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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cystine (0):
Recent article
Cystine
New England Journal of Medicine (365)13 2011
Abstract
We conducted a single-center, randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive cytisine or matching placebo for 25 days; participants in both groups received a minimal amount of counseling during the study. The primary outcome measure was sustained,...
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PMID: 21991893
PDF is available here.
PDF is available here.
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Abstract
Crystallization of L-cystine is a critical step in the pathogenesis of cystine kidney stones. Treatments for this disease are somewhat effective but often lead to adverse side effects. Real-time in situ atomic force microscopy (AFM) reveals that L-cystine dimethylester (L-CDME) and L-cystine methyle...
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PMID: 20947757
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)10 2010
Abstract
We evaluated the long-term beneficial effect of NAC against oxidative stress-induced brain injury. Newborn piglets were randomly assigned to a sham-operated group (without H-R, n = 6), and two H-R experimental groups (n = 8 each), with 2 h normocapnic alveolar hypoxia and 1 h of 100% oxy...
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PMID: 20649480
PDF is available here.
PDF is available here.
Abstract
The collision-induced dissociations are reported for Cu(II) complexes containing 1,4,7-triazacyclononane (tacn) as the auxiliary ligand and a peptide containing one cystine residue. For six of the complexes examined, cleavage of the S-S bond in the peptide was the dominant fragmentation pathway. The...
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PMID: 20539872
PDF is available here.
PDF is available here.
Abstract
In epilepsy, traumatic brain injury, and ischemic stroke, toxic levels of zinc released from neurons contribute to the brain damage associated with these disorders. Zinc causes oxidative stress by increasing the generation of reactive oxygen species and by inhibiting glutathione reductase (GR). This...
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PMID: 20570723
PDF is available here.
PDF is available here.
Abstract
Variations in plasma sulfur amino acid (SAA) pools are associated with disease risks, but little information is available about the factors affecting plasma SAA pools. Drug metabolism by glutathione (GSH) and sulfate conjugation can, in principle, represent a quantitatively important burden on SAA s...
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PMID: 20207721
PDF is available here.
PDF is available here.
Abstract
A variety of N-alkyl-beta-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt(3)](2)MoS(4)) in a sequential, one-pot, multistep reaction. The tolerance of multifariou...
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PMID: 20392054
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of two GSH (glutathione) precursors, NAC (N-acetylcysteine) and cystine as the physiological carrier of cysteine in GSH with added selenomethionine (F1) in preventing spermine (uraemic toxin)-induced apoptosis in cultured human aortic VSMC (vascular smooth muscle cells). V...
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PMID: 20121705
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
We should think about clays not just sink of molecules, but as primitive vessels of production of biomolecules. At pH 8.00, an increasing expansion was observed in the following order for both minerals: thiourea > thiocyanate > cysteine. At pH 3.00, the same order was not observed and thiourea had a...
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PMID: 19579002
PDF is available here.
PDF is available here.
Biology of Reproduction (82)4 2010
Abstract
We showed that when supplemented alone, neither cystine nor cysteamine promoted GSH synthesis of mouse DOs, but they did when used together. Although goat CCs required either cysteamine or cystine to promote GSH synthesis, mouse CCs required both. In the presence of cystine, goat CCs produced cystei...
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PMID: 20075397
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of supplementation with cystine, a dipeptide of cysteine, and theanine (CT), a precursor of glutamate, on immune variables during high-intensity resistance exercise. Cysteine and glutamate are involved in the formation of glutathione, which modulates the activity of natur...
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PMID: 20145562
PDF is available here.
PDF is available here.
Nephron Clinical Practice (116)3 2010
Abstract
Renal stone disease covers kidney and lower urinary tract stones caused by a variety of conditions, including metabolic and inherited disorders, and anatomical defects with or without chronic urinary infection. Most cases are idiopathic, in which there is undoubtedly a genetic predis...
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PMID: 20606476
PDF is available here.
PDF is available here.
Nephron Clinical Practice (116)3 2010
Abstract
Renal stone disease covers kidney and lower urinary tract stones caused by a variety of conditions, including metabolic and inherited disorders, and anatomical defects with or without chronic urinary infection. Most cases are idiopathic, in which there is undoubtedly a genetic predis...
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PMID: 20606476
PDF is available here.
PDF is available here.
Abstract
Severity of psychomotor impairment and depression, and TSH level during hypothyroidism appeared to correlate with CBF to brain regions associated with motor activity, mood and vision, respectively; and previously shown to manifest significantly altered rCBF during hypothyroidism....
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PMID: 20150864
PDF is available here.
PDF is available here.
Abstract
These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer....
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PMID: 20057121
PDF is available here.
PDF is available here.
Abstract
We were able to obtain a maximal refolding efficiency of 57%, defined as a percentage of correctly folded, bioactive dimer protein from inclusion-body slurries produced from Escherichia coli. The final method involved dissolution of IBs for 30 min at 2 mg/ml protein, 6 M urea, 2 mM DTT and 50 mM Tri...
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PMID: 19435462
PDF is available here.
PDF is available here.
Abstract
The deposits were absent in the surface epithelium and basal cells of the central cornea before and after treatment. We found crystals mainly in the anterior and medium stroma; they had various shapes; were intracellular, rectangular, or fusiform; and showed hyperreflectivity. The posterior stroma s...
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PMID: 19654516
PDF is available here.
PDF is available here.
Abstract
Biochemistry (Washington) (48)26 2009
Abstract
We show that the Cys(2) mutant enzyme or the N-terminal reaction center alone can reduce Se-containing substrates selenocystine and selenite with only slightly less activity than the wild-type enzyme, in stark contrast to when Trx is used as the substrate when the enzyme suffers a 175-550-fold reduc...
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PMID: 19366212
PDF is available here.
PDF is available here.
Abstract
The xc- cystine/glutamate antiporter is potentially useful as a target for therapy of SCLC based on glutathione depletion. Sulfasalazine may be readily used for this approach, especially in combination chemotherapy....
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PMID: 19104813
PDF is available here.
PDF is available here.
Abstract
The experimental sulfur K-edge X-ray absorption near-edge structure (XANES) spectra of the amino acids cysteine, homocysteine, penicillamine, methionine, including the oxidation products methionine sulfoxide and the disulfide cystine, have been analyzed by transition potential DFT calculations. The...
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PMID: 19381417
PDF is available here.
PDF is available here.
BJU International (103)9 2009
Abstract
Stone rates and rates of stone-related procedures declined in all five cohorts, as did 24-h urinary stone risk indices. We found no diminution of treatment effects for any of these three over time. CONCLUSION: Those patients who remained under active care had significant reductions in stone recurren...
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PMID: 19021617
PDF is available here.
PDF is available here.
Ophthalmology (116)5 2009
Abstract
In patients with nephropathic cystinosis, IVCM could precisely quantify the density of crystals within the central cornea. Anterior segment OCT and IVCM should be used in further studies evaluating crystal deposition in patients with nephropathic cystinosis. FINANCIAL DISCLOSURE(S): The authors have...
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PMID: 19410944
PDF is available here.
PDF is available here.
Abstract
Athletes become increasingly susceptible to infection with intense training that results in immune suppression. The immune state was investigated after administering cystine/theanine (CT), which has been reported to have an immune reinforcement effect, to athletes before training involving a prolong...
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PMID: 19352043
PDF is available here.
PDF is available here.
Abstract
Our results suggest a possible role of ROS as a mediator of the signaling pathway of selenocystine-induced, DNA damage-mediated apoptosis in susceptible cancer cells....
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PMID: 18511231
PDF is available here.
PDF is available here.
BMC Physiology (9)1 2009
Abstract
Glutathione depletion aggravated ileal inflammation after infection as indicated by increased levels of mucosal myeloperoxidase and interleukin-1beta. Remarkably, intestinal permeability and Salmonella translocation were not increased. Cystine supplementation maintained glutathione in the intestinal...
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PMID: 19374741
PDF is available here.
PDF is available here.
Redox Report (14)3 2009
Abstract
We investigated the provision of cysteine for glutathione synthesis to the human erythrocyte (red blood cell; RBC). Almost all plasma cysteine exists as cystine, its oxidized form. In vitro, extracellular cystine at 1.0 mM sustained glutathione synthesis in glutathione-depleted RBCs, at a rate of 0....
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PMID: 19490753
PDF is available here.
PDF is available here.
Abstract
Different mercaptans were used to prepare reduced hair and permed hair samples. The reduced hair showed much higher protease degradation than the permed hair; also, the protease degradability of permed hair increased with repetitive treatments. The degradability of reduced hair was c...
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PMID: 19822110
PDF is available here.
PDF is available here.
Abstract
We observed distinct effects of endotoxin on the GSH and Cys redox systems during the acute phase; plasma E(h) Cys/CySS was selectively oxidized early in response to endotoxin, while E(h) GSH/GSSG remained unchanged. Unexpectedly, subsequent oxidation of E(h) GSH/GSSG and E(h) Cys/CySS occurred as a...
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PMID: 18664641
PDF is available here.
PDF is available here.
Abstract
The way in which veterinary scientists think about and approach the study of genetic disease has not changed, but the tools available to veterinary scientists have and will continue to change, allowing us to study increasingly complex problems and to make more rapid advances in the context of simple...
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PMID: 19038654
PDF is available here.
PDF is available here.
Abstract
Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.
Abstract
Abstract
We present the first case of cystine crystal deposition within an odontogenic cyst, confirmed by the correlation of the clinical, radiographic, and histologic findings on this patient....
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PMID: 18926732
PDF is available here.
PDF is available here.
Abstract
A 31-year-old woman who presented with photophobia was found to have bilateral corneal and conjunctival crystal deposition. Ocular cystinosis was diagnosed upon observation of typical crystals and lack of systemic involvement. In vivo confocal microscopy confirmed crystal deposition of the corneas a...
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PMID: 19128385
PDF is available here.
PDF is available here.
Abstract
Extracellular domains of some cellular receptors expressed in the organisms at different levels of development belong to three-fingered protein (TFP) fold. The Homo sapiens genome encodes at least 45 genes containing from one to three TFP domains (TFPDs), namely diverse paralogues of the Ly6 gene, C...
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PMID: 18821057
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)3 2008
Abstract
We described a series of compounds derived from the conjugation of epicatechin (EC) with cysteine and cysteine derivatives that protected nerve cells in culture from oxidative glutamate toxicity by maintaining GSH levels. In this study, we characterize an additional EC conjugate, cysteamine-EC, that...
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PMID: 18702664
PDF is available here.
PDF is available here.
Clinica Chimica Acta (396)1-2 2008
Abstract
The analysis by LC-FTMS is suitable for high-throughput analysis of plasma cysteine, cystine and cysteine/cystine steady-state redox potential as clinical measures of oxidative stress....
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PMID: 18634771
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)1 2008
Abstract
Repeated cocaine exposure enhances glutamatergic output from the medial prefrontal cortex to subcortical brain regions. Loss of inhibitory control of cortical pyramidal neurons may partly account for this augmented cortical glutamate output. Recent research indicated that repeated cocaine exposure r...
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PMID: 18673447
PDF is available here.
PDF is available here.
Abstract
We showed that SeC triggered time- and dose-dependent apoptosis in A375 human melanoma cells by activating the mitochondria-mediated and death receptor-mediated apoptosis pathways. Pretreatment of cells with a general caspase inhibitor z-VAD-fmk significantly prevented SeC-induced apoptosis. A375 ce...
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PMID: 18661100
PDF is available here.
PDF is available here.
Abstract
We propose that underlying waves of glutamate clearance by astrocytes are activation of cystine import and taurine efflux that result, respectively, from a shared transporter and an increase in solute concentration that triggers osmoregulatory responses....
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PMID: 18703339
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (112)33 2008
Abstract
A Gemini surfactant, sodium N, N'-di(4-n-butyloxy cinnamoly)-L-cystine, containing a cinnamoyl moiety in the alkyl chains and disulfide bond in the spacer was designed and synthesized. The incorporation of a cinnamoyl moiety into the alkyl chains of Gemini surfactant makes it easy to probe the confo...
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PMID: 18661936
PDF is available here.
PDF is available here.
Neuroscience (155)2 2008
Abstract
We undertook two approaches to determine the significance of plasticity involving system xc-. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc-. Rats were trained to self-administer cocaine (1 mg/kg/200 microl, i.v.) unde...
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PMID: 18601982
PDF is available here.
PDF is available here.
Abstract
We postulate that it is involved in growth and drug resistance of pancreatic cancer. To examine this, we characterised expression of the x(c)(-) transporter in pancreatic cancer cell lines, MIA PaCa-2, PANC-1 and BxPC-3, as subjected to cystine-depletion and oxidative stress. The results indicate th...
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PMID: 18648370
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (112)30 2008
Abstract
Peptide cysteine thiyl radicals were generated through UV-photolysis of disulfide precursors, in order to follow intramolecular reactions of those radicals with neighboring amino acids. When reactions were carried out in D(2)O, there was a significant incorporation of deuterium specifically into the...
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PMID: 18611046
PDF is available here.
PDF is available here.
Abstract
Some selected drugs including captopril, fudosteine and racecadotril have been analyzed by infrared (IR) laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (PIMS). The molecular ions of captopril and racecadotril are exclusively observed without any fragm...
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PMID: 18636426
PDF is available here.
PDF is available here.
Abstract
Acetazolamide was effective in increasing the urinary pH in patients with uric acid and cystine stone formation who were already taking potassium citrate. Caution must be taken when prescribing acetazolamide, because it could be poorly tolerated and can induce calcium phosphate stone formation....
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PMID: 18533229
PDF is available here.
PDF is available here.
European Journal of Pharmacology (589)1-3 2008
Abstract
Glucose-fed rat is a model of insulin resistance that displays sensory polyneuropathy and hypertension. This study aimed at comparing the beneficial effects of N-acetyl-L-cysteine (NAC, antioxidant) and ramipril (angiotensin-1 converting enzyme inhibitor) on tactile and cold allodynia induced by chr...
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PMID: 18555989
PDF is available here.
PDF is available here.
Journal of Chromatography B (870)2 2008
Abstract
Active oxygen species from the photocatalytic reaction in aqueous solution react with luminol to emit strong chemiluminescence (CL), and this can be inhibited by the UV decomposed-products of selenocystine (SeCys) or selenomethionine (SeMet). Based on this phenomenon, a novel hyphenated technique, H...
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PMID: 18585988
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)26 2008
Abstract
Giardia lamblia is a protozoan parasite and the earliest branching clade of eukaryota. The Giardia life cycle alternates between an asexually replicating vegetative form and an infectious cyst form. Encystation and excystation are crucial processes for the survival and transmission of Giardia. Cyste...
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PMID: 18445589
PDF is available here.
PDF is available here.
Metabolic Brain Disease (23)2 2008
Abstract
Cystinosis is a systemic genetic disease caused by a lysosomal transport deficiency accumulating cystine in the lysosomes of all tissues. Although tissue damage might depend on cystine accumulation, the mechanisms of tissue damage are still obscures. Considering that thiol-containing enzymes are cri...
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PMID: 18418703
PDF is available here.
PDF is available here.
Journal of Neurotrauma (25)6 2008
Abstract
We now report on the performance of DDC in experimental TBI. Closed head injury was induced in mice by weight-drop. DDC was administered intravenously in vivo. Two hours later, animals were sacrificed, and brain tissue was subjected to fluorescent microcopy, for assessment of DDC uptake, in correlat...
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PMID: 18447626
PDF is available here.
PDF is available here.
The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases.
Abstract
The x(c) (-) cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate. Its main functions in the body are mediation of cellular cystine uptake for synthesis of glutathione essential for cellular protection from oxi...
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PMID: 18181196
PDF is available here.
PDF is available here.
Reproduction (135)5 2008
Abstract
We observed the interactive effects of cysteamine, cystine and cumulus cells on the glutathione (L-gamma-glutamyl-L-cysteinyl-glycine; GSH) level and developmental capacity of goat IVM oocytes. Cysteamine supplementation increased the GSH level and blastocyst rates of both cumulus-oocyte complexes (...
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PMID: 18411409
PDF is available here.
PDF is available here.
Abstract
These results suggest that disulfide S-monoxides have the potential to increase the generation of reactive oxygen species through the conversion of XD to XO in liver....
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PMID: 18451537
PDF is available here.
PDF is available here.
Abstract
Protease degradation of matrix (Ma) protein and microfibril (Mf) protein, which are the major components of human hair, were investigated. Ma or Mf protein was partially extracted from human hair and four types of keratins were prepared: Ma film, Mf film, Ma-rich fiber, and Mf-rich fiber. Of the two...
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PMID: 18451533
PDF is available here.
PDF is available here.
Abstract
We have isolated from a human kidney cDNA library a cystinosin isoform, which is generated by an alternative splicing of exon 12 that removes the GYDQL motif. Based on its last three amino acids, we have termed this protein cystinosin-LKG. Contrary to the lysosomal cystinosin isoform, expression exp...
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PMID: 18337546
PDF is available here.
PDF is available here.
Abstract
These results demonstrated the control of surface properties and aggregation behavior by the reversible transition between the Gemini surfactant and its monomer via reduction/oxidation reactions....
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PMID: 18313685
PDF is available here.
PDF is available here.
Journal of Biochemistry (143)5 2008
Abstract
We prepared mutants C99S, C194S and C99S/C194S (WSS), in which Cys69-Cys99, Cys163-Cys194 and both of these disulphide bonds, respectively, were disrupted by replacing Cys residues with Ser residues. All mutants were expressed stably in Escherichia coli. The C99S mutant was 68% as active as the wild...
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PMID: 18216068
PDF is available here.
PDF is available here.
Abstract
We discuss the possible role of sulfenyl thiocyanates in vivo....
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PMID: 18351774
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (112)14 2008
Abstract
Reactions of hydroxyl radicals (*OH) with selenocystine (SeCys) and two of its analogues, diselenodipropionic acid (SeP) and selenocystamine (SeA), have been studied in aqueous solutions at pHs of 1, 7, and 10 using the pulse radiolysis technique coupled with absorption detection. All of these disel...
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PMID: 18341323
PDF is available here.
PDF is available here.