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Aza Compounds (4):
Recent article
Aza Compounds
Abstract
A simple and rapid HPLC method with UV detection was developed for the separation of ciprofloxacin, levofloxacin and moxifloxacin. Chromatography was carried out using a BDS Hypersil C18 (100 x 4.6 mm, 2.4 microm) HPLC column and an isocratic mobile phase consisting of MeOH/25 mM pho...
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PMID: 21612150
PDF is available here.
PDF is available here.
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Nature Medicine (16)12 2010
Abstract
Abstract
We specifically investigated the influence of PRIMA-1 on cellular localization of mutated p53-R280K endogenously expressed in tumour cells. By using immunofluorescence staining, we found a strong nucleolar redistribution of mutant p53 following PRIMA-1 treatment. This subcellular localization was as...
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PMID: 20946886
PDF is available here.
PDF is available here.
Abstract
Ru(ii) complexes that bring together the properties of the dppz (dipyrido[3,2-a:2',3'-c]phenazine) intercalating residue and the properties of metal-coordinating macrocycles (L = 4,4'-(2,5,8,11,14-pentaaza[15])-2,2'-bipyridilophane) have been synthesised and their protonation and affinity for copper...
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PMID: 20838679
PDF is available here.
PDF is available here.
Biodegradation (21)6 2010
Abstract
These results demonstrate that indigenous Fe(III)-reducing microorganisms in RDX-contaminated environments utilize extracellular electron shuttles to enhance RDX mineralization. Electron shuttle-mediated RDX mineralization may become an effective in situ option for contaminated environments....
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PMID: 20424887
PDF is available here.
PDF is available here.
Abstract
Treatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use. This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-rela...
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PMID: 20839321
PDF is available here.
PDF is available here.
Abstract
An efficient methodology taking advantage of the excellent nucleophilicity of aminoquinone to assemble the azaanthraquinone framework was developed via an iodine-induced 6-endo-dig electrophilic cyclization. Therefore, starting from N-propargylaminoquinones, various 3-iodo-1-azaanthraquinones were o...
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PMID: 20652179
PDF is available here.
PDF is available here.
Carbohydrate Research (345)13 2010
Abstract
A series of eight novel, highly modified mono-, di- and trisaccharide derivatives, each containing an iminoalditol moiety, has been synthesized in the quest for potential heparanase inhibitors.
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PMID: 20630499
PDF is available here.
PDF is available here.
Abstract
After topical preoperative administration, moxifloxacin 0.5% ophthalmic solution had a 38-fold to 50-fold higher concentration in the aqueous humor than besifloxacin 0.6% ophthalmic suspension. Besifloxacin was undetectable in more than half the aqueous humor samples.
Copyright (c) 2010 ASCRS and ES...
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PMID: 20692561
PDF is available here.
PDF is available here.
Abstract
Experiments on rats showed that meta-chlorophenylpiperazine, as well as serotonin, decreases cerebral blood flow registered in internal carotid artery of narcotized animals. Therefore, this agonist of postsynaptic 5HT(2B/2C) receptors can be used for directed search of new antimigraine drugs. Tropox...
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PMID: 21086646
PDF is available here.
PDF is available here.
Abstract
This review deals with 2-azapurine (imidazo[4,5-d] [1,2,3]triazine) nucleosides and closely related analogs. Different routes are described to yield the desired target compounds, including a sequence of ring-opening and ring-closure reactions performed on purine nucleosides or dire...
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PMID: 20860023
PDF is available here.
PDF is available here.
Journal of Chemotherapy (22)4 2010
Abstract
The aim of this study was to compare outcomes for patients with community-acquired pneumonia (CAP) caused by Legionella spp. following treatment with moxifloxacin or a range of comparator antimicrobial agents. Data were pooled from four sequential I.V./P.O. trials of moxifloxacin in the treatment of...
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PMID: 20685631
PDF is available here.
PDF is available here.
Journal of Chemotherapy (22)4 2010
Abstract
The aim of this study was to compare the activities of moxifloxacin and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) biofilms. The study was conducted using a novel in vitro pharmacodynamic model where the biofilms...
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PMID: 20685626
PDF is available here.
PDF is available here.
Abstract
Intravitreal injection of bevacizumab may cause corneal changes. The safety and effects of bevacizumab on the cornea should be evaluated in detail....
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PMID: 20662658
PDF is available here.
PDF is available here.
Abstract
A new class of antibacterials, diarylquinolines, was identified. The lead compound, R207910 (TMC207), was able to inhibit Mycobacterium tuberculosis in vitro, in mice and in patients. R207910 targets the mycobacterial ATP synthase. In vitro, it displayed potent activities against both drug-sensitive...
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PMID: 19954909
PDF is available here.
PDF is available here.
Wiener klinische Wochenschrift (122)13-14 2010
Abstract
The main aim of this meta-analysis was to compare the efficacy and safety of clarithromycin and second-generation fluoroquinolone-based triple therapy vs. bismuth-based quadruple therapy for the treatment of persistent Helicobacter pylori infection.
A systematic literature search was conducted for a...
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PMID: 20628905
PDF is available here.
PDF is available here.
Abstract
To our knowledge, this is the first-described case of spontaneous subconjunctival abscess formation in an immunocompetent individual unrelated to preexisting ocular pathology, previous ocular surgery, or trauma. H. influenzae species may possess the ability to penetrate an intact conjunctiva and dev...
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PMID: 20489592
PDF is available here.
PDF is available here.
Abstract
A total of 61 patients were enrolled [cefazolin and tobramycin (n = 20), gatifloxacin (n = 21), and moxifloxacin (n = 20)]. Overall, 57 patients (93%) healed on treatment. On comparison of the mean time taken to heal, no statistically significant difference was found among all the 3 treatment groups...
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PMID: 20489580
PDF is available here.
PDF is available here.
Abstract
In an attempt to explore the biosynthetic potential of the endolichenic fungus Corynespora sp. BA-10763, its metabolite profiles under several culture conditions were investigated. When cultured in potato dextrose agar, it produced three new heptaketides, 9-O-methylscytalol A (1), 7-desmethylherbari...
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PMID: 20521776
PDF is available here.
PDF is available here.
Abstract
I clinical trial. Improved understanding of the p53 pathway should lead to better diagnosis and treatment of cancer in the future.
2010 Elsevier Inc. All rights reserved....
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PMID: 20494116
PDF is available here.
PDF is available here.
Analytica Chimica Acta (667)1-2 2010
Abstract
Simple or even rapid bioanalytical methods are rare, since they generally involve complicated, time-consuming sample preparation from the biological matrices like LLE or SPE. SPME provides a promising approach to overcome these limitations. The full potential of this innovative technique for medical...
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PMID: 20441869
PDF is available here.
PDF is available here.
Abstract
The synthesis and fluorescence properties of novel purine analogues linked azacrown ether at C6 position were investigated. These new purine analogues could be prepared from a series of 6-chloropurines and showed selective and efficient signaling behaviors toward micromolar concentration of Ag(+) io...
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PMID: 20399655
PDF is available here.
PDF is available here.
Abstract
An efficient synthesis of fully aromatic, fused-ring, monoaza-acenes through a nucleophile initiated cascading cyclization is illustrated. Photophysical properties of the resulting molecules are reported.
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PMID: 20377276
PDF is available here.
PDF is available here.
Carbohydrate Research (345)7 2010
Abstract
Various known inhibitors of glycosidases were assessed for their ability to inhibit, both independently as well as with UDP, the cholesterol alpha-glucosyltransferase from Helicobacter pylori. The sub-cloning, expression and purification of the glucosyltransferase is also discussed.
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PMID: 20307874
PDF is available here.
PDF is available here.
Abstract
A new template of C-4'-truncated phosphonated nucleosides (TPCOANs) has been obtained in good yields according to two different routes which exploit the reactivity of a phosphonated nitrone. The one-step procedure based on the 1,3-dipolar cycloaddition of a phosphonated nitrone with vinyl nucleobase...
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PMID: 20394405
PDF is available here.
PDF is available here.
Abstract
Mean +/- SD AH concentrations of ciprofloxacin and moxifloxacin were 0.009 +/- 0.008 microg/mL and 0.071 +/- 0.029 microg/mL, respectively. The AH moxifloxacin concentrations were significantly greater than those of ciprofloxacin. Mean +/- SD plasma concentrations of ciprofloxacin were less than the...
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PMID: 20433383
PDF is available here.
PDF is available here.
Abstract
A 1-year-old, entire male Tasmanian devil living in captivity was presented because of a nodular inguinal lesion that subsequently developed a draining sinus tract. A second, similar lesion developed later in the ipsilateral axillary region. A deep representative biopsy specimen of abnormal subcutan...
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PMID: 20529031
PDF is available here.
PDF is available here.
Abstract
Abstract
We report a case of Mycobacterium abscessus keratitis after elective laser in situ keratomileusis in a 19-year-old woman. The infection started 3 weeks after uneventful surgery, and the patient received multiple antimicrobial treatments without response. A corneal scrape isolate showed an acid-fast...
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PMID: 20457379
PDF is available here.
PDF is available here.
Abstract
We cultured feces from C. difficile-infected patients. Use of fluoroquionolones with enhanced antianaerobic activity was not associated with increased infection rates....
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PMID: 20409374
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambu...
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PMID: 20160054
PDF is available here.
PDF is available here.
Abstract
The results indicate that fesoterodine is not associated with QTc prolongation or other ECG abnormalities at either therapeutic or supratherapeutic doses....
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PMID: 20420787
PDF is available here.
PDF is available here.
Chemical Communications (46)16 2010
Abstract
A facile, efficient and selective solvent-free synthesis of ketones from secondary alcohols with tert-butylhydroperoxide (TBHP) as the oxidant under microwave irradiation is achieved, where the copper(ii) 2,4-alkoxy-1,3,5-triazapentadienato complexes are efficient catalysts providing high yields (up...
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PMID: 20369176
PDF is available here.
PDF is available here.
Abstract
We describe a facile synthetic route to this anthraquinone, and we use this material to determine the mechanism by which DNQ induces death in cancer cells. DNQ was synthesized in seven linear steps through a route employing three palladium-mediated coupling reactions. Experiments performed on cancer...
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PMID: 20345134
PDF is available here.
PDF is available here.
Abstract
A fascinating mechanistic study of ynamido-palladium-pi-allyl complexes is described that features isolation of a unique silyl ketenimine via aza-Claisen rearrangement, which can be accompanied by an unusual thermal N-to-C 1,3-Ts shift in the formation of tertiary nitriles and a novel cyclopentenimi...
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PMID: 20337418
PDF is available here.
PDF is available here.
Chemical Communications (46)15 2010
Abstract
The asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-Ts-1-aza-1,3-butadienes derived from 3-argiocarbonylcoumarins and acetaldehyde has been developed using chiral secondary aminocatalysis, giving tricyclic chroman-2-one derivatives in high enantioselectivities (up to 95% ee).
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PMID: 20449332
PDF is available here.
PDF is available here.
Abstract
Helical chiral 2-aminopyridinium ions were designed as a significantly more acidic (active) dual hydrogen-bonding catalyst than commonly used (thio)urea-based systems. The helicene framework was specifically utilized to position an inherently chiral barrier on the hydrogen-bonding side of the cataly...
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PMID: 20232867
PDF is available here.
PDF is available here.
Abstract
Patients treated with moxifloxacin dropped out less frequently (OR=2.22 [1.62-3.03]; p<0.001), had less treatment failure (OR=3.61 [2.30-5.65]; p<0.001), and experienced clinical cure more often (OR=1.59 [1.21-2.04]; p=0.001) than placebo-treated patients. In comparison to ofloxacin, patients treate...
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PMID: 20223557
PDF is available here.
PDF is available here.
Paediatric Drugs (12)2 2010
Abstract
This analysis included 815 pediatric patients aged 1-17 years (447 with culture-confirmed bacterial conjunctivitis). Clinical resolution was significantly greater (p < 0.05) in the besifloxacin group than in the vehicle group at both visit 2 (53.7% vs 41.3%) and visit 3 (88.1% vs 73.0%). Similarly,...
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PMID: 20218747
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
A novel series of macrocyclic complexes of the type [M(C(18)H(14)N(10)S(2))X]X(2) where M=Cr(III), Fe(III) and Mn(III); X=Cl(-), NO(3)(-) and CH(3)COO(-) have been synthesized by [2+2] condensation of thiocarbohydrazide and isatin in the presence of trivalent metal salts in methanolic medium by temp...
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PMID: 20034706
PDF is available here.
PDF is available here.
Abstract
We tested the propensity of three quinolones to select for resistant Streptococcus pneumoniae mutants by determining the mutant prevention concentration (MPC) against 100 clinical strains, some of which harbored mutations in type II topoisomerases. Compared with levofloxacin and gemifloxacin, moxifl...
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PMID: 20008781
PDF is available here.
PDF is available here.
Abstract
We have analyzed them in this minireview. The so-called standard reactions involve "naked" enolates which therefore should lead to the syn adducts as the major products, irrespective of the E, Z stereochemistry of the enolate. Accordingly, provided the second step is rate determining step, the desig...
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PMID: 20335941
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)2 2010
Abstract
The 7-day moxifloxacin-based triple therapy has a high eradication rate with fewer side-effects. This regimen can be a safe and effective option as second-line treatment for H. pylori infection....
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PMID: 20356487
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)2 2010
Abstract
In ITT analysis, the Hp-eradication rate was 89.8% (95%CI: 86.7% - 93.0%) in Group A, 81.2% (75.3% - 90.9%) in Group B and 81.2% (66.1% - 92.6%) in Group C, among which no significant difference was observed (chi(2) = 4.339, P > 0.05). However, in PP analysis there was a significant difference among...
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PMID: 20356488
PDF is available here.
PDF is available here.
Archiv fur Kriminologie (225)3-4 2010
Abstract
The sensitivity of DFO (1,8-diazafluoren-9-one), a substance known since 1989, is clearly superior to that of ninhydrin for the visualization of latent fingerprints. Nevertheless DFO has not replaced ninhydrin in Germany up to now. One reason is its unreliability. The DFO working solutions commonly...
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PMID: 20506707
PDF is available here.
PDF is available here.
Abstract
Besifloxacin is a novel fluoroquinolone that, like other fluoroquinolones, acts by inhibiting the essential bacterial enzymes DNA gyrase and topoisomerase IV. Topical besifloxacin ophthalmic suspension 0.6% is indicated for use in patients with bacterial conjunctivitis caused by susceptible bacteria...
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PMID: 20030427
PDF is available here.
PDF is available here.
Abstract
We found a synergistic effect for in vitro tests but failed to demonstrate it in vivo. When 100 microg moxifloxacin/0.1 mL is given intravitreally, it has some toxic effects that are limited to the inner retinal layers....
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PMID: 20130687
PDF is available here.
PDF is available here.
Chemotherapy (56)1 2010
Abstract
Following intravenous administration, the half life of elimination, the volume of distribution at steady state and the area under the curve were 3.29 h, 0.94 l/kg and 24.72 microg x h/ml, respectively. After intramuscular and subcutaneous administration of moxifloxacin at the same dose, the peak pla...
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PMID: 20197659
PDF is available here.
PDF is available here.
Abstract
Abstract
We predict, using the median percentile that our studies have 80% power to detect the following changes: HR (+/-10bpm), LV +dP/dt max (+/-375mmHg/s), MBP (+/-5mmHg) and QTc (+/-4ms).
Super-intervals are a simple way to handle the high degree of natural variability seen with any ambulatory cardiovasc...
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PMID: 20570743
PDF is available here.
PDF is available here.
Abstract
Abstract
138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradication rates were 84% (57/68) and 76% (57/75) in the 7 days moxifloxacin group and 90% and 84% in the second group (63/70, 63/75) according to the PP and ITT analysis; p = n.s. Among 129 patients (86% of study g...
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PMID: 20398300
PDF is available here.
PDF is available here.
Abstract
The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a base in the presence of tetrabutylammonium bromide (TBAB). The products were obtained in g...
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PMID: 20966877
PDF is available here.
PDF is available here.
Abstract
Based on the results of this study of healthy subjects, it can be concluded that sugammadex alone or in combination with rocuronium or vecuronium is not associated with QTc prolongation....
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PMID: 20568829
PDF is available here.
PDF is available here.
Respiratory Research (11)1 2010
Abstract
Intermittent pulsed therapy with moxifloxacin reduced the odds of exacerbation by 20% in the ITT population, by 25% among the PP population and by 45% in PP patients with purulent/mucopurulent sputum at baseline. There were no unexpected adverse events and there was no evidence of resistance develop...
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PMID: 20109213
PDF is available here.
PDF is available here.
Abstract
We evaluated the activities of new types of azaphenothiazines in the following immunological assays: the proliferative response of human peripheral blood mononuclear cells induced by phytohemagglutin A or anti-CD3 antibodies; lipopolysaccharide-induced cytokine production by human PBMC; the secondar...
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PMID: 19557312
PDF is available here.
PDF is available here.
Abstract
These results give a new impulsion to the control of nitrogen chirality, which remained limited to small cycles for 60 years....
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PMID: 19807190
PDF is available here.
PDF is available here.