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Suramin (0):
Recent article
Suramin
Abstract
We determined the solution structure of hEGF under physiological conditions and investigated the interaction of suramin with hEGF using isothermal titration calorimetry and NMR spectroscopy techniques. The solution structure of hEGF presented in this paper is different from the bound form of hEGF pr...
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PMID: 21029725
PDF is available here.
PDF is available here.
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Abstract
We investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic polysulphonated naphtylurea) on the mast cell-mediated allergy model, and studied the possible mechanism of their action. Both gossypin and suramin inhibited (P<0.001) compound 48/80-induced systemic anaphylaxis reaction...
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PMID: 20521621
PDF is available here.
PDF is available here.
Abstract
These results indicate that the rat proximal colon has two types of pacemaker cells. Myenteric pacemaker cells which receive predominantly nitrergic, but also cholinergic, peptidergic and NANCNN innervation, and submucosal pacemaker cells that are not markedly influenced by intramural nerves....
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PMID: 20093794
PDF is available here.
PDF is available here.
Emerging Infectious Diseases (15)11 2009
Abstract
Abstract
In the liver, adenosine triphosphate (ATP) is an extracellular signaling molecule that is released into bile and stimulates a biliary epithelial cell secretory response via engagement of apical P2 receptors. The molecular identities of the ion channels involved in ATP-mediated secretory responses ha...
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PMID: 20501432
PDF is available here.
PDF is available here.
Abstract
We monitored the ATP-induced release of neuropeptide Y (NPY), a neuropeptide that increases neuroproliferation in the olfactory epithelium. To visualize NPY release, slices of olfactory epithelium from neonatal mice were cultured on nitrocellulose paper. Immunoassays of the nitrocellulose demonstrat...
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PMID: 19115410
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)6 2009
Abstract
We found three peptide antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin com...
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PMID: 19407848
PDF is available here.
PDF is available here.
Abstract
We show that astrocytes in culture exhibit basal P2X7R activity. Primary mouse astrocytes were found to take up the P2X7R permeant dyes YO-PRO-1 (YP) and propidium iodide in absence of any added ligands. By contrast, cultured rat astrocytes took up very little YP, consistent with their much lower le...
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PMID: 18942742
PDF is available here.
PDF is available here.
Inflammation Research (58)4 2009
Abstract
These results demonstrate that suramin selectively inhibits the activity of the hsPLA(2) GIIA against macrophages, whilst leaving the anti-bacterial function unchanged....
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PMID: 19169647
PDF is available here.
PDF is available here.
Biochemical Pharmacology (77)7 2009
Abstract
We report its ability to inhibit the important CD40-CD154 costi-mulatory interaction required for T cell activation and the development of an effective immune response. In vitro, it inhibited the binding of both human and murine CD154 (CD40L) to their receptor (CD40) even in the presence of protein-...
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PMID: 19283894
PDF is available here.
PDF is available here.
Journal of Hypertension (27)4 2009
Abstract
The blood pressure of the pregnant Suramin-treated rats successively increased during pregnancy and differed by 17 mmHg at gestational day 20 compared with the pregnant control rats. In the pregnant Suramin-treated rats group, the renin levels increased (+122%) and the sFlt-1 levels decreased (-58%)...
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PMID: 19516182
PDF is available here.
PDF is available here.
Abstract
Ca(2+)CaM activated or inhibited single RyR2, but activation was much more likely at low (50-100 nmol.L(-1)) concentrations. Also, suramin displaced CaM from a peptide of the CaM binding domain of RyR2, indicating that, like the skeletal isoform (RyR1), suramin directly competes with CaM for its bin...
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PMID: 19220289
PDF is available here.
PDF is available here.
Abstract
Xenopus follicle-enclosed oocytes are endowed with purinergic receptors located in the follicular cell membrane; their stimulation by ATP elicits an electrical response that includes generation of a fast inward current (F(Cl)) carried by Cl(-). Here, it was found that mechanical stimulation of the f...
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PMID: 18932209
PDF is available here.
PDF is available here.
The Journal of Medical Investigation (56 Suppl) 2009
Abstract
We found that the changes in DIC images reflected spontaneous cell swelling of ductal cells. Electron microscopic analysis after Ca(2+) imaging indicated that the spontaneously oscillating duct cells contained numerous granules at the luminal side, which is characteristic of the granular duct cells....
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PMID: 20224231
PDF is available here.
PDF is available here.
Protein Science (18)3 2009
Abstract
We report the solution NMR structure of PA1324, a protein of unknown function identified in these studies, and provide a putative biological functional assignment based on the observed prealbumin-like fold and FAST-NMR ligand screening studies. PA1324 is postulated to be involved in the binding and...
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PMID: 19241370
PDF is available here.
PDF is available here.
Ophthalmic Research (41)2 2009
Abstract
Suramin 200 mg/ml and MMC 0.2 mg/ml seem to be comparatively nontoxic to the ciliary body of the rabbit eye. Concentrations higher than these values caused severe damage.
(c) 2008 S. Karger AG, Basel....
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PMID: 19122470
PDF is available here.
PDF is available here.
Brain Research Bulletin (77)6 2008
Abstract
We conclude that activation of muscarinic receptors by cholinergic agonist, carbachol or by endogenous acetylcholine (ACh) induce a cascade of events that leads to diminished purinergic response and consequently an inhibition of the bladder NANC response....
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PMID: 18755252
PDF is available here.
PDF is available here.
Abstract
In vitro: Suramin stimulated the differentiation of myoblasts and MDSCs in a dose-dependent manner. Moreover, suramin neutralized the inhibitory effect of MSTN on MDSC differentiation. In vivo: Suramin treatment significantly promoted muscle regeneration, decreased fibrosis formation, reduced myosta...
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PMID: 18725651
PDF is available here.
PDF is available here.
Neuroscience Letters (446)2-3 2008
Abstract
We found that stimulation of P2Y2 receptor (P2Y2R), which is endogenously expressed in CHO-K1 cells, induced intracellular calcium ([Ca2+]i) oscillation with a low frequency of 11.4 +/- 2.7 mHz. When CHO-K1 cells expressing GFP-tagged kinase-negative gammaPKC (gammaPKC-KN-GFP), which is a neuron-spe...
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PMID: 18832012
PDF is available here.
PDF is available here.
Neuroscience Letters (445)3 2008
Abstract
It is well known that intestinal anaphylaxis results in a disturbed intestinal motility. It is hypothesized that the chronic intestinal anaphylaxis-induced changes in the enteric neuronal circuitry cause intestinal motor malfunctions. However, detailed mechanisms largely remain unclear. The aim of t...
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PMID: 18804146
PDF is available here.
PDF is available here.
Abstract
We examine its modes of action and discuss its structure-activity relationships....
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PMID: 18991754
PDF is available here.
PDF is available here.
Annals of Oncology (19)11 2008
Abstract
Noncytotoxic suramin did not increase paclitaxel/carboplatin's toxicity and the suramin dose was predicted from clinical parameters. No clinically significant reversal of primary resistance was documented, but a modulatory effect in chemotherapy-naive patients cannot be excluded. Controlled randomiz...
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PMID: 18632723
PDF is available here.
PDF is available here.
Abstract
We report that ATP can activate P2x receptors directly to modify outer hair cell (OHC) electromotility, which is an active cochlear amplifier determining hearing sensitivity and frequency selectivity in mammals. We found that ATP, but not UTP, a P2y receptor agonist, reduced the OHC electromotility-...
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PMID: 18491132
PDF is available here.
PDF is available here.
Abstract
The effects of luminal ATP between rabbit pulmonary (PAs) and coronary arteries (CAs) were compared to understand the role of purinoceptors in the regulation of pulmonary arterial pressure (PAP) under hypoxia. Diameters of vessels were video analyzed under luminal perfusion. ATP-induced membrane cur...
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PMID: 18542991
PDF is available here.
PDF is available here.
Abstract
We extend the characterization of Cl(-) channels in mice Leydig cells (50-60 days old) by describing volume-activated Cl(-) currents (I(Cl,swell)). The amplitude of I(Cl,swell) is dependent on the osmotic gradient across the cell membrane, with an apparent EC(50) of approximately 75 mOsm. These curr...
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PMID: 18574591
PDF is available here.
PDF is available here.
Abstract
We examined the effects of supernatants of culture media of MDA-MB-231 and MCF-7 cells on the expression of adhesion molecules on human lymphatic endothelial cells (LECs) and evaluated whether the overexpression of adhesion molecules facilitated the attachment of carcinoma cells to LECs. The 48-h st...
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PMID: 18768924
PDF is available here.
PDF is available here.
Abstract
These results indicate that a transmembrane Ca(2+) influx, mainly through NCX, may play a protective role during HFF development in soleus muscle....
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PMID: 18560877
PDF is available here.
PDF is available here.
Protein Science (17)10 2008
Abstract
We demonstrate a new universal method for fishing orphan target proteins from a complex mixture of biomolecules using isothermal titration calorimetry (ITC) as a tracking tool. We took snake venom, a crude mixture of several hundred proteins/peptides, as a model to demonstrate our proposed ITC metho...
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PMID: 18621915
PDF is available here.
PDF is available here.
Biophysical Journal (95)7 2008
Abstract
We also examined interactions of ecarpholin S with phosphatidylglycerol and lauric acid, using surface plasmon resonance, and of suramin with isothermal titration calorimetry. Most Ca(2+)-dependent PLA(2) enzymes have Asp in position 49, which plays a crucial role in Ca(2+) binding. The three-dimens...
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PMID: 18586854
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of ATP and ethanol on spontaneous inhibitory postsynaptic currents (sIPSCs) and the spontaneous firings in the VTA dopaminergic neurons, obtained using an enzyme-free procedure. These neurons preserved some functional GABA-releasing terminals after isolation. We found tha...
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PMID: 18583548
PDF is available here.
PDF is available here.
Abstract
We examined the role of endogenous ATP in the neurohypophysis. Stimulation of NHT caused the release of both AVP and ATP. ATP induced a potentiation in the stimulated release of AVP, but not of oxytocin (OT), which was blocked by the presence of suramin. In loose-patch clamp recordings, from intact...
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PMID: 18481265
PDF is available here.
PDF is available here.
Abstract
Twenty-three patients were enrolled in the study: 6 in the phase I portion and 17 in phase II. Seventy-eight percent of patients were men, the mean age was 58.8 years, 96% had previous nephrectomy, and 70% had received previous systemic therapy. Histologic subtype was clear cell in 91%. Dose-limitin...
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PMID: 18824429
PDF is available here.
PDF is available here.
Hepatology (48)3 2008
Abstract
We investigated whether increased energy demand on the remnant liver after PHx contributes to regenerative signals. Changes in the tissue's energy state were determined from adenine nucleotide levels. Adenosine triphosphate (ATP) levels in remnant livers decreased markedly and rapidly (to 48% of con...
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PMID: 18697206
PDF is available here.
PDF is available here.
Medical Science Monitor (14)8 2008
Abstract
To the best of our knowledge, this is the first study in the English language to show in vitro cytotoxic effect of suramin via telomerase inhibition on C6 glioma cells and spheroids....
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PMID: 18667993
PDF is available here.
PDF is available here.
Neuropsychopharmacology (33)9 2008
Abstract
We recorded field excitatory post-synaptic potential (fEPSP) and evoked excitatory post-synaptic current (eEPSC) in the medial prefrontal cortex (mPFC) of rats, using in vivo field-potential recording and in vitro whole-cell patch-clamp recording techniques, and examined the effects of the alpha2-AR...
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PMID: 17957212
PDF is available here.
PDF is available here.
Abstract
We observed beta-galactosidase staining in cortical vasculature and glomeruli, with specific localization to the JGA region. Renal vascular localization of Cx45 was further confirmed with the use of conditional Cx45-deficient (Cx45fl/fl:Nestin-Cre) mice, which express enhanced green fluorescence pro...
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PMID: 18579650
PDF is available here.
PDF is available here.
Abstract
Our results suggest that P2X7R is a highly sensitive P2 receptor for fluid flow-induced ERK activation in osteoblasts....
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PMID: 18501702
PDF is available here.
PDF is available here.
Life Sciences (83)5-6 2008
Abstract
To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a ho...
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PMID: 18625250
PDF is available here.
PDF is available here.
European Journal of Pharmacology (589)1-3 2008
Abstract
We conclude that in pre-eclampsia, the increase of contraction responses, the decrease of relaxation responses and the decrease of cGMP content can depend on insufficiency about synthesis or release of relaxant factors which was released from the vessel endothelium. The results in this study show th...
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PMID: 18538317
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (100)1 2008
Abstract
Our goal was to analyze the role of sphingosine 1-phosphate (S1P) and its receptors in the up-regulation of cyclooxygenase-2 (Cox-2) induced by HDL in human vascular smooth muscle cells (VSMC). S1P induces Cox-2 expression in a time-and dose-dependent manner at concentrations (0.02-1 microM) compati...
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PMID: 18612546
PDF is available here.
PDF is available here.
Abstract
We conclude that ATP and adenosine, through stimulation of PLC and intracellular Ca2+, may be rapidly acting regulators of BGT1 transport especially in response to a fall in extracellular osmolarity....
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PMID: 18448594
PDF is available here.
PDF is available here.
Cancer Letters (265)1 2008
Abstract
It is well known that suramin influences proliferation and differentiation of tumour cells. To study whether and how suramin effects osteosarcoma (OS) cells, proliferation, differentiation, LOX mRNA expression and telomerase activity (TA) was analysed in the human MG-63 and U-2 OS, and the rat UMR-1...
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PMID: 18374478
PDF is available here.
PDF is available here.
Orthopedics (31)6 2008
Abstract
Peritendinous adhesions are the most common complication of flexor tendon injuries. Overproduction of transforming growth factor Beta has been reported as a major cause of tissue fibrosis. This study investigated the effects of suramin, a known inhibitor of transforming growth factor Beta, on the fo...
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PMID: 19292358
PDF is available here.
PDF is available here.
Abstract
We detected a significant elevation in extracellular ATP (Delta = 76 +/- 2 microM) during calcium wave propagation, which was abolished by Cx40 siRNA treatment (Delta = 6 +/- 1 microM). These studies suggest that connexin 40 hemichannels and extracellular ATP are key molecular elements of the glomer...
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PMID: 18401004
PDF is available here.
PDF is available here.
Experimental Parasitology (119)2 2008
Abstract
We describe the ability of living trophozoites of Giardia lamblia to hydrolyze extracellular ATP. In the absence of any divalent cations, a low level of ATP hydrolysis was observed (0.78+/-0.08 nmol Pi x h(-1)x10(-6) cells). The ATP hydrolysis was stimulated by MgCl(2) in a dose-dependent manner. Ha...
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PMID: 18413274
PDF is available here.
PDF is available here.
Abstract
Secreted protein acidic, rich in cysteine could act as a chemotactic factor and facilitate migration, possibly through the G-protein coupled receptor, alphavbeta3 integrin and ERK. The data support that SPARC could play a crucial role in dental pulp tissue repair by inducing dental pulp cell migrati...
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PMID: 18410576
PDF is available here.
PDF is available here.
Abstract
HCV recovered from low density fractions of infected blood is associated with lipid and host apo-lipoproteins in lipo-viro-particles (LVP). It has been proposed that these particles are capable of binding and entering hepatocytes by viral glycoprotein independent mechanisms utilizing uptake pathways...
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PMID: 18360895
PDF is available here.
PDF is available here.
Abstract
In vitro, proliferation was inhibited by suramin up to 95%. In vivo, all controls developed extensive tumor growth and spread. No tumor was detectable in half of the suramin-treated animals after 8 weeks; tumor dissemination was almost completely depressed. Suramin therapy resulted in a complete reg...
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PMID: 18320288
PDF is available here.
PDF is available here.
Abstract
We presented in vivo evidence for a physiological significance of cAMP-regulated CFTR Cl(-) channels in Ca(2+)-activated Cl(-) reabsorption in the ductal system of the rat submandibular gland. Here, we address the mechanism by which basal CFTR activation contributes to the transepithelial Cl(-) move...
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PMID: 18337312
PDF is available here.
PDF is available here.
Abstract
We investigated a role for the SK2 member of the SK family (SK1-3) utilizing: 1) mice expressing beta-galactosidase (beta-gal) under the direction of the SK2 promoter (SK2 beta-gal mice) to localize SK2 expression and 2) mice lacking SK2 gene expression (SK2(-/-) mice) to assess SK2 function. In SK2...
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PMID: 18353877
PDF is available here.
PDF is available here.
Abstract
These results suggest, therefore, that Ca2+ entrance mediated by P2X7 receptor induces glutamate release and in parallel synapsin-I phosphorylation....
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PMID: 18242779
PDF is available here.
PDF is available here.
Abstract
These findings demonstrate that PPAR alpha and PPAR gamma activation stimulates neoangiogenesis through a VEGF-dependent mechanism. Neoangiogenesis is a crucial pathological event in type 2 diabetes. The ability of PPAR alpha and PPAR gamma agonists to induce neoangiogenesis might have important imp...
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PMID: 18268046
PDF is available here.
PDF is available here.
Acta Tropica (106)1 2008
Abstract
The effect of treatment on relapses of Trypanosoma brucei (T. b.) brucei infections in mice in relation to passage of the parasites across the blood-brain barrier (BBB) as visualized by immunohistochemistry was studied. Three daily intraperitoneal injections of 20mg/kg suramin starting at 15 days po...
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PMID: 18329619
PDF is available here.
PDF is available here.
Abstract
DDP and suramin used alone or in combination significantly inhibited the growth of LA795 cells in mice (P<0.05), with growth inhibition rates of 34.9%, 23.8% and 57.3%, respectively. The occurrence rate of lung metastasis and the number of metastatic foci on lung surface were significantly lower in...
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PMID: 18423120
PDF is available here.
PDF is available here.
Abstract
We studied contractile effects in isolated electrically driven (1 Hz) atrial preparations from patients undergoing cardiac bypass surgery. ATP concentration dependently (10, 30, and 100 microM) and rapidly decreased force of contraction (negative inotropic effect, NIE) and thereafter more slowly inc...
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PMID: 18263715
PDF is available here.
PDF is available here.
Abstract
Our results also show that trypomastigotes obtained from suramin-treated host cells were significantly less infective than control parasites and that amastigotes derived from those trypomastigote forms were less proliferative....
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PMID: 18191547
PDF is available here.
PDF is available here.
Abstract
We previously reported that endothelins (ETs) are involved in the short-term tyrosine hydroxylase (TH) regulation in both the AHR and PHR. TH is crucial for catecholaminergic transmission and is tightly regulated by well-characterized mechanisms. In the present study, we sought to establish the effe...
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PMID: 18094067
PDF is available here.
PDF is available here.
Life Sciences (82)9-10 2008
Abstract
We have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of heart left ventricle. We observe divalent cation-dependent enzymes...
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PMID: 18201730
PDF is available here.
PDF is available here.
Journal of Membrane Biology (222)2 2008
Abstract
We established a stable, inducible HEK 293 cell line expressing full-length rabbit RyR2 cDNA and assessed the single-channel properties of the recombinant RyR2, with particular reference to ligand regulation with Ca2+ as the permeant ion. We found that the single-channel conductances of recombinant...
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PMID: 18418540
PDF is available here.
PDF is available here.
Current Eye Research (33)3 2008
Abstract
The data suggest that purinergic P2 receptors are involved in neovascularization associated with OIR....
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PMID: 18350440
PDF is available here.
PDF is available here.