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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cysteine (5):
Recent article
Cysteine
Abstract
The objective of this study is to develop and evaluate gastroretentive particulate delivery systems using Riboflavin-5'-monophosphate sodium salt dihydrate (RF5'PNa) as model drug. Poly(acrylic acid)-cysteine and chitosan-4-thiobuthylamidine were evaluated and compared as anionic and cationic polyme...
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PMID: 20021230
PDF is available here.
PDF is available here.
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Abstract
We have recently shown that prohibitin (PHB) , a protein present in the plasma membranes of various cell types, interacts with Eps 15 homology domain protein 2 (EHD2), a lipid raft protein. However, the mechanism involved in membrane translocation of PHB is not known.We report that PHB undergoes pal...
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PMID: 20555396
PDF is available here.
PDF is available here.
Abstract
Molecular Microbiology (76)5 2010
Abstract
Many bacteria transport mannitol via the mtlAF-encoded phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS). In most firmicutes the transcriptional activator MtlR controls expression of the mtl operon. MtlR possesses an N-terminal DNA binding domain, two PTS regulation domains (PRD...
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PMID: 20444094
PDF is available here.
PDF is available here.
Abstract
Variations in plasma sulfur amino acid (SAA) pools are associated with disease risks, but little information is available about the factors affecting plasma SAA pools. Drug metabolism by glutathione (GSH) and sulfate conjugation can, in principle, represent a quantitatively important burden on SAA s...
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PMID: 20207721
PDF is available here.
PDF is available here.
Abstract
We suspected that the chylomicronemia might be caused by mutations in GPIHBP1. Indeed, all three affected siblings were compound heterozygotes for missense mutations involving highly conserved cysteines in the Ly6 domain of GPIHBP1 (C65S and C68G). The mutant GPIHBP1 proteins reached the surface of...
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PMID: 20026666
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)6 2010
Abstract
Eukaryotic secretory pathway cargo fold to their native structures within the confines of the endoplasmic reticulum (ER). To ensure a high degree of folding fidelity, a multitude of covalent and noncovalent constraints are imparted upon nascent proteins. These constraints come in the form of topologi...
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PMID: 19891995
PDF is available here.
PDF is available here.
Abstract
We now report that the maximum metal-to-MT stoichiometries for the individual domain fragments and the entire 2-domain protein are Bi(3)-S(9)-betahMT, Bi(4)-S(11)-alphahMT, and Bi(7)-S(20)-betaalphahMT, respectively. Electrospray mass spectrometry data also unambiguously show the existence of partia...
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PMID: 20398631
PDF is available here.
PDF is available here.
Abstract
This study was aimed at improving the mucoadhesive properties of carboxymethyl dextran by the covalent attachment of cysteine. Mediated by a carbodiimide, l-cysteine was covalently attached to the polymer. The resulting CMD-cysteine conjugate (CMD-(273) conjugate) displayed 273+/-20 micromol thiol g...
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PMID: 20117156
PDF is available here.
PDF is available here.
Abstract
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis poses a serious threat to human health and has led to world-wide efforts focusing on the development of novel vaccines and antibiotics against this pathogen. Sulphur metabolism in this organism has been linked to essential pr...
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PMID: 20494107
PDF is available here.
PDF is available here.
Abstract
We have developed a simple, rapid, selective, and ultra-sensitive assay to detect cysteine by means of gold nanorods assembly. This methodology is based on the end-to-end assembly of gold nanorods and it is very sensitive due to the useful formation of the gold nanorods chain in the presence of cyst...
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PMID: 20197234
PDF is available here.
PDF is available here.
Abstract
We have identified a single cysteinyl residue in the TAP complex that modulates peptide binding and translocation, thereby restricting the epitope repertoire. Cysteine 213 in human TAP2 was found to be part of a newly uncovered substrate-binding site crucial for peptide recognition. This residue con...
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PMID: 20439763
PDF is available here.
PDF is available here.
Abstract
It is observed in this study that the chirality of cysteine stabilizers has a distinct effect on both the growth kinetics and the optical properties of CdTe nanocrystals synthesized in aqueous solution. The effect was studied by circular dichroism spectroscopy, temporal UV-vis spectroscopy, photolum...
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PMID: 20384329
PDF is available here.
PDF is available here.
Abstract
A method for identifying cysteine (Cys) residues with sulfhydryl (SH) groups exhibiting slow hydrogen exchange rates has been developed for proteins in aqueous media. The method utilizes the isotope shifts of the C(beta) chemical shifts induced by the deuteration of the SH groups. The 18.2 kDa E. co...
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PMID: 20384326
PDF is available here.
PDF is available here.
Microbiology (156)Pt 5 2010
Abstract
Corynebacterium glutamicum cgR_2930 (cyeR) encodes a transcriptional regulator of the ArsR family. Its gene product, CyeR, was shown here to repress the expression of cyeR and the cgR_2931 (cye1)-cgR_2932 operon, which is located upstream of cyeR in the opposite orientation. The cye1 gene encodes an...
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PMID: 20110293
PDF is available here.
PDF is available here.
Microbiology (156)Pt 5 2010
Abstract
We employed random and site-directed mutagenesis of FinR. Among 18 single amino acid mutants, three mutants (T39A, R194A and E225A) abolished fpr induction without any alteration of their DNA-binding ability, whereas other mutants also abrogated their DNA-binding abilities. Interestingly, two mutant...
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PMID: 20056701
PDF is available here.
PDF is available here.
Abstract
We have synthesized a biocompatible polyaspartic acid-based polymer (molecular weight approximately 15,000-25,000) with cysteine on its backbone for use as a capping ligand for functionalized Au, Ag, and CdSe@ZnS nanoparticles. Nearly monodisperse, hydrophobic Au and Ag nanoparticles and CdSe@ZnS qu...
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PMID: 20112990
PDF is available here.
PDF is available here.
Abstract
We previously described a coding mutation (L60F) in the mitochondrial superoxide dismutase (SOD2) gene of the human T cell leukemia-derived cell line Jurkat. In cell extracts the L60F mutant enzyme showed unusual inhibition by thiol reagents not seen in wild-type enzyme. Here we compare the properti...
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PMID: 20144705
PDF is available here.
PDF is available here.
Current Eye Research (35)5 2010
Abstract
The inhibitory action of L-cysteine in isolated porcine irides is dependent on the endogenous production of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase. Furthermore, prostanoids and K(ATP) channels are involved in the inhibitory action of L-cysteine in this tissue....
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PMID: 20450253
PDF is available here.
PDF is available here.
Abstract
The effect of binding PTH covalently to a synthetic, RGD-modified PEG hydrogel marginally significantly improved bone formation at 2 weeks of healing compared to the use of PEG alone. Bone regeneration within the defects increased in all groups at week 4 of healing without statistically significant...
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PMID: 20429653
PDF is available here.
PDF is available here.
Abstract
We infer that S0 is next to S3 and S4, but not to S1 and S2. Furthermore, of the two beta1 TM helices, TM2 is next to S0, and TM1 is next to TM2. Coexpression of alpha with two substituted Cys's, one in S0 and one in S2, and beta1 also with two substituted Cys's, one in TM1 and one in TM2, resulted...
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PMID: 20385746
PDF is available here.
PDF is available here.
Abstract
We have examined the potency, voltage dependence, and kinetics of spermine block in dimeric Kir2.1 constructs containing one nonreactive subunit and one cysteine-substituted subunit before and after modification by methanethiosulfonate (MTS) reagents. At position 169C (between the D172 "rectificatio...
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PMID: 20421374
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)5 2010
Abstract
We report the applications of Mn(2+)-doped ZnS@cysteine nanoparticles (NPs) as matrices for analysis of coccidiostats (lasalocid, monensin, salinomycin and narasin) and peptide mixtures (Met-enk, Leu-enk, HW6 and gramicidin) in surface-assisted laser desorption/ionization time-of-flight mass spectro...
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PMID: 20419264
PDF is available here.
PDF is available here.
Abstract
Compounds containing cysteine residues, such as glutathione, can affect the redox potential of must and wine by reduction of o-quinones and hydrogen peroxide. The oenological yeast cell wall fractions contain cysteine residues in their protein structure, and they could affect both oxidative and odor...
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PMID: 20359223
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)14 2010
Abstract
These results indicate that cyanylated cysteine could be a widely useful probe of structure-forming events in proteins with large in vitro structural distributions....
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PMID: 20297787
PDF is available here.
PDF is available here.