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Cyanates (1):
Recent article
Cyanates
Abstract
To identify if 1,6-hexamethylene diisocyanate (HDI) workers demonstrated an increased prevalence of occupational asthma or accelerated decline in pulmonary function.
Employees from two plants manufacturing or producing 1,6-HDI monomer and/or HDI polyisocyanates were matched to a control population b...
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PMID: 20881627
PDF is available here.
PDF is available here.
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Abstract
A variety of N-alkyl-beta-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt(3)](2)MoS(4)) in a sequential, one-pot, multistep reaction. The tolerance of multifariou...
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PMID: 20392054
PDF is available here.
PDF is available here.
Abstract
An unsaturated terminal diol, 1,18-octadec-9-endiol (ODEDO), and a saturated terminal diol, 1,9-nonanediol (NDO), were synthesized from oleic acid. The feasibility of utilizing these new diols for the production of thermoplastic polyurethanes (TPUs) was demonstrated by reacting them with a fatty aci...
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PMID: 20232886
PDF is available here.
PDF is available here.
Abstract
The findings indicated that these vitamins inhibit LDL carbamylation and the most effective vitamin of the three is lycopene. Moreover, the effect of lycopene on this process increased in the presence of ascorbic acid and alpha-tocopherol. CONCLUSION: This study indicated that ascorbic acid, alpha-t...
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PMID: 20156036
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of creatinine concentration and specific gravity on urine 1,6-hexamethylene diamine (HDA) levels in multiple mixed linear regression models using quantitative dermal and inhalation exposure data derived from a survey of automotive spray painters occupationally exposed to 1...
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PMID: 20445846
PDF is available here.
PDF is available here.
Abstract
Poly(thiourethane-urethane)s with varying amounts of sulphur were synthesised by a two-step polycondensation consisting of the sequential addition of 1,6-hexamethylene diisocyanate and bis(2-mercaptoethyl) ether in a poly(epsilon-caprolactone) diol solution. Polymers prepared had high weight-average...
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PMID: 20233504
PDF is available here.
PDF is available here.
Abstract
Otherwise inaccessible tropolonylureas were prepared by reaction of t-butylurea with appropriate amines, with elimination of t-butylamine. This method is also generally applicable for urea synthesis.
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PMID: 20045971
PDF is available here.
PDF is available here.
La Medicina del lavoro (101)1 2010
Abstract
This was an unusual case of double sensitization to different occupational compounds to which the patient was exposed in different time periodsj suggesting the role of a pre-existing occupational aSthma in the development and/or worsening of sensitization to other occupational agents....
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PMID: 20415049
PDF is available here.
PDF is available here.
Abstract
Journal of Bacteriology (191)10 2009
Abstract
We found that this activity depends on the cynABD genes, which encode a putative cyanate (NCO(-)) ABC-type transporter. Accordingly, nitrite transport by CynABD was competitively inhibited by NCO(-) with a K(i) value of 0.025 microM. The transporter was induced under conditions of nitrogen deficienc...
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PMID: 19286804
PDF is available here.
PDF is available here.
Autonomic Neuroscience (146)1-2 2009
Abstract
We conclude that GABA(A) and nitric oxide in the PVN are involved in the maintenance of the baseline MAP but not in the modulation of the responses to chemoreflex. The results also show that Glutamate receptors in the PVN are not involved in maintenance of the baseline MAP, HR or in the cardiovascul...
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PMID: 19131279
PDF is available here.
PDF is available here.
Autonomic Neuroscience (146)1-2 2009
Abstract
We conclude that GABA(A) and nitric oxide in the PVN are involved in the maintenance of the baseline MAP but not in the modulation of the responses to chemoreflex. The results also show that Glutamate receptors in the PVN are not involved in maintenance of the baseline MAP, HR or in the cardiovascul...
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PMID: 19131279
PDF is available here.
PDF is available here.
Autonomic Neuroscience (146)1-2 2009
Abstract
We conclude that GABA(A) and nitric oxide in the PVN are involved in the maintenance of the baseline MAP but not in the modulation of the responses to chemoreflex. The results also show that Glutamate receptors in the PVN are not involved in maintenance of the baseline MAP, HR or in the cardiovascul...
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PMID: 19131279
PDF is available here.
PDF is available here.
Biomaterials (30)5 2009
Abstract
We hypothesized that cmvIL-10 downmodulates the FBR, impairing degradation of biomaterial. We studied the effect of cmvIL-10 on the FBR to subcutaneously implanted hexamethylenediisocyanate-crosslinked dermal sheep collagen (HDSC) discs in rats. CmvIL-10 impaired macrophage influx, vascularization a...
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PMID: 19038442
PDF is available here.
PDF is available here.
Abstract
alpha-cyanation of N-protected cyclic amines was achieved using a direct electrochemical method. Unsubstituted N-protected cyclic amines were easily cyanated at the alpha-position using an undivided cell in high yields; moreover, alpha-cyanation of alpha'-substituted pyrrolidine and alpha'-,beta'- o...
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PMID: 19109681
PDF is available here.
PDF is available here.
Metallomics (1)6 2009
Abstract
The well-known anticancer drug candidate bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene ) was reacted with sodium azide or potassium cyanate, thiocyanate or selenocyanate in order to give pseudo-halide analogues of Titanocene . and were characterised by s...
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PMID: 21305159
PDF is available here.
PDF is available here.
Abstract
Cyanase catalyzes the decomposition of cyanate into CO(2) and ammonium, with carbamate as an unstable intermediate. The cyanase of Pseudomonas pseudoalcaligenes CECT5344 was negatively regulated by ammonium and positively regulated by cyanate, cyanide, and some cyanometallic complexes. Cyanase activ...
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PMID: 18708510
PDF is available here.
PDF is available here.
Abstract
The microwave spectra of propa-1,2-dienyl selenocyanate, H(2)C==C==CHSeC[triple bond]N, and cyclopropyl selenocyanate, C(3)H(5)SeC[triple bond]N, are reported. The spectra of the ground and two vibrationally excited states of the (80)Se isotopologue and the spectrum of the ground state of the (78)Se...
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PMID: 18612517
PDF is available here.
PDF is available here.
Abstract
The arylacetonitrilase of Pseudomonas fluorescens EBC191 catalyzes the conversion of (S)-mandelonitrile to (S)-mandelic acid and (S)-mandeloamide. This biotransformation is optimally performed under acidic pH values because (S)-mandelonitrile rapidly decomposes under neutral conditions. Therefore, t...
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PMID: 18523765
PDF is available here.
PDF is available here.
Phytochemistry (69)10 2008
Abstract
We propose that oximes produced by CYP79 orthologs are common intermediates and that their conversion into beta- and gamma-hydroxynitrile glucosides is mediated by evolutionary diversified multifunctional orthologs to CYP71E1. We designate these as CYP71(betagamma) and CYP71(alphabetagamma); in comb...
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PMID: 18539303
PDF is available here.
PDF is available here.
Abstract
Gene vectors, (dextran-hexamethylenediisocyanate)-g-polyethylenimines ((Dex-HMDI)-g-PEIs), were synthesized through grafting low molecular weight (800 Da) branched polyethylenimine (PEI) to HMDI functionalized dextrans with two different molecular weights. The buffer capabilities of (Dex-HMDI)-g-PEI...
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PMID: 18439698
PDF is available here.
PDF is available here.
Neuroscience (153)4 2008
Abstract
We have documented that near-infrared light via light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCN-induced apoptotic cell death. The current study t...
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PMID: 18440709
PDF is available here.
PDF is available here.
Inflammopharmacology (16)3 2008
Abstract
The aurocyanide anion, Au(CN) (2) (-) , is a human metabolite of several anti-rheumatic gold complexes containing monovalent gold (I) bound to a sulphur ligand. This article reviews some of the chemical and pharmacological properties of this intriguing metabolite, and reports its anti-arthritic and...
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PMID: 18521543
PDF is available here.
PDF is available here.
Abstract
Previously unrecognized innate immune responses to HDI and HDI-albumin conjugates could influence the clinical spectrum of exposure reactions....
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PMID: 18498542
PDF is available here.
PDF is available here.
Toxicology In Vitro (22)4 2008
Abstract
We aimed at gaining more insight in changes of human macrophages transcriptome and to identify selective genetic markers for respiratory sensitization in response to hexamethylene diisocyanate (HDI). In vitro cultures of human THP-1 cells were differentiated into macrophages and exposed to 55 microg...
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PMID: 18395406
PDF is available here.
PDF is available here.
Bioresource Technology (99)7 2008
Abstract
Corn stover was liquefied by using ethylene carbonate (EC) as liquefying solvent and 97% sulfur acid as catalyst at 170 degrees C for 90 min. Polyurethane (PU) foams were prepared from liquefied corn stover (LCS) with variable amount of polymethylene polyphenylisocyanate (PAPI) by one-shot method, w...
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PMID: 17604162
PDF is available here.
PDF is available here.
Toxicology (247)1 2008
Abstract
The aliphatic diisocyanate monomer 1,6-hexamethylene diisocyanate (HDI) is used as a building block for non-volatile polycondensation products, such as HDI-isocyanurate (HDI-IC) and HDI-biuret (HDI-BT). This paper describes the results from acute inhalation studies with these types of polyisocyanate...
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PMID: 18375034
PDF is available here.
PDF is available here.
Abstract
A one-pot procedure for the synthesis of substituted 2,6-dicyanoanilines starting from readily available ynones and malononitrile has been developed. For instance, penta-1,4-diyn-3-one is converted into the acetylene-substituted aniline derivative 1 in good yield. Upon photoexcitation, this chromoph...
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PMID: 18341285
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)18 2008
Abstract
We studied the role of glycine residues in EmrE, a small multidrug transporter from Escherichia coli. EmrE extrudes various drugs across the plasma membrane in exchange with protons and, as a result, confers resistance against their toxic effects. Each of 12 glycine residues was replaced by site-dir...
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PMID: 18321856
PDF is available here.
PDF is available here.
Abstract
An example of precise evaluation of backbone scalar J couplings using random sampling of evolution time space in 3D NMR experiments is presented. The recorded spectrum, due to violation of the Nyquist theorem limitation, exhibits ultrahigh resolution in indirect dimensions compared to standard NMR e...
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PMID: 18376830
PDF is available here.
PDF is available here.
Abstract
We have developed and evaluated a liquid chromatography/mass spectrometry (LC-MS) method capable of quantifying HDI and its oligomers (uretidone, biuret, and isocyanurate) in air, tape-stripped skin, and paint samples collected in the automotive refinishing industry. To generate analytical standards...
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PMID: 18385871
PDF is available here.
PDF is available here.
Journal of Chromatography A (1185)2 2008
Abstract
This paper presents a novel application of active single-drop microextraction (SDME) for the determination of mixtures of four gaseous diisocyanates: 2,4- and 2,6-toluene diisocyanate (TDI), hexamethylene diisocyanate (HDI) and methylene diphenyl diisocyanate (MDI). The optimised simultaneous extrac...
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PMID: 18291409
PDF is available here.
PDF is available here.
Abstract
We report the discovery of new small molecule aminothiazole inhibitors of Aurora kinases with exceptional kinase selectivity and report a 1.7 A cocrystal structure with the Aurora B:INCENP complex from Xenopus laevis. The compounds recapitulate the hallmarks of Aurora kinase inhibition, including de...
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PMID: 18307303
PDF is available here.
PDF is available here.
Abstract
The equilibrium geometries, stability, and isomerisation of pseudohalogen isomers, C(2)N(2)O(2), have been investigated by DFT calculations at the B3LYP level and by ab initio calculations at the CCSD(T) level of theory using the 6-311+G(2d) and cc-pVTZ basis sets, as well as at the CBS-QB3 level. M...
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PMID: 18309397
PDF is available here.
PDF is available here.
Abstract
The reduction of auricyanide ([Au(CN)(4)](-), a potential gold(III) metabolite of antiarthritic gold(I) compounds), by glutathione (G(-)SH, an anionic biological reductant) proceeds through two intermediates (I(230) and I(290)) which have previously been identified by their UV-vis spectra, but not i...
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PMID: 18255156
PDF is available here.
PDF is available here.
Abstract
Electrospray ionization spectra of potential cyanide-containing gold-drug metabolites revealed additional, weak, unanticipated peaks at approximately twice the mass of the gold(I) and gold(III) cyanide complexes. The exact masses correspond to proton-linked bimetallic complexes, [H[Au(CN)(m)](2)](-)...
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PMID: 18255157
PDF is available here.
PDF is available here.
Abstract
Abstract
Modified DP extract (allergoid) seems to be a good candidate for immunotherapy of patients affected by specific allergy.
2007 S. Karger AG, Basel...
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PMID: 17914274
PDF is available here.
PDF is available here.
Abstract
Surgical adhesives consist on an attractive alternative to suturing or stapling since they can accomplish other tasks, such as haemostasis and the ability to seal air leakages. The application of adhesives would also reduce the surgeries procedure time since they represent an easier and faster metho...
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PMID: 17587150
PDF is available here.
PDF is available here.
Abstract
Medical Hypotheses (70)5 2008
Abstract
Neurotoxicology (29)1 2008
Abstract
We evaluated the cytoprotective effects of alpha-ketoglutarate (A-KG) and N-acetylcysteine (NAC) against cyanide-induced cytotoxicity and altered energy metabolism in PC12 cells. Cyanide-antagonism by A-KG is attributed to cyanohydrin formation whereas NAC is known for its antioxidant properties. Da...
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PMID: 18078672
PDF is available here.
PDF is available here.
Inorganic Chemistry (46)25 2007
Abstract
Four octacyanometalate-based bimetallic Cu-M (M = Mo, W) assemblies coordinated by tetradentate macrocyclic ligands were prepared via self-assembly process in a stoichiometric ratio of [M(CN)8]3- and Cu(macrocycle)2+ and characterized in terms of structures and magnetic properties. The crystal struc...
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PMID: 17985870
PDF is available here.
PDF is available here.
Journal of Comparative Neurology (176)11 2007
Abstract
Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers.
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PMID: 17656675
PDF is available here.
PDF is available here.
Carbohydrate Research (342)15 2007
Abstract
Methods were developed for binding a glycosaminoglycan (GAG, a 50 kDa chondroitin sulfate) to thin agarose membranes using 1-cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP) as the activating agent. Process conditions were optimized to achieve high yields and spatially uniform concentratio...
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PMID: 17610855
PDF is available here.
PDF is available here.
Cancer Research (67)21 2007
Abstract
We initially showed that the inhibition of NF-kappaB DNA binding by benzyl selenocyanate (BSC) and 1,4-phenylenebis(methylene)selenocyanate (p-XSC) was reversed by the addition of DTT; this suggests the formation of DTT-reducible selenium-sulfur bonds between selenocyanate moieties and cysteine resi...
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PMID: 17974991
PDF is available here.
PDF is available here.
Nature Medicine (13)10 2007
Abstract
We now report the discovery of an alternative and quantitatively dominant mechanism for cyanate formation and protein carbamylation at sites of inflammation and atherosclerotic plaque: myeloperoxidase-catalyzed oxidation of thiocyanate, an anion abundant in blood whose levels are elevated in smokers...
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PMID: 17828273
PDF is available here.
PDF is available here.
Abstract
1,6-Hexamethylene diisocyanate biuret trimer (HDI-BT) is a nonvolatile isocyanate that is a component of polyurethane spray paints. HDI-BT is a potent irritant that when inhaled stimulates sensory nerves of the respiratory tract. The role of sensory nerves in modulating lung injury following inhalat...
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PMID: 17673270
PDF is available here.
PDF is available here.
Abstract
Wildlife deaths associated with cyanide-bearing mine waste solutions have plagued the gold mining industries for many years, yet there is little published data showing the relationship between wildlife mortality and cyanide toxicity. A gap of knowledge exists in monitoring, understanding the causal...
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PMID: 17540445
PDF is available here.
PDF is available here.
Brain Research (1168) 2007
Abstract
Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ische...
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PMID: 17706620
PDF is available here.
PDF is available here.
Abstract
The structural characteristics of diisocyanate chemical protein antigens vary depending upon the methods of production, and may influence diisocyanate antigen immunoassays. The impact of different antigen preparation methods on immunoassay sensitivity, specificity, and predictive value for identifyin...
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PMID: 17581205
PDF is available here.
PDF is available here.
Analytical Biochemistry (364)2 2007
Abstract
We applied this method to live cultures of two different bacteria in two different growth media in time course experiments following the changes in metalloid-containing anion concentrations. The results show that this method is a useful means of following the biological processing of these analytes...
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PMID: 17407759
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (111)15 2007
Abstract
A combined matrix isolation FT-IR and theoretical DFT(B3LYP)/6-311++G(d,p) study of the molecular structure and photochemistry of 5-ethoxy-1-phenyl-1H-tetrazole (5EPT) was performed. A new method of synthesis of the compound is described. Calculations show three minima, very close in energy and sepa...
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PMID: 17388403
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (111)15 2007
Abstract
We apply computational methods to investigate the behavior of ammonium cyanate in the solid state under high pressure, employing a theoretical approach based on the self-consistent-charges density-functional tight-binding method (SCC-DFTB). The ammonium cyanate crystal structure was relaxed under ex...
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PMID: 17388562
PDF is available here.
PDF is available here.
Abstract
Formulation of nanocapsules based on polyureas and polyamides have been tested using a patented process. This method based on polycondensation reaction of two complementary monomers and spontaneous formation of oil in water emulsion, is an alternative concept to the known technique based on the same...
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PMID: 17174494
PDF is available here.
PDF is available here.
Abstract
We have carried out laboratory simulations to determine equilibrium concentrations as a function of pH (in PIPES buffer) with added NaCl and CaCl(2). Consistent with expectations, solubility declines with higher pH and [CaCl(2)], but increases only slightly with [NaCl]. Significantly, PIPES shows no...
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PMID: 17136436
PDF is available here.
PDF is available here.
Abstract
1,6-Diisocyanatohexane and dimethyl sulfoxide were exploited as crosslinking agent and reaction solvent, respectively, for gelatin modification. Crosslinked samples were fractionated and analyzed by thermogravimetric analysis, infrared spectroscopy, acid and base titrations, and swelling measurement...
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PMID: 17370271
PDF is available here.
PDF is available here.
Abstract
We report for the first time the effect of metabolic stress on synaptic input to motor neurons by recording postsynaptic currents in the hypoglossal nucleus. Chemical anoxia with NaCN (1 mm) and anoxia with 95% N(2) induced a persistent inward current and a marked and robust increase in action poten...
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PMID: 17408431
PDF is available here.
PDF is available here.
Abstract
The conjugate hydrocyanation of 17-acetylgona-11-carbomethoxy-1,3,5(10),13(17)-tetraenes using diethylaluminum cyanide (Nagata reaction) is reported. This methodology has allowed the introduction of an angular cyano group at the C-13 position of the steroid skeleton. Subsequent reduction of the nitr...
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PMID: 17207507
PDF is available here.
PDF is available here.
Biophysical Journal (92)4 2007
Abstract
We suggest that the CFTR pore has at least two anion binding sites at which Au(CN)2(-) and Pt(NO2)4(2-) block Cl- permeation. The T-338A mutation decreases a barrier for Au(CN)2(-) movement between different sites, leading to significant changes in its blocking action. Our finding that apparent bloc...
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PMID: 17142267
PDF is available here.
PDF is available here.