2007
Abstract
The observed differences in progenitor cell responses between 2-AAF/RP and RP animals strongly suggest that SHPCs are not the progeny of oval cell precursors, but represent an independent liver progenitor cell population....
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PMID: 17434228
PDF is available here.
PDF is available here.
Journal of Virology (81)10 2007
Abstract
We show here for the first time that a single exposure of monocytes (M(o)) or CD34(+) progenitors (CD34) to sc rAAV1 or sc rAAV2 leads to high transduction levels (5 to 59%) of differentiated M(o)-DC, M(o)-Langerhans cells (LC), CD34-LC, or CD34-plasmacytoid DC (pDC), with no impact on their phenoty...
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PMID: 17314166
PDF is available here.
PDF is available here.
Abstract
We studied the effects of C-Phycocyanin (C-PC), a biliprotein from Spirulina platensis on the 2-acetylaminofluorene (2-AAF)-induced expression of MDR1, encoded by the multidrug resistance (MDR1) gene, in mouse macrophage cell line (RAW 264.7). Our experimental and In silico studies revealed a signif...
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PMID: 17303067
PDF is available here.
PDF is available here.
Biochemistry (Washington) (46)10 2007
Abstract
I (Klenow fragment) were used to study DNA synthesis on DNA modified with the carcinogen N-2-aminofluorene (AF). Running-start synthesis studies showed that full-length synthesis past the AF adduct was inhibited for all of the mutants, but that this inhibition was substantially less for the F762A mu...
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PMID: 17305316
PDF is available here.
PDF is available here.
Gastroenterology (132)3 2007
Abstract
Our results suggest that under certain physiologic conditions, a portion of hepatic stem cells might arise from the bone marrow and can differentiate into hepatocytes....
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PMID: 17383429
PDF is available here.
PDF is available here.
Cell and Tissue Research (327)3 2007
Abstract
Our results suggest that these ECM proteins can be used in protocols of OC transdifferentiation aimed at reducing the period necessary for complete transdifferentiation....
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PMID: 17149594
PDF is available here.
PDF is available here.
Mutation Research (627)1 2007
Abstract
The report from the 2002 International Workshop on Genotoxicity Tests (IWGT) Strategy Expert Group emphasized metabolic considerations as an important area to address in developing a common strategy for genotoxicity testing. A working group convened at the 2005 4th IWGT to discuss this area further...
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PMID: 17141553
PDF is available here.
PDF is available here.
Oncology Reports (17)1 2007
Abstract
In hepatocarcinogenesis-resistant DRH rats, preneoplastic hepatocytic lesions are smaller than those of usual rats during carcinogenesis. When preneoplastic hepatocytes from DRH and Donryu (original strain of DRH) were reciprocally transplanted into the livers of DRH and Donryu treated with 2-acetyl...
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PMID: 17143478
PDF is available here.
PDF is available here.
Abstract
Picrorrhiza kurroa has been shown to impart significant hepatoprotective activities, partly by modulation of free radical--induced lipid peroxidation. Lipid peroxidation and reactive oxygen species are associated with hepatic injury. The effect of P. kurroa treatment on the antiproliferative respons...
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PMID: 18197835
PDF is available here.
PDF is available here.
Hepatology (45)1 2007
Abstract
We studied progenitor/oval cell surface markers in the liver of rats subjected to 2-acetylaminofluorene treatment followed by partial hepatectomy (2-AAF/PH) by using rat genome 230 2.0 Array chips and subsequent RT-PCR, immunofluorescent (IF), immunohistochemical (IHC) and in situ hybridization (ISH...
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PMID: 17187413
PDF is available here.
PDF is available here.
Mutation Research (611)1-2 2006
Abstract
Antimutagenic activity of aqueous extracts of the South African herbal teas, Aspalathus linearis (rooibos) and Cyclopia spp. (honeybush) was compared with that of Camellia sinensis (black, oolong and green) teas in the Salmonella mutagenicity assay using aflatoxin B(1) (AFB(1)) and 2-acetylaminofluo...
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PMID: 16949333
PDF is available here.
PDF is available here.
Abstract
These results indicate that SDF-1 is an essential molecule needed in oval cell activation....
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PMID: 17148669
PDF is available here.
PDF is available here.
Abstract
The oval cells in high dose matrine groups were larger and contained more rough endoplasmic reticula than those in control group. The expression index of Thy-1 was 8.15+/-2.64 in model group, 5.27+/-1.32 in low dose matrine group, 3.83+/-0.35 in high dose matrine group, and 1.63+/-0.22 in control gr...
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PMID: 17166375
PDF is available here.
PDF is available here.
Abstract
Oval cells constitute a heterogeneous population of proliferating progenitors found in rat livers following carcinogenic treatment (2-acetylaminofluorene and 70% hepatectomy). The aim of this study was to investigate the cellular pattern of various differentiation and cell type markers in this model...
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PMID: 16835754
PDF is available here.
PDF is available here.
Abstract
At 25th d after CT CAPE reduced the observed increase of GGT+AHF by 84% and liver expression of ggt mRNA by 100%. In case of the GSTp protein, the level was reduced by 90%. As indicative of oxidative stress generated by diethylnitrosamine (DEN) 12 h after its administration, we detected a 68% increa...
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PMID: 17106925
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to analyse the changes of Prospero-related homeobox 1 (Prox1) gene expression in rat liver under different experimental conditions of liver injury, regeneration and acute phase reaction, and to correlate it with that of markers for hepatoblasts, hepatocytes, cholangiocytes...
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PMID: 16770575
PDF is available here.
PDF is available here.
Experimental Cell Research (312)15 2006
Abstract
We identified a subpopulation of OV6/CK19/Rab3b-expressing cells that was activated in the periportal region of traumatized livers. We also characterized a second subpopulation that expressed the HSCs marker c-kit but not Thy1. Although we successfully isolated both cell types, OV6/CK19/Rab3b(+) cel...
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PMID: 16781709
PDF is available here.
PDF is available here.
Life Sciences (79)15 2006
Abstract
We have previously reported that Tamarix gallica caused a marked inhibition of thioacetamide-induced hepatotoxicity, oxidative damage and early tumor promotion related events in the liver. These results strongly indicates that T. gallica may have chemopreventive potential. Therefore, in the present...
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PMID: 16698044
PDF is available here.
PDF is available here.
Abstract
The hepatoma model displayed the dynamic expression of hepatic telomerase during HCC development. The telomerase activities were consistent with liver total RNA levels (r = 0.83, P<0.01) at the stages of degeneration, precancerosis, and cancerization of hepatocytes. In HCC patients, the telomerase l...
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PMID: 16937491
PDF is available here.
PDF is available here.
Mathematical Biosciences (202)2 2006
Abstract
Several hypotheses are established to describe the formation and progression of foci of altered hepatocytes (FAH). A common model of hepatocarcinogenesis is the mutation model (MM), which is based on the assumption that cells have to undergo multiple successive changes on their way from the normal t...
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PMID: 16603206
PDF is available here.
PDF is available here.
Abstract
A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or...
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PMID: 16898170
PDF is available here.
PDF is available here.
Toxicology (222)3 2006
Abstract
These results suggest that only NFLX has an initiation activity in rats under the conditions used in the present study....
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PMID: 16580113
PDF is available here.
PDF is available here.
Life Sciences (78)24 2006
Abstract
We conclude the significant role of vanadium in limiting cell proliferation and chromosomal aberrations during the preneoplastic stages of hepatocarcinogenesis in rats....
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PMID: 16352317
PDF is available here.
PDF is available here.
Laboratory Investigation (86)5 2006
Abstract
We hypothesized that SST could act as a chemoattractant for HOCs by stimulating SSTRs. Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot assay revealed an increased expression of SST in the 2-acetyl-aminofluorene (2AAF)/partial hepatectomy (PHx) HOC induction model. Immunohis...
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PMID: 16534498
PDF is available here.
PDF is available here.
Mutation Research (604)1-2 2006
Abstract
It has been reported that the phosphorylated form of histone variant H2AX (gammaH2AX) plays an important role in the recruitment of DNA repair and checkpoint proteins to sites of DNA damage, particularly at double strand breaks (DSBs). Using gammaH2AX foci formation as an indicator for DNA damage, s...
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PMID: 16423555
PDF is available here.
PDF is available here.
Cell Proliferation (39)2 2006
Abstract
We previously reported that a sub-necrogenic dose (20 mg/kg) of diethylnitrosamine (DENA) can induce the development of liver cancer when rats undergo a fasting-re-feeding regimen. The present study was undertaken to establish whether fasting followed by re-feeding builds up mechanisms able to trigg...
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PMID: 16542346
PDF is available here.
PDF is available here.