Abstract
We tested a range of clinically important tetracycline compounds (oxytetracycline, doxycycline, minocycline and tigecycline) and showed that they all inhibited LPS-induced nitric oxide production. We made the novel finding that tigecycline inhibited LPS-induced nitric oxide production to a greater e...
|
PMID: 21182193
PDF is available here.
Abstract
We could not eradicate H. pylori using the standard triple therapy including amoxicillin. Additionally, H. pylori was resistant to both clarithromycin and metronidazole. So she was treated with minomycin (MINO), levofloxacin (LVFX), and rabeprazole (RPZ) based on a drug sensitivity test. MINO+LVFX+R...
|
PMID: 20948264
PDF is available here.
Abstract
No adverse effects were observed in any of the mares after minocycline administration. The mean+/-SD elimination half-life was 7.70+/-1.91 hours. The total body clearance was 0.16+/-0.04 L/h/kg, and the volume of distribution at steady state was 1.53+/-0.09 L/kg. The percentage of plasma protein bin...
|
PMID: 20807146
PDF is available here.
Abstract
Two Japanese travelers from Bali were diagnosed with murine typhus in Japan during the same period. Although one had only mild illness, the other experienced liver and kidney dysfunction. Murine typhus may be missed not only in endemic areas around the world, but also in travelers, especially those...
|
PMID: 20920060
PDF is available here.
Abstract
The aim of this study was to determine the economic impact on hospital budget expenditure for two different prescribing practices: use of tigecycline in second or first-line therapy (when appropriate). This empirical study was carried out at the Intensive Care Unit (ICU) (Chief, Dr. Alberto Costanti...
|
PMID: 21030933
PDF is available here.
Abstract
We aimed to determine whether or not minocycline, a semi-synthetic tetracycline antibiotic capable of inhibiting microglial activation, could prevent the inflammatory response and reduce the toxicity induced by MDMA. Adult male Dark Agouti rats were given minocycline twice a day for 2 days (45 mg/kg...
|
PMID: 19777321
PDF is available here.
Abstract
We report here a case of anaphylaxis to oral minocycline. A 56-yr-old woman visited our hospital after three episodes of recurrent anaphylaxis. We performed an oral challenge test, the standard method for diagnosing drug allergies, with minocycline, one of the drugs she had taken previously. She dev...
|
PMID: 20676339
PDF is available here.
Abstract
Human and mouse melanoma cells were treated with doxycycline or minocycline but only doxycycline was cytotoxic. This cell death (apoptosis) in A2058 cells involved activation of caspase-3, -7 and -9 and contributed to inhibition, by doxycycline, of matrix metalloproteinase (MMP) activity and migrati...
|
PMID: 20590610
PDF is available here.
Abstract
We report a 70-year-old man who developed severe Clostridium difficile infection, was admitted to the intensive care unit and eventually succumbed to complications of his illness despite receiving tigecycline for approximately three weeks in combination with vancomycin, metronidazole and intravenous...
|
PMID: 20715744
PDF is available here.
Abstract
Minocycline is a semi-synthetic tetracycline antibiotic effective against a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is highly active in the pilosebaceous complex, due to its great lipophilicity, and therefore it has been used in the treatment of moderate to s...
|
PMID: 20461050
PDF is available here.
A J Brink,
D Bizos,
K D Boffard,
C Feldman,
D C Grolman,
J Pretorius,
G A Richards,
M Senekal,
E Steyn,
N Welkovic,
Association of Surgeons of South Africa,
Critical Care Society of Southern Africa,
Federation of Infectious Diseases Societies of Southern Africa,
South African Thoracic Society and
Trauma Society of South Africa
Abstract
INTRODUCTION: Tigecycline, the first of a new class of antibiotics, the glycylcyclines, was licensed in South Africa for the parenteral treatment of adult patients with complicated intra-abdominal infections (cIAIs) and complicated skin and soft-tissue infections (cSSTIs). METHODS: A multidisciplina...
|
PMID: 20529440
PDF is available here.
Abstract
Inflatable penile prostheses are the definitive therapy for erectile dysfunction refractory to medical therapy. For years mechanical malfunction was the most common cause of device failure, but recent advances in design have largely eliminated this, and now infection is the most significant problem...
|
PMID: 20420554
PDF is available here.
Abstract
Although statistically significant difference was found only for the inflammatory infiltrate (P < .05), Group 1 presented more exuberant mineralized formations, more structured apical and periapical connective tissue, and a more advanced repair process than Group 2. CONCLUSION: From the histological...
|
PMID: 20416538
PDF is available here.
Abstract
The in vivo activity of tigecycline was evaluated in an experimental pneumonia model (C57BL/6 mice) by Acinetobacter baumannii. Two clinical strains were used: minimum inhibitory concentrations (MICs) of imipenem and tigecycline 1 and 2 microg/mL (imipenem-susceptible, IPM-S), and 8 and 2 microg/mL...
|
PMID: 20182760
PDF is available here.
Abstract
The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5...
|
PMID: 20186450
PDF is available here.
Abstract
A 70-year-old woman was admitted to our hospital because of fever, numbness in her extremities and right drop foot. Because her hip prosthesis had loosened as a result of infection, she had been taking 100 mg of minocycline orally for eight months. Three months before admission, she had had melena s...
|
PMID: 20535977
PDF is available here.
Abstract
A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterize...
|
PMID: 20010311
PDF is available here.
Abstract
As initial evidence, our results suggest that tigecycline may be an acceptable alternative for therapy in patients with VAP. Nevertheless, only controlled clinical trials will provide the evidence to support approval for new indications....
|
PMID: 20424523
PDF is available here.
Abstract
We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macropha...
|
PMID: 20042984
PDF is available here.
Abstract
Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections....
|
PMID: 19942947
PDF is available here.
Abstract
Minocycline treatment was associated with improvement in negative symptoms and executive functioning, both related to frontal-lobe activity. Overall, the findings support the beneficial effect of minocycline add-on therapy in early-phase schizophrenia. TRIAL REGISTRATION: clinicaltrials.gov Identifi...
|
PMID: 19895780
PDF is available here.
Abstract
Minocycline accelerated the recovery of sensorimotor and cognitive functions, attenuated the loss of neuron density, and inhibited astrogliosis in the boundary zone around the ischemic core, but did not affect infarct volume. Minocycline significantly inhibited the increased 5-LOX expression in the...
|
PMID: 20006627
PDF is available here.
Abstract
These results extended previous studies with ceftriaxone, indicating that antibiotic treatment is unable to clear persisting spirochetes, which remain viable and infectious, but are nondividing or slowly dividing....
|
PMID: 19995919
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Antibacterial drug discovery and development has slowed considerably in recent years, with novel classes discovered decades ago and regulatory approvals tougher to get. Traditional approaches and the newer genomic mining approaches have not yielded novel classes of antibacte...
|
PMID: 20053150
PDF is available here.
Abstract
Tigecycline, a glycylcycline, has been approved by the United States Food and Drug Administration (USA-FDA) for the treatment of complicated skin and skin structure infections, intra-abdominal infections and community-acquired bacterial pneumonia. based on broth microdilution minimum inhibitory conc...
|
PMID: 20227986
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.
Richard Dodel,
Annika Spottke,
Alexander Gerhard,
Alexander Reuss,
Sylvia Reinecker,
Nicole Schimke,
Claudia Trenkwalder,
Friederike Sixel-Döring,
Birgit Herting,
Christoph Kamm,
Thomas Gasser,
Martin Sawires,
Felix Geser,
Martin Köllensperger,
Klaus Seppi,
Manja Kloss,
Martin Krause,
Christine Daniels,
Günther Deuschl,
Silke Böttger,
Markus Naumann,
Axel Lipp,
Doreen Gruber,
Andreas Kupsch,
Yansheng Du,
Federico Turkheimer,
David J Brooks,
Thomas Klockgether,
Werner Poewe,
Gregor Wenning,
Carmen Schade-Brittinger,
Wolfgang H Oertel and
Karla Eggert
Abstract
The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). The primary ou...
|
PMID: 20014118
PDF is available here.