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Demeclocycline (0):
Recent article
Demeclocycline
Abstract
Up to 80% of endodontic patients who report with preoperative pain continue to experience some level of pain following the endodontic procedure. Various classes of drugs have been studied for the management of post-treatment endodontic pain. Since endodontic pain is often associated with chronic inf...
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PMID: 19998665
PDF is available here.
PDF is available here.
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Orvosi Hetilap (149)29 2008
Abstract
Etiopathogenesis, diagnostics and therapy of hyponatremias are summarized for clinicians. Hyponatremia is the most common electrolyte abnormality. Mild to moderate hyponatremia and severe hyponatremia are found in 15-30% and 1-4% of hospitalized patients, respectively. Pathophysiologically, hyponatr...
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PMID: 18617466
PDF is available here.
PDF is available here.
Journal of Chromatography A (1195)1-2 2008
Abstract
Eight antibiotics, chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, tetracycline and rolitetracycline, were separated and quantified in Spanish honey extracts of different floral origin using a commercial RP-C18 HPLC column and two different on-line detecto...
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PMID: 18501371
PDF is available here.
PDF is available here.
Abstract
The purpose of this research is to investigate the frequency of endodontic flare-ups using a visual analogue scale. Definitions of flare-ups vary widely as does their reported frequency. A flare-up was defined as an increase of 20 or more points on the visual analogue scale for a given tooth, within...
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PMID: 18076580
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (65 Suppl 8) 2007
Abstract
Abstract
A rapid, specific, and sensitive procedure for determining residues of 4 widely used tetracycline antibiotics and 3 of their 4-epimers in cheese is presented. The method is based on the matrix solid-phase dispersion (MSPD) technique followed by liquid chromatography/tandem mass spectrometry (LC/MS/M...
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PMID: 17580641
PDF is available here.
PDF is available here.
Abstract
We examined iliac crest cortical bone from 97 B (49 male, 48 female) aged 22-80 and 111 W (60 male, 51 female) aged 21-84 histomorphometrically for differences between B and W and effects of age. B had thicker (P = 0.02) and less porous (P = 0.0007) cortices, fewer haversian (H) osteons (P < 0.0001)...
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PMID: 17160576
PDF is available here.
PDF is available here.
Cleveland Clinic Journal of Medicine (73 Suppl 3) 2006
Abstract
Hyponatremia is a common electrolyte disorder among hospitalized patients and has been associated with increased mortality. Most patients are asymptomatic, but many do present with symptoms, usually of a generalized neurologic nature. Based-on medical history, physical examination (including volume-...
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PMID: 16970147
PDF is available here.
PDF is available here.
Abstract
After consideration of a review of extensively searched literature, a protocol and key points document have been developed to assist clinicians in their treatment planning. Further long-term studies with the highest level of evidence (i.e. randomized controlled trials) are required to enable us to i...
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PMID: 16430526
PDF is available here.
PDF is available here.
Journal of Endodontics (32)2 2006
Abstract
The aim of this study was to evaluate the time required by four different root canal medications coupled with the temporary filling material Cavit (ESPE, Seefeld, Germany) to prevent penetration of bacteria into the root canal. There were 145 roots prepared in a standardized manner. Four groups with...
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PMID: 16427460
PDF is available here.
PDF is available here.
Journal of Endodontics (32)1 2006
Abstract
The study was aimed at comparing the efficacy of disinfection of root canals with periapical radiolucencies when treated with either antibiotics/steroid medicaments (Ledermix or Septomixine) or a calcium hydroxide paste (Calasept). Microbiological samples were taken before and after two-visit endodo...
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PMID: 16410062
PDF is available here.
PDF is available here.
Abstract
We have shown an altered response of osteocytes from osteoporotic patients to mechanical loading, and osteocyte density is reduced in osteoporotic patients, which might relate to imperfect bone remodeling, leading to lack of bone mass and strength. Hence, information on osteocyte density will contri...
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PMID: 16307389
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)40 2005
Abstract
We examined the protective properties of chlortetracycline (CTC) and demeclocycline (DMC) and showed that these two tetracyclines were also potent neuroprotective against glutamate-induced neuronal death in vitro and cerebral ischemia in vivo. However, CTC and DMC appeared to confer neuroprotection...
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PMID: 16091365
PDF is available here.
PDF is available here.
Abstract
Demeclocycline (DM) and methacycline (MT) have been determined by europium-sensitized fluorescence, using EDTA as co-ligand and cetyltrimethylammonium chloride as surfactant. The methods have been developed in slightly alkaline solutions, with the formation of a new chelate where the lanthanide ion...
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PMID: 15862691
PDF is available here.
PDF is available here.
Abstract
There are a number of drug interactions reported for tetracyclines with many other drugs. In present study in vitro release of five different tetracyclines i.e., tetracycline, demeclocycline, oxytetracycline, methacycline and doxycycline in presence of cimetidine and ranitidine has been studied by U...
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PMID: 16431401
PDF is available here.
PDF is available here.
Abstract
A confirmatory method coupling liquid chromatography to tandem mass spectrometry (LC/MS/MS) is described for the determination of tetracycline, oxytetracycline, doxycycline and chlortetracycline in honey. Demeclocycline, another tetracycline molecule not reported for its usage in honey, was used as...
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PMID: 15655801
PDF is available here.
PDF is available here.
Abstract
Traumatized teeth present a clinical challenge with regard to their diagnosis, treatment plan and prognosis. The injuries to the permanent dentition include crown and root fractures, subluxations, luxations and tooth avulsion. Common complications are pulp necrosis, periapical pathosis and root reso...
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PMID: 15503546
PDF is available here.
PDF is available here.
Journal of Medicine (35)1-6 2004
Abstract
We herein describe a rare case of hyponatremia that was aggravated by a burn injury. The patient was also found to have hypothyroidism, followed by SIADH, and finally CSWS, which showed complicated clinical features. A 68-year-old man was admitted for evaluation and treatment of a thermal burn. On a...
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PMID: 18084871
PDF is available here.
PDF is available here.
Caries Research (38)5 2004
Abstract
This study investigated the efficiency of a chlorhexidine varnish and an antibiotic paste in suppressing the cultivable microflora of deep dentine cavities in a stepwise excavation procedure. Subsequent to enamel preparation and removal of the central biomass, infected dentine was sampled from the c...
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PMID: 15316187
PDF is available here.
PDF is available here.
Abstract
The mean score pain for all three groups was between 42 and 48 prior to treatment being commenced. After 4 days, the pain score for Group 2 was 10, for Group 3 was 7 and for Group 1 was 4. Mean preoperative pain level was 44.4 (of a maximum 100) for all groups, and declined by 50% (to 22.1) after 24...
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PMID: 14641427
PDF is available here.
PDF is available here.
Abstract
Of 550 sampled teeth, 251 were examined. The mean observation period was 74 months. The failure rate was 44% (n = 111), with a median survival time of 113 months (mean, 91 months). Use of the Cox Regression model revealed that tooth type was significant in affecting the survival time of the treatmen...
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PMID: 12075211
PDF is available here.
PDF is available here.
Abstract
Vital pulp therapy for cariously exposed permanent teeth remains one of the most controversial areas in dentistry. Because a vital, functioning pulp is capable of initiating several defence mechanisms to protect the body from bacterial invasion, it is beneficial to preserve the vitality and health o...
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PMID: 12360679
PDF is available here.
PDF is available here.
Age and Ageing (31)2 2002
Abstract
Abstract
Electrophoresis (22)13 2001
Abstract
A mixture of five tetracycline (TC) derivatives: minocycline (MC), demeclocycline (DMCTC), doxycycline (DC), and sancycline (SC), as well as each TC derivative from its main degradation product were separated by capillary zone electrophoresis (CZE). The influence of the pH and the concentration and...
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PMID: 11545407
PDF is available here.
PDF is available here.
Spinal Cord (39)6 2001
Abstract
Family Practice (18)3 2001
Abstract
Antibiotic had no impact on the resolution of symptoms of cough at 1 and 2 weeks, respectively; adjusted odds ratio 1.2 [95% confidence interval (CI) 0.7--2.1] and 0.8 (95% CI 0.4--1.6). In those 220 (73%) individuals who suffered a cough, 48 (44%) and 19 (17%) of patients taking placebo were still...
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PMID: 11356728
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine whether intracanal medication prior to root canal obturation has an inhibitory effect on corono-apical penetration of bacteria. 93 single rooted teeth were instrumented and sterilized with ethylene oxide. They were assigned to three control groups and four test g...
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PMID: 11202895
PDF is available here.
PDF is available here.
Abstract
Abstract
It was concluded that Ledermix paste may cause discolouration of teeth. Such effects can be minimized if placement of the paste is restricted to below the gingival margin. Clinicians should ensure that Ledermix paste is not left on the walls of access cavities....
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PMID: 11307439
PDF is available here.
PDF is available here.
Abstract
After 12 weeks, sunlight exposure had caused dark grey-brown staining in the Ledermix groups but this did not occur when the teeth were kept in the dark. More severe staining was noted when Ledermix paste filled the pulp chamber than when the paste was restricted to below the CEJ and when teeth were...
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PMID: 11307440
PDF is available here.
PDF is available here.
Abstract
The secondary metabolite 6-demethylchlortetracycline (6-DCT), which is produced by Streptomyces aureofaciens, is used as a precursor of semisynthetic tetracyclines. Strains that produce 6-DCT also produce a melanin-like pigment (MP). The correlation between MP production and 6-DCT production was inv...
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PMID: 10742218
PDF is available here.
PDF is available here.
Orvosi Hetilap (140)51 1999
Abstract
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common cause of hyponatremia. In this study a case of SIADH caused by head trauma is reported, in which severe hyponatraemia, escorted by life-threatening neurological symptoms was observed that could only be managed by par...
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PMID: 10647278
PDF is available here.
PDF is available here.
Sexually Transmitted Infections (75 Suppl 1) 1999
Abstract
Abstract
We studied the effect of tetracyclines on the Na+/K+ pump activity in Calu-3, a human airway cell line. To estimate Na+/K+ pump capacity on the basolateral membrane, an ouabain-sensitive component of the short-circuit current (Isc) was measured in the presence of nystatin, an ionophore of Na+. The a...
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PMID: 10381336
PDF is available here.
PDF is available here.
Endocrine Journal (46)2 1999
Abstract
We examined the response of AVP secretion to osmotic stimulus by hypertonic saline infusion and analyzed the possible causative factors in six patients with SIAD associated with head trauma or cerebral infarction. Hyponatremia developed after head trauma in four patients and cerebral infarction in t...
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PMID: 10460011
PDF is available here.
PDF is available here.
Abstract
We have no effective therapeutic methods other than administrating sodium chloride solution and diuretics, or restricting the intake itself. A case was reported stating that demeclocycline, used in case where there is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), was effec...
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PMID: 10374240
PDF is available here.
PDF is available here.
Laryngoscope (108)4 Pt 1 1998
Abstract
Mucosal changes have been well described in chronic sinusitis, yet little is known about the underlying bone, despite clinical and experimental evidence suggesting that bone may be involved in chronic sinusitis. Techniques of undecalcified bone analysis were used for detailed histologic examination...
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PMID: 9546260
PDF is available here.
PDF is available here.
American Surgeon (64)3 1998
Abstract
We conclude that perioperative administration of demeclocycline reliably inhibits the effects of increased VP secretion commonly seen in patients undergoing CABG procedures. Applying these findings to surgical patients who are at increased risk of complicated fluid and electrolyte problems requires...
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PMID: 9520826
PDF is available here.
PDF is available here.
Abstract
Abstract
A sensitive high-performance liquid chromatographic technique with amperometric detection has been developed for the determination of seven commercially used tetracyclines in bulk powders and pharmaceutical preparations. The technique is based on the oxidation of these compounds and their contaminan...
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PMID: 9502164
PDF is available here.
PDF is available here.
Abstract
We have performed a histomorphometric analysis of the three regions of the proximal tibial cancellous bone of bone formed before, during, and after drug treatment. Male rats (190-220 g) were treated subcutaneously for 10 days with zoledronate (0.028-2.8 microg/kg) or pamidronate (3.7-370 microg/kg)...
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PMID: 9415453
PDF is available here.
PDF is available here.
Abstract
Optimized methods for the analysis of some tetracyclines by capillary electrophoresis are described. Different buffer systems were employed for the separation of tetracycline, oxytetracycline and demeclocycline from their respective major impurities, including the 2-acetyl-2-decarboxamido derivative...
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PMID: 9215958
PDF is available here.
PDF is available here.
Abstract
Abstract
Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion o...
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PMID: 9260333
PDF is available here.
PDF is available here.
Abstract
Journal of Endodontics (22)9 1996
Abstract
The effects of Ledermix+calcium hydroxide (Ca(OH)2) or Ca(OH)2 alone on inflamed pulp tissues of dogs were studied. Fifty-nine upper incisor teeth of 10 dogs were used. Class V cavities were prepared and filled with amalgam after placement of decayed dentin particles. After 7 days, the decayed denti...
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PMID: 9198422
PDF is available here.
PDF is available here.
Primary Dental Care (3)1 1996
Abstract
There was a significant difference between the rates of tertiary dentine formation for all materials except zinc oxide-eugenol and Ledermix paste. For each material there was a increased rate of tertiary dentine formation in the second period (29-49 days) compared to the first period (0-28 days). Th...
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PMID: 8941804
PDF is available here.
PDF is available here.
Abstract
Six patients are with inappropriate secretion of antidiuretic hormone syndrome are reported (two with bacterial acute meningitis, two with bacterial pneumonia, one with oat cell lung carcinoma, other with mediterranean fever boutonneuse) and the clinical manifestations were: mind changes (four cases...
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PMID: 8679842
PDF is available here.
PDF is available here.
Abstract
By genomic Southern blot analysis, the DNA sequences homologous to the gene cluster responsible for biosynthesis of 6-demethyl-chlortetracycline in Streptomyces aureofaciens NRRL3203 were shown to be highly conserved in independent chlortetracycline- or tetracycline producing Streptomyces strains. B...
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PMID: 7670200
PDF is available here.
PDF is available here.
Abstract
Two cosmid clones containing distinct types of self-defense gene of a 6-demethylchlortetracycline producer, Streptomyces aureofaciens NRRL3203, were isolated. The gene responsible for chlorination of tetracycline (chl gene) was subcloned from one of the cosmid clones by complementation of a chlorina...
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PMID: 7612997
PDF is available here.
PDF is available here.
Journal of Endodontics (21)2 1995
Abstract
A quantitative assessment of dentin bridges was conducted on sections prepared from teeth capped with four pulp-capping agents (Bioglass, Life, Demineralized Dentin Matrix, and Teflon) in a micro-swine model. The degree of mineralization of the dentin bridges relative to the adjacent primary dentin...
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PMID: 7714442
PDF is available here.
PDF is available here.
Abstract
1. This study was aimed at investigating the effects of demeclocycline (DMC), minocycline (MC), and lithium (Li) in vitro on cyclic AMP (cAMP) accumulation in rat cerebral cortex stimulated by noradrenaline, forskolin, and ouabain. 2. DMC, MC, and Li dose-dependently reduced noradrenaline-stimulated...
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PMID: 7708928
PDF is available here.
PDF is available here.
Abstract
The effects of different intracanal medicaments and zinc oxide-eugenol based root canal sealers on an experimentally induced apical periodontitis were studied histologically in mesial roots of lower molars of Wistar rats. After root canal instrumentation each canal was filled either with an intracan...
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PMID: 7843066
PDF is available here.
PDF is available here.
Abstract
Once serum sodium concentrations had normalized after carbamazepine discontinuation, demeclocycline prevented further decreases in sodium levels upon rechallenge with carbamazepine in five of six patients. Gender, smoking, and neurologic compromise may have played a role in the development of carbam...
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PMID: 8071279
PDF is available here.
PDF is available here.
Abstract
Abstract
Once recognized, acute, subacute, and chronic complications of the polydipsia-hyponatremia syndrome are readily treatable. Besides treating the patient, consultation/liaison psychiatrists can teach their medical colleagues about this syndrome. In so doing, they will enhance the quality of their pati...
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PMID: 7737786
PDF is available here.
PDF is available here.
Abstract
Abstract
We present a case of a 14-year-old boy who developed chronic SIADH after TBI in which caloric needs could not be adequately provided, with concomitant fluid restriction as the first line of treatment. Demeclocycline was ultimately used, which allowed for increased fluid liberalization and for provis...
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PMID: 8239967
PDF is available here.
PDF is available here.