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Onium Compounds (2):
Recent article
Onium Compounds
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated the regulatory mechanism of Srx induction by lipopolysaccharide (LPS) in mouse macrophages. LPS up-regulated Srx expression on the transcriptional level. The promoter region of the Srx gene contained putative NF-κB and AP-1 (activator protein-1) sites, and the proximal site of three...
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PMID: 20826812
PDF is available here.
PDF is available here.
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Abstract
Proton dissociation and transfer were examined with ab initio molecular dynamics (AIMD) simulations of carbon nanotubes (CNT) functionalized with perfluorosulfonic acid (-CF(2)SO(3)H) groups with 1-3 H(2)O/SO(3)H. The CNT systems were constructed both with and without fluorine atoms covalently bound...
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PMID: 20556301
PDF is available here.
PDF is available here.
Abstract
We found that the co-treatment with hepatocyte growth factor (HGF) and TGF-beta1 resulted in enhanced migration of HaCaT cells compared with either growth factor alone, and that N-acetylcysteine, an antioxidant agent, was the most effective among several inhibitors tested, suggesting the involvement...
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PMID: 20177149
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (114)16 2010
Abstract
Using (1)H and (13)C NMR and DFT calculations, the structure and interactions of the symmetric ethereally fenced hexaarylbenzene receptor 1 with hydronium ions were studied. Both 1 and its equimolecular complex 1.H(3)O(+) exhibit C(3v) symmetry. According to DFT, two similar optimal structures of th...
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PMID: 20364854
PDF is available here.
PDF is available here.
Biochemistry (New York) (75)5 2010
Abstract
The effect of Ca2+ on programmed death of guard cells (GC) and epidermal cells (EC) determined from destruction of the cell nucleus was investigated in epidermis of pea leaves. Ca2+ at concentrations of 1-100 microM increased and at a concentration of 1 mM prevented the CN(-)-induced destruction of...
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PMID: 20632941
PDF is available here.
PDF is available here.
Abstract
We examined the roles of angiotensin II receptor and NADPH oxidase in ischemia/reperfusion-induced gastric damage in rats. Under urethane anesthesia, male Sprague-Dawley rat stomachs were mounted in an ex-vivo chamber, had 100 mM HCl applied to them, and then a catheter was passed through the femora...
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PMID: 20436217
PDF is available here.
PDF is available here.
Journal of Plant Physiology (167)5 2010
Abstract
We investigated the signaling role of hydrogen peroxide (H(2)O(2)) in regulating the ascorbate (AsA) level after exogenous methanol (MeOH) application. The endogenous H(2)O(2) and AsA levels as well as the expression of related genes were monitored after MeOH treatment of cultures of Oncidium protoc...
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PMID: 19939499
PDF is available here.
PDF is available here.
Abstract
We tested glycerol trinitrate (GTN) and other well-known NO donors together with those bearing a >C=N-OH group for possible conversion to NO (or nitrites, respectively) by diaphorase (DP) and lipoamide dehydrogenase (LAD). Both, DP and LAD were unable to convert formamidoxime (FAM), acetone oxime (A...
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PMID: 20097961
PDF is available here.
PDF is available here.
Abstract
We have now systematically tested site-directed replacements for the residues involved in sugar binding, as well as H+ translocation and coupling, in order to determine which residues may be responsible for this alkaline pKa. Mutations in the sugar-binding site (Glu126, Trp151, Glu269) markedly decr...
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PMID: 19689129
PDF is available here.
PDF is available here.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (40)4 2009
Abstract
Diaryliodonium led to greater DC, CS, and CD of the light-curing composite resin. The DC, CS, and CD of the light-curing composite resin increased more with bis (p-tolyl) iodonium hexafluorophosphate than with diphenyliodonium hexafluorophosphate. CONCLUSION: Diaryliodonium can improve the DC, CS, a...
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PMID: 19764577
PDF is available here.
PDF is available here.
Radiation Research (171)3 2009
Abstract
2-Deoxyribonolactone lesions were identified as major products of radiation damage to DNA mediated by o,o'-diphenyleneiodonium cations in a hydroxyl radical-scavenging environment. The highest selectivity toward deoxyribonolactone formation (up to 86% of all sugar-phosphate damages) and the overall...
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PMID: 19267561
PDF is available here.
PDF is available here.
Abstract
We provide evidence that HDQ likely targets another P. falciparum mitochondrial enzyme, dihydroorotate dehydrogenase (pfDHOD), which is essential for de novo pyrimidine biosynthesis....
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PMID: 19097788
PDF is available here.
PDF is available here.
Abstract
We here report an improved method for synthesis of authentic PBDE congeners applying bromophenols and symmetrical brominated diphenyliodonium salts as building blocks. Altogether, 13 PBDEs were synthesized of which seven are new. The improved coupling reaction between the bromophenol and the bromina...
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PMID: 18996562
PDF is available here.
PDF is available here.
Abstract
We found that static pressure promoted rat aortic smooth muscle cell proliferation and cell cycle progression. Static pressure treatment increased volume-regulated chloride currents and ClC-3 expression. Inhibition of chloride channel with pharmacological blockers or knockdown of ClC-3 with ClC-3 an...
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PMID: 19910686
PDF is available here.
PDF is available here.
Plant Journal (56)5 2008
Abstract
We propose that this ROS response is characteristic of the symbiotic interaction. Furthermore, we discuss the remarkable spatial and temporal coincidences between ROS and transiently increased calcium levels observed in root hair cells immediately after the detection of NFs....
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PMID: 18680562
PDF is available here.
PDF is available here.
Plant, Cell & Environment (31)12 2008
Abstract
We have focused here on the role of hydrogen peroxide (H(2)O(2)) in high-temperature signalling in relation to changes in membrane fluidity in cells of tobacco (Nicotiana tabacum L.) cv. Bright Yellow 2 (BY2). As final indicators of the heat-signalling cascade, we have monitored the synthesis of sma...
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PMID: 18761700
PDF is available here.
PDF is available here.
Abstract
We investigated the differential role of diphenyleneiodonium (DPI), which is widely used as an inhibitor of NADPH oxidase, on the activation of cell cycle regulators in the cell cycle progression. DPI efficiently blocked the transition from G0/G1 to S phase by serum stimulation in quiescent HCT-116...
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PMID: 19020764
PDF is available here.
PDF is available here.
Endocrinology (149)11 2008
Abstract
We studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DPI on glucose- and nonfuel-stimulated insulin secretion, islet glucose metabolism, and intracellular Ca2+ concentration ([Ca2+]i) dynamics in rat is...
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PMID: 18617620
PDF is available here.
PDF is available here.
European Journal of Pharmacology (595)1-3 2008
Abstract
We showed antioxidant properties of pirfenidone beyond its well-known antifibrotic effect. These features make pirfenidone an attractive drug for trying fibrotic diseases accompanied by oxidative stress processes....
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PMID: 18652820
PDF is available here.
PDF is available here.
Abstract
In the plasma membrane fraction from Caco-2 human colon carcinoma cells, active Nox1 (NADPH oxidase 1) endogenously co-localizes with its regulatory components p22(phox), NOXO1, NOXA1 and Rac1. NADPH-specific superoxide generating activity was reduced by 80% in the presence of either a flavoenzyme i...
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PMID: 18518859
PDF is available here.
PDF is available here.
Abstract
Our data outline a role of ROS as important molecules in the transduction of an intracellular signal during the neuronal differentiation of ES cells....
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PMID: 18987612
PDF is available here.
PDF is available here.
Abstract
Our results show that LPS-activated mononuclear cells can be used ex vivo as a convenient and adequate experimental system for evaluation of the efficiency of various substances in protection of lymphocyte DNA from the damaging effect of reactive oxygen species of LPS-stimulated monocytes....
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PMID: 19240845
PDF is available here.
PDF is available here.
Abstract
We tested how shear-conditioned EC responded to reduction in flow, either by spontaneously binding leukocytes, or by increasing sensitivity to TNF. Human umbilical vein EC were exposed to shear stress of 2.0 Pa (20 dyn/cm(2)) for 24 h. Shear was then reduced to stasis (30 sec perfusion each hour to...
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PMID: 18393276
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)35 2008
Abstract
We recently showed that a novel disulfide reductase, TRP14, inhibits tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation, and we identified the dynein light chain LC8, which interacts with the NF-kappaB inhibitor IkappaBalpha, as a potential substrate of TRP14. We now show the molecu...
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PMID: 18579519
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)32 2008
Abstract
We investigated the source of Ca(res) and its contribution to posttetanic potentiation (PTP). After TS (100 Hz for 4 s), posttetanic Ca(res) at the calyx of Held was largely abolished by tetraphenylphosphonium (TPP(+)) or Ru360, which inhibit mitochondrial Na(+)-dependent Ca(2+) efflux and Ca(2+) un...
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PMID: 18685020
PDF is available here.
PDF is available here.
Abstract
We systematically investigated pro-survival and pro-death pathways and discovered that the rapid and transient burst of H2O2 activates the AKT survival pathway. Activation of the apoptotic machinery takes place following the decline of H2O2 to basal levels. To substantiate this proposed pro-survival...
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PMID: 18404155
PDF is available here.
PDF is available here.
Journal of Experimental Biology (211)Pt 16 2008
Effects of dietary polyunsaturated fatty acids on mitochondrial metabolism in mammalian hibernation.
Abstract
Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) were fed one of four isocaloric, isolipemic diets containing 16, 22, 35 or 55 mg linoleic acid (18:2n-6) per gram. Mitochondrial properties were compared between hibernating and summer active states, and between diet groups. As in other...
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PMID: 18689422
PDF is available here.
PDF is available here.
Abstract
These results validated 4-aminocyclophosphamide as a prodrug form of phosphoramide mustard and suggest that compound 4 can potentially be used as a prodrug of phosphoramide mustard for bioreductive activation....
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PMID: 18556201
PDF is available here.
PDF is available here.
Abstract
We discuss the implications of this assumption and the difficulty in reconciling it with experimental phenomena. We show how presenting chrono-amperometric transients as log-log plots for potentials steps in the presence and absence of an adlayer of carbon monoxide on polycrystalline platinum is par...
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PMID: 18563231
PDF is available here.
PDF is available here.
Abstract
We find that a hydrophobic double layer is formed in the contact layer....
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PMID: 18563221
PDF is available here.
PDF is available here.
Life Sciences (83)1-2 2008
Abstract
We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice. In the pres...
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PMID: 18538348
PDF is available here.
PDF is available here.
Dental Materials (24)6 2008
Abstract
The purpose of this study was to evaluate the effects of photoinitiator type and water content on the polymerization rate (Rp) and degree of conversion (DC) of a model BisGMA/HEMA-based resin.
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PMID: 18045679
PDF is available here.
PDF is available here.
Free Radical Research (42)6 2008
Abstract
Diphenyleneiodonium (DPI) is often used as a molecular tool in unravelling redox-sensitive cellular events involving NADPH oxidase. However, to better understand unexpected actions of DPI, it was ascertained if DPI affects cellular DNA. DPI induced single-strand breaks in DNA of HCT-116 cells, altho...
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PMID: 18569011
PDF is available here.
PDF is available here.
Abstract
We investigated the role of two NADPH oxidases in the necrotrophic phytopathogenic fungus, Botrytis cinerea. The genes bcnoxA and bcnoxB were cloned and characterized; their deduced amino acid sequences show high homology to fungal NADPH oxidases. Analyses of single and double knock-out mutants of b...
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PMID: 18624644
PDF is available here.
PDF is available here.
Abstract
Reactive oxygen species (ROS) are produced in NIH3T3 fibroblasts during hypotonic stress, and H(2)O(2) potentiates the concomitant release of the organic osmolyte taurine (Lambert IH. J Membr Biol 192: 19-32, 2003). The increase in ROS production [5-(and-6)-carboxy-2', 7'-dichlorodihydrofluorescein...
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PMID: 18417717
PDF is available here.
PDF is available here.
Abstract
We present the synthesis and evaluation of six new 64Cu-labeled triphenylphosphonium (TPP) cations. Biodistribution studies were performed using the athymic nude mice bearing U87MG human glioma xenografts to explore the impact of TPP moieties, linkers, bifunctional chelators (BFCs), and molecular ch...
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PMID: 18419113
PDF is available here.
PDF is available here.
Abstract
Synoviocyte hyperplasia is critical for rheumatoid arthritis, therefore, potentially an important target for therapeutics. It was found in this work that a TRPV1 agonist capsaicin, and acidic solution (pH 5.5) induced increases in cytosolic calcium concentration ([Ca(2+)](c)) and reactive oxygen spe...
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PMID: 18331834
PDF is available here.
PDF is available here.
Experimental Physiology (93)5 2008
Abstract
We hypothesized that diabetes upregulates PRR expression through enhanced angiotensin subtype 1 (AT1) receptor-NADPH oxidase cascade activity. Using real-time polymerase chain reaction, Western blot analysis and immunostaining, we studied renal localization of the PRR in the streptozotocin-induced d...
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PMID: 18192338
PDF is available here.
PDF is available here.
Plant Journal (54)3 2008
Abstract
We observed that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked accumulation of the purine catabolic products allantoin and allantoate. In contrast, Arabidopsis mutants of XDH, Atxdh1, accum...
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PMID: 18266920
PDF is available here.
PDF is available here.
Biochemical Journal (411)3 2008
Abstract
We compared the uptake into both isolated mitochondria and mitochondria within cells of two hydrophobic TPP derivatives, [3H]MitoQ (mitoquinone) and [3H]DecylTPP, with the more hydrophilic TPP cation [3H]TPMP (methyltriphenylphosphonium). Uptake of MitoQ by mitochondria and cells was described by th...
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PMID: 18294140
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1777)5 2008
Abstract
We investigated the effects of diphenyleneiodonium (DPI) on superoxide production by complex I in mitochondria isolated from rat skeletal muscle. Superoxide production was measured indirectly as hydrogen peroxide production. In a conventional medium containing chloride, DPI strongly inhibited supero...
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PMID: 18395512
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)18 2008
Abstract
We studied the role of glycine residues in EmrE, a small multidrug transporter from Escherichia coli. EmrE extrudes various drugs across the plasma membrane in exchange with protons and, as a result, confers resistance against their toxic effects. Each of 12 glycine residues was replaced by site-dir...
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PMID: 18321856
PDF is available here.
PDF is available here.
Cellular Signalling (20)4 2008
Abstract
These results provide direct evidence that O2- could be locally produced via NOX on the SR and that this local O2- producing system is controlled by cADPR-RyR/Ca2+ signaling pathway....
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PMID: 18207366
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the up-regulation of ICAM-1 is due to a transient increase in production of reactive oxygen species (ROS). ROS may initiate signalling of the ICAM-1 gene promoter, enhancing up-regulated ICAM-1 protein on the cell surface. Single-cell suspensions of thyroid follicular cells from...
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PMID: 18241232
PDF is available here.
PDF is available here.
Abstract
We tested the role of 12/15-LO products using MPM and the mouse macrophage cell line, J774A.1 cells. We found that 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] increased MCP-1 mRNA and protein expression in J774A.1 cells and MPM. In contrast, 12(R)-HETE, a lipid not derived from 12/15-LO, did not...
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PMID: 18296557
PDF is available here.
PDF is available here.
Abstract
We have shown that both Rac1 and c-Jun NH(2)-terminal kinase (JNK1/2) are key proapoptotic molecules in tumor necrosis factor (TNF)-alpha/cycloheximide (CHX)-induced apoptosis in intestinal epithelial cells, whereas the role of reactive oxygen species (ROS) in apoptosis is unclear. The present studi...
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PMID: 18218673
PDF is available here.
PDF is available here.
Journal of Membrane Biology (222)3 2008
Abstract
The antioxidant activity of mitochondria-targeted small molecules, SkQ1 and MitoQ (conjugates of a lipophilic decyltriphenylphosphonium cation with an antioxidant moiety of a plastoquinone and ubiquinone, respectively), was studied in aqueous solution and in a lipid environment, i.e., micelles, lipo...
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PMID: 18493812
PDF is available here.
PDF is available here.
Abstract
We report ab initio molecular dynamics simulations of hydroxide and hydronium ions near a hydrophobic interface, indicating that both ions behave like amphiphilic surfactants that stick to a hydrophobic hydrocarbon surface with their hydrophobic side. We show that this behavior originates from the a...
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PMID: 18311970
PDF is available here.
PDF is available here.
Abstract
Additions of iodonium-X reagents to N-alkoxycarbonyl-2-azabicyclo[2.2.1]hept-5-enes and the homologous 2-azabicyclo[2.2.2]oct-5-enes have been found to mirror the outcomes of additions of bromonium-X reagents. Only rearranged products were observed for reactions of either of these halonium ion reage...
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PMID: 18290656
PDF is available here.
PDF is available here.
Abstract
We apply a newly parameterized central force field to highlight the problem of proton transport in fuel cell membranes and show that central force fields are potential candidates to describe chemical reactions on a classical level. After a short sketch of the parameterization of the force field, we...
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PMID: 18204868
PDF is available here.
PDF is available here.
Abstract
Interaction of H3O+ or H5O2+ with 1,3-alternate tetrapropoxycalix[4]arene (1) was studied in nitrobenzene and dichloromethane using 1H and 13C NMR including transverse and rotating-frame relaxations and density functional level of theory (DFT) quantum calculations. According to NMR, the ion forms an...
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PMID: 18236442
PDF is available here.
PDF is available here.
Abstract
We investigated whether BLT2, a low-affinity leukotriene B(4) receptor, is involved in the generation of ROS in H-Ras(V12)-transformed fibroblasts. We show that downregulation of BLT2 using RNA interference or antisense oligonucleotides inhibits ROS generation, and that Nox1 acts downstream of BLT2....
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PMID: 18082638
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that NADPH oxidase subunits and activity are regulated by LRs in human renal proximal tubule cells. We report that a high proportion of p22(phox) and the small GTPase Rac1 are expressed in LRs in human renal proximal tubule cells. The D(1)-like receptor agonist, fenoldopam (...
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PMID: 18195159
PDF is available here.
PDF is available here.
Abstract
We show that GSH loss induced by L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH biosynthesis, leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells. BSO susceptibility of SK-N-BE-2C, a representative example of MYCN-amplified c...
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PMID: 17991446
PDF is available here.
PDF is available here.
Abstract
We investigated the induction of OPN expression in renal mesangial cells (MCs) by aldosterone and the inflammatory cytokines IL-1beta/TNFalpha. Incubation with aldosterone resulted in a time- and concentration-dependent increase in OPN mRNA and protein. OPN mRNA expression followed a biphasic time c...
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PMID: 17546625
PDF is available here.
PDF is available here.
Animal Reproduction Science (103)3-4 2008
Abstract
In the present study attempts were made to detect and quantify the generation of superoxide anion (O(2)(*-)) and hydrogen peroxide (H(2)O(2)) by capacitating buffalo spermatozoa. Ejaculated buffalo spermatozoa were suspended in sp-TALP medium at 50x10(6)mL(-1) and incubated at 38.5 degrees C with 5%...
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PMID: 17270367
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (279)1 2008
Abstract
The catalytic properties of sodium-translocating NADH:quinone oxidoreductases (Na+-NQRs) from the marine bacterium Vibrio harveyi, the enterobacterium Klebsiella pneumoniae, and the soil microorganism Azotobacter vinelandii have been comparatively analyzed. It is shown that these enzymes drastically...
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PMID: 18300384
PDF is available here.
PDF is available here.
Abstract
We have recently shown that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit enhanced expression of Gialpha proteins, which was attributed to the enhanced oxidative stress. Since C-ANP(4-23) that specifically interacts with natriuretic peptide C (NPR-C) receptor...
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PMID: 18162186
PDF is available here.
PDF is available here.
Abstract
We propose that ATM performs a critical function in mediating normal cellular proliferation that is regulated by nonphagocytic NAD(P)H oxidase enzymes activity, which may serve as a novel target for arresting cancer cells in G(1)....
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PMID: 17637756
PDF is available here.
PDF is available here.