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Evans Blue (0):
Recent article
Evans Blue
Journal of Trauma (70)1 2011
Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats.
Abstract
We used small interfering RNA (siRNA) to knock down caveolin-1 expression in rat lungs and to confirm the important role of caveolin-1 in regulating pulmonary edema.
After pulmonary injection of siRNA against caveolin-1 messenger RNA incorporated in liposomes with three concentrations of 0.4, 0.8, a...
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PMID: 20693910
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas.
Abstract
We tested the hypothesis that the BBB is disrupted by HCA.
Forty-one piglets (mean weight 11 kg) were randomly allocated to acute and survival experiments. Five groups (25 piglets, 5 per group) underwent acute studies: anesthesia alone (control); CPB at 37°C with full-flow (FF); CPB at 25°C with v...
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PMID: 21095352
PDF is available here.
PDF is available here.
Journal of Insect Physiology (56)11 2010
Abstract
The division of labor between the different worker castes of leaf-cutting ants may reflect in their capacity to exchange liquids by trophallaxis. The crop capacity of and trophallactic exchanges between different size classes of worker leaf-cutting ants of the sub-species Acromyrmex subterraneus sub...
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PMID: 20615411
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Approximately 15% of acute coronary syndrome (ACS) cases have no significant coronary stenosis. Mechanisms underlying the attacks are, however, unknown.
The clinical study had 254 patients with ACS; 38 patients (31 females and 7 males; aged 51.0 ± 8.0 years) had no significant coronary stenosis on...
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PMID: 20827027
PDF is available here.
PDF is available here.
Abstract
The spin-echo T1W images at 10 minutes post-contrast enhancement showed the best correlation with EB staining in both quantity of EB extravasation (r = 0.812; P < 0.01) and spatial distribution (r = 0.528, P < 0.01). This capability was more robust than the gradient-echo sequence. CONCLUSION: Our re...
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PMID: 20512883
PDF is available here.
PDF is available here.
Neurosurgery (66)4 2010
Abstract
Daily maximum intensity correlated strongly with tumor volume. At postinjection day 23, histology and BLI demonstrated an exponential growth of the tumor mass. Slopes were calculated to reflect the flow in the vessels feeding the tumor (adjusted slope = I90/Im). The increase in BLI intensity was cor...
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PMID: 20305496
PDF is available here.
PDF is available here.
Fitoterapia (81)3 2010
Abstract
This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-ind...
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PMID: 19755140
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
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PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
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PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH group...
|
PMID: 19823933
PDF is available here.
PDF is available here.
Abstract
This study was carried out to image subendocardial myocardial blood flow (SMBF) by dye-staining cardioscopy (DSC) in patients with coronary artery disease.In patients with epicardial coronary artery disease, SMBF plays a direct and critical role in determining the extent and severity of cardiac func...
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PMID: 20966601
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)1 2010
Abstract
We measured brain water content and electrolytes (series 1); BBB permeability based on Evans blue (EB) dye extravasation (series 2); and AQP4 expression using immunoblotting (series 3) at 1 h and 5 h following cortical contusion injury (CCI). Secondary insults significantly worsened BBB function at...
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PMID: 19705963
PDF is available here.
PDF is available here.
Abstract
Nanoparticles are small sized (1-100 nm) particles derived from transition metals, silver, copper, aluminum, silicon, carbon and metal oxides that can easily cross the blood-brain barrier (BBB) and/or produce damage to the barrier integrity by altering endothelial cell membrane permeability. However...
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PMID: 19812977
PDF is available here.
PDF is available here.
Abstract
Metabolic brain imaging is widely used to evaluate brain function and disease, and quantitative assays require local retention of compounds used to register changes in cellular activity. As labeled metabolites of [1- and 6-(14)C]glucose are rapidly released in large quantities during brain activatio...
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PMID: 19794399
PDF is available here.
PDF is available here.
Abstract
Gingival overgrowth is an adverse side effect of cyclosporine A (CsA) in the treatment of transplanted patients. The purpose of this study was to evaluate the effects of CsA on new-onset diabetes mellitus and gingival overgrowth in rats, by measuring collagen, nitric oxide and microvascular permeabil...
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PMID: 21638966
PDF is available here.
PDF is available here.
Abstract
Aerosol delivery through an endotracheal tube during mechanical ventilation of small animals, simulating neonates and small infants, has shown to be influenced by a variety of factors including aerosol generator type, droplet/particle size, ventilator circuitry and ventilation regime...
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PMID: 19415985
PDF is available here.
PDF is available here.
Abstract
Administration of oseltamivir phosphate in the presence of inflammation increased the brain concentration of both parent drug and active metabolite, which may explain the central nervous system side-effects observed with this agent....
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PMID: 19814874
PDF is available here.
PDF is available here.
Abstract
We used the Affymetrix GeneChip Wheat Genome Array to compare gene expression in a sensitive wheat cultivar possessing the Tsn1 gene with the insensitive wheat cv. Nec103, which lacks the Tsn1 gene. This analysis was performed at early timepoints after infiltration with ToxA (e.g., 0.5 to 12 h posti...
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PMID: 19656041
PDF is available here.
PDF is available here.
In vitro method to characterize diffusion of dye from polymeric particles: a model for drug release.
Abstract
The release profile of a drug delivery system is a key factor in determining its efficacy. In the case of a polymeric particle based system, the release profile is a function of several parameters including particle diameter and porosity. The effects of these parameters are usually investigated expe...
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PMID: 19658422
PDF is available here.
PDF is available here.
Medical Physics (36)8 2009
Abstract
Noninvasive photoacoustic sentinel lymph node (SLN) mapping with high spatial resolution has the potential to improve the false negative rate and eliminate the use of radioactive tracers in SLN identification. In addition, the demonstrated high spatial resolution may enable physicians to replace SLN...
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PMID: 19746805
PDF is available here.
PDF is available here.
Abstract
The oxidative stress induced by GSH depletion played a positive role in the regulation of function and expression of P-glycoprotein at the blood-brain barrier in rats....
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PMID: 19505374
PDF is available here.
PDF is available here.
Abstract
An investigation of collagen fiber reorientation, as well as fluid and matrix movement of equine articular cartilage and subchondral bone under compressive mechanical loads, was undertaken using small angle X-ray scattering measurements and optical microscopy. Small angle X-ray scattering measuremen...
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PMID: 19154067
PDF is available here.
PDF is available here.
Brain Research (1254) 2009
Abstract
The aim of this study was to evaluate the effect of tacrolimus on recombinant tissue-plasminogen activator (rt-PA)-induced hemorrhagic transformation, and to characterize its suppressive action for hemorrhage. Thrombotic occlusion of the middle cerebral artery (MCA) was induced by photochemical reac...
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PMID: 19101526
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)3 2009
Abstract
We have shown that normobaric hyperoxia (NBO) treatment reduces MMP-9 increase in the ischemic brain. The aim of this study was to determine whether NBO could attenuate MMP-9-mediated early BBB disruption following ischemic stroke. Rats were exposed to NBO (95% O(2)) or normoxia (30% O(2)) during 90...
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PMID: 19187098
PDF is available here.
PDF is available here.
Abstract
sTNFR-Fc administration markedly reduced infarct size (P < 0.01) and decreased LV dilation as assessed by the echocardiographic measurement of the LV end diastolic area, 7 days post-MI (P < 0.01). Moreover, LV end-diastolic pressure was significantly preserved by sTNFR-Fc 1 week after myocardial inf...
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PMID: 18690528
PDF is available here.
PDF is available here.
Abstract
The soluble radiotracer 99mTc-EB appeared to be a useful lymphoscintigraphic agent in sheep, in which radioactive counts from superficial lymphatic channels and lymph nodes were sufficient for planar imaging. In comparison with 99mTc-antimony trisulfide colloid, both tracers discriminated the sentin...
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PMID: 19039556
PDF is available here.
PDF is available here.
Parasite Immunology (30)10 2008
Abstract
We evaluated the BBB permeability and BBB injury as assessed by the cerebral Evans blue (EB) concentration as well as by pathological changes and glial fibrillary acidic protein (GFAP) expression in T. canis -infected mice monitored from 3 days (dpi) to 8 weeks post-infection (wpi). The vasodilation...
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PMID: 18627507
PDF is available here.
PDF is available here.
Abstract
A new method for determining brain regions with blood-brain barrier (BBB) alterations is described. In this method, mice were perfused intracardially with Evans Blue (EB) and Hoechst tracers added in a standard formaldehyde fixative solution. This cocktail method was tested after a localized cryoles...
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PMID: 18647619
PDF is available here.
PDF is available here.
Brain Research (1221) 2008
Abstract
We tested the hypothesis that homocysteine (Hcy) antagonizes the GABA(A) receptor and behaves as an excitotoxic neurotransmitter that causes blood brain barrier (BBB) permeability and vascular dementia. The BBB permeability was measured by infusing Evan's blue dye (2% in saline 5 ml/kg concentration...
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PMID: 18547546
PDF is available here.
PDF is available here.
Pharmacological Research (57)6 2008
Abstract
Intestinal ischemia/reperfusion (I/R) injury remains associated with high morbidity and mortality. The protective efficacy of the following endothelin (ET) receptor blockers: BQ-123 (ET(A) receptor), BQ-788 (ET(B)); tezosentan (dual ET blocker) was tested against the inhibition of gastrointestinal (...
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PMID: 18511293
PDF is available here.
PDF is available here.
Abstract
This study suggests that the monoclonal tumor necrosis factor alpha antibody, infliximab, can reduce inflammatory activity in experimental otitis media in rats....
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PMID: 18646445
PDF is available here.
PDF is available here.
Abstract
In control rats, BK (0.1-10 nmol) dose-dependently increased plasma extravasation, which was inhibited by Hoe140 (0.2 nmol), whereas des-Arg(9)-BK (0.1 and 1 nmol) was without effect. B(1) receptor mRNA was markedly increased in retinas of diabetic rats, and this was prevented by N-acetyl-L-cysteine...
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PMID: 18311190
PDF is available here.
PDF is available here.
Abstract
We conclude that lymphatic CSF absorption is impaired in a kaolin-communicating hydrocephalus model and that the degree of this impediment may contribute to the severity of the induced disease....
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PMID: 18305019
PDF is available here.
PDF is available here.
Abstract
In order to compare the relative efficacy of topical antihistamines with balanced saline solution (BSS) and benzalkonium chloride (BC) in the early phase of allergic conjunctivitis in an animal model of ocular anaphylaxis, 96 male guinea pigs were sensitized with intraperitoneal egg albumin (EA) and...
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PMID: 18378229
PDF is available here.
PDF is available here.
Neuroscience (153)1 2008
Abstract
We observed BBB leakage for both gadolinium and Evans Blue as early as 25 min after reperfusion. Thereafter, BBB remained open for up to 3 weeks for Evans Blue and up to 5 weeks for gadolinium. Our results show that BBB leakage after ischemia-reperfusion injury in the rat is continuous and long-last...
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PMID: 18367342
PDF is available here.
PDF is available here.
Journal of Bacteriology (1205) 2008
Abstract
We tested administration of L-histidine and thioperamide in surgical brain injury in mice. Mice were randomized to one of three groups: Sham surgery (n=18), surgical brain injury without treatment (SBI) (n=33), and surgical brain injury with combined l-histidine and thioperamide treatment (SBI+H) (n...
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PMID: 18343355
PDF is available here.
PDF is available here.
Abstract
Our results suggest that ATP release is an early event and that eATP plays a signaling role in the elicitation of plant cell responses; Ca2+ is required for activation of the elicitor-induced ATP release and the eATP signal transduction. This is the first report on ATP release induced by a fungal el...
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PMID: 18325935
PDF is available here.
PDF is available here.
Microvascular Research (75)3 2008
Abstract
These results suggest that NO, OH(-) and peroxynitrite play a role in increased vascular permeability induced by arsenic exposure....
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PMID: 18243249
PDF is available here.
PDF is available here.
Abstract
We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX show...
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PMID: 18226910
PDF is available here.
PDF is available here.
Neuropharmacology (54)3 2008
Abstract
We demonstrate that cannabinoids act at several levels: data on the 3rd day suggest a strong involvement of substance P (SP) and calcitonin gene-related peptide (CGRP) in the control of vascular tone, whereas at the 7th and 14th days the major role seems to be played by prostaglandins (PGs) and nitr...
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PMID: 18093621
PDF is available here.
PDF is available here.
Journal of Neurotrauma (25)3 2008
Abstract
We examined MMP-9 expression after SCI using copper/zinc-superoxide dismutase (SOD1) transgenic (Tg) rats. Our results show that MMP-9 activity significantly increased after SCI in both SOD1 Tg rats and their wild-type (Wt) littermates, although the increase was less in the SOD1 Tg rats. This patter...
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PMID: 18352832
PDF is available here.
PDF is available here.
Abstract
The results are consistent with the hypothesis that the host toxicity of high-dose DMXAA is mediated by effects on host vasculature. Co-administration of thalidomide increases the effective dose of DMXAA by reducing clearance but also, by inhibiting production of circulating TNF, reduces the host to...
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PMID: 17473922
PDF is available here.
PDF is available here.
Abstract
We developed a liposomal formulation of Gemcitabine, GemLip (Ø: 36 nm: 47% entrapment). Its anti-tumoral activity was tested on MIA PaCa-2 cells growing orthotopically in nude mice. Bioluminescence measurement mediated by the stable integration of the luciferase gene was employed to randomize the m...
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PMID: 17554540
PDF is available here.
PDF is available here.
Abstract
These results substantiate earlier reports of regional differences in BBB opening after stroke and provide the first in vivo evidence for this phenomenon. They also support the possible use of T(1sat) in quantifying stroke-induced graded BBB damage in the absence of contrast-enhanced MRI....
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PMID: 18174480
PDF is available here.
PDF is available here.