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Guanidines (19):
Recent article
Guanidines
Abstract
Serine proteases are important in the pathogenesis of intestinal inflammation. Recent studies have shown that nafamostat mesilate (NM) can inhibit the colonic mucosal inflammation induced by TNBS in rats. The aim of this study was to investigate the anti-inflammatory effects of NM on...
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PMID: 21187179
PDF is available here.
PDF is available here.
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Anesthesiology (113)6 2010
Abstract
We investigated (1) whether SevoPC is strengthened by multiple preconditioning cycles, (2) whether SevoPC is blocked by aprotinin, and (3) whether endothelial NOS plays a crucial role in SevoPC.
Anesthetized male Wistar rats were randomized to 15 groups (each n = 6) and underwent 25-min regional myo...
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PMID: 21068666
PDF is available here.
PDF is available here.
Brain research (1352) 2010
Abstract
In the present study, effect of curcumin (10 and 20mg/kg), an active constituent of Curcuma longa was evaluated for its antianxiety-like activity in mice subjected to immobilization-induced restraint stress for 6h. The effect on anxiety was assessed by employing elevated plus maze, open field test,...
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PMID: 20633542
PDF is available here.
PDF is available here.
Abstract
We have to pay attention to oseltamivir-resistant influenza virus. Almost no zanamivir-resistant influenza virus has been so far reported. In Japan, peramivir is the first drip infusion medicine and is expected to be used in severe cases....
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PMID: 20845747
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (295)1-2 2010
Abstract
Our discovery suggested AG inhibition of iNOS activity could significantly reverse cerebral vasospasm after SAH via restoration of dysfunctional endothelial cells by the upregulation of eNOS, indicating a regulatory cross-talk between eNOS and iNOS in the pathogenesis of SAH.
Copyright (c) 2010 Els...
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PMID: 20537662
PDF is available here.
PDF is available here.
Abstract
A randomized controlled trial was conducted to clarify whether continuous regional arterial infusion (CRAI) of protease inhibitor and antibiotic could reduce mortality rate of severe acute pancreatitis (SAP).
Seventy-eight patients with SAP were included in the study. Thirty-nine patients were treat...
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PMID: 20431422
PDF is available here.
PDF is available here.
Abstract
I (Fe(+4)=O, porph+(.)) or Compound ES (Fe(+4)=O, Trp+(.)). R48A/W191F formed a Fe(+2)O2 complex upon photolysis of Fe(+2)CO in the presence of O2, and N-hydroxyguanidine was observed to react with this species to produce products, distinct from N-nitrosoguanidine, that gave a positive Griess reacti...
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PMID: 20346907
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
These results provide a link between the hPepT1 transporter and the metabolic state of this model enterocyte....
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PMID: 20430871
PDF is available here.
PDF is available here.
Abstract
Peramivir is a neuraminidase (NA) inhibitor (NAI) under development that must be administered by the systemic route. The prophylactic activity of intramuscular (IM) peramivir was evaluated with mice infected with wild-type (WT) and oseltamivir-resistant (H274Y NA mutant) recombinant...
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PMID: 20404128
PDF is available here.
PDF is available here.
Abstract
We explore the idea that these dysautonomias results, in part, from a defect in synaptic transmission. To test this idea, we investigated cultured sympathetic neurons and show that hyperglycemia inactivates nAChRs through a mechanism involving an elevation in reactive oxygen species and an interacti...
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PMID: 20620869
PDF is available here.
PDF is available here.
Abstract
TRIzol solubilization and extraction is a relatively recently developed general method for deproteinizing RNA. This method is particularly advantageous in situations where cells or tissues are enriched for endogenous RNases or when separation of cytoplasmic RNA from nuclear RNA is impractical. TRIzo...
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PMID: 20516177
PDF is available here.
PDF is available here.
Abstract
A set of chiral imidazolylpropylguanidines and 2-aminothiazolylpropylguanidines bearing N(G)-3-phenyl- or N(G)-3-cyclohexylbutanoyl residues was synthesized and investigated for histamine H(2) receptor (H(2)R) agonism (guinea pig (gp) right atrium, GTPase assay on recombinant gp and human (h)H(2)R)...
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PMID: 20409707
PDF is available here.
PDF is available here.
Abstract
We describe the preparation of self-assembled monolayers consisting of benzylguanine thiols (BGT) to which SNAP-tag fusion proteins can be covalently linked. The SNAP-tag, a modified O(6)-alkylguanine-DNA alkyltransferase (AGT), reacts with the headgroup of BGT and becomes covalently bound upon the...
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PMID: 20369837
PDF is available here.
PDF is available here.
Journal of Trauma (68)5 2010
Abstract
Pigs treated with GL + NM had significantly higher mean postoperative recovery scores (3.8 +/- 0.4, essentially normal behavior with no early deaths) compared with animals within the shock only and shock + GL groups (2.1 +/- 1 with one early death and 2.2 +/- 1.2 with two early deaths, respectively,...
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PMID: 20453762
PDF is available here.
PDF is available here.
Abstract
We hypothesized that these abnormalities are mainly mediated by oxidative stress, endothelial dysfunction and impaired intracellular communications. Thus, we examined vasoactivity and expression of connexin (Cx) 43 and 40, protein kinase C-epsilon (PKCepsilon) and NADPH oxidase of the vasculature of...
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PMID: 20609064
PDF is available here.
PDF is available here.
Annals of Internal Medicine (152)9 2010
Abstract
Abstract
Zn(OTf)(2) acts as an excellent catalyst precursor for addition of various amine N-H bonds to carbodiimides under an atmosphere of air, offering a convenient synthesis of substituted guanidines with high functional-group tolerance. A Zn-N amido species is shown to act as the active species.
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PMID: 20449484
PDF is available here.
PDF is available here.
Abstract
A selected fungal strain, for production of the raw-starchdigesting enzyme by solid-state fermentation, was improved by two repeated sequential exposures to gamma-irradiation of Co60, ultraviolet, and four repeated treatments with Nmethyl- N'-nitrosoguanidine. The mutant strain Aspergillus sp. XN15...
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PMID: 20467244
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
We report the synthesis and biological evaluation of a series of new non-peptide PAR(1) mimetic receptor antagonists, based on conformational analysis of the S(42)FLLR(46) tethered ligand (TL) sequence of PAR(1). These compounds incorporate the key pharmacophore groups in the TL sequence, guanidyl,...
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PMID: 19484400
PDF is available here.
PDF is available here.
Abstract
We conducted a study in a high-shear arterial environment to explore the potential for a cooperative antithrombotic effect with a thrombin inhibitor (argatroban), a factor Xa inhibitor (YM-60828), and a dual thrombin/factor Xa inhibitor (RWJ-445167). We employed a platelet-dependent vascular injury...
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PMID: 20010091
PDF is available here.
PDF is available here.
Abstract
We used a more potent and specific NHE1 inhibitor HOE 694 (HOE) to test whether inhibition of NHE1 during ischemia limits increases in Nai and [Ca]i in newborns. NMR was used to measure pHi, Nai, [Ca]i, and ATP in isolated newborn rabbit hearts. Perfusion pressure, left ventricular developed pressur...
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PMID: 20010437
PDF is available here.
PDF is available here.
Journal of Cell Biology (188)4 2010
Abstract
We detected the accumulation of metabolically generated acid at sites of macropinocytosis, an effect counteracted by Na(+)/H(+) exchange and greatly magnified when amiloride or HOE-694 were present. The acidification observed in the presence of the inhibitors did not alter receptor engagement or pho...
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PMID: 20156964
PDF is available here.
PDF is available here.
Abstract
We report a two-step TRIzol-based procedure for RNA extraction from Arabidopsis siliques and dry seeds. This procedure employs a modified, high pH (pH 9.5) extraction buffer. High pH plus the addition of either DTT or beta-mercaptoethanol in the extraction buffer effectively inhibits RNase activity...
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PMID: 20108272
PDF is available here.
PDF is available here.
Abstract
We report a two-step TRIzol-based procedure for RNA extraction from Arabidopsis siliques and dry seeds. This procedure employs a modified, high pH (pH 9.5) extraction buffer. High pH plus the addition of either DTT or beta-mercaptoethanol in the extraction buffer effectively inhibits RNase activity...
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PMID: 20108272
PDF is available here.
PDF is available here.
Abstract
We report a two-step TRIzol-based procedure for RNA extraction from Arabidopsis siliques and dry seeds. This procedure employs a modified, high pH (pH 9.5) extraction buffer. High pH plus the addition of either DTT or beta-mercaptoethanol in the extraction buffer effectively inhibits RNase activity...
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PMID: 20108272
PDF is available here.
PDF is available here.
Abstract
We report a two-step TRIzol-based procedure for RNA extraction from Arabidopsis siliques and dry seeds. This procedure employs a modified, high pH (pH 9.5) extraction buffer. High pH plus the addition of either DTT or beta-mercaptoethanol in the extraction buffer effectively inhibits RNase activity...
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PMID: 20108272
PDF is available here.
PDF is available here.
Abstract
We report a two-step TRIzol-based procedure for RNA extraction from Arabidopsis siliques and dry seeds. This procedure employs a modified, high pH (pH 9.5) extraction buffer. High pH plus the addition of either DTT or beta-mercaptoethanol in the extraction buffer effectively inhibits RNase activity...
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PMID: 20108272
PDF is available here.
PDF is available here.
Molecular Diversity (14)1 2010
Abstract
The role of o-bisguanidinobenzenes (BGBs) as new Brønsted base ligands for arsenic and phosphoric acids was examined. In solution state, complexation was evaluated by Job's plot in (1)H NMR experiment, indicating a 1:1 complex formation, whereas in solid state crystalline structures...
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PMID: 19452258
PDF is available here.
PDF is available here.
Molecular Diversity (14)1 2010
Abstract
The role of o-bisguanidinobenzenes (BGBs) as new Brønsted base ligands for arsenic and phosphoric acids was examined. In solution state, complexation was evaluated by Job's plot in (1)H NMR experiment, indicating a 1:1 complex formation, whereas in solid state crystalline structures...
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PMID: 19452258
PDF is available here.
PDF is available here.
Molecular Diversity (14)1 2010
Abstract
The role of o-bisguanidinobenzenes (BGBs) as new Brønsted base ligands for arsenic and phosphoric acids was examined. In solution state, complexation was evaluated by Job's plot in (1)H NMR experiment, indicating a 1:1 complex formation, whereas in solid state crystalline structures...
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PMID: 19452258
PDF is available here.
PDF is available here.
Abstract
Our study suggests that antiexcitotoxic properties may underlie some of the anti-ischemic effect of caffeinol. This study provides strong evidence that the anti-ischemic effect of NMDA receptor blockers in general can be dramatically augmented by caffeine, thus opening a possibility for new use of N...
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PMID: 20044532
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (88)2 2010
Abstract
We evaluated the involvement of the central NO-cGMP pathway in thermoregulation during sepsis induced by cecal ligation and puncture (CLP), and analyzed its effect on survival rate. Male Wistar rats with a Tb probe inserted in their abdomen were intracerebroventricularly injected with 1 microL NG-ni...
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PMID: 20237585
PDF is available here.
PDF is available here.
Abstract
We tested for the first time the hypothesis that EM TRIzol extraction allows proteomic Surface Enhanced Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry (SELDI-TOF MS) analysis and that these proteomic data can be related to mRNA (microarray) data obtained from the same EM sample from wo...
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PMID: 20964823
PDF is available here.
PDF is available here.
Abstract
A new method for fixation of biological material is described, and its effectiveness is compared to that one of formalin fixation. As an embalming agent, polyhexamethylenguanidine (PHMG) hydrochloride was used. Using the proposed method of fixation, the anatomical and histological preparations of hum...
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PMID: 20593590
PDF is available here.
PDF is available here.
Abstract
Rinsho Ketsueki (51)1 2010
Abstract
Abstract
An in situ gelable glycation-resistant hydrogel has been prepared from oxidized alginate (Oalg) and gelatin. Aminoguanidine, an effective inhibitor of the glycation reaction, was first encapsulated in gelatin microspheres followed by incorporation into the hydrogel. The gelation process was monitore...
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PMID: 20178689
PDF is available here.
PDF is available here.
Abstract
We successfully used the guanidine isothiocyanate method for isolation of total RNA from leaf, stem, and root tissues of the aromatic plant Origanum onites. The RNA was extracted with TRI Reagent at room temperature and was recovered by isopropanol precipitation. The isolated RNA was capable of reve...
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PMID: 20469647
PDF is available here.
PDF is available here.
Abstract
We also examined whether FUT promotes rebleeding in a model in which ICH was induced by intracerebral injection of collagenase. Systemic administration of FUT starting 6 h after ICH reduced brain water content in the ipsilateral basal ganglia 72 h after ICH compared with vehicle. FUT attenuated ICH-...
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PMID: 19812969
PDF is available here.
PDF is available here.
Revista Medico-Chirurgicala (114)1 2010
Abstract
We characterized the pharmacological activity of some new fluorescent and nonfluorescent ligands derived from aminopotentidine and squaramide with respect to the interaction with human (h) and guinea pig (gp) H2R species isoforms on Spodoptera frugiperda (Sf9) cell membranes expressing H2R-Gsalpha f...
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PMID: 20509312
PDF is available here.
PDF is available here.
Abstract
We examined the effect of structural analogue of AG, its Schiff base with pyridoxal-pyridoxylidene aminoguanidine (PAG) on the level of selected markers of oxidative stress. We found that PAG decreased total damage to DNA in controls as well as in diabetic group of rats. However, we also found that...
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PMID: 20097957
PDF is available here.
PDF is available here.
Abstract
1) Inducible NOS (iNos) activity and NO content in model group was significantly higher (F = 522.860, P < 0.01), in acupotomology group and aminoguanidine group was significantly lower than the model group (FiNOS = 28.894, P < 0.01), and iNOS activity and NO content in all groups was in competence w...
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PMID: 20084944
PDF is available here.
PDF is available here.
Abstract
A simple, and stability-indicating liquid chromatographic method was developed and validated for the analysis of metformin hydrochloride and its related compound (1-cyanoguanidine) in tablet formulations. Liquid chromatography with a UV detector at a wavelength of 232 nm using a Nova-Pak silica colu...
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PMID: 19635372
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: The guanidine group defines chemical and physicochemical properties of many compounds of medical interest and guanidine-containing derivatives constitute a very important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases. OBJECTIVE: To review the most...
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PMID: 19780701
PDF is available here.
PDF is available here.
Abstract
We revealed an increase in activity of aconitase, which was reduced during toxic hepatitis. The content of citrate in the liver and serum was returned to normal under these conditions. IMMG also increased activities of superoxide dismutase and catalase and total antioxidant activity in rat liver. Ou...
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PMID: 20396755
PDF is available here.
PDF is available here.
Abstract
We report the case of a one-month male infant who presented with a large cutaneous tumor in his right axilla with ecchymosis, thrombocytopenia, and chronic consumption coagulopathy. Three-dimensional computed tomography was useful for accurate diagnosis of the cutaneous tumor and for determining the...
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PMID: 19579084
PDF is available here.
PDF is available here.
Abstract
A simple and straightforward methodology toward the synthesis of novel 4,5-biphenyl-2-pyrimidinylguanidine compounds has been developed by one-pot reaction of biguaninde or dimethyldiguanide with isoflavones. A series of 20 new compounds was reported. All of them were characterized by FT-IR, NMR, an...
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PMID: 19621921
PDF is available here.
PDF is available here.
Abstract
Seven new guanidine alkaloids (1-7) together with the known batzelladines A, F, H, and L, ptilomycalin A, and fromiamycalin were isolated from the Caribbean marine sponges Monanchora arbuscula and Clathria calla. Molecular structures were assigned on the basis of detailed analysis of 1D and 2D NMR s...
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PMID: 19743809
PDF is available here.
PDF is available here.
Abstract
Previous studies on agmatine and its derivatives suggested that the presence of hydrophobic groups on the guanidine moiety was a crucial key for inhibitory activity of maize polyamine oxidase. Accordingly, new lipophilic agmatine and iminoctadine derivatives were synthesized and tested for their abi...
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PMID: 19591488
PDF is available here.
PDF is available here.
Abstract
We tested whether FUT-175, a clinical pharmaceutical that has been shown to inhibit the formation of C3/C5 convertases, can attenuate myelin-specific T-cell responses, as well as disease severity in experimental autoimmune encephalomyelitis. In vitro, FUT-175 inhibited local C5a/C3a production by an...
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PMID: 19608865
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (87)8 2009
Abstract
To determine whether changes in membrane potential affect the extent of mast cell degranulation, compound 48/80 was added to rat peritoneal mast cell suspensions in the absence or presence of potassium channel openers (KCOs). Changes were compared between the field potential (FP) and the amount of h...
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PMID: 19767887
PDF is available here.
PDF is available here.
Abstract
We show that brostallicin induces gamma-H2AX nuclear foci that colocalize with 53BP1 and are dependent on glutathione, as shown by inhibition of those gamma-H2AX foci by l-buthionine sulfoximine. To differentiate brostallicin from the clinically approved minor groove binder trabectedin (ecteinascidi...
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PMID: 19584235
PDF is available here.
PDF is available here.
Abstract
We examined iNOS expression and the effect of iNOS inhibitors in the RVLM on BP and heart rate in SHR and WKY. iNOS levels in the RVLM were significantly higher in SHR than in WKY. Bilateral microinjection of aminoguanidine into the RVLM dose-dependently decreased BP and heart rate in SHR, but not i...
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PMID: 19387904
PDF is available here.
PDF is available here.
Abstract
We recently reported that complement activation exacerbates I/R injury in the type 2 diabetic heart. The purpose of this study was to isolate and examine MBL pathway activation following I/R injury in the diabetic heart. ZLC and ZDF rats underwent 30 minutes of left coronary artery occlusion followe...
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PMID: 20216929
PDF is available here.
PDF is available here.
Abstract
We investigated the presence of IL-6 in lymph after intestinal ischemia and its effects on human umbilical vein endothelial cells (HUVECs) detachment. The involvement of NO on the increase of lung and intestinal microvascular permeability and the lymph effects on HUVEC detachment were also studied....
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PMID: 18838940
PDF is available here.
PDF is available here.
Abstract
iNOS activation plays a pathological role in retinal NV in a mouse model of ischemic retinopathy. Administration of AG significantly suppressed retinal NV. Therefore, AG appears to be a novel and effective therapeutic approach for retinal NV....
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PMID: 19301028
PDF is available here.
PDF is available here.
Abstract
Life Sciences (85)1-2 2009
Abstract
Lactic acidosis causes atrial fibrillation (AF), and pulmonary veins (PVs) are the most important focus for the generation of AF. Cariporide (HOE642), a Na(+)/H(+) blocker, can prevent atrial tachycardia-induced electrical remodeling. The purpose of this study was to investigate whet...
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PMID: 19422839
PDF is available here.
PDF is available here.