Abstract
A randomized, controlled, blinded clinical trial was performed at a research feedlot in western Canada. Auction-market-derived steers (n = 288) were randomly assigned to 1 of 3 treatments: 1) no antimicrobials on arrival; 2) oxytetracycline in the starter ration for 14 d; and 3) long-acting oxytetra...
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PMID: 21037885
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Abstract
We determined the toxicity of sulphamethoxazole, trimethoprim, flumequine, tylosin, streptomycin, and oxytetracycline, using the NAT adapted for water exposure. The sensitivity of the NAT was compared to that of bioassays with bacteria (Microtox), cyanobacteria and green algae. In the Microtox test...
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PMID: 20430416
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Abstract
Tetracycline antibiotics (TCs) including tetracycline (TTC), chlorotetracycline (CTC) and oxytetracycline (OTC) adsorb strongly to aluminum oxide (Al(2)O(3)), and the surface interaction promotes structural transformation of TCs. The latter phenomenon was not widely recognized previously. Typically,...
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PMID: 20378149
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Abstract
Nine lactating dairy cows were evaluated because of eye lesions. Examination revealed mild to severe ulceration of the lower and/or upper eyelids, mild to severe swelling surrounding affected eyes, and profuse lacrimation. Lesions typically affected 1 eye, and involved the eyelid skin and conjunctiv...
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PMID: 20592830
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Abstract
Oxytetracycline ((2Z,4S,4aR,5S,5aR,6S,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione) is a member of tetracycline antibiotics family and is widely administered to farm animals for the purpose of therapeutical treatm...
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PMID: 20390934
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Abstract
We investigated the adsorption-desorption by multiwalled carbon nanotubes (MWCNTs) of two pharmaceuticals, oxytetracycline (OTC) and carbamazepine (CBZ). The pharmaceuticals demonstrated relatively fast sorption kinetics on MWCNTs. All adsorption isotherms were nonlinear and fit the Polanyi-Manes mo...
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PMID: 20000507
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Abstract
The objective of this study was to evaluate the bone response to a nanothickness bioceramic ion beam-assisted deposition (IBAD) on endosteal implants in a canine model.
Alumina-blasted/acid-etched (control) and IBAD-modified (test) implants were characterized by scann...
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PMID: 18783412
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Abstract
7 of 8 alpacas had positive PCR assay results 4 to 6 days after experimental infection. When organisms were detectable on a blood smear, they were seen 2 to 6 days after positive results of PCR assay. Infection was often associated with mild anemia that was usually transient. No alpacas became hypog...
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PMID: 19719425
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Abstract
Oxytetracycline (OTC) and Zn2+ are both widely used as growth promoters in concentrated animal feeding operations, which are discharged into soil system by manure application. There is special environment significance to study the sorption and interaction of OTC with accompanied metal cations on cla...
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PMID: 19799309
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Abstract
Oxytetracycline (OTC) is a wide spectrum antibiotic, but it is known to be degradated when it is stored under adverse conditions. It is classified as short-acting based on serum half-lives of 6-8 h. The stabilizing effect of colloidal carrier systems and their ability to sustain drug release for OTC...
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PMID: 19746838
PDF is available here.
Parasitology (96 ( Pt 2))02 2009
Abstract
A Theileria parva lawrencei isolate in the form of a sporozoite stabilate, derived by feeding clean Rhipicephalus appendiculatus nymphal ticks on an African buffalo (Syncerus caffer) captured in the Laikipia District, Kenya, was inoculated into groups of cattle at dilutions between 10(0) and 10(-3)....
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PMID: 3131722
PDF is available here.
Abstract
Lipid spray beads (LSB) were evaluated for delivery of the low-molecular weight, water-soluble antibiotic, oxytetracycline.HCl (OTC) to fish larvae. Various OTC core-to-lipid ratios and OTC core concentrations were evaluated to maximize OTC delivery efficiency by LSB. Acceptability and digestion of...
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PMID: 19236554
PDF is available here.
Abstract
On the basis of the OECD Guideline 106, batch sorption methods were employed to reveal the effect of different cations (0.01 mol x L(-1) Ca2+, K+ and Na+) on oxytetracycline (OTC) adsorption and desorption process in two tested soils (cinnamon soil and red soil). Results show that the Freundlich mod...
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PMID: 19402514
PDF is available here.
Abstract
In the veterinary industry, short-acting or conventional oxytetracycline formulations are recommended for use once a day for 4 days, at a dose of 10 mg/kg. With the large degree of antimicrobial resistance reported, the efficacy of this dose was assessed using pharmacodynamic modelling. The specific...
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PMID: 19496316
PDF is available here.
Abstract
The giant river shrimp (Macrobrachium rosenbergii), a native species of Thailand, is either exported for commercial purposes or supplied to meet the local requirements in Thailand. Limited pharmacokinetic information of the major antibiotic, oxytetracycline (OTC), is available for this freshwater sh...
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PMID: 19000273
PDF is available here.
Abstract
Chronic infection with Pseudomonas aeruginosa is common in cystic fibrosis (CF) and certain strains are more transmissible and virulent than others. Of these, the Liverpool Epidemic Strain (LES) is highly transmissible and cross infection has been reported between patients with CF and healthy non-CF...
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PMID: 18728207
PDF is available here.
Abstract
A micro-dilution technique with changes in optical density (OD) used to measure bacterial growth over 72 h in culture media containing 0, 5, 10, 20, 40, 80 and 160 microg OTC (oxytetracycline)ml(-1) was applied to determine growth inhibition (GI) in mixed bacterial strains cultured from samples of m...
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PMID: 18589456
PDF is available here.
Abstract
Subinhibitory levels of antibiotics can promote the development of antibiotic resistance in bacteria. However, it is unclear whether antibiotic concentrations released into aquatic systems exert adequate pressure to select populations with resistance traits. To examine this issue, 15 mesocosms conta...
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PMID: 18754392
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Abstract
We examined the fate of tetracycline-resistance genes in bacterial hosts released in cattle feedlot wastewater using field-scale mesocosms to quantify ARG attenuation rate in the water column and also the migration of ARGs into peripheral biofilms. Feedlot wastewater was added to fifteen cylindrical...
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PMID: 18754359
PDF is available here.
Abstract
A rapid analytical method for the determination of oxytetracycline (OTC), tetracycline (TC) and chloramphenicol (CAP) antibiotics in animal feeds has been developed based on subcritical water extraction (SWE) without further sample clean-up followed by high performance liquid chromatography (HPLC) w...
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PMID: 18539174
PDF is available here.
Abstract
Eight antibiotics, chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, tetracycline and rolitetracycline, were separated and quantified in Spanish honey extracts of different floral origin using a commercial RP-C18 HPLC column and two different on-line detecto...
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PMID: 18501371
PDF is available here.
Abstract
An automated system using on-line solid-phase extraction (SPE) high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the determination of tetracyclines (TCs), such as tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), metacycline (MC), and do...
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PMID: 18585209
PDF is available here.
Abstract
The present study was undertaken to evaluate porous hydroxyapatite (HAp), the powder of which was prepared by a novel aqueous solution combustion technique, as a bone substitute in healing bone defects in vivo, as assessed by radiologic and histopathologic methods, oxytetracycline labeling, and angi...
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PMID: 18487940
PDF is available here.
Abstract
A randomized intervention study was conducted to determine if discontinuing use of calf milk replacer medicated with oxytetracycline results in increased tetracycline susceptibility in Salmonella and Campylobacter spp. and Escherichia coli in dairy calves over a 12-month period. Dairy herds with ent...
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PMID: 18417664
PDF is available here.
Abstract
A simple and sensitive methodology to simultaneously quantify tetracycline and oxytetracycline in bovine serum samples is described. The method combines the advantages of the lanthanide-sensitized luminescence (i.e., sensitivity and selectivity) with partial least-squares (PLS) analysis, and require...
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PMID: 18585179
PDF is available here.
Abstract
Antibiotic formulation effluents are well known for their difficult elimination by traditional bio-treatment methods and their important contribution to environmental pollution due to its fluctuating and recalcitrant nature. In the present study the effect of ozonation on the degradation of oxytetra...
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PMID: 18355893
PDF is available here.
Abstract
The thermostability parameters of three tetracycline antibiotics at high and ultrahigh temperatures (110-140 degrees C) as well as the influence of treatment medium pH and water activity on their thermotolerance have been investigated. The thermal degradation of the three antibiotics followed a firs...
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PMID: 18373348
PDF is available here.
Abstract
A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmol l(-1) borate, 20 mmol l(-1) phosphate, pH 8.4, containing 20 mmol l(-1) sodium dode...
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PMID: 18348041
PDF is available here.
Abstract
Oxytetracycline HCl microbeads were prepared with sodium alginate and pectin using ionic gelation method and evaluated for morphology, flow properties, drug content and in vitro drug release study. SEM confirmed spherical structure of microbeads with rough and porous surfaces and microbeads possesse...
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PMID: 18390438
PDF is available here.
Abstract
We present methods of interpreting immunization trials and apply these methods to previously unpublished data from two such trials: one with a mixture of three T. parva stocks and one with a single T. parva stock. We explain why titration trials conducted with a cocktail of antigens could predict a...
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PMID: 18155195
PDF is available here.
Abstract
Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured...
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PMID: 18468050
PDF is available here.
Abstract
Oxytetracycline (OTC) is a major member of tetracyclines, which are widely administered to animals in confined feeding operations. To diminish the contamination of OTC in the environment, which results from the application of OTC-containing manure as fertilizer in agricultural lands, OTC degradation...
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PMID: 18257526
PDF is available here.
Abstract
Two experiments were designed to determine the efficacy of intraglandular antibiotic treatment in beef bulls. Experiment 1 was designed to evaluate the glandular tissue reaction to intraglandular antibiotic treatment. Experiment 2 was conducted to determine the efficacy intraglandular injection of a...
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PMID: 17399921
PDF is available here.
Abstract
Self-reinforced polylactide-polyglycolide (80/20) composite rods, 2 mm in diameter and 36 mm in length, were implanted into the dorsal subcutaneous tissue of 20 rabbits. Osteotomies of the distal femur were fixed with these rods (2x15 mm) in the rabbits. The follow-up times varied from 3 to 104 week...
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PMID: 17701306
PDF is available here.
Abstract
In 1 of the bears, a CBC and serum biochemical analyses revealed mild anemia, mild eosinophilia, moderate lymphopenia, moderate hypoalbuminemia, and high serum G-glutamyltransferase activity. Ultrasonographic examination of the same bear revealed ascites and mesenteric lymphadenopathy. Histologic ex...
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PMID: 18279100
PDF is available here.
Abstract
Our results indicated that the aptamers No. 4, 5, and 20 with variable 40-base oligonucleotides can be good candidates for selectively binding to OTC with high molecular discrimination over its analogs such as tetracycline and doxycycline....
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PMID: 17988875
PDF is available here.
Abstract
Four hundred and thirteen oxytetracycline-resistant bacteria were recovered from six freshwater giant prawn farms with a history of oxytetracycline use. Most oxytetracyclineresistant isolates were Gram-negative bacteria. Six groups of oxytetracycline-resistant bacteria were classified using cluster...
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PMID: 18309262
PDF is available here.
Abstract
A rapid and precise determination residues of 4 tetracyclines (TCs) (oxytetracycline (OTC), tetracycline (TC), chlortetracycline (CTC) and doxycycline (DOXY)) in meat was developed by employing three analyses; a microbiological screening, HPLC and LC/MS/MS. TCs were extracted with pH 4.0 McIlvaine b...
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PMID: 18344657
PDF is available here.
Abstract
This is a non-controlled experimental prospective clinical study that evaluates the satisfactory results in the chemical synovectomy (synoviorthesis) with oxytetracycline clorhydrate (Emicine, Lab. Pfizer Ltda, Guarulhos, Sao Paulo, Brazil) in recurrence haemarthrosis in different joints, demonstrat...
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PMID: 18005152
PDF is available here.
Abstract
At 6 h following topical application the mean DXM concentration was highest in the anterior structures of the eye (third eyelid: 18 ng/g, cornea: 36 ng/g). The concentration in the posterior structures was below detection level. A decreased DXM concentration in the anterior structures was measured 1...
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PMID: 19046294
PDF is available here.
Abstract
The extensive use of antibiotics has been a worldwide environmental issue. In this study the fate of oxytetracycline (OTC), under photoirradiation, was investigated. The results showed that OTC photolysis followed first order model kinetics. Direct photolysis rate was found to be dependent on the in...
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PMID: 18814575
PDF is available here.
Abstract
Genes of zwf1 and zwf2 encode two isozymes of glucose-6-phosphate dehydrogenase (G6PDH) of Streptomyces, respectively. G6PDH is the first enzyme in the oxidative pentose phosphate pathway (PPP) and the key enzyme for NADPH generation. Based on thermal sensitive plasmid pKC1139, a recombinant plasmid...
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PMID: 18338571
PDF is available here.
Abstract
This study investigated the occurrence and fate of oxytetracycline (OTC) and its related substances, 4-epi-oxytetracycline (EOTC), alpha-apo-oxytetracycline (alpha-apo-OTC), and beta-apo-oxytetracycline (beta-apo-OTC), in a wastewater treatment plant (WWTP) treating OTC production wastewater and a r...
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PMID: 18092864
PDF is available here.
Abstract
The concentration of Terramycin and Furazolidone residues in broiler meat following their subtherapeutic use in the ration of the birds were detected as 296 ng/g, 174 ng/g, 40 ng/g, 60 ng/g and 124 ng/ml in kidney, liver, thigh muscle, breast muscle and serum for Terramycin and 270 ng/g 160 ng/g and...
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PMID: 18700719
PDF is available here.
Abstract
The aim of this study was to investigate the presence of tetracycline and oxytetracycline resistance determinants in Bacillus cereus strains isolated from honey samples. Of a total of 77 isolates analyzed, 30 (39%) exhibited resistance to tetracyclines according to the results of a disk diffusion me...
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PMID: 19213248
PDF is available here.
Abstract
The aim of this study was to assess the in vitro activity of a number of antimicrobial agents (Sultrim, Oxytetracycline, enrofloxacin and florfenicol) produced by different Iranian manufacturers against E. coli K12. Comparison of the MICs of reference antimicrobials with Disk Diffusion (DD) results...
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PMID: 19093536
PDF is available here.
Abstract
Paenibacillus larvae is the causal agent of American Foulbrood (AFB) disease, the most virulent bacterial disease of honeybee (Apis mellifera L.) brood. Oxytetracycline is the main antibiotic used for prevention and control of AFB. Using the polymerase chain reaction, isolates were screened for the...
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PMID: 17601687
PDF is available here.
Abstract
The occurrence of two species of opportunistic pathogens in crop-associated materials poses a risk to consumers in the community. SIGNIFICANCE AND IMPACT OF THE STUDY: The phenotypic and genotypic data presented could support epidemiologist and physicians dealing with infections caused by environmen...
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PMID: 18045439
PDF is available here.
Abstract
There is the risk of multidrug-resistant bacteria contamination in mariculture environments and marine Vibrio and Pseudoalteromonas species serve as reservoirs of specific antibiotic resistance determinants. SIGNIFICANCE AND IMPACT OF THE STUDY: This paper and similar findings from Korea and Japan i...
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PMID: 18045442
PDF is available here.
Abstract
We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresponding to the current index divided now by 24 h. This is the scaling factor without units by which the targeted MIC should be multiplied to estimate the average in vivo plasma con...
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PMID: 17932075
PDF is available here.
Abstract
Eight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 mg/kg diclofenac intramuscularly. Blood samples were drawn at different times until 168 h after administration. Two experimental animals were slaughtered by humane means at weekly intervals up to 28 days after a...
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PMID: 18293616
PDF is available here.
Abstract
No differences in pregnancy and calving rates between treatment and control groups were detected. Pregnancy rate following artificial insemination was lower among cows in locations positive for leptospirosis than among cows in locations negative for leptospirosis; however, overall pregnancy rate, ca...
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PMID: 18052809
PDF is available here.
Abstract
Bacterial isolates from aquaculture sources in Australia harbour a variety of tetracycline resistance genes, which can be transferred to other bacteria of different origin. SIGNIFICANCE AND IMPACT OF THE STUDY: Bacteria from aquaculture sources in Australia contribute to the resistance gene pool res...
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PMID: 17953612
PDF is available here.
Abstract
Milk samples were collected at one day intervals after the last dose from 31 cows that had received an intrauterine infusion of oxytetracycline once daily between one and five times. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the...
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PMID: 17965369
PDF is available here.
Abstract
The American horseshoe crab, Limulus polyphemus, is regularly cultured and maintained in research laboratories and public aquaria. Rising concerns over the health of these captive animals makes the diagnosis and treatment of pathological conditions in L. polyphemus essential. This study investigated...
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PMID: 17803738
PDF is available here.
Abstract
A method was optimised and validated for simultaneous monitoring of several drugs of different classes of antibiotics such as quinolones (oxilinic acid and flumequine), tetracyclines (oxytetracycline), sulfonamides (sulfadiazine) and trimethoprim in fish muscle and skin. The method is based on solid...
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PMID: 17644050
PDF is available here.