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Tetracyclines (9):
Recent article
Tetracyclines
Proteomics (11)1 2011
Abstract
We tested a range of clinically important tetracycline compounds (oxytetracycline, doxycycline, minocycline and tigecycline) and showed that they all inhibited LPS-induced nitric oxide production. We made the novel finding that tigecycline inhibited LPS-induced nitric oxide production to a greater e...
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PMID: 21182193
PDF is available here.
PDF is available here.
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Journal of Antibiotics (63)12 2010
Abstract
Treatment of a variety of tetracyclines (tigecycline, minocycline, tetracycline and doxycycline) with Ag(2)CO(3)/EDTA or Hg(OAc)(2) cleanly gave the 4,11a-bridged derivatives in high yields. The reactions proceeded through a novel, intramolecular Mannich cyclization of an iminium species generated b...
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PMID: 20978515
PDF is available here.
PDF is available here.
Abstract
We present new configurations of the tetracycline-dependent gene regulation (tet) system for Staphylococcus aureus. To provide improved and expanded modes of control, strains and plasmids were constructed for the constitutive expression of tetR or a variant allele, rev-tetR(r2). The encoded regulato...
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PMID: 19966017
PDF is available here.
PDF is available here.
Abstract
The residue levels of selected fluoroquinolones, sulfonamides and tetracyclines in 143 animal dung samples collected in 2007 from large-scale livestock and poultry feedlots in 8 provinces were determined by using ultrasonic extraction and liquid chromatography. Recoveries from spiked pig dung sample...
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PMID: 19954821
PDF is available here.
PDF is available here.
Abstract
We have analyzed 69 experimental datasets on the characteristics of biologicacally important features altered by TATA-box mutations. Among these features, the TBP/TATA-complex parameters, the transcription level, the activity of gene products, yeast colony growth at a dose of growth inhibitor (pheno...
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PMID: 20586319
PDF is available here.
PDF is available here.
Abstract
Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue...
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PMID: 19968600
PDF is available here.
PDF is available here.
Abstract
Reassuringly, penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. Sulfonamides and nitrofurantoins were associated with several birth defects, indicating a need for additional scrutiny....
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PMID: 19884587
PDF is available here.
PDF is available here.
Abstract
Increased fibroblast growth factor receptor-2 (FGFR2) signaling has been proposed to be involved in acne pathogenesis and explains acne lesions in Apert syndrome and unilateral acneiform nevus associated with gain-of-function point mutations of FGFR2. If, indeed, increased FGFR2 signaling plays a ma...
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PMID: 19225542
PDF is available here.
PDF is available here.
Abstract
Glycylcyclines were derived from the chemical structure of tetracyclines. After they started to be used in clinical practice, tetracycline group came into focus as a whole. First-generation tetracyclines feature low lipophilia and they are usually available in peroral form only, except rolitetracycl...
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PMID: 19399726
PDF is available here.
PDF is available here.
Abstract
We have developed a molecular mechanics force field for 12 tetracyclines, consistent with the CHARMM force field. We considered each Tc variant in its zwitterionic tautomer, with and without a bound Mg(2+). We used structures from the Cambridge Crystallographic Data Base to identify the conformation...
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PMID: 18615434
PDF is available here.
PDF is available here.
Abstract
Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of inflammatory nature. Tetracyc...
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PMID: 19786821
PDF is available here.
PDF is available here.
Abstract
The most important constituent of the bleaching process is the hydrogen peroxyde. The bleaching effect is the result of a change in the chemical structure of organic molecules in the teeth. Different bleaching techniques are described on the basis of the concentration of the hydrogen peroxyde used a...
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PMID: 19994547
PDF is available here.
PDF is available here.
Abstract
There is no reliable trial evidence for interventions in inherited EB. In future, it may be that gene treatment becomes the best treatment approach for these diseases....
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PMID: 18828848
PDF is available here.
PDF is available here.
Abstract
Antibiotics work by exploiting differences between human and bacterial cells. They are grouped according to their targets of action: cell wall synthesis, protein synthesis, and nucleic acid replication. Generally they should be used as an adjunct to local measures that aim to remove the source of in...
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PMID: 19928373
PDF is available here.
PDF is available here.
Abstract
We review the pathology, diagnosis and treatment of this entity....
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PMID: 19177761
PDF is available here.
PDF is available here.
Abstract
About one million Chlamydia trachomatis urogenital infections occur in Japan. Infections of Chlamydia trachomatis or gonococci are associated many clinical syndromes, ranging from urethritis and epididymitis in men to cervicitis, salpingitis, acute urethra syndrome, endometritis, ectopic pregnancy,...
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PMID: 19177771
PDF is available here.
PDF is available here.
Abstract
Besides Chlamydia trachomatis, various microorganisms could cause non-gonococcal urethritis (NGU). Recently, Mycoplasma genitalium and Ureaplasma urealyticum (biovar 2) have been suggested to be other pathogens of NGU independent of C. trachomatis. Clinical findings of non-chlamydial NGU, including...
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PMID: 19177768
PDF is available here.
PDF is available here.
Acta Paediatrica (97)12 2008
Characteristics of Streptococcus pyogenes strains isolated from Chinese children with scarlet fever.
Abstract
A total of 97.9% of the isolates exhibited resistance to the macrolides, while 96.6% manifested resistance to tetracycline. All isolates were sensitive to chloramphenicol, penicillin, cefradine, and ofloxacin. Moreover, 94.5% exhibited a cMLSB phenotype, while 90.3% had the ermB gene. Five emm types...
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PMID: 18691162
PDF is available here.
PDF is available here.
Abstract
Our data suggest that thiostrepton enhances the cytotoxic effects of ATO through a ROS-dependent mechanism. Co-administration of oxidative stress-inducing drugs such as thiostrepton in order to enhance the efficacy of ATO in the treatment of melanoma warrants further investigation....
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PMID: 18297286
PDF is available here.
PDF is available here.
Nippon Saikingaku Zasshi (63)2-4 2008
Abstract
Abstract
We carried out a three-dimensional quantitative structure-activity relationship (3D-QSAR) study to investigate the stereoelectronic features required for anti-fibrillogenic activity. A preliminary variable reduction technique was used to search for grid points where statistical indexes of interactio...
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PMID: 18629550
PDF is available here.
PDF is available here.
Abstract
As a part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.), Gram-positive and Gram-negative bacterial isolates were collected from 33 centers in Latin America (centers in Argentina, Brazil, Chile, Colombia, Guatemala, Honduras, Jamaica, Mexico, Panama, Puerto Rico, and Venezuela) from...
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PMID: 19219281
PDF is available here.
PDF is available here.
Chemistry & Biodiversity (5)10 2008
Abstract
We studied the cytotoxic effect and the uptake of Pd(II) complexes of doxycycline (Dox), [Pd(Dox)Cl2], and tetracycline (Tc), [Pd(Tc)Cl2], in chronic myelogenous leukemia cells. The effect of the compounds on macrophage viability was also investigated. Compound 1 is more effective than compound 2 in...
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PMID: 18972502
PDF is available here.
PDF is available here.
Journal of Antibiotics (61)10 2008
Abstract
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin...
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PMID: 19168978
PDF is available here.
PDF is available here.
Abstract
Tetracyclines have long been used to treat a wide variety of medical conditions, especially in the field of dermatology. Unfortunately, safety concerns, especially gastrointestinal (GI), have always been present. Other safety concerns have included tooth development in children, candidiasis, vestibu...
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PMID: 18759709
PDF is available here.
PDF is available here.
Abstract
Tick-borne infections have been recognized in the United States for more than a century. Patients who present with nonspecific fever after exposure to ticks should be evaluated by clinical examination and routine laboratory testing to determine if the illness is potentially a tick-borne infection. T...
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PMID: 18755383
PDF is available here.
PDF is available here.
Abstract
Q fever is a worldwide zoonosis caused by the pathogen Coxiella burnetii causing acute and chronic clinical manifestations. The name "Q fever" derives from "Query fever" and was given in 1935 following an outbreak of febrile illness in an abattoir in Queensland, Australia. C burnetii is considered a...
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PMID: 18755387
PDF is available here.
PDF is available here.
Abstract
We identified 4 classes (B, F, T, and X) of erm genes in fresh fecal samples collected at wk 2, 17, and 21 of feeding. From wk 2 to 17, the abundance of erm(T) and erm(X) increased (P < 0.05), whereas that of erm(B) and erm(F) did not. The abundance of the erm genes did not further change from wk 17...
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PMID: 18469042
PDF is available here.
PDF is available here.
Journal of Chromatography A (1202)2 2008
Abstract
These results reveal the representative concentration levels of selected antibiotics in the swine wastewaters of Beijing area....
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PMID: 18649883
PDF is available here.
PDF is available here.
Abstract
OVX induced a rapid decline in the biomechanical properties of pelvic tissues in young but not middle-aged rats. Supplementation with E2, E2 plus P4, or CMT-8 restored tissues of young rats to control levels with no effect on middle-aged tissues. Parity did not have an impact on tissue behavior. CON...
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PMID: 18395691
PDF is available here.
PDF is available here.
Abstract
Tetracyclines (TCs) are a group of antibiotics comprising of a common tetracycline (TET) nucleus with variable X(1) and X(2) positions on 5 and 6 carbon atoms, such as oxytetracycline (OTC) and doxycycline (DOX). In this study, the tetracycline group specific (TGS) ssDNA aptamers were identified by...
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PMID: 18617415
PDF is available here.
PDF is available here.
Abstract
Several groups of popular antibacterial agents (i.e., phenols, fluoroquinolones, aromatic N-oxides, and tetracyclines) were demonstrated in earlier studies to be highly susceptible to oxidation by manganese oxides, a common oxidant in soils. However, because of the high complexity, the reaction kine...
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PMID: 18754474
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)13 2008
Abstract
We investigated the origin of this activity reversal by limited proteolysis, CD spectroscopy and X-ray crystallography. We show that the TetR mutant Leu17Gly switches its function via a disorder-order mechanism that differs completely from the allosteric mechanism of wild-type TetR. Our study emphas...
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PMID: 18587152
PDF is available here.
PDF is available here.
Journal of Periodontology (79)8 Suppl 2008
Abstract
Periodontal diseases are initiated by Gram-negative tooth-associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast-related mediators target the destruction of alveol...
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PMID: 18673015
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)8 2008
Abstract
I restriction-modification enzymes. The IncI1 transmissible plasmid ColIb-P9 ardA and bacteriophage T7 0.3(ocr) genes were cloned in pUC18 vector. Both ArdA (ColIb-P9) and Ocr (T7) proteins inhibit both restriction and modification activities of the type I restriction-modification enzyme (EcoKI) in...
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PMID: 18774937
PDF is available here.
PDF is available here.
Abstract
Laminin-332 degradation is pH-dependent and differences exist between studied Candida strains. Lm-332 degradation can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues. Certain synthetic matrix metalloproteinase inhibitors (CMTs, CTT) ca...
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PMID: 18284540
PDF is available here.
PDF is available here.
Journal of Chromatography A (1195)1-2 2008
Abstract
Eight antibiotics, chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, tetracycline and rolitetracycline, were separated and quantified in Spanish honey extracts of different floral origin using a commercial RP-C18 HPLC column and two different on-line detecto...
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PMID: 18501371
PDF is available here.
PDF is available here.
Abstract
An automated system using on-line solid-phase extraction (SPE) high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the determination of tetracyclines (TCs), such as tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), metacycline (MC), and do...
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PMID: 18585209
PDF is available here.
PDF is available here.
Abstract
An efficient clean-up procedure was developed for the trace residue determination of tetracyclines (TCs) in dark-colored honeys. TCs were extracted from samples with McIlvaine buffer (pH 4.0) containing 0.01 mol/L Na(2)EDTA. The extracts were treated with both a polymeric cartridge (GL-Pak PLS-2) an...
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PMID: 18633204
PDF is available here.
PDF is available here.
Abstract
We report the identification and reconstitution of the minimum set of enzymes required for the biosynthesis of anhydrotetracycline (ATC, 5), the first intermediate in the tetracycline biosynthetic pathway that contains the fully functionalized ring A. Using a combination of in vivo and in vitro appr...
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PMID: 18422316
PDF is available here.
PDF is available here.
Journal of Physiology (586)10 2008
Abstract
Abstract
We used a mouse model that allows anhydrotetracycline (ATc)-controlled downregulation of ERBB2 in tumour tissue. ERBB2 mRNA and protein expression were downregulated below detection limit leading to a macroscopically complete tumour remission within 14 days. Tumour remission was accompanied by a str...
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PMID: 18454161
PDF is available here.
PDF is available here.
Electrophoresis (29)10 2008
Abstract
We used voltage-assisted SPE for the first time as an alternative to conventional treatments for preconcentrating and purifying analytes. To this end, we used a simple flow system coupled on-line to CE-MS equipment. The system is quite robust and provides reproducible peak areas (the precision range...
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PMID: 18409165
PDF is available here.
PDF is available here.
Abstract
We demonstrate that this assay can detect the association of small molecules with Abeta fibrils at concentrations of small molecule in the nanomolar to millimolar range. By comparing results from the screening of a small set of 30 compounds, we illustrated that this assay can rapidly analyze the rel...
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PMID: 18380488
PDF is available here.
PDF is available here.
Journal of Chromatography A (1188)2 2008
Abstract
Molecularly imprinted polymer (MIP) is widely used in many fields because of its characteristics of high selectivity, chemical stability and easy preparation. To enhance the selectivity and applicability of solid-phase microextraction (SPME), a novel MIP-coated SPME fiber was firstly prepared by mul...
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PMID: 18325526
PDF is available here.
PDF is available here.
Abstract
We discuss recent findings that have clarified the mode of action and the biosynthetic pathway of tetracyclines and that have shed light on the chemical biology of tetracycline antibiotics....
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PMID: 18443626
PDF is available here.
PDF is available here.
Journal of Chromatography A (1184)1-2 2008
Abstract
Hydrophilic interaction chromatography (HILIC) is important for the separation of highly polar substances including biologically active compounds, such as pharmaceutical drugs, neurotransmitters, nucleosides, nucleotides, amino acids, peptides, proteins, oligosaccharides, carbohydrates, etc. In the...
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PMID: 18294645
PDF is available here.
PDF is available here.
Removal of tetracycline and sulfonamide classes of antibiotic compound by powdered activated carbon.
Abstract
Removal of sulfonamide (SAs) and tetracycline (TAs) classes of antibiotic compound from deionized water and DOC water by powdered activated carbon (PAC) adsorption was evaluated in this study. According to the study results, TAs were more easily adsorbed than SAs although TAs were more hydrophilic t...
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PMID: 18610795
PDF is available here.
PDF is available here.
Journal of Chromatography A (1181)1-2 2008
Abstract
Restricted access materials (RAM) based on alkyl diol silica (ADS) porous particles were evaluated for the sample clean-up in tetracyclines analysis in milk and water samples by liquid chromatography. RAM with C(4), C(8) and C(18) bonded to the inner pore surfaces were tested, with C(8) providing th...
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PMID: 18190920
PDF is available here.
PDF is available here.
Virus Genes (36)1 2008
Abstract
I contained the BAC replicon at the intended target region between the genes of UL48 and UL49. In BAC genomes of type II, the BAC sequences were found to be aberrantly fused between the termini of the HSV-1 genome. Both the BAC types were used to establish a conditional gene expression system for HS...
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PMID: 18193347
PDF is available here.
PDF is available here.
Abstract
A rapid and precise determination residues of 4 tetracyclines (TCs) (oxytetracycline (OTC), tetracycline (TC), chlortetracycline (CTC) and doxycycline (DOXY)) in meat was developed by employing three analyses; a microbiological screening, HPLC and LC/MS/MS. TCs were extracted with pH 4.0 McIlvaine b...
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PMID: 18344657
PDF is available here.
PDF is available here.
Abstract
Susceptibility to tigecycline of the A. baumannii OXA-23 clone 1 prevalent in the UK is reduced (approximately 2-fold) by the presence of the efflux inhibitor NMP. NMP does not have the same effect on susceptibility to other tetracyclines....
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PMID: 19056750
PDF is available here.
PDF is available here.
Journal of Chromatography A (1179)2 2008
Abstract
A new powerful algorithm (unfolded-partial least squares followed by residual bilinearization (U-PLS/RBL)) was applied for first time on second-order liquid chromatography with diode array detection (LC-DAD) data and compared with a well-known established method (multivariate curve resolution-altern...
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PMID: 18067904
PDF is available here.
PDF is available here.
Journal of Chromatography A (1179)2 2008
Abstract
The effect of piecewise direct standardization (PDS) and baseline correction approaches was evaluated in the performance of multivariate curve resolution (MCR-ALS) algorithm for the resolution of three-way data sets from liquid chromatography with diode-array detection (LC-DAD). First, eight tetracy...
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PMID: 18093603
PDF is available here.
PDF is available here.
Abstract
There is insufficient evidence to support one tetracycline rather than another in terms of efficacy. In the range of investigated dosages, the antibiotic dosage seems to have no impact on efficacy. Despite increased resistance to antibiotics, oral tetracycline formulations displayed no change in eff...
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PMID: 17986300
PDF is available here.
PDF is available here.
Abstract
We also found an increase in tetracycline resistance and two tet(M)-positive isolates that were susceptible to tetracyclines....
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PMID: 18025113
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that MMP inhibition alone is insufficient to explain the pro-apoptotic action of CMTs in osteoclast lineage cells and we have explored additional mechanisms of action. We compared the characteristics of apoptosis in RAW264.7 murine monocyte and osteoclast cultures treated...
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PMID: 18036558
PDF is available here.
PDF is available here.
Abstract
A single-step end point method is presented for determination of the activity of the enzyme alkaline phosphatase (ALP) using the effect of enhancement of fluorescence of the easily accessible europium(III)-tetracycline 3:1 complex (Eu(3)TC). Its luminescence, peaking at 616 nm if excited at 405 nm, i...
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PMID: 18227222
PDF is available here.
PDF is available here.
Abstract
We report here an ultra-performance liquid chromatography coupled with tandem mass spectrometric (MS/MS) method for the simultaneous quantitation of multiclass veterinary drugs in egg. The analysis of the target compounds, including 7 tetracyclines and 4 types of quinolones, may be accomplished in 1...
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PMID: 18476361
PDF is available here.
PDF is available here.
Abstract
Among the emerging pathogens involved in the nosocomial infections, Acinetobacter baumannii strains have become, in the past decades, a real health issue, due to the variety and seriousness of clinical symptoms. Through the constant increase of the cases number, and the difficulty of applying an eff...
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PMID: 19856849
PDF is available here.
PDF is available here.