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Dibucaine (0):
Recent article
Dibucaine
Abstract
We have used human brain slices and in vivo real-time two-photon laser scanning microscopy in the mouse neocortex to study potentially useful therapeutics against spreading depolarization-induced injury.
We have shown that anoxic or terminal depolarization, a spreading depolarization...
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PMID: 21789251
PDF is available here.
PDF is available here.
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Abstract
We found that hippocampal and caudate volumes were decreased in patients with first-episode schizophrenia. We found no ventricular enlargement, differences in global volume or significant associations between tissue volume and duration of untreated illness or psychopathology. The hippocampal volume...
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PMID: 20184807
PDF is available here.
PDF is available here.
Abstract
Biophysical Chemistry (139)2-3 2009
Abstract
We report the interaction effects of the local anesthetic dibucaine (DBC) with lipid patches in model membranes by Atomic Force Microscopy (AFM). Supported lipid bilayers (egg phosphatidylcholine, EPC and dimyristoylphosphatidylcholine, DMPC) were prepared by fusion of unilamellar vesicles on mica a...
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PMID: 19010585
PDF is available here.
PDF is available here.
Journal of Chromatography B (872)1-2 2008
Abstract
A simple, sensitive, and specific liquid chromatography-mass spectrometry (LC-MS) method for simultaneous determination of dibucaine and naphazoline from serum was developed and validated. The extraction procedure was performed using a monolithic silica spin column. Chromatographic separation of dib...
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PMID: 18657485
PDF is available here.
PDF is available here.
Drug Delivery (15)5 2008
Abstract
The skin permeation enhancement of many kinds of drugs and cosmetic substances by microemulsions has been widely known; however, the correlations between microemulsion microstructures and the efficiency of skin permeation are not fully elucidated. Therefore, the aim of our study was to investigate t...
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PMID: 18763163
PDF is available here.
PDF is available here.
Contact Dermatitis (58)1 2008
Abstract
Abstract
A novel type of lipid vesicles, propylene glycol-embodying liposomes or PG-liposomes, composed of phospholipid, propylene glycol and water, is introduced. The new lipid vesicles were developed and investigated as carriers for skin delivery of the model drug, cinchocaine base. PG-liposomes showed hig...
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PMID: 17910822
PDF is available here.
PDF is available here.
Abstract
Based on universal thermodynamic principles (Schwarz in Biophys Chem 86:119-129, 2000) it is shown how measured enthalpy changes can be utilized to determine the relevant binding isotherm as well as the variation of the molar enthalpy change. This is carried out in a novel way involving multiple tit...
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PMID: 17345079
PDF is available here.
PDF is available here.
Abstract
A simple, rapid, accurate, precise and specific analytical method has been developed, validated and applied for determination of cinchocaine in guinea pig and albino rabbit dorsal skins, after in vivo application of cinchocaine formulations. Extraction was performed using a solvent mixture of ethano...
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PMID: 17294504
PDF is available here.
PDF is available here.
Abstract
We studied dibucaine's effects on specific locations of n-(9-anthroyloxy)palmitic acid or stearic acid (n-AS) within phospholipids of synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex (SPMV) and model membranes. Giant unilamellar vesicles (GUVs) were prepared with total lipi...
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PMID: 17241620
PDF is available here.
PDF is available here.
Abstract
We detail biochemical and molecular investigations of succinylcholine sensitivity in a prairie Hutterite kindred. Our results establish that BChE activities in the family members are impacted by two distinct BCHE mutations, namely, c.209A>G p. D70G and c.1615G>A p. A539T. However, homozygotes for th...
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PMID: 17166756
PDF is available here.
PDF is available here.
Abstract
Column liquid chromatography (LC) and thin-layer chromatography (TLC)-densitometry methods are described for simultaneous determination of acediasulfone (Ace) and cinchocaine (Cinco). In the LC method, the separation and quantitation of the 2 drugs was achieved on a Zorbax C8 column (5 microm, 150 x...
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PMID: 17474511
PDF is available here.
PDF is available here.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques (10)3 2007
Abstract
The characterization results showed that incorporation of the model drugs into the microemulsions did not change the microemulsion type. The permeation data exhibited that the nature of the microemulsions was a crucial parameter for transdermal drug delivery. The o/w microemulsions containing hydrop...
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PMID: 17727792
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that the V-ATPase inhibitors bafilomycin A1 and concanamycin A similarly induce NO production and the newly produced NO participates partially in the V-ATPase inhibitor-induced apoptosis in RAW 264.7 cells....
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PMID: 16895977
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1758)10 2006
Abstract
We study the effect of verapamil on the bacterium Escherichia coli. The drug was shown to inhibit cell division at growth sub inhibitory concentrations, independently of the SOS response. We show verapamil is a membrane active drug, with similar effects to dibucaine, a local anesthetic. Thus, both v...
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PMID: 16836975
PDF is available here.
PDF is available here.
European Journal of Pharmacology (546)1-3 2006
Abstract
We established a mouse allergic dermatitis model involving frequent scratching behavior by repeated painting with 2,4-dinitrofluorobenzene (DNFB) acetone solution onto the mouse skin, and comparatively examined the effects of tacrolimus and dexamethasone on the dermatitis and associated scratching b...
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PMID: 16914137
PDF is available here.
PDF is available here.
Parasitology Research (99)4 2006
Abstract
We observed that 50 mM dibucaine reduced the rates of uptake of bovine serum albumin (BSA) and immunoglobulin to 60% of control values in addition to the delay of exocytosis of cysteine proteases. Fusion among endocytic compartments was not inhibited in the presence of dibucaine because previously l...
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PMID: 16612626
PDF is available here.
PDF is available here.
Acta Pharmaceutica (56)3 2006
Abstract
A method for determining the rate of hydrophilic and hydrophobic drugs release from different types of liposomal dispersions and gels using a dialysis method is described. Dibucaine base and 5-fluorouracil were used as model drugs for a hydrophobic and a hydrophilic drug, respectively. A dialysis te...
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PMID: 19831280
PDF is available here.
PDF is available here.
Abstract
We report the case of a prolonged neuromuscular blockade in an 18-month-old age girl following administration of a usual dose of succinylcholine. The diagnosis was highly suggested by the clinical history while cholinesterase activity was included in adult normal values but below values of a persona...
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PMID: 16581221
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (102)6 2006
Abstract
We report a rare complication of spinal anesthesia-divergence paresis-which is characterized by an acquired horizontal diplopia at distance without evidence for abducens palsy. A 64-yr-old man underwent prostatectomy under spinal anesthesia with 2.5 mL of dibucaine hydrochloride 0.3% injected throug...
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PMID: 16717340
PDF is available here.
PDF is available here.
Abstract
A novel protein RGPR-p117 was discovered as a regucalcin gene promoter region-related protein that binds to the TTGGC motif using a yeast one-hybrid system. Whether overexpression of RGPR-p117 can modulate gene expression in the cloned normal rat kidney proximal tubular epithelial NRK52E cells was i...
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PMID: 16273285
PDF is available here.
PDF is available here.
Abstract
The Universal Coverage Policy (UCP) or "30 Baht Scheme" was launched in Thailand in 2001. The policy caused a cutback in the budgets of all public hospitals and health service centers. Traditional medicine was then viewed as an alternative to save costs. This study examines whether this had any infl...
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PMID: 16295562
PDF is available here.
PDF is available here.
Abstract
Two sensitive spectrophotometric and atomic absorption spectrometric procedures have been developed for determination of cinchocaine hydrochloride (Cin.Cl) in pure form and in pharmaceutical formulation. The spectrophotometric method was based on formation of an insoluble colored ion-associate betwe...
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PMID: 15910814
PDF is available here.
PDF is available here.
Abstract
Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time-of-flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained...
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PMID: 16287035
PDF is available here.
PDF is available here.
Abstract
Formulation of local anesthetics in liposomal topical drug delivery system could provide a sustained and localized anesthesia. The aim of this study was to develop a liposomal dibucaine base (DB) local anesthetic delivery system. DB-loaded multilamellar vesicles (MLVs) were prepared through varying...
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PMID: 16459486
PDF is available here.
PDF is available here.
Abstract
We found that rotenone exerted a strong protective action both against Ca2+ and Cd2+-produced mitochondrial membrane permeabilization (MMP). In contrast to Ca2+, catalase and dibucaine did not influence on main Cd2+ effects. In NH4NO3 medium N-ethylmaleimide (NEM) at low concentrations increased mar...
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PMID: 15560892
PDF is available here.
PDF is available here.
Abstract
The effect of regucalcin, a regulatory protein in intracellular signaling pathway, on cell death was investigated by using the cloned rat hepatoma H4-II-E cells overexpressing regucalcin. The hepatoma cells (wild-type) and stable regucalcin (RC)/pCXN2 transfectants were cultured for 72 h in medium c...
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PMID: 15378600
PDF is available here.
PDF is available here.
Abstract
Glucose may have a protective role in local anesthetic-induced neural damage....
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PMID: 15500098
PDF is available here.
PDF is available here.
Abstract
Blue light controls the sexual life cycle of Chlamydomonas, mediated by phototropin, a UV-A/blue-light receptor that plays a prominent role in multiple photoresponses. By using fractionation experiments and immunolocalization studies, this blue-light receptor, in addition to its known localization t...
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PMID: 15155806
PDF is available here.
PDF is available here.
Abstract
European Journal of Pharmacology (495)2-3 2004
Abstract
We investigated the effects of several agents on the established itching model in NC/Nga mice, model of atopic dermatitis-like disease, to elucidate related characteristics. The number of spontaneous scratching behaviors (the duration time is over 1.5 s) by NC/Nga mice with severe skin lesions was m...
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PMID: 15249165
PDF is available here.
PDF is available here.
Abstract
Interaction of the local anesthetic dibucaine with small unilamellar vesicles of dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) containing different mole percents of monosialoganglioside (GM1) has been studied by fluorescence spectroscopy. Fluorescence measurements on d...
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PMID: 15172834
PDF is available here.
PDF is available here.
Abstract
We have examined the interaction of tertiary amine local anesthetics with the bovine hippocampal serotonin1A (5-HT1A) receptor, an important member of the G-protein-coupled receptor superfamily. 2. The local anesthetics inhibit specific agonist and antagonist binding to the 5-HT1A receptor at a clin...
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PMID: 15206822
PDF is available here.
PDF is available here.
Analytical Biochemistry (328)2 2004
Abstract
Assay conditions were established to screen a panel of drugs for binding to liposome surfaces using a surface plasmon resonance (SPR) biosensor. Drugs were found to bind negligibly or reversibly or were retained on the liposome surface. Cationic amphiphilic drugs fell into the last class and correla...
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PMID: 15113702
PDF is available here.
PDF is available here.
Abstract
We report three cases of cauda equina syndrome following spinal anesthesia with dibucaine. In two cases, the lumbar puncture was repeated and additional doses of dibucaine were administered to obtain adequate sensory blockade. In the last case, spinal anesthesia worked well with single injection of...
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PMID: 15160665
PDF is available here.
PDF is available here.
Abstract
We quantitatively examined major control mechanisms of PT in rat brain (RBM) and liver (RLM) mitochondria. Compared with RLM, RBM were less sensitive to cyclosporin A (CsA), but the combined action of CsA+ADP was much more pronounced in RBM. Carboxyatractyloside abrogated the effects of all mPTP inh...
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PMID: 15019835
PDF is available here.
PDF is available here.
Abstract
Nippon Geka Gakkai zasshi (105)2 2004
Abstract
Redox Report (9)2 2004
Abstract
Our data suggest that p-bromophenacyl bromide prevents hydroperoxide-induced deterioration of mitochondria via interaction with glutathione rather than through inhibition of phospholipase A2....
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PMID: 15274248
PDF is available here.
PDF is available here.
Abstract
Topical nitroglycerine produces 'chemical sphincterotomy' with reduction in mean anal resting pressure. Pain relief and healing of fissure occurred earlier with GTN than with other treatments. GTN should be considered as the treatment of choice for the non-surgical management of patients with chroni...
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PMID: 15250565
PDF is available here.
PDF is available here.
Abstract
Correct recognition of butyrylcholinesterase (BChE; EC 3.1.1.8) variants in human serum is essential if patients susceptible to a prolonged reaction following treatment with short acting muscle relaxants, like suxamethonium, are to be reliably identified. The dimethylcarbamate Ro 02-0683 is used in...
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PMID: 14994645
PDF is available here.
PDF is available here.
Abstract
These findings indicated that the mechanism of dibucaine-induced hemolysis within a few seconds is through membrane lysis, whereas dibucaine-induced hemolysis at 30 min is caused by another mechanism. Because each mechanism is enhanced by high ionic strength, dibucaine dissolved in salt solution sho...
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PMID: 14661561
PDF is available here.
PDF is available here.
Abstract
Resonance energy transfer from dibucaine (DC) to acriflavine (AF) has been investigated both in homogeneous aqueous solutions and in polystyrene latex dispersions. The energy transfer reaction is observed by monitoring fluorescence quenching of DC as well as sensitized emission of AF. It is found th...
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PMID: 12962641
PDF is available here.
PDF is available here.
Anaesthesist (52)6 2003
Abstract
An incidence of 1:1,400 of dibucaine numbers below 30 is higher than documented in the literature. Therefore, routine measurement of dibucaine number is a cost-effective method of identifying patients at increased risk of prolonged neuromuscular blockade due to atypical cholinesterase....
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PMID: 12835869
PDF is available here.
PDF is available here.
Pharmacogenetics (13)5 2003
Abstract
Data obtained from this study help to better define the etiology of low BChE activity and the role of the rather common K allele. It is the first time that such a large population has been screened for so many mutations. BChE is also implicated in detoxifying cocaine; therefore genetic analysis coul...
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PMID: 12724618
PDF is available here.
PDF is available here.
Journal of Neuroscience (23)7 2003
Abstract
These results suggest that dibucaine and propranolol inhibit Bax-induced permeability changes through a direct interaction with the lipid membrane and present a novel target for the development of neuroprotective, antiapoptotic therapeutics....
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PMID: 12684459
PDF is available here.
PDF is available here.
Abstract
The dibucaine number (DN) was determined for serum cholinesterase (EC 3.1.1.8, SChE) in plasma samples. The ones with a DN of 79-82 were used, because they had the "usual" SChE variant. The enzyme was assayed colorimetrically by the reaction of 5,5'-dithiobis-[2-nitrobenzoic acid] (DTNB) with the fr...
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PMID: 12689511
PDF is available here.
PDF is available here.
Abstract
We evaluated six different methods for the measurement of ChE activity; 131 subjects were subdivided according to ChE phenotype and, therefore, to succinyldicholine sensitivity. ChE phenotype was determined by measuring dibucaine and fluoride numbers. DNA analysis was also performed to confirm corre...
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PMID: 12705341
PDF is available here.
PDF is available here.
Abstract
Membrane-perturbing agents that cause transformation of biconcave erythrocytes into echinocytes or stomatocytes were used to investigate the influence of erythrocyte shape on the rate of Ca(2+)-induced scrambling of phospholipids. Erythrocytes were treated with a variety of lipid-soluble compounds t...
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PMID: 12745928
PDF is available here.
PDF is available here.
FEBS Letters (532)3 2002
Abstract
The quinoline-based tertiary amine dibucaine has been shown to bind the membrane skeletal protein spectrin with a dissociation constant of 3.5x10(-5) M at 25 degrees C. Such binding is detected by monitoring the quenching of the tryptophan fluorescence intensity with increasing concentrations of dib...
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PMID: 12482599
PDF is available here.
PDF is available here.
Abstract
We have routinely applied an extra-strong graduated compression stocking to cesarean section patients to reduce the incidence of spinal anesthesia hypotension. Because bupivacaine has recently become available in Japan, we compared the incidence of spinal hypotension using either 2.0 ml of hyperbari...
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PMID: 12439553
PDF is available here.
PDF is available here.
Abstract
We planned spinal anesthesia using 0.5% bupivacaine, 2.0 ml. This time, he did not complain of leg pain during anesthesia, and postoperative conditions were satisfactory. We can conclude that bupivacaine is very useful for spinal anesthesia especially in patients with a history of leg pain by spinal...
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PMID: 12481453
PDF is available here.
PDF is available here.
Abstract
A 71-year-old man with a history of allergic rhinitis for 6 years received spinal anesthesia using 2 ml of 0.3% dibucaine for transurethral prostatectomy. Two months previously he had undergone prostate biopsy and cystoscopy under spinal anesthesia with isobaric bupivacaine uneventfully. Forty five...
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PMID: 12481454
PDF is available here.
PDF is available here.
Abstract
A 64-year-old man was scheduled for transure thral resection of the prostate. The patient's medical history showed borderline diabetic state and two uncomplicated surgeries under spinal anesthesia. Spinal anesthesia was performed at the L 3/4 interspace using hyperbaric 0.24% dibucaine 2.2 ml, which...
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PMID: 12428328
PDF is available here.
PDF is available here.
Abstract
Membrane destructive action of dibucaine HCl and bupivacaine HCl was examined in vitro using red blood cells. The EC50 value (local anesthetic concentration needed to destroy half of red blood cells in vitro) of each local anesthetic was determined at pH 5.0, 6.0 and 7.0 to obtain a pH-EC50 curve. T...
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PMID: 12229132
PDF is available here.
PDF is available here.
Abstract
We investigated a role of nitric oxide (NO) on ionomycin-evoked [3H]GABA release using mouse cerebral cortical neurons. lonomycin dose-dependently released [3H]GABA up to 1 microM. The extent of the release by 0.1 microM ionomycin was in a range similar to that by 30 mM KCl. The ionomycin (0.1 micro...
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PMID: 12067225
PDF is available here.
PDF is available here.
Abstract
Reserpine inhibited batrachotoxin-elicited sodium influx in guinea pig brain synaptoneurosomes with an IC50 of about 1 microM. In the presence of brevetoxin the IC50 increased to about 80 microM. Reserpine inhibited binding of batrachotoxinin-A [3H]benzoate ([3H]BTX-B) binding in a complex manner ca...
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PMID: 12064513
PDF is available here.
PDF is available here.
Biophysical Chemistry (94)1-2 2001
Abstract
These results show that liposomes are a better model membrane than an isotropic two-phase solvent system, such as water-octanol, to predict drug-membrane partition coefficients, as they mimic better the hydrophobic part and the outer polar charged surface of the phospholipids of natural membranes....
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PMID: 11744194
PDF is available here.
PDF is available here.
Life Sciences (69)8 2001
Abstract
We determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were either treated or non-treated with 34.2 micromol/L UCB for 10 min prior to the incubation with toxic concentrations of TFP (0.12 mmol/L), DBC (1.5 mmol/L) or PZQ (3.0 mmol/L),...
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PMID: 11488400
PDF is available here.
PDF is available here.