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Acrylamides (1):
Recent article
Acrylamides
Abstract
Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,N-diethylacrylamide (DEAAm), N,N'-methylenebisacrylamide and methacrylic acid in the presence of (NH₄)₂SO₄ or NaCl. The hydrogels were characterized by low-vacuum scanning ele...
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PMID: 21563303
PDF is available here.
PDF is available here.
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Abstract
Hydrogels are three-dimensional networks of crosslinked hydrophilic polymers widely used for protein delivery and tissue engineering. To be eligible for in vivo applications, the hydrogels should not evoke an adverse tissue response. In this study the angiogenic and inflammatory resp...
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PMID: 21442723
PDF is available here.
PDF is available here.
Abstract
We report the synthesis and characterization of a novel cross-linked N-isopropylacrylamide-acrylic acid-hydroxyethyl methacrylate [P (NIPASM-AA-HEM)] hydrogel nanoparticles (NPs) containing amoxicillin. The aim of present study was to investigate whether these hydrogel NPs have the potential to be u...
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PMID: 21280053
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)2 2011
Abstract
We demonstrated that the thermosensitive matrices promoted cell detachment, thus P(D,L)LA scaffolds have the potential to be used as substrates for cell growth and expansion avoiding enzymatic and mechanical methods of cell harvesting. The harvested cells were replated to evaluate their viability, w...
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PMID: 20883833
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We report a mechanistic study of how flow and recirculation in a microreactor can be used to optimize the capture and release of stimuli-responsive polymer-protein reagents on stimuli-responsive polymer-grafted channel surfaces. Poly(N-isopropylacrylamide) (PNIPAAm) was grafted to polydimethylsiloxa...
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PMID: 20882219
PDF is available here.
PDF is available here.
Lab On a Chip (10)18 2010
Abstract
Generating cell aggregates is beneficial for various applications ranging from biotechnology to regenerative therapies. Previously, poly(ethylene glycol) (PEG) microwells have been demonstrated as a potentially useful method for generating controlled-size cell aggregates. In addition to controlling...
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PMID: 20664846
PDF is available here.
PDF is available here.
Biomaterials (31)22 2010
Abstract
We evaluated the influence of PDMDOMA on blood hemostasis by studying the fibrin polymerization process, the three-dimensional clot structure, and the mechanical properties and fibrinolysis. PDMDOMA altered the normal fibrin polymerization by changing the rate of protofibril aggregation and resultin...
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PMID: 20435346
PDF is available here.
PDF is available here.
Abstract
To assess integration of a biosynthetic corneal implant in dogs.
Three normal adult laboratory Beagles underwent ophthalmic examinations, including slit-lamp biomicroscopy, indirect ophthalmoscopy, applanation tonometry, and Cochet-Bonnet aesthesiometry. Biosynthetic corneas fabricated from glutaral...
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PMID: 20539221
PDF is available here.
PDF is available here.
Abstract
We describe the de novo computational design and experimental characterization of enzymes catalyzing a bimolecular Diels-Alder reaction with high stereoselectivity and substrate specificity. X-ray crystallography confirms that the structure matches the design for the most active of the enzymes, and...
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PMID: 20647463
PDF is available here.
PDF is available here.
Abstract
We report here electrical measurements to examine how Na/K pump interactions with extracellular Na ions are influenced by C-terminal truncations. We deleted the last two (YY) or five (KESYY) residues in Xenopus laevis alpha1 Na/K pumps made ouabain resistant by either of two kinds of point mutations...
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PMID: 20548052
PDF is available here.
PDF is available here.
Lab On a Chip (10)10 2010
Abstract
The use of a water-soluble, thermo-responsive polymer as a highly sensitive fluorescence-lifetime probe of microfluidic temperature is demonstrated. The fluorescence lifetime of poly(N-isopropylacrylamide) labelled with a benzofurazan fluorophore is shown to have a steep dependence on temperature ar...
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PMID: 20445879
PDF is available here.
PDF is available here.
Abstract
In this study, thermo-sensitive N-alkyl substituted polyacrylamide polymer P(NNB) was synthesized by using N-hydroxymethyl acrylamide(NHAM), N-isopropyl acrylamide (NIPA) and butyl acrylate (BA) as monomers, and its low critical solution temperature (LCST) was controlled to be 28 degrees C. The reco...
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PMID: 20363673
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
The shell cross-linked (SCL) thermoresponsive hybrid poly(N-isopropylacrylamide-co-aminoethyl methacrylate)-b-polymethyl methacrylate (P(NIPAAm-co-AMA)-b-PMMA) micelle consisting of a cross-linked thermoresponsive hybrid shell and a hydrophobic core domain was fabricated via a two-step process: mice...
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PMID: 20369878
PDF is available here.
PDF is available here.
Abstract
We have created a cell culture platform that allows for mechanical conditioning and then subsequent nondamaging detachment of those cells. We have modified silicone culture surfaces, to incorporate thermally responsive polymers of N-isopropylacrylamide (NIPAAm) to create an elastic substrate that ca...
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PMID: 20358641
PDF is available here.
PDF is available here.
Abstract
A novel protein molecularly imprinted membrane (PMIM) was synthesized on the surface of multiwalled carbon nanotubes (MWNTs) through a surface molecular imprinting technique by using bovine serum albumin (BSA) as the template molecule, acrylamide (AAm) as the functional monomer, N,N'-methylenebisacr...
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PMID: 20188903
PDF is available here.
PDF is available here.
Abstract
The inhibitory mechanism of niacin, which was found in our previous study to effectively reduce acrylamide (AA) formation in both chemical models and fried potato strips, was investigated in the present study. Maillard chemical models containing the amino acid asparagine and glucose with or without...
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PMID: 20235591
PDF is available here.
PDF is available here.
The Journal of Chemical Physics (132)15 2010
Abstract
The origin of poly(N-isopropylacrylamide) (PNIPAM) cononsolvency in tetrahydrofuran-water (THF-water) mixture was studied from the point of view of mixed solvent structure. The dynamic equilibrium of THF-water composition fluctuation in the mixed solvent system was found to be the main variable for...
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PMID: 20423196
PDF is available here.
PDF is available here.
Abstract
Copolymerization of N-isopropylacrylamide (NIPAM) with technical hardwood kraft lignin (HWKL) was achieved by atom transfer radical polymerization (ATRP) using a selectively modified lignin-based macroinitiator. The degree of polymerization (DP) of polyNIPAM graft side chains was affected by varying...
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PMID: 20187613
PDF is available here.
PDF is available here.
Abstract
This work describes a novel tunable bioadhesive hydrogel of thermoresponsive N-isopropylacrylamide (NIPAAm) containing zwitterionic sulfobetaine methacrylate (SBMA). This novel hydrogel highly regulates general bioadhesive foulants through the adsorption of plasma proteins, the adhesion of human pla...
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PMID: 20201492
PDF is available here.
PDF is available here.
Abstract
The facile synthesis of polymer-stabilized Au nanoparticles (AuNPs) capable of forming neutral, sterically stable complexes with small interfering RNA (siRNA) is reported. The amine-containing cationic block of poly(N-2-hydroxypropyl methacrylamide(70)-block-N-[3-(dimethylamino)propyl] methacrylamid...
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PMID: 20337403
PDF is available here.
PDF is available here.
Chemical Communications (46)13 2010
Abstract
Chimeras of poly(n-isopropyl acrylamide) and immunogenic peptides from the cancer-associated glycoprotein MUC1 were synthesised using a combination of solid-phase peptide synthesis, RAFT polymerisation and copper-catalysed alkyne-azide cycloaddition reactions.
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PMID: 20234901
PDF is available here.
PDF is available here.
Abstract
In this study the properties of poly(D,L-lactide-co-glycolide) (PLGA) dispersions containing a thermoresponsive cationic copolymer were investigated. The PLGA dispersions were prepared by interfacial deposition in aqueous solution and were rendered thermoresponsive by addition of a cationic poly(N-i...
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PMID: 20070971
PDF is available here.
PDF is available here.
Abstract
We isolated four LCNVAs from Capsicum oleoresin. Their structures were determined to be N-vanillyl-hexadecanamide (palvanil, 2), N-vanillyl-octadecanamide (stevanil, 3), N-vanillyl-9E-octadecenamide (olvanil, 4), and N-vanillyl-9E,12E-octadecadienamide (livanil, 5) by spectroscopic analysis and gas...
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PMID: 20192218
PDF is available here.
PDF is available here.
Biomacromolecules (11)3 2010
Abstract
Stimulus responsive materials hold great promise in biological applications as they can react to changes in physiological stimuli to produce a desired effect. Stimulus responsive macromers designed to respond to temperature changes at or around 37 degrees C and the presence of divale...
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PMID: 20121076
PDF is available here.
PDF is available here.
Bioscience Reports (30)3 2010
Abstract
We used benzophenone-initiated photopolymerization to graft PNIPAAm on PDMS substrates to construct the PNIPAAm-grafted PDMS surface and this PDMS surface was highly thermo-responsive. hMSCs (human mesenchymal stem cells) were used to analyse the proliferation and multi-differentiation of stem cells...
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PMID: 19445653
PDF is available here.
PDF is available here.
Abstract
We studied a subsample from a population-based case-control study of prostate cancer in Sweden (CAPS). Questionnaire data for alcohol intake estimates was compared to the ratio of hemoglobin-adduct levels for acrylamide and glycidamide, used as a measure of individual differences in metabolism. Data...
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PMID: 20034532
PDF is available here.
PDF is available here.
Abstract
A new type of pH-responsive block copolymer nanoparticle has been synthesized and characterized. The amphiphilic diblock copolymer, PEG-b-PMYM, contains acid-labile ortho ester side-chains in the hydrophobic block and can self-assemble into micelle-like nanoparticles in water at neut...
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PMID: 19904722
PDF is available here.
PDF is available here.
Abstract
Abstract
The shelf life of one-component self-etching adhesives is determined by their chemical composition. In conventional methacrylate-based adhesives, the inherently acidic environment of such formulations leads to monomer degradation due to hydrolysis. In contrast, methacrylamide-based adhesives are sta...
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PMID: 20155224
PDF is available here.
PDF is available here.
Abstract
Expanders achieved the peak of swelling in two weeks. During the observation period their mass significantly increased. NIPAAm polymers demonstrated the highest tendency to retain their preformed shape. Histological analysis revealed that implantation of AAc devices was associated with serious tissu...
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PMID: 20156789
PDF is available here.
PDF is available here.
Journal of Chromatography A (1217)4 2010
Abstract
A surfactant-bound monolithic stationary phase based on the co-polymerization of 11-acrylamino-undecanoic acid (AAUA) is designed for capillary high performance liquid chromatography (HPLC). Using D-optimal design, the effect of the polymerization mixture (concentrations of monomer, crosslinker and...
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PMID: 20031139
PDF is available here.
PDF is available here.
Abstract
Two phenylboronic acid based glucose-sensitive hydrogels, A.PBA-DMAPMA-EGDMA and A.PBA-PEG, were initially prepared by free-radical polymerization. Swelling properties of the gels were studied by determining the diameter changes in different buffer solutions, with or without glucose or fructose. The...
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PMID: 20036909
PDF is available here.
PDF is available here.
Abstract
pH-sensitive liposomes have been designed to deliver active compounds, specifically to acidic intracellular organelles and to augment their cytoplasmic concentrations. These systems combine the protective effects of other liposomal formulations with specific environment-controlled drug release. They...
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PMID: 20072905
PDF is available here.
PDF is available here.
Cardiology (115)3 2010
Abstract
Increased cell engraftment was observed 48 h after injection when cells were encapsulated in hydrogel; 30 days after treatment, echocardiographic studies showed that injection of BMMNCs in hydrogel preserved LV ejection fraction and attenuated LV dilatation compared with other groups. Histological a...
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PMID: 20145396
PDF is available here.
PDF is available here.
Cardiology (115)3 2010
Abstract
Abstract
A series of interpenetrating polymer networks (IPNs) of vinyl-terminated polyurethane (VTPU) and poly(N-isopropylacrylamide) (PNIPAAm) was prepared by free radical polymerization. The effects of IPN composition and cross-linking density on the thermo-responsive and mechanical properties have been st...
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PMID: 20507708
PDF is available here.
PDF is available here.
Abstract
A compositional gradient structure in hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PIPAAm) blend film was self-organized from a homogeneous aqueous solution in a plasma-treated polystyrene dish (PTPSD), and the formation mechanisms of the gradient structure were studied by casting the same...
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PMID: 20974045
PDF is available here.
PDF is available here.
Polimery w medycynie (40)2 2010
Abstract
In this study thermosensitive polymeric microspheres obtained in former research were evaluated in vitro for their photoprotective activity. The UVA/UVB ratio was assessed at so called shelf temperature, i.e., at 25 degrees C, and at elevated temperature of 45 degrees C. The evaluated polymers absor...
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PMID: 20649088
PDF is available here.
PDF is available here.
Abstract
We developed a simple and easy method for solution mixing based on the heat-induced regulation of capillary action in thermo-responsive polymer-coated microchannels. The channels having two T-junctions were fabricated on a glass plate by a sand-blast technique and then coated with a poly(N-isopropyl...
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PMID: 19836588
PDF is available here.
PDF is available here.
Journal of Drug Targeting (17)10 2009
Abstract
Synthesis and characterization of N-(2-hydroxypropyl)methacrylamide (HPMA)-copolymer-based drug carriers targeted on specific receptors in the membrane of endothelial cells by oligopeptides (GRGDG, cyclo(RGDfK), and PHSCN) are described in this study. The copolymers containing targeting oligopeptide...
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PMID: 19863198
PDF is available here.
PDF is available here.
Biomaterials (30)35 2009
Abstract
Due to mild reaction conditions and temporal and spatial control over material formation, photopolymerization has become a valuable technique for the encapsulation of living cells in three dimensional, hydrated, biomimetic materials. For such applications, 2-hydroxy-1-[4-(2-hydroxyethoxy) phenyl]-2-...
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PMID: 19783300
PDF is available here.
PDF is available here.
Abstract
With the growing interest in nanocomposites and their applications in biology and medicine, studies examining the biocompatibility of those materials are critical. Magnetic hydrogel nanocomposites based on poly(N-isopropylacrylamide) and iron oxide nanoparticles were fabricated via UV-polymerization...
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PMID: 19090484
PDF is available here.
PDF is available here.
Abstract
Despite their immense potential, the ability to control the dispersion and microstructure of carbon nanotubes remains a hurdle for their widespread use. Poly(N-cyclopropylacrylamide), containing 5 mol % pyrene-bearing repeat units (p-PNCPA), is shown to vary the dispersion state of single-walled car...
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PMID: 19736943
PDF is available here.
PDF is available here.
Abstract
We examine the interaction between thin films composed of terminally anchored poly(N-isopropyl acrylamide) (PNIPAAm) immersed in water and test surfaces. Understanding this force of interaction can be important when using PNIPAAm surfaces in biotechnological applications such as biological cell cult...
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PMID: 19735134
PDF is available here.
PDF is available here.
Abstract
Streaming current measurements were performed on poly(N-isopropylacrylamide)-co-N-(1-phenylethyl) acrylamide [P(NIPAAm-co-PEAAm)] thermoresponsive thin films above and below the transition temperature of the polymer (i.e., at 22 and 4 degrees C, respectively). Electrokinetic measurements (ionic stre...
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PMID: 19518102
PDF is available here.
PDF is available here.
Abstract
Fibrous tissue encapsulation may slow the diffusion of the target analyte to an implanted sensor and compromise the optical signal. Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels are thermoresponsive, exhibiting temperature-modulated swelling behavior that could be used to prevent biofouling. Unfor...
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PMID: 18563815
PDF is available here.
PDF is available here.
Abstract
Reversibly stabilized DNA nanoparticles (rSDN) were prepared by coating reducible polycation/DNA complexes with multivalent N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers. RGD-targeted rSDN were formulated by linking cyclic c(RGDyK) to the surface layer of rSDN. Cellular uptake in B16F10...
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PMID: 19263264
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (113)33 2009
Abstract
We investigated the dielectric properties of aqueous solutions of a grafted copolymer, consisting of a polysaccharide, Dextran, grafted with a thermo-sensitive polymer, poly(N-isopropylacrylamide), [pNIPAAM], over broad temperature and frequency ranges. The graft copolymers, prepared by atom-transfe...
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PMID: 19637897
PDF is available here.
PDF is available here.
Abstract
We describe a novel method for preparing a stimuli-responsive semi-interpenetrating polymer network (semi-IPN) hydrogel microsphere using a thermoresponsive-type coacervation. The coacervate droplets were formed in the two-component nonionic poly(N-isopropylacrylamide-co-2-hydroxyisopropylacrylamide...
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PMID: 19492785
PDF is available here.
PDF is available here.
Abstract
A new hybrid hydrogel based on poly[N-(2-hydroxypropyl)methacrylamide] grafted with a beta-sheet peptide, Beta11, was designed. Circular dichroism spectroscopy indicated that the folding ability of beta-sheet peptide was retained in the hybrid system, whereas the sensitivity of the peptide toward te...
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PMID: 19591463
PDF is available here.
PDF is available here.
Abstract
Thermoresponsive statistical copolymers of zwitterionic sulfobetaine methacrylate (SBMA) and nonionic N-isopropylacrylamide (NIPAAm) were prepared with an average molecular weight of about 6.0 kDa via homogeneous free radical copolymerization. The aqueous solution properties of poly(SBMA-co-NIPAAm)...
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PMID: 19572632
PDF is available here.
PDF is available here.
Abstract
We confirmed the expression of TRPV1 in masseter afferents in rat trigeminal ganglia (TG), and provided new data that TRPA1 is also expressed in primary afferents innervating masticatory muscles in double-labeling immunohistochemistry experiments. We then examined whether the activation of each TRP...
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PMID: 19464796
PDF is available here.
PDF is available here.
Abstract
The alpha2u-globulin (alpha2u) is a pheromone carrier urinary protein believed to be relevant for sexual communication among rats and is characterized in laboratory rats. In the present study 17 kDa protein and the bound pheromones were characterized in a population of wild-type Indian common house...
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PMID: 19788064
PDF is available here.
PDF is available here.
Abstract
The cellular material was adequate for evaluation in 28 (93%) of 30 eyes in pNIPAM-coated parylene group and in 18 (60%) of 30 eyes in the nitrocellulose group (P = 0.0002). pNIPAM-coated parylene technique was superior to the nitrocellulose technique regarding the mean number of cells per microscop...
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PMID: 19574910
PDF is available here.
PDF is available here.
Abstract
These results indicate that hydrophobic and rough surface properties of the microchannel can enhance the site-specific targeting of PNIPAM microspheres caused by the phase transition. The results in this study provide valuable information for the application of thermo-responsive drug carriers in sit...
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PMID: 19394620
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (113)29 2009
Abstract
Gold nanoparticles grafted with poly(N-isopropylacrylamide) (PNIPAM) are rendered amphiphilic and thermosensitive. When spread on the surface of water, they form stable Langmuir monolayers that exhibit surface plasmon resonance. Using Langmuir balance and contrast-matched neutron reflectivity, the d...
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PMID: 19569632
PDF is available here.
PDF is available here.
Optics Express (17)15 2009
Abstract
We present a main hypothesis related to the dye concentration into the layer and with the molecular weight of the polymer chains generated in the polymerization process in order to explain this effect....
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PMID: 19654725
PDF is available here.
PDF is available here.
Abstract
We have synthesized an N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer-drug conjugate with an AB(3) self-immolative dendritic linker. HPMA copolymers are known to accumulate selectively in tumors. The water-soluble polymer-drug conjugate was designed to release a triple payload of the hydrophobi...
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PMID: 19482477
PDF is available here.
PDF is available here.
Abstract
Novel polymeric nanoparticles based on a beta-cyclodextrin-poly(4-acryloylmorpholine) mono-conjugate (beta-CD-PACM), a tadpole-shaped polymer in which the beta-CD ring is the hydrophilic head and the PACM chain the amphiphilic tail, were prepared by the solvent injection technique. A...
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PMID: 19361545
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (134)7 2009
Abstract
Capacitively coupled contactless conductivity detection (C4D) is utilised as a simple, rapid and non-invasive technique for the quantitative evaluation of the ion-exchange capacity of charged polymer monoliths in capillary format. A charged monomer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS...
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PMID: 19562196
PDF is available here.
PDF is available here.