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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Carbocyanines (0):
Recent article
Carbocyanines
Biopolymers (95)5 2011
Abstract
With the expansion of super-resolution fluorescence microscopy methods, it is now possible to access the organization of cells and materials at the nanoscale by optical means. This review discusses recent progress in super-resolution imaging of isolated and cell DNA using single-molecule localization...
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PMID: 21184489
PDF is available here.
PDF is available here.
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Abstract
We developed a homogenous microtiter based assay using the cationic dye 3, 3'-Diethyloxacarbocyanine iodide, DiOC2(3), to measure the effect of compounds on membrane potential in Staphylococcus aureus. In a screen of 372 compounds from a synthetic compound collection with anti-Escherichia coli activ...
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PMID: 20801170
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
A novel approach for selectively encapsulating Cy5 dye molecules via DNA hybridization in cationic phosphorus dendrimers (G(4)(+))/polystyrenesulfonate (PSS) microcapsules has been developed. The hybridization between Cy5 labeled single strand DNA (ssDNA) targets and complementary ssDNA probes was p...
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PMID: 20844779
PDF is available here.
PDF is available here.
Advanced Materials (FRG) (22)35 2010
Abstract
Abstract
The eukaryotic cell has evolved to compartmentalize its functions and transport various metabolites among cellular compartments. Therefore, in cell biology, the study of organization and structure/function relationships are of great importance. The endoplasmic reticulum is a highly convoluted, singl...
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PMID: 20810627
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time the applicability of fluorescence lifetime correlation spectroscopy (FLCS) to monitor the interaction of an antagonist antibody with the epidermal growth factor receptor (EGFR) in live cells. As a proof of concept, we demonstrate the interaction of Cy5 labeled IgG a...
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PMID: 20586411
PDF is available here.
PDF is available here.
Abstract
We questioned whether telomerase overexpression and the resulting immortalization would affect the functional phenotype of human endothelial cells. Our comparative analysis addressed (1) distinct cell adhesion to different ECM-proteins analyzed on miniaturized multisubstrate arrays (MSA), (2) protei...
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PMID: 20352467
PDF is available here.
PDF is available here.
Optics Express (18)12 2010
Implantable semiconductor biosensor for continuous in vivo sensing of far-red fluorescent molecules.
Abstract
We have fabricated miniature implantable fluorescence sensors for continuous fluorescence sensing applications in living subjects. These monolithically integrated GaAs-based sensors incorporate a 675 nm vertical-cavity surface-emitting laser (VCSEL), a GaAs PIN photodiode, and a fluorescence emissio...
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PMID: 20588377
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (9)12 2010
Abstract
We evaluate an improved orthotopic rat bladder tumor model, to be used for the evaluation of the therapeutic potential of novel cancer therapeutics. Before instilling AY-27 tumor cells into chemically denudated rat bladders, AY-27 cells were labeled with the fluorescent carbocyanine dye 1,1'-dioctad...
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PMID: 20404568
PDF is available here.
PDF is available here.
Abstract
We demonstrate image extraction from a large background to yield >>10-fold sensitivity improvements through synchronously amplified fluorescence image recovery (SAFIRe)....
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PMID: 20397664
PDF is available here.
PDF is available here.
Abstract
Investigation of the intracellular fate of small interference RNA (siRNA), after their delivery into cells by nanoparticles, is of great interest to the development of more efficient methods for transfection of siRNA. The fluorescence resonance energy transfer (FRET) based method using upconversion...
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PMID: 20073488
PDF is available here.
PDF is available here.
Nanotechnology (21)17 2010
Abstract
We report the synthesis and characterization of a dual-modality nanoprobe that couples the magnetic properties of ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) with the near infrared fluorescence of Cy5.5. The fluorophore is encapsulated in a biocompatible shell of silica surroundin...
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PMID: 20368682
PDF is available here.
PDF is available here.
Abstract
Sensitivity experiment showed that 5pg DNA as starting template gave detectable signals on the array. In 13 cases (65%), the paternal-derived beta-gene mutation and/or informative mutant-associated SNP were detected. A subsequent invasive procedure was required to determine if the fetus had a beta-t...
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PMID: 20206431
PDF is available here.
PDF is available here.
Abstract
We reported a method to fabricate fluorescent probes preferentially end-linked to Au nanorods. In comparison with organic dyes, the single nanocomplexes provide significant improvement in signal brightness. The bioconjugated nanoantenna structure implicates an approach that is more convenient and ame...
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PMID: 20364827
PDF is available here.
PDF is available here.
Chemical Communications (46)15 2010
Abstract
A new cyanine-based near-infrared fluorescent probe has been developed for monitoring tyrosinase activity.
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PMID: 20449308
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
Abstract
We have synthesized a series of homopurine DNA and DNA/LNA 14-mers to which an amino acid (glycine or l-tryptophan) and a cyanine dye are covalently linked. Two cyanine dyes were examined that include a quinolinium ring linked to a benzothiazolium ring through a monomethine (TO1) or trimethine (TO2)...
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PMID: 20345124
PDF is available here.
PDF is available here.
Abstract
We have developed the first example of a one-donor/three-acceptor multicolor time-resolved fluorescence energy transfer (TR-FRET) system, and we have exemplified its use by monitoring a ligand-regulated protein-protein exchange process in a four-component biological system. By careful quantification...
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PMID: 20230029
PDF is available here.
PDF is available here.
Biomaterials (31)11 2010
Abstract
We utilized dopamine to modify the surface of IONPs, yielding nanoconjugates that can be easily encapsulated into human serum albumin (HSA) matrices (clinically utilized drug carriers). This nanosystem is well-suited for dual encapsulation of IONPs and drug molecules, because the encapsulation is ac...
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PMID: 20092887
PDF is available here.
PDF is available here.
Abstract
We evaluated whether the ciclosporin derivative, NIM811 reduces mPT and ameliorates delayed neuronal death in the hippocampal CA1 sectors in mice when subjected to transient forebrain ischaemia.
Male C57BL/6 mice were treated with 50 mg/kg ciclosporin, 10, 50 or 100 mg/kg NIM811 or phosphate-buffere...
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PMID: 20604838
PDF is available here.
PDF is available here.
Abstract
Tumor cell internalization of targeting agents is of interest, since internalization influences the local retention time of a radionuclide and thereby imaging quality in PET and SPECT and effects of radionuclide therapy. In cases where nuclear methods are not applicable at the cellular level, quanti...
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PMID: 20198317
PDF is available here.
PDF is available here.
Abstract
The overall results show that the present platform is very promising for rapid identification of DNA sequence variations in an integrated, cost effective and convenient silicon chip format....
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PMID: 20020819
PDF is available here.
PDF is available here.
Journal of Fluorescence (20)2 2010
Abstract
We describe an approach to developing lifetime standards in any wavelength range, based on Förster resonance energy transfer (FRET). These standards are bright, highly reproducible, have a broad decrease in observed lifetime, and an emission wavelength in the red to near infrared making them well s...
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PMID: 19953311
PDF is available here.
PDF is available here.
Abstract
During avian corneal development the nerves make close associations with a specialized type of ACE cell. There they form synapse-like structures, suggesting that not all nerves within the CE terminate as free nerve endings....
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PMID: 19741242
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)4 2010
Abstract
We applied the tract-tracing technique to GFP (green fluorescent protein)-expressing transgenic zebrafish to identify habenular neurons that project to the raphe nuclei, a major target of the mammalian lateral habenula. Axonal tracing in live and fixed fish showed projection of zebrafish ventral hab...
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PMID: 20107084
PDF is available here.
PDF is available here.
Abstract
We have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alt...
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PMID: 20204823
PDF is available here.
PDF is available here.
Abstract
Using this biotin label-based antibody array technology, the expression levels of 507 human, 308 mouse and 90 rat target proteins can be simultaneously detected, including of cytokines, chemokines, adipokines, growth factors, angiogenic factors, proteases, soluble receptors, soluble adhesion molecul...
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PMID: 20551245
PDF is available here.
PDF is available here.
Abstract
It remains controversial whether blastomeres of 2-cell stage mouse embryos show bias in their contribution to the blastocyst and whether there is any effect of superovulation. Two-cell stage embryos from CF1 mice were derived by either natural breeding (N) or superovulation (S) and cultured in vitro...
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PMID: 20209440
PDF is available here.
PDF is available here.
Biomedical Research (30)6 2009
Abstract
We demonstrate that a cyanine dye, lumin, significantly suppressed cytopathic effect by herpes simplex virus (HSV)-1 toward human amnionic FL cell and also it reduced replication of HSV-1 in a dose-dependent manner. In addition, lumin additively augmented the antiviral effect of interferon (IFN)-alp...
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PMID: 20051646
PDF is available here.
PDF is available here.
Molecular Imaging (8)6 2009
Abstract
We investigated a molecular imaging approach for the detection of collagen-induced arthritis in rats by targeting the extra domain B (ED-B) of the extracellular matrix protein fibronectin. ED-B is a highly conserved domain (identical in human and rats) that is produced by alternative splicing during...
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PMID: 20003891
PDF is available here.
PDF is available here.
Acta Radiologica (50)10 2009
Abstract
The maximum excitation/emission wavelength for the Erbitux-Cy5.5 probe was 674/697 nm, similar to that of free Cy5.5 (674/712 nm). Confocal microscopy confirmed receptor-specific uptake in MDA-MB-231 and MCF-7 cells. In flow cytometry probe specificity assay, Erbitux-Cy5.5 showed a 9.32-fold higher...
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PMID: 19922304
PDF is available here.
PDF is available here.
Abstract
We show that dynamic covalent chemistry is an efficient tool for functionalizing surfaces in such a way that their interfacial properties can be varied controllably in space and time. Modulation of pH is used to tune the fast, selective and reversible attachment of functional amines (with different...
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PMID: 21378957
PDF is available here.
PDF is available here.
Abstract
Among various factors affecting operation of oligonucleotide microchips, the variations in concentration and in homogeneous distribution of immobilized probes over the cells are one of the most important. The labeling of immobilized probes ensures the complete current monitoring on the probe distrib...
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PMID: 19583448
PDF is available here.
PDF is available here.
Abstract
We exploited a previously reported promiscuous binding interaction between a single-chain, variable fragment antibody protein and a family of cyanine dyes to create new protein-dye fluoromodules that exhibit enhanced photostability while retaining high affinity protein-dye binding. Modifications to...
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PMID: 19737016
PDF is available here.
PDF is available here.
Carbohydrate Research (344)13 2009
Abstract
The interaction between pinacyanol chloride and sodium alginate or guluronate-rich alginate is found to effect profound changes in the visible absorbance and circular dichroism spectra. Two different types of aggregates are observed depending on the relative dye/alginate concentrations. With a dye/a...
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PMID: 19664760
PDF is available here.
PDF is available here.
Abstract
We present a procedure for quantifying single protein molecules affixed to a surface by counting bound antibodies. We systematically investigate many of the parameters that have prevented the robust single-molecule detection of surface-immobilized proteins. We find that a chemically adsorbed bovine...
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PMID: 19601620
PDF is available here.
PDF is available here.
Abstract
We modeled the aggregation of thea-monomethinecyanine dyes in water. Various modifications of the hypernetted-closure expression for the excess free energy have been studied. We found that the partial wave approximation with semiempirical corrections for excluded volume and hydrogen bonding effects...
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PMID: 19708747
PDF is available here.
PDF is available here.
Abstract
The early stage of molecular excitonics and its quantum-kinetic dynamics in the multiband, bitubular cyanine dye aggregate C(8)O(3) at room temperature are revealed by employing two-dimensional (2D) coherent electronic spectroscopy in the visible spectral region. The sub-20 fs measurements provide a...
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PMID: 19673577
PDF is available here.
PDF is available here.
Chromosoma (118)4 2009
Abstract
Discrete chromatin domains (ChrD), containing an average of approximately 1 Mbp DNA, represent the basic structural units for the regulation of DNA organization and replication in situ. In this study, a bio-computational approach is employed to simultaneously measure the translational motion of larg...
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PMID: 19296120
PDF is available here.
PDF is available here.
Cancer Research (69)15 2009
Abstract
We present a nanoprobe that shows an ability to cross the blood-brain barrier and specifically target brain tumors in a genetically engineered mouse model, as established through in vivo magnetic resonance and biophotonic imaging, and histologic and biodistribution analyses. The nanoprobe is compris...
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PMID: 19638572
PDF is available here.
PDF is available here.
Bioscience Reports (29)4 2009
Abstract
We report that insulin stimulates the phosphorylation of Sec8 on Ser-32 in 3T3-L1 adipocytes. On the basis of the sequence around Ser-32 and the finding that phosphorylation is inhibited by the PI3K (phosphoinositide 3-kinase) inhibitor wortmannin, it is likely that Akt is the kinase for Ser-32. We...
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PMID: 19006485
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (113)30 2009
Abstract
We analyze the many different contributions to photocurrent of the various portions of a prototypical device and, as a proof of principle, we propose the addition of specific ligands to control the increase of the photocurrent yield in the cyanin-based electrochemical device....
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PMID: 19583237
PDF is available here.
PDF is available here.
Brain Research (1283) 2009
Abstract
We investigated in the rat whether hypoglossal innervation extended to facial muscles other than the extrinsic musculature of the mystacial pad. Results showed that hypoglossal neurons also innervate the masseter muscle. Dil injected into the XII nucleus showed hypoglossal axons in the ipsilateral m...
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PMID: 19523459
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)31 2009
Abstract
We utilize cyanine dye 3,3'-diethyl-9-methyl-thiacarbocyanine iodide (C11) to modulate Tau polymerization in two model systems, an organotypic slice culture model derived from Tau transgenic mice and a split green fluorescent protein complementation assay in Tau-expressing cells. In slice cultures,...
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PMID: 19478088
PDF is available here.
PDF is available here.
Molecular Cell (35)1 2009
Abstract
We have examined the mechanism of disassembly of Rad51 nucleoprotein filaments by Srs2 and find that a physical interaction between Rad51 and the C-terminal region of Srs2 triggers ATP hydrolysis within the Rad51 filament, causing Rad51 to dissociate from DNA. This allosteric mechanism explains the...
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PMID: 19595720
PDF is available here.
PDF is available here.
Abstract
We established a novel technique for differential activity-based gel electrophoresis (DABGE) of lipolytic enzymes from two different biological samples. For this purpose, a set of three fluorescent suicide inhibitors was developed. These probes possess the same substrate analogous structures but car...
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PMID: 19282273
PDF is available here.
PDF is available here.
Neurotoxicity Research (16)1 2009
Abstract
We showed that sera from children with autism alter the maturation of human neuronal progenitor cells (NPCs) in culture. Results suggest that pre-programmed neurogenesis, i.e., neuronal proliferation, migration, differentiation, growth, and circuit organization, can be affected differently by factor...
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PMID: 19526302
PDF is available here.
PDF is available here.
Oncology Reports (21)6 2009
Abstract
Our results suggest that MnSOD may be a potential serum marker for molecular diagnosis of gastric carcinoma, and DIGE is a useful technique for screening differentially expressed proteins in cancer tissues....
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PMID: 19424620
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)14 2009
Abstract
The cultured fibroblasts were labeled with CM-Dil within 15 minutes, appearing as red fluorescent discs with bilayer membrane structure. The PI of the labeled fibroblasts was (76.9 +/- 2.8), not significant different from that of the cells not labeled (75.8 +/- 2.0, t = 0.80, P > 0.05). The area wit...
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PMID: 19671314
PDF is available here.
PDF is available here.
Abstract
Capsular polysaccharides (SPS) are an integral component of gram-negative bacteria, and also have potential use as vaccine. In this paper, interactions of SPS isolated from Klebsiella strains K20 and K51 with cationic dyes pinacyanol chloride (PCYN) and acridine orange (AO) were studied by absorbanc...
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PMID: 19517998
PDF is available here.
PDF is available here.
Abstract
Morphological properties of chick retinal ganglion cells (RGCs) were studied in relation to their central projections in 23 chicks. A total of 217 RGCs were retrogradely labeled by applying a carbocyanine dye (DiI) to the thalamus and optic tectum. The labeled RGCs were classified into six groups on...
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PMID: 19263477
PDF is available here.
PDF is available here.
Biophysical Journal (96)6 2009
Abstract
Organic fluorophores common to fluorescence-based investigations suffer from unwanted photophysical properties, including blinking and photobleaching, which limit their overall experimental performance. Methods to control such processes are particularly important for single-molecule fluorescence and...
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PMID: 19289062
PDF is available here.
PDF is available here.
Abstract
A novel cyanine dye supramolecular assembly was designed to recognize mixed G-quadruplex in human telomeres.
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PMID: 19225650
PDF is available here.
PDF is available here.
Abstract
Unsymmetrical functionalised cyanine dyes, covering the whole colour range, were readily synthesised (in 100 mg amounts) by a combination of microwave and solid-phase methodologies.
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PMID: 19225665
PDF is available here.
PDF is available here.
Medical Physics (36)3 2009
Abstract
Optoacoustic imaging is emerging as a noninvasive imaging modality that can resolve optical contrast through several millimeters to centimeters of tissue with the resolution achieved by ultrasound imaging. More recently, applied at multiple illumination wavelengths, multispectral optoacoustic tomogr...
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PMID: 19378754
PDF is available here.
PDF is available here.
Acta Biomaterialia (5)3 2009
Abstract
We have used the layer-by-layer film deposition approach to construct ultrathin multilayer assemblies for in vitro controlled release of plasmid DNA (pDNA). Layer-by-layer assemblies containing alternate layers of cationic poly(l-tartaramidopentaethylenetetramine) (T4), and anionic pDNA were fabrica...
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PMID: 19249723
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of wall shear stress and water filtration rate (or perfusion pressure) on the luminal surface LDL concentration (c(w)) and the LDL uptake by human vascular endothelial cells and smooth muscle cells co-cultured on a permeable membrane using a parallel-plate flow chamber te...
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PMID: 19204832
PDF is available here.
PDF is available here.
Abstract
We show that the flagella of bacteria that are immobilized on a surface often interact with each other, and that the flagella of these bacteria do not often form multi-flagella bundles that are aligned with the cell body....
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PMID: 19220696
PDF is available here.
PDF is available here.
Abstract
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-s...
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PMID: 19097889
PDF is available here.
PDF is available here.
Abstract
We examined interstitial alterations during postmyocardial infarction (MI) remodeling and assessed the efficacy of antiangiotensin and antimineralocorticoid intervention, alone and in combination.
The antagonists of the renin-angiotensin-aldosterone axis restrict myocardial fibrosis...
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PMID: 19356555
PDF is available here.
PDF is available here.
Abstract
We expect to develop an approach that can be used to quantify the amount of target molecules on the cell surfaces using the cell intensity and lifetime images at the single cell level....
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PMID: 19113832
PDF is available here.
PDF is available here.