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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Acetylcysteine (0):
Recent article
Acetylcysteine
Critical Care Medicine (39)11 2011
Abstract
There is controversy regarding the benefits of N-acetylcysteine in acute kidney injury. This study was to compare three commonly used regimens and explore which regimen is best for the protection of acute kidney injury.
Prospective experimental study....
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PMID: 21705900
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Critical Care Medicine (39)11 2011
Abstract
There is controversy regarding the benefits of N-acetylcysteine in acute kidney injury. This study was to compare three commonly used regimens and explore which regimen is best for the protection of acute kidney injury.
Prospective experimental study....
|
PMID: 21705900
PDF is available here.
PDF is available here.
Critical Care Medicine (39)11 2011
Abstract
There is controversy regarding the benefits of N-acetylcysteine in acute kidney injury. This study was to compare three commonly used regimens and explore which regimen is best for the protection of acute kidney injury.
Prospective experimental study....
|
PMID: 21705900
PDF is available here.
PDF is available here.
Abstract
Cisplatin (CP), a broadly used anticancer drug, is widely known to induce acute renal failure as a result of renal tubular injury.
In this study, the effect of N-acetyl cysteine (NAC) or taurine (TAU) for protection against CP-induced nephrotoxicity was investigated....
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PMID: 21470069
PDF is available here.
PDF is available here.
Abstract
Cisplatin (CP), a broadly used anticancer drug, is widely known to induce acute renal failure as a result of renal tubular injury.
In this study, the effect of N-acetyl cysteine (NAC) or taurine (TAU) for protection against CP-induced nephrotoxicity was investigated....
|
PMID: 21470069
PDF is available here.
PDF is available here.
Abstract
Cisplatin (CP), a broadly used anticancer drug, is widely known to induce acute renal failure as a result of renal tubular injury.
In this study, the effect of N-acetyl cysteine (NAC) or taurine (TAU) for protection against CP-induced nephrotoxicity was investigated....
|
PMID: 21470069
PDF is available here.
PDF is available here.
Abstract
We show that the proliferating cell nuclear antigen-associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hematopoiesis. Mice lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed progenitors; and leukopenia. These...
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PMID: 21844206
PDF is available here.
PDF is available here.
Abstract
In Wistar rats, specific inhibitor UPS lactacystin induced degeneration of 24% of the dopaminergic neurons in the black substance. The work shows that a moderate weakening of the UPS function is characterized by an enhanced activity of the shaperon system. This process seems to resto...
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PMID: 21961290
PDF is available here.
PDF is available here.
Abstract
We have shown an effective recovery from arsenic-induced death signaling in erythrocytes in response to treatment with atorvastatin (ATV) and N-acetyl cysteine (NAC) in rats. Our results emphasized on the importance of cholesterol in the promotion of ROS-mediated Fas signaling in red cells. Arsenic-...
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PMID: 20946910
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We investigated the metabolism of Ser-129-phosphorylated a-Syn. In SH-SY5Y cells, inhibition of protein phosphatase 2A/1 by okadaic acid, and inhibition of the proteasome pathway by MG132 or lactacystin accumulated Ser-129-phosphorylated a-Syn. However, these inhibitions did not alter the amounts of...
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PMID: 20959456
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We show that loss of Foxo3 causes a myeloproliferative syndrome with splenomegaly and increased hematopoietic progenitors (HPs) that are hypersensitive to cytokines. These mutant HPs contain increased ROS, overactive intracellular signalling through the AKT/mammalian target of rapamycin signalling p...
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PMID: 21113129
PDF is available here.
PDF is available here.
Abstract
We present the concept of metallophilic hydrogels, supramolecular systems in which the gelator species are metal-thiolates that self-assemble through metallophilic attractions. The principle is applied for a small drug, the mucolytic agent N-acetyl-l-cysteine (NAC), which readily forms hydrogels in...
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PMID: 20882249
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated the regulatory mechanism of Srx induction by lipopolysaccharide (LPS) in mouse macrophages. LPS up-regulated Srx expression on the transcriptional level. The promoter region of the Srx gene contained putative NF-κB and AP-1 (activator protein-1) sites, and the proximal site of three...
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PMID: 20826812
PDF is available here.
PDF is available here.
Abstract
We have applied a novel mitochondria-targeted antioxidant: plastoquinone conjugated with decyltriphenylphosphonium (SkQ1). This antioxidant at nanomolar concentration prevented ROS accumulation and cell death induced by H(2)O(2) in fibroblasts. We found that scavenging of ROS produced by mitochondri...
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PMID: 20446771
PDF is available here.
PDF is available here.
Pediatric Research (68)5 2010
Abstract
Complications after cardiac surgery in neonates can occur because of activation of the inflammatory system. This study used lipopolysaccharide (LPS) endotoxin exposure to cause cytokine activation in neonatal mice and examine left ventricular (LV) function and the effects of antioxidant treatment on...
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PMID: 20613681
PDF is available here.
PDF is available here.
Current Eye Research (35)11 2010
Abstract
Our results clearly showed that NAC inhibited indicators of oxidative stress and the activation of NF-κB induced by laser injury, and, consequently, suppressed macrophage and neutrophil infiltration and the development of CNV. This suggests novel preventative and interventional therapeutic strategi...
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PMID: 20958190
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
Abstract
We observed that the cell-proliferation-related phosphoinositide 3-kinase/Akt pathway is activated by HBx in vivo and in vitro. Increased ROS were detected by HBx. Tumor suppressor PTEN, via dephosphorylation of Akt, was oxidized and inactivated by increased ROS. Increased oxidized PTEN activated th...
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PMID: 20954279
PDF is available here.
PDF is available here.
Abstract
I (IGF-I) (or insulin). Under these conditions, T3 and T4 are secreted but so are other factors such as growth factors, plasminogen activators, their inhibitors known as serpins, and so on. What is the function of these factors? Do thyroid cells respond to them or are these paracrine/endocrine facto...
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PMID: 20616713
PDF is available here.
PDF is available here.
Oral Diseases (16)7 2010
Abstract
Hypoxia inducible factor (HIF)-1α gene expression is mainly induced by tissue hypoxia. Overexpression of HIF-1α has been demonstrated in a variety of cancers. The aim of this study was to compare HIF-1α expression in normal human oral epithelium and areca quid chewing-associated oral squamous cel...
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PMID: 20846156
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of MG132 on the growth of endothelial cells (ECs), especially calf pulmonary artery endothelial cells (CPAECs), in relation to cell death, ROS, and glutathione (GSH) levels. MG132 dose dependently inhibited the growth of CPAEC and human umbilical vein endothelial cells (HUVE...
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PMID: 20088736
PDF is available here.
PDF is available here.
Abstract
We investigated the use of urinary (u) trans,trans-muconic acid (t,t-MA), S-phenylmercapturic acid (SPMA), and unmodified benzene (UB) for assessing exposure to low concentrations of environmental benzene and the role of living environment on benzene exposure in childhood. u-t,t-MA, u-SPMA, u-UB and...
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PMID: 20591482
PDF is available here.
PDF is available here.
Abstract
I (n=32), drug regimen included daily doses of isoniazid, rifampicin, pyrazinamide, and ethambutol. Patients in group II (n=28) were treated with the same regimen and NAC. The patients were followed up for 2 weeks. Liver enzymes and bilirubins were measured at baseline, after 1 and 2 weeks of treatm...
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PMID: 20461008
PDF is available here.
PDF is available here.
Neurochemical Research (35)10 2010
Abstract
We report here that PPX treatment significantly improves rotarod performance, attenuates DA neuron loss and striatal DA reduction, and alleviates proteasomal inhibition and microglial activation in the substantia nigra of lactacystin-lesioned mice. PPX can increase the levels of brain-derived neurot...
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PMID: 20635141
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
Ninety female Balb/c mice were used. The animals were allocated to evenly six groups. While the first group was maintained as control, Groups 3, 4, 5, and 6 were administered 750 ppm, 1500 ppm, 3000 ppm, and 6000 ppm of N-acetylcysteine, respectively, for a period of 15 days. After day 15, Groups 2-...
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PMID: 20637250
PDF is available here.
PDF is available here.
Abstract
We propose a new treatment for AKU using the antioxidant N-acetylcysteine (NAC) administered in combinations with ascorbic acid (ASC) since it has been proven that NAC counteracts the side-effects of ASC. We established an in vitro cell model using human articular primary chondrocytes challenged wit...
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PMID: 20648626
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)5 2010
Abstract
We studied in a prospective, double blinded, randomized controlled, cross over trial 14 adult HD patients who were randomized into two groups; one group received NAC in a dose of 600 mgs twice daily for 10 days prior to intravenous iron therapy and the other group received placebo. Both the groups w...
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PMID: 20814119
PDF is available here.
PDF is available here.
Pneumologie (64)9 2010
Abstract
Sarcoidosis and lung fibrosis were first described by histopathology in the 19th century. Since then a large number of different forms of diffuse parenchymal lung diseases has been identified. Although all these diseases manifest in the lung interstitium, there is a wide range of predominanthy infla...
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PMID: 20827641
PDF is available here.
PDF is available here.
Abstract
The cause of interstitial lung diseases (ILDs) such as lung fibrosis or sarcoidosis is still largely unknown. Pharmacotherapeutic treatment in ILD lacks a firm mechanistic molecular basis. A striking paradox is that ILDs result in a shortage of oxygen and that at the same time reactive oxygen specie...
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PMID: 20592594
PDF is available here.
PDF is available here.
Abstract
I (rotenone) and III (antimycin) increased ethanol-induced H3AcK9 (P<.01). Oxidative stress also affected ethanol-induced alcohol dehydrogenase 1 mRNA expression. These results demonstrate for the first time that oxidative stress is involved in the ethanol-induced histone H3 acetylation in hepatocyt...
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PMID: 20705415
PDF is available here.
PDF is available here.
Abstract
We asked whether N-acetylcysteine could preserve striated muscle contractility and modify neutrophil infiltration and activation after simulated compartment syndrome release.
Fifty-seven rats were randomized to control, simulated compartment syndrome, and simulated compartment syndro...
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PMID: 20309660
PDF is available here.
PDF is available here.
Abstract
We investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2...
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PMID: 20439934
PDF is available here.
PDF is available here.
Abstract
The high-osmolar contrast medium was associated with significantly elevated levels of apoptosis compared with the mannitol control (percentage apoptosis, 27.98 +/- 1.08 vs 6.19 +/- 0.771; p < 0.001). This effect was less pronounced after incubation with the low-osmolar agent but was still significan...
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PMID: 20566779
PDF is available here.
PDF is available here.
Abstract
IV and oral NAC are generally mild adverse drug reactions....
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PMID: 20524832
PDF is available here.
PDF is available here.
Minerva ginecologica (62)3 2010
Abstract
During and after menopause the skin shows up clearly how the lack of estrogen affects tissues, and menopause can in fact be considered a "multisystemic" disorder of connective tissue. The low menopausal estrogen levels combined with age-related skin changes, accelerating skin aging. This affects bot...
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PMID: 20595944
PDF is available here.
PDF is available here.
Mutation Research (688)1-2 2010
Abstract
We demonstrate that the effects of curcumin on cell viability and telomerase activity can be blunted by reactive oxygen species (ROS) inhibitor N-acetyl cysteine (NAC). The ROS induced by curcumin in A549 cells was detected by flow cytometry. Using Western blot and RT-PCR, human telomerase reverse t...
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PMID: 20363232
PDF is available here.
PDF is available here.
Molecular Therapy (18)6 2010
Abstract
We evaluated the therapeutic and prophylactic use of bortezomib in these conditions using murine models. Bortezomib prophylaxis significantly reduced serum levels of many cytokines and chemokines induced by BSAg. However, at 3 hours, serum level of TNF-a, an important cytokine implicated in TSS, was...
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PMID: 20372109
PDF is available here.
PDF is available here.
Abstract
Despite extensive educational and preventive efforts, fatality from poisoning is a growing public health concern. While strategies to reduce fatal unintentional poisoning in children have been largely successful, growing numbers of deaths from suicidality and substance abuse present unique challenge...
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PMID: 21125061
PDF is available here.
PDF is available here.
Biomaterials (31)18 2010
Abstract
These results suggest that HEPES coating of titanium surfaces maintained their superhydrophilicity for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity similar to freshly prepared surfaces. This coating technology may be useful for preventing biological a...
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PMID: 20350765
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that gliotoxin and patulin increase the allergic immune response in mice by modulating the Th1/Th2 balance via direct effects on IL-12 secretion in DCs and by inducing oxidative stress....
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PMID: 20194814
PDF is available here.
PDF is available here.
Abstract
The incidence of CIN was relatively low in patients treated with saline and NAC. The development of CIN predisposed to poor kidney survival in the long term.
Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved....
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PMID: 20097462
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
MG132 as a proteasome inhibitor can induce apoptotic cell death through formation of reactive oxygen species (ROS). In this study, the effects of N-acetyl cysteine (NAC; an antioxidant) on MG132-induced HeLa cell death in relation to ROS and glutathione (GSH) were investigated. MG132 induced cell gr...
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PMID: 20651358
PDF is available here.
PDF is available here.
Abstract
Clinicians successfully utilize high uptake of radiolabeled glucose via PET scanning to localize metastases in melanoma patients. To take advantage of this altered metabolome, 3-bromopyruvate (BrPA) was used to overcome the notorious resistance of melanoma to cell death. Using four melanoma cell lin...
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PMID: 20430010
PDF is available here.
PDF is available here.
Abstract
Glutathione (GSH) depletion is often detected in chronic pathological conditions like hepatitis C infection, alcohol consumption or xenobiotic assault with simultaneous reactive oxygen species (ROS) generation and hepatic iron overload. However, relation between GSH depletion and regulators of iron...
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PMID: 20211720
PDF is available here.
PDF is available here.
Abstract
The anticancer effects of 6-dehydrogingerdione (6-DG), a compound isolated from the rhizomes of Zingiber officinale , and its mechanisms of sensitization to TRAIL-induced apoptosis were studied using human hepatoblastoma Hep G2 cells. This study demonstrates for the first time that 6-DG-induced apop...
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PMID: 20356045
PDF is available here.
PDF is available here.
Psychopharmacology (209)4 2010
Abstract
These findings provide evidence that the interactions between mGluR5 and NMDA receptors are involved in the regulation of PPI and suggest that activation of glutamate receptors, other than group II receptors, by increased endogenous glutamate transmission, may ameliorate the behavioral abnormalities...
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PMID: 20217053
PDF is available here.
PDF is available here.
Abstract
We observed an inhibitory effect of PEITC and its metabolite, NAC-PEITC, on cancer cell proliferation, cell-cycle progression, and apoptosis in LNCaP human prostate cancer cells. PEITC and NAC-PEITC suppressed LNCaP cell proliferation in a dose-dependent manner, and exposure to 5 microM PEITC or NAC...
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PMID: 20402549
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of two GSH (glutathione) precursors, NAC (N-acetylcysteine) and cystine as the physiological carrier of cysteine in GSH with added selenomethionine (F1) in preventing spermine (uraemic toxin)-induced apoptosis in cultured human aortic VSMC (vascular smooth muscle cells). V...
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PMID: 20121705
PDF is available here.
PDF is available here.
Abstract
We explored the hypothesis that the apical transport of Ac-DCVC and/or DCVC may be mediated by the multidrug resistance associated protein 2 (Mrp2, ABCC2), which is known to mediate proximal tubular apical ATP-dependent transport of glutathione and numerous xenobiotics and endogenous substances conj...
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PMID: 20060011
PDF is available here.
PDF is available here.
Abstract
We found that garcinol potentiated TRAIL-induced apoptosis of cancer cells as indicated by intracellular esterase activity, DNA strand breaks, accumulation of the membrane phospholipid phosphatidylserine, mitochondrial activity, and activation of caspase-8, -9, and -3. We found that garcinol, indepe...
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PMID: 20371723
PDF is available here.
PDF is available here.
Abstract
By 4 hours after RF ablation alone, a 0.48-mm +/- 0.13 (standard deviation) peripheral band with 57.0% +/- 7.3 cleaved caspase-3 positive cells was noted at the ablation margin, whereas a 0.73-mm +/- 0.18 band with 77.7% +/- 6.3 positivity was seen for combination therapy (P < .03 for both compariso...
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PMID: 20160000
PDF is available here.
PDF is available here.
Abstract
Investigative Radiology (45)4 2010
Abstract
Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of reactive oxygen species (ROS) within the kidney following the administration of iodinated contrast media, which may play a role in the development of contrast media-induced nephropathy. Clinical studies indee...
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PMID: 20195159
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of N-acetyl cysteine (NAC; a well-known antioxidant), L-buthionine sulfoximine (BSO; an inhibitor of GSH synthesis) or diethyldithiocarbamate (DDC; an inhibitor of Cu/Zn-SOD) on MG132-treated Calu-6 or A549 lung cancer cells in relation to cell growth, ROS and GSH levels....
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PMID: 20198316
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)4 2010
Abstract
The antiproliferative and apoptotic effects of cucurbitacin E, a natural product isolated from Cucurbitaceae, were determined in human leukemia HL-60 cells. Cucurbitacin E at low concentrations (3-50 nmol/l) inhibited the growth of HL-60 cells, which was associated with G2/M cell-cycle arrest, decre...
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PMID: 20110807
PDF is available here.
PDF is available here.
Vincristine-induced peripheral neuropathy in a neonate with congenital acute lymphoblastic leukemia.
Abstract
We report the case of a 46-day-old boy with a fulminant vincristine-induced peripheral neuropathy after treatment for congenital acute lymphoblastic leukemia. Flaccid paralysis developed at the end of the first phase of induction, requiring intubation and ventilation for 51 days. Treatment was initi...
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PMID: 20216233
PDF is available here.
PDF is available here.
Abstract
The urine concentration of N-acetyl-S-(N-methylcarbamoyl)-cysteine (AMCC), one of the metabolites of DMF, was positively correlated with activities of liver function enzymes. About 60% subjects with urine AMCC concentration above 40 mg/g creatinine showed raised liver enzymes activities. In terms of...
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PMID: 20151308
PDF is available here.
PDF is available here.
Neurochemical Research (35)4 2010
Abstract
We have recently demonstrated that mitochondrial respiratory chain and creatine kinase (CK) are altered in the brain of rats after cecal ligation and perforation (CLP) and that a combination of N-acetylcysteine/deferoxamine (NAC/DFX), taurine and RC-3095 were shown to be an effective treatment of se...
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PMID: 20238483
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (337)1-2 2010
Abstract
We have shown that moderately high salt, 4% NaCl (MHS) alone in diet does not cause hypertension, and when given along with 4% FR it does not have an additive effect. N-acetylcysteine (NAC) or L-arginine (ARG), treatment alone does not prevent hypertension in this model. The objectives of this study...
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PMID: 19806432
PDF is available here.
PDF is available here.