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Lymecycline (0):
Recent article
Lymecycline
Annales de Dermatologie et de Vénéréologie (134)5 Pt 1 2007
Abstract
BACKGROUND: Reports of severe drug-induced bullous reactions to tetracyclines are rare. A case of Stevens-Johnson syndrome in a patient treated with lymecycline is reported herein. CASE REPORT: A 22 year-old woman with acne was referred for Stevens-Johnson syndrome occurring ten days after starting...
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PMID: 17507845
PDF is available here.
PDF is available here.
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Abstract
Topical retinoids are often recommended for preventing acne recurrence, but there are relatively few well-controlled maintenance studies published. The objective of the present study was to assess the maintenance effect of adapalene gel 0.1% relative to gel vehicle in subjects successfully treated i...
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PMID: 17324827
PDF is available here.
PDF is available here.
Abstract
We report the case of a 31-year-old woman affected by Melkersson-Rosenthal syndrome, who has been successfully treated with lymecycline, after variable results with steroids alone or combined with antihistamines, sulphasalazine and clofazimine....
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PMID: 15246942
PDF is available here.
PDF is available here.
Journal of the American Academy of Dermatology (49)3 Suppl 2003
Abstract
This multicenter, randomized, investigator-blinded study compared the efficacy and tolerability of a combination of lymecycline 300 mg/day orally and adapalene topical gel 0.1% (n = 118) to lymecycline 300 mg/day orally plus vehicle gel (n = 124) in patients with moderate to moderately severe acne v...
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PMID: 12963898
PDF is available here.
PDF is available here.
Abstract
16/17 (94%) patients reported some kind of back pain and 10/17 (59%) peripheral joint symptoms during the follow up. Two patients had unilateral grade 1 sacroiliitis, one patient grade 4 sacroiliitis, and one patient bilateral grade 2 sacroiliitis. In one patient the disease had progressed to ankylo...
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PMID: 12810429
PDF is available here.
PDF is available here.
Abstract
We compared the efficacy and safety of lymecycline 300 mg od vs lymecycline 150 mg bid or placebo in the treatment of moderate to severe acne. 271 patients received either oral lymecycline 300 mg od + placebo od, lymecycline 150 mg bid, or placebo bid, for 12 weeks. Reduction in inflammatory lesion...
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PMID: 12609781
PDF is available here.
PDF is available here.
Abstract
A comparison of efficacy, safety and cost-effectiveness of lymecycline and minocycline in the treatment of acne vulgaris has been addressed. This was a multicenter, randomized, investigator-masked, parallel group trial involving patients with moderate to moderately severe acne vulgaris, receiving ei...
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PMID: 12695127
PDF is available here.
PDF is available here.
Abstract
Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacter...
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PMID: 11867968
PDF is available here.
PDF is available here.
Abstract
Abstract
The dissimilar bioavailability and antimicrobial efficacy between the two bacteriostatic agents may impart different clinical efficacy....
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PMID: 9646139
PDF is available here.
PDF is available here.
Abstract
A multicentre, randomised, double-blind and double-dummy study was conducted to compare the efficacy and safety of lymecycline (n = 71) with that of minocycline (n = 73) in 144 patients with moderately severe acne vulgaris. Patients with an acne score of 1-5 on the Leeds scale received oral lymecycl...
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PMID: 9649660
PDF is available here.
PDF is available here.
Helicobacter (2)4 1997
Abstract
BACKGROUND. This double-blind, randomized study evaluated the efficacy of dual and triple therapies including ranitidine for treatment of Helicobacter pylori infection. MATERIALS AND METHODS. Dyspeptic patients (n = 105) with a positive rapid urease test formed the intention-to-treat population (ITT...
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PMID: 9421122
PDF is available here.
PDF is available here.
Dermatology (195)1 1997
Abstract
We report the case of a large subacute pyoderma gangrenosum stabilized with lymecycline, topical benzoyl peroxide and successfully treated by an autograft. This observation supports the opinion that the risk of pathergy of a graft can be avoided by the stabilization of the disease....
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PMID: 9267739
PDF is available here.
PDF is available here.
Lakartidningen (93)5 1996
Abstract
Abstract
To compare the clinical and microbiological efficacy of azithromycin in curing chlamydial infections in women with that of lymecycline, and with a view of the possibility of minimizing the problem of compliance by means of single-dose administration, 146 women with culture-positive Chlamydia trachom...
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PMID: 8953672
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Resistance against vaginal colonisation by Mycoplasma pulmonis in strain TO mice after exposure to the mycoplasma was investigated. Eighteen mice from which M. pulmonis had been eliminated from the vagina, either naturally or by antibiotic therapy, were resistant to vaginal recolonisation. Specific...
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PMID: 8114070
PDF is available here.
PDF is available here.
Abstract
We conclude that doxycycline has a higher phototoxic potency than lymecycline, and this is in agreement with earlier in vitro experimental data. We recommend that therapy with doxycycline is avoided during summer-time, and during holidays in a sunny climate....
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PMID: 8148278
PDF is available here.
PDF is available here.
Lakartidningen (90)34 1993
Abstract
Pathologie Biologie (41)4 1993
Abstract
I or R was respectively: doxycycline (2.7), minocycline (5.5), lymecycline (15.2), erythromycin (100), clindamycin (1.4), ofloxacin (2.7), josamycin (0) and pristinamycin (0). Comparable results were observed in the different geographic areas. The frequency of acquired resistances does not justify m...
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PMID: 8233624
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (35)2 1992
Abstract
We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA). METHODS. Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. RESULTS. Therapeutic levels of lymecyclin...
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PMID: 1310409
PDF is available here.
PDF is available here.
Molecular Immunology (28)6 1991
Abstract
Serotonin release from rat basophilic leukemia (RBL) cells, sensitized with a DNP-binding monoclonal IgE, was stimulated with solid surface (polystyrene)-bound DNP-amino acids. The stimulatory potency of DNP-amino acids was dependent on the structure of amino acid attached to DNP. Generally, DNP-ami...
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PMID: 1861680
PDF is available here.
PDF is available here.
Abstract
We studied the wives in 40 consecutive infertile couples. Monoclonal direct immunofluorescence (DIF) for C trachomatis was performed on fixed smears from endocervical swabs. M hominis and U urealyticum were isolated by inoculation of Hayflick (HF) medium, HF broth and Ureaplasma A7 agar with endocer...
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PMID: 2030488
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (34)1 1991
Abstract
We conducted a double-blind, placebo-controlled, randomized study of 3-month treatment with lymecycline, a form of tetracycline, in reactive arthritis (ReA). Lymecycline therapy significantly decreased the duration of the illness in patients with Chlamydia trachomatis-triggered ReA, but not in other...
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PMID: 1670621
PDF is available here.
PDF is available here.
Abstract
In a clinical, controlled trial 55 women with a history of pelvic inflammatory disease (PID) undergoing first-trimester abortion were randomized to either lymecycline therapy or placebo. Twenty-four women received lymecycline capsules 300 mg b.i.d. for 14 days starting on the morning of the abortion...
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PMID: 3061846
PDF is available here.
PDF is available here.
Abstract
In a study at the University Hospital in Trondheim during 1983, the frequency of Chlamydia trachomatis among women terminating their pregnancies was 8.2%. Younger women were infected by C. trachomatis at a more frequent rate than older women (p less than 0.001). Treatment of chlamydia-positive women...
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PMID: 3387707
PDF is available here.
PDF is available here.
Abstract
Electron beam therapy applied to a lymph node metastasis from a squamous cell carcinoma was followed by the development of histologically and immunologically typical bullous pemphigoid, the lesions being initially strictly confined to the irradiation area. This observation suggests that the bullous...
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PMID: 2963841
PDF is available here.
PDF is available here.
Photo-dermatology (4)6 1987
Abstract
A double blind cross-over phototoxicity study using demethylchlortetracycline (DMCT) 0.3 g x 2, doxycycline 0.1 g x 2, lymecycline 0.6 g x 2 and placebo was performed on 8 healthy human volunteers. Drugs were given for 3 consecutive days, and on the third day the volunteers were tested with differen...
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PMID: 3127815
PDF is available here.
PDF is available here.
Abstract
Motile curved rods, Mobiluncus species, were identified in 20 women whose main complaints were sparse vaginal bleeding and/or foul-smelling discharge. After treatment with metronidazole all the women were free of symptoms and no Mobiluncus could be detected.
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PMID: 3946485
PDF is available here.
PDF is available here.
Abstract
Seventy-five men with gonococcal urethritis were treated with a single oral dose of thiamphenicol, and 88 men with this infection were treated with two 1.5-g oral doses of lymecycline taken 12 hr apart. Of the 75 subjects treated with thiamphenicol, 72 (96%) were cured, as compared with 80 (91%) tre...
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PMID: 3094172
PDF is available here.
PDF is available here.
Abstract
A clinical, controlled trial was performed to study the effect of prophylaxis with lymecycline and the role of Chlamydia trachomatis and Mycoplasma hominis in postabortal genital infection. Of 532 women who were to undergo first-trimester abortion, 269 were randomized to treatment with oral lymecycl...
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PMID: 3890229
PDF is available here.
PDF is available here.
Chemotherapy (31)4 1985
Abstract
In an open, random, cross-over trial, 8 young healthy volunteers were given standard doses of lymecycline and doxycycline for 2 days to achieve steady state. The pharmacokinetics of each tetracycline in serum and dermal, suction blister fluid were determined after oral doses of 300 mg lymecycline or...
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PMID: 4028871
PDF is available here.
PDF is available here.
Abstract
The relative bioavailability of lymecycline and tetracycline hydrochloride was compared in 12 healthy volunteers in a double-blind cross-over study using a high performance liquid chromatographic method for plasma and urine analyses. A statistical significant difference in favour of tetracycline hyd...
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PMID: 6487493
PDF is available here.
PDF is available here.
Abstract
Pathologie Biologie (31)6 1983
Abstract
Results of sensitivity to antibiotic in vitro and results of antibiotic treatment in vivo seem to recognize so far lymecycline as the tetracycline to prescribe in infections by mycoplasmas.
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PMID: 6410346
PDF is available here.
PDF is available here.
Abstract
The interaction between glucocorticoids and antibiotics in the treatment of brain abscesses has been examined in rats. After stereotactic inoculation of Bacteroides melaninogenicus in the right frontal lobe to induce abscess formation, the animals were divided into two groups those treated with anti...
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PMID: 6841306
PDF is available here.
PDF is available here.
Laryngoscope (93)2 1983
Abstract
Medication with oral drugs has not been considered as a cause of esophageal lesions in the general literature of esophageal disease. This study demonstrates 40 patients with complaints of sudden onset of intense retrosternal pains and odynophagia during treatment with oral tetracyclines. All patient...
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PMID: 6823189
PDF is available here.
PDF is available here.
Abstract
Concentration of lymecycline, a lipophilic tetracycline, in the human sinusal mucosa tissue, as measured by the "punch method" technique are fairly high. The median value of all examined pieces of mucosa amounts to 1.2 mcg/g.
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PMID: 6417972
PDF is available here.
PDF is available here.
Abstract
After evaluation of the clinical efficacy and the tolerance of lymecycline 2 x 300 mg/day in patients with subacute sinusitis, we may conclude that lymecycline can be considered a first choice antibioticum in the treatment of acute and subacute sinusitis (Tetralysal).
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PMID: 6650154
PDF is available here.
PDF is available here.
Abstract
A comparison between different methods of determining the levels of lymecycline in tissue is presented. The drug levels have been compared with those registered, during the steady state condition, in interstitial fluid obtained from subcutaneously implated tissue cages in rabbits. The 'tissue piece...
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PMID: 6822773
PDF is available here.
PDF is available here.
New Zealand Medical Journal (95)709 1982
Abstract
Abstract
On the basis of a comparison of different methods used to determine the concentration of active lymecycline in Fallopian tube tissue, a method was adopted which allowed the determination of lymecycline in serosa and mucosa tissue of the Fallopian tube in 16 women undergoing hysterectomy. A differenc...
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PMID: 7046335
PDF is available here.
PDF is available here.
Abstract
A group of 782 patients with a diagnosis of acute salpingitis (a few of the patients because of other infection in the pelvis) were treated with the recommended oral dose of doxycycline (200 mg the first day and 100 mg once daily for at least the following 9-12 days) in combination with 1 g benzyl p...
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PMID: 7090752
PDF is available here.
PDF is available here.
Abstract
The treatment of chlamydial urethritis in males depends on the susceptibility of Chlamydia trachomatis to different antimicrobial agents. Tetracyclines seem to be the drugs of choice; long-acting tetracyclines are recommended, as these are more convenient for the patient. Both lymecycline and doxycy...
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PMID: 6958014
PDF is available here.
PDF is available here.
Abstract
Chlamydia trachomatis was isolated from the urethra in 71 of 275 men primarily attending the outpatient clinic of the Department of Urology because of symptoms of acute urethritis, and with more than four polymorphonuclear leukocytes in each of at least five fields of the swabbed urethral exudate (x...
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PMID: 6172944
PDF is available here.
PDF is available here.
Acta urologica Belgica (48)3 1980
Abstract
Abstract
Abstract
A group of 213 men with non-gonococcal urethritis and their sexual partners were treated either with erythromycin stearate 500 mgx2 for 15 days or with lymecycline 300 mgx2 for 10 or 20 days. Chlamydia trachomatis was isolated from 40% of the men, from 26% of their female partners and from 56% of th...
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PMID: 87096
PDF is available here.
PDF is available here.
Abstract
The influence of 2 etracycline preparations, lymecycline and doxycycline, on leukocyte chemotaxis, was investigated in vitro and in vivo. Doxycycline in high concentrations caused a severe depression of both spontaneous and induced migration, an effect which was more pronounced than that caused by s...
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PMID: 462129
PDF is available here.
PDF is available here.
Abstract
It has been suggested in the past that milk causes an impaired absorption of tetracycline and this paper describes a study set up to examine any inhibition of absorption of a tetracycline derivative, lymecycline (Tetralysal) with the concurrent intake of milk. The results of the study show no clinic...
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PMID: 583042
PDF is available here.
PDF is available here.
Abstract
Abstract
The effect of lymecycline treatment on arthritis in C3H mice produced 5 months previously by i.v. inoculation of Mycoplasma pulmonis was examined. Treatment had little effect on the severity of the clinical disease. However, there was a marked reduction the severity of the histopathological inflamma...
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PMID: 656320
PDF is available here.
PDF is available here.
Abstract
Abstract
The urine and serum concentrations of lymecycline and doxycycline were investigated in a cross-over study in ten volunteers. Both drugs were found in therapeutic serum levels but lymecycline had a mean urine concentration of 240 microgram per ml compared to 60 microgram per ml of doxycycline. The re...
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PMID: 732594
PDF is available here.
PDF is available here.
Abstract
A micro-method was developed for determination of the concentrations of antibiotics in the mucous membranes of the maxillary sinus in man. At different times after the administration of antibiotics (potassium phenoxymethylpenicillin, lymecycline and bacampicillin) the concentration was determined in...
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PMID: 100874
PDF is available here.
PDF is available here.
Abstract
Men with non-gonococcal urethritis (NGU) were divided into two groups and treated with either lymecycline or tinidazole; anaerobic cultures were performed before and after treatment. Neither treatment affected the anaerobic flora. However, the men treated with lymecycline were relieved of symptoms a...
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PMID: 606333
PDF is available here.
PDF is available here.
New Zealand Medical Journal (84)575 1976
Abstract
New Zealand Medical Journal (84)574 1976
Abstract
One thousand and sixty patients with non-specific urethritis were treated with lymecycline (Tetralysal). An initial course of 600mg 12-hourly for one week was successful in 90.5% of cases, while 2% responded to a further course of 300mg 12-hourly for three weeks.
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PMID: 1071140
PDF is available here.
PDF is available here.
Abstract
A single-blind comparison of lymecycline and amoxycillin was performed by three general practitioners in the treatment of acute bronchitis. A total of 132 patients were treated for seven days with lymecycline (204 mg) two capsules twice daily or amoxycillin 250 mg three times daily. Symptoms and sig...
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PMID: 799979
PDF is available here.
PDF is available here.