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Oseltamivir (0):
Recent article
Oseltamivir
Audio, Transactions of the IRE Professional Group on (204)6 Suppl 1 2011
Abstract
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Epidemiology and Infection (139)1 2011
Abstract
We carried out an epidemiological investigation to delineate the characteristics of the outbreak, gauge the extent of secondary household transmission, and assess the protective role of oseltamivir in household contacts. We interviewed pH1N1-confirmed cases using a standardized questionnaire. Sixty-...
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PMID: 20561390
PDF is available here.
PDF is available here.
Abstract
Influenza surveillance was implemented in Kolkata, eastern India in 2005 to identify the circulating subtypes and characterize their genetic diversity. Throat and nasal swabs were collected from outpatients with influenza-like illness (ILI). Of 2844 ILI cases identified at two referr...
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PMID: 20678590
PDF is available here.
PDF is available here.
Abstract
The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from s...
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PMID: 20957346
PDF is available here.
PDF is available here.
Epidemiology (21)6 2010
Abstract
Abstract
Little is known about whether neuraminidase inhibitors are effective for children infected with oseltamivir-resistant influenza A(H1N1) viruses.
Children aged 15 years and younger having influenza-like illness and who visited outpatient clinics within 48 hours of fever onset were enrolled from 2006-...
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PMID: 20442686
PDF is available here.
PDF is available here.
Abstract
We credit this patient's recovery to our facility's heightened surveillance for influenza even among the vaccinated individuals, and also in those without classic influenza-like illness....
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PMID: 21053711
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
Abstract
Data on influenza in tropical countries remain scarce compared with that in temperate countries. However, the emergence of avian influenza virus (H5N1) and the 2009 pandemic represented a major stimulus for advances in knowledge about influenza in many of these countries. This review summarizes rece...
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PMID: 20644472
PDF is available here.
PDF is available here.
Neuraminidase inhibitors for preventing and treating influenza in healthy adults: a Cochrane review.
Abstract
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, issue 3) which contains the Acute Respiratory Infections Group's Specialised Register, MEDLINE (1950 to August 2009) and EMBASE (1980 to August 2009).
Randomised controlled trials (RCTs) or quasi-ran...
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PMID: 20945587
PDF is available here.
PDF is available here.
Abstract
Newborns should be considered to be at high risk of developing complications of novel influenza like pandemic influenza A (H1N1) 2009, because maternal antibodies are not transferred via crossing the placenta. In Japan, some newborns with pandemic influenza A (H1N1) 2009 appeared non-specific sympto...
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PMID: 20845743
PDF is available here.
PDF is available here.
Abstract
In Japan, about 20 million people were infected with pandemic (H1N1) 2009 virus between July 2009 and March 2010. About 60% of them were under 15 years, but only 38 pediatric deaths were reported. The reasons for hospitalization were respiratory and neurological complications. Children with pneumoni...
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PMID: 20845741
PDF is available here.
PDF is available here.
Abstract
Against pandemic influenza A (H1N1) 2009, anti-influenza drugs were useful to save the disease aggravation and reduce the mortality. In addition to the existing anti-influenza drugs, novel drugs, including neuraminidase inhibitors (peramivir and laninamivir) and RNA polymerase inhibitors (favipiravi...
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PMID: 20845748
PDF is available here.
PDF is available here.
Abstract
In 2009/10 season pandemic (H1N1) 2009 epidemic, pregnant women were recognized as high risk group, and taken different measures from non-pregnant adults. This new recommendations for pregnant women was also different from Japanese conventional management for pregnant women suffering from seasonal f...
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PMID: 20845742
PDF is available here.
PDF is available here.
Abstract
Amantadine resistance has become increasingly common among recent seasonal influenza viruses. In addition, almost all pandemic (H1N1) 2009 viruses are resistant to this drug. Between 2007 and early 2009, the prevalence of oseltamivir-resistant seasonal H1N1 variants that possess the His274Tyr neuram...
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PMID: 20845746
PDF is available here.
PDF is available here.
Abstract
We have to pay attention to oseltamivir-resistant influenza virus. Almost no zanamivir-resistant influenza virus has been so far reported. In Japan, peramivir is the first drip infusion medicine and is expected to be used in severe cases....
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PMID: 20845747
PDF is available here.
PDF is available here.
Abstract
We report molecular dynamics (MD) simulations of calcium-bound and calcium-free N1 complexes with the inhibitor oseltamivir (marketed as the drug Tamiflu), independently using both the AMBER FF99SB and GROMOS96 force fields, to give structural insight into calcium stabilization of key framework resi...
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PMID: 20602360
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)32 2010
Abstract
During the last two influenza seasons, one of the predominant influenza A types (H1N1) has developed complete resistance to oseltamivir, the primary treatment option. The virus does, however, remain sensitive to zanamavir and amantadine. There is no unequivocal explanation for this slide in the deve...
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PMID: 20696118
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We generated recombinant human A/Vietnam/1203/04 (VN; clade 1) and A/Turkey/15/06 (TK; clade 2.2) influenza viruses containing the H274Y neuraminidase (NA) mutation, which confers resistance to NA inhibitors, and compared the fitness levels of the wild-type (WT) and resistant virus pairs in ferrets....
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PMID: 20519385
PDF is available here.
PDF is available here.
Abstract
Numerous inconsistencies detected in the available evidence, followed by an inability to adequately access the data, has undermined confidence in the authors' previous conclusions for oseltamivir. Independent RCTs to resolve these uncertainties are needed....
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PMID: 20672786
PDF is available here.
PDF is available here.
Abstract
In 2009, a pandemic novel influenza virus (H1N1) outbreak was declared by the World Health Organization and resulted in significant worldwide illness. This report describes a 50-year-old male with end-stage lung disease secondary to alpha(1)-anti-trypsin deficiency and chronic obstructive pulmonary...
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PMID: 20538489
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)27 2010
Abstract
To study the impact of avian influenza virus H5N1 neuraminidase mutations I117V, I314V and I117V + I314V on the sensibility of neuraminidase inhibitors (NAIs) and the activity of neuraminidase (NA).
The mutations were introduced into NA genes of virus strain A/Vietnam/1203/04 (H5N1) by site-directed...
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PMID: 20979914
PDF is available here.
PDF is available here.
Intensive Care Medicine (36)7 2010
Abstract
Journal of Virology (84)13 2010
Abstract
Changes in the receptor binding characteristics of human H3N2 viruses have been evident from changes in the agglutination of different red blood cells (RBCs) and the reduced growth capacity of recently isolated viruses, particularly in embryonated eggs. An additional peculiarity of viruses circulati...
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PMID: 20410266
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe laboratory-confirmed influenza A pandemic (H1N1) 2009 in 17 hospitalized recipients of a hematopoietic stem cell transplant (HSCT) (8 allogeneic) and in 15 patients with malignancy treated at 6 Australian tertiary centers during winter 2009. Ten (31.3%) patients were admitted to intensiv...
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PMID: 20587176
PDF is available here.
PDF is available here.
Abstract
During March 2006-March 2009, a total of 6,355 suspected cases of avian influenza (H5N1) were reported to the Ministry of Health in Egypt. Sixty-three (1%) patients had confirmed infections; 24 (38%) died. Risk factors for death included female sex, age > or = 15 years, and receiving the first dose...
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PMID: 20587181
PDF is available here.
PDF is available here.
Abstract
Abstract
Earlier treatment with antiviral agents is associated with improved outcomes for pregnant women and further actions are needed in future pandemics to ensure that antiviral agents and vaccines are provided promptly to pregnant women, particularly in the primary care setting. Further research is neede...
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PMID: 20630123
PDF is available here.
PDF is available here.
Medical Journal of Australia (192)12 2010
Abstract
Abstract
We show that H274Y decreases the amount of neuraminidase that reaches the cell surface and that this defect can be counteracted by secondary mutations that also restore viral fitness. Two such mutations occurred in seasonal H1N1 shortly before the widespread appearance of H274Y. The evolution of ose...
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PMID: 20522774
PDF is available here.
PDF is available here.
Abstract
Toxic epidermal necrolysis is a rare acute and potentially life-threatening drug-related reaction. Osetalmivir is one of the drugs responsible for these reaction. We describe the case of a Down syndrome patient with toxic epidermal necrolysis previously treated with oseltamivir.
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PMID: 20544126
PDF is available here.
PDF is available here.
Brain and Development (32)6 2010
Abstract
Our observations suggest that oseltamivir is not a prerequisite for the development of abnormal behavior and does not worsen the clinical manifestations of abnormal behaviors, although further investigations are needed to determine whether oseltamivir is necessary, or even useful, for patients with...
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PMID: 19200672
PDF is available here.
PDF is available here.
Brain and Development (32)6 2010
Abstract
Abstract
The clinical presentation of influenza and outcome of oseltamivir treatment in infants <1 year was similar to that previously reported in older children, but mild gastrointestinal symptoms were common....
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PMID: 20035245
PDF is available here.
PDF is available here.
Abstract
We collected data on all specimens tested for influenza (including H1N1) by polymerase chain reaction between May and August 2009 at Townsville Hospital. Patients requiring admission to hospital and a proportion of non-admitted patients had clinical characteristics recorded. Multi-variable logistic...
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PMID: 20677419
PDF is available here.
PDF is available here.
Abstract
We describe a case of an adolescent with a bizarre neuropsychiatric picture associated with novel influenza A (H1N1) virus infection....
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PMID: 20173676
PDF is available here.
PDF is available here.
Abstract
We retrospectively reviewed medical records of 237 patients with laboratory-confirmed cases reported in Shanghai, China, during May-July 2009. Surveillance activities effectively contained the outbreak and provided useful epidemiologic data for future strategies....
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PMID: 20507760
PDF is available here.
PDF is available here.
Abstract
Abstract
We analyzed 3,216 clinical samples by NA sequencing and/or NA inhibition assay. The total frequency of ORVs was 2.6% (45/1,734) during the 2007-08 season and 99.7% (1,477/1,482) during the 2008-09 season, indicating a marked increase in ORVs in Japan during 1 influenza season. The NA gene of ORVs in...
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PMID: 20507742
PDF is available here.
PDF is available here.
Archives of Internal Medicine (170)10 2010
Abstract
Abstract
A new synthetic route to Tamiflu was developed via the Diels-Alder reaction of pyrrole and bromoacetylene.
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PMID: 20364872
PDF is available here.
PDF is available here.
Abstract
A short and practical synthesis of oseltamivir was accomplished in 11 steps from inexpensive and abundant diethyl D-tartrate starting material. This azide-free route featured an asymmetric aza-Henry reaction and a domino nitro-Michael/Horner-Wadsworth-Emmons (HWE) reaction as the key steps to constr...
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PMID: 20394411
PDF is available here.
PDF is available here.
Abstract
We report the development and validation of high-throughput real-time reverse transcriptase PCR assays for the detection of the H275Y substitution in the neuraminidase 1 gene that can be accomplished in 3 to 4 h....
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PMID: 20220153
PDF is available here.
PDF is available here.
Abstract
Chemosphere (79)8 2010
Abstract
The antiviral drug oseltamivir (Tamiflu) has received recent attention due to the potential use as a first-line defense against H5N1 and H1N1 influenza viruses. Research has shown that oseltamivir is not removed during conventional wastewater treatments, thus having the potential to enter surface wa...
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PMID: 20226496
PDF is available here.
PDF is available here.
Abstract
Our findings highlight the potential for emergence and persistence of multidrug-resistant influenza viruses in oseltamivir-treated immunocompromised subjects and also highlight challenges for drug resistance diagnosis due to the genetic instability of the virus population upon propagation in cell cu...
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PMID: 20194700
PDF is available here.
PDF is available here.
Abstract
Abstract
The emergence of oseltamivir-resistant strains is related to the administration of the drug, supporting the restriction of oseltamivir use to carefully defined high-risk groups. Infection due to pandemic virus with the H275Y mutation can be associated with a severe clinical course, supporting the sy...
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PMID: 20335065
PDF is available here.
PDF is available here.
Abstract
We have described two case reports of acute severe asthma exacerbation combined to influenza A H1N1, caracterized by severe respiratory failure. The diagnosis of influenza A H1N1 was confirmed with the multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay. These patients, apart fr...
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PMID: 20556930
PDF is available here.
PDF is available here.
Abstract
We have learned that clinical diagnosis of influenza has a laboratory confirmation in about 80% of cases but its correlation is lower in kids under 5 years old, especially in infants when RSV co-circulates with influenza virus. Laboratory diagnostic methods like DFA and immuno-chromatography have ab...
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PMID: 20556317
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Given the limited database, there is a high level of consent among recommendations issued by health authorities regarding treatment with Oseltamivir and breast-feeding. DISCUSSION: The majority of recommendations do not regard treatment with Oseltamivir as a contraindication to breast-feeding. Antiv...
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PMID: 20411471
PDF is available here.
PDF is available here.
Critical Care Medicine (38)4 Suppl 2010
Abstract
The clinical course of pandemic H1N1 2009 influenza can be severe, particularly in the very young and patients with comorbidities. Pandemic H1N1 2009 is sensitive to the antiviral agents oseltamivir and zanamivir but is resistant to the M2 inhibitors. Although few clinical data are yet available, tr...
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PMID: 19935416
PDF is available here.
PDF is available here.
Abstract
To analysis the clinical and laboratory characteristics of Patients infected with new influenza A (HIN1) virus.
All cases with new influenza A (H1N1) confirmed on polymerase chain reaction assay on throat swabs. There were included in a prospective evaluation of clinical characteristics, laboratory...
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PMID: 21110436
PDF is available here.
PDF is available here.
Abstract
Prescrire international (19)106 2010
Abstract
Abstract
The recently emerged novel influenza A H1N1 virus continues to spread globally. The use of oseltamivir for treatment and prophylaxis of infection is recommended and its use has climbed steeply although there is little data available on its benefit in critically unwell patients with H1N1 influenza. A...
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PMID: 20369775
PDF is available here.
PDF is available here.
Abstract
This is the largest report to date of oseltamivir use in children less than 12 months of age. Neurologic events were not more common with use of oseltamivir compared with that of the adamantanes. Dosing of oseltamivir was variable, illustrating the need for pharmacokinetic data in this younger popul...
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PMID: 19949363
PDF is available here.
PDF is available here.