Abstract
Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the c...
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PMID: 20106563
PDF is available here.
Abstract
We investigated its enantioselective interactions, and that of its (S)-isomer, with Penicillium expansum alkaline lipase and phosphatase. UV differential spectroscopy and fluorescence spectrophotometry studies were conducted in phosphate buffered solution at pH 7. Chiral differences in the UV absorp...
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PMID: 20390958
PDF is available here.
Gaku Takahashi,
Nobuhiro Sato,
Yasunori Yaegashi,
Masahiro Kojika,
Naoya Matsumoto,
Tomohiro Kikkawa,
Tatsuyori Shozushima,
Shinji Akitomi,
Kiichi Aoki,
Naoko Ito,
Koichi Hoshikawa,
Yasushi Suzuki,
Yoshihiro Inoue,
Go Wakabayashi and
Shigeatsu Endo
Abstract
The purpose of this study was to assess lipopolysaccharide (LPS)-stimulated cytokine production in the presence of linezolid (LZD) in comparison with the drug effect on the plasma endotoxin level. Peripheral venous whole-blood samples collected from five healthy subjects were stimulated with 10 micr...
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PMID: 20094752
PDF is available here.
Abstract
26 patients with unilateral postoperative endophthalmitis with a systemic combination regimen of meropenem (2 g TID, mean duration of treatment 5.5 days) and linezolid (600 mg BID, mean duration of treatment 8.9 days) (group 1, mean follow-up time 140 days) were included in this study and compared t...
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PMID: 20408069
PDF is available here.
Abstract
MRSA is one of the most common pathogens of ventilator associated pneumonia, whereas its estimated incidence for hospital acquired pneumonia, healthcare associated pneumonia and community acquired pneumonia has risen in the past decades. Although vancomycin at standard doses remains as the mainstay...
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PMID: 20075728
PDF is available here.
Abstract
A series of tetrahydropyrido-pyrazole cathepsin S (CatS) inhibitors with thioether acetamide functional groups were prepared with the goal of improving upon the cellular activity of amidoethylthioethers. This Letter describes altered amide connectivity, in conjunction with changes to other binding e...
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PMID: 20188543
PDF is available here.
Abstract
Soil incubation and germination tests were conducted to assess zerovalent iron (ZVI), organic compost, moisture and their combinations on metolachlor degradation in soil. The ZVI alone degraded 91% of metolachlor in soil within 40 days following bi-phasic kinetics. Organic amendment alone facilitate...
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PMID: 20352186
PDF is available here.
Abstract
We exposed three common species of tadpoles to conservative levels of atrazine, S-metolachlor, and glyphosate end-use herbicide formulations throughout the larval period to test for survival differences or life-history trait alterations. Exposure to the glyphosate product Roundup WeatherMax at 572 p...
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PMID: 19768486
PDF is available here.
Abstract
We present the relative risks of a variety of exposure scenarios and recovery potentials from damage, using herbicides with different modes of action. Toxicity was assessed on the basis of both EC50 and relative growth rate (RGR) compared with untreated controls in exposure and recovery. The EC50 of...
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PMID: 20094883
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection o...
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PMID: 20305109
PDF is available here.
Stephen D Goble,
Liping Wang,
K Lulu Howell,
Alka Bansal,
Richard Berger,
Linda Brockunier,
Jerry DiSalvo,
Scott Feighner,
Bart Harper,
Jiafang He,
Amanda Hurley,
Donna Hreniuk,
Emma Parmee,
Michael Robbins,
Gino Salituro,
Anthony Sanfiz,
Eric Streckfuss,
Eloisa Watkins,
Ann E Weber,
Mary Struthers and
Scott D Edmondson
Abstract
A series of amide derived beta(3)-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from 1, is used to lay the SAR foundation for second generation beta(3)-AR agonists for the treatment of overactive bladder.
Copyright 2010 Elsevier...
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PMID: 20181479
PDF is available here.
Abstract
We experimentally searched for other organic molecules of prebiotic interest, namely, oxidized acid labile compounds. In a setup that simulates conditions relevant to the ISM and Solar System icy bodies such as comets, a condensed CH(3)OH:NH(3) = 1:1 ice mixture was UV irradiated at approximately 80...
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PMID: 20402585
PDF is available here.
Abstract
Our results suggest that linezolid pharmacokinetics in critically ill patients with ARF undergoing ED is not comparable to that in healthy subjects and patients without ARF. The best method of managing linezolid dosage in such a complex group of patients, whose physiology can vary daily, would be to...
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PMID: 20013257
PDF is available here.
Abstract
The method offers a fast and simple approach to determine linezolid in pulmonary tissue which could be of use in pharmacokinetic studies....
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PMID: 20113250
PDF is available here.
Abstract
This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS ra...
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PMID: 20336030
PDF is available here.