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Amino Acids, Sulfur (10):
Recent article
Amino Acids, Sulfur
Journal of Bacteriology (192)13 2010
Abstract
The genome of Streptococcus mutans encodes 4 LysR-type transcriptional regulators (LTTRs), three of which, MetR, CysR (cysteine synthesis regulator), and HomR (homocysteine synthesis regulator), are phylogenetically related. MetR was previously shown to control methionine metabolic gene expression....
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PMID: 20418399
PDF is available here.
PDF is available here.
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Journal of Proteomics (73)8 2010
Abstract
A deficiency in major seed storage proteins is associated with a nearly two-fold increase in sulfur amino acid content in genetically related lines of common bean (Phaseolus vulgaris). Their mature seed proteome was compared by an approach combining label-free quantification by spect...
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PMID: 20353836
PDF is available here.
PDF is available here.
Abstract
Sulfation and glutathione (GSH) conjugation are important pathways for elimination of acetaminophen (APAP). Previous studies in rodents show that limitation of dietary sulfur amino acids (SAAs) reduces biosynthesis of 3'-phosphoadenosine-5'-phosphosulfate, the precursor for sulfation, and GSH, the p...
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PMID: 20207720
PDF is available here.
PDF is available here.
Abstract
Variations in plasma sulfur amino acid (SAA) pools are associated with disease risks, but little information is available about the factors affecting plasma SAA pools. Drug metabolism by glutathione (GSH) and sulfate conjugation can, in principle, represent a quantitatively important burden on SAA s...
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PMID: 20207721
PDF is available here.
PDF is available here.
Proteomics (9)24 2009
Abstract
Furfural, one of the main inhibitory compounds in lignocellulosic hydrolytes, inhibits the growth and ethanol production rate of yeast. To get a global view of the dynamic expression pattern of proteins in Saccharomyces cerevisiae during the fermentation with the introduction of 8 g/...
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PMID: 19834894
PDF is available here.
PDF is available here.
Abstract
We recently showed that SAA deficiency significantly suppresses intestinal mucosal growth and reduces intestinal epithelial cell proliferation, and increases intestinal oxidant stress in piglets. These recent findings indicate that intestinal metabolism of dietary methionine and cysteine is nutritio...
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PMID: 19835653
PDF is available here.
PDF is available here.
Abstract
We therefore wanted to measure and compare the intake of selenium and sulphur amino acids in smear-positive TB patients and appropriately matched adults. We found a low intake of selenium but no significant difference in intake of selenium and sulphur amino acids between the groups in this study....
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PMID: 19793440
PDF is available here.
PDF is available here.
Abstract
Metschnikowia pulcherrima is a highly effective biocontrol yeast due to its pigment pulcherrimin that accumulates in the cells and in the growth medium. Three different strains of M. pulcherrima were isolated from local grapes. The yeast isolates were characterized on the basis of their biochemical,...
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PMID: 19678547
PDF is available here.
PDF is available here.
Journal of Nutrition (139)1 2009
Abstract
We examined the early changes in sulfur-amino acid metabolism and their implication in nonalcoholic fatty liver disease (NAFLD). Male rats were provided with a standard liquid diet or a high-fat liquid diet (HF) for 3 wk. An additional group of rats received the HF diet supplemented with betaine (1%...
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PMID: 19056644
PDF is available here.
PDF is available here.
Abstract
We established the first map of the cytosolic proteome of S. thermophilus LMG18311 grown in milk. It comprises 203 identified proteins corresponding to 32% of theoretical proteome. In addition, using proteomic and transcriptomic approaches, we analyzed the physiology of LMG18311 during its late stag...
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PMID: 18814336
PDF is available here.
PDF is available here.
Abstract
The contents of sulfur amino acids in seeds of common bean ( Phaseolus vulgaris L.) are suboptimal for nutrition. They accumulate large amounts of a gamma-glutamyl dipeptide of S-methyl-cysteine, a nonprotein amino acid that cannot substitute for methionine or cysteine in the diet. Protein accumulat...
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PMID: 18588315
PDF is available here.
PDF is available here.
Abstract
This is the first study to report the TSAA requirement of postsurgical, PN-fed human neonates. The estimated methionine requirement expressed as a proportion of the methionine content of current commercial pediatric PN solutions was 90% (range: 48-90%) of that found in the lowest methionine-containi...
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PMID: 18614731
PDF is available here.
PDF is available here.
Abstract
We investigated the induction of oxidative damage in association with changes in hepatic concentrations of sulfur-containing substances in mice challenged with binge-like ethanol administration. Also the protective effect of dietary betaine against ethanol-induced liver injury was determined. Serum...
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PMID: 18267108
PDF is available here.
PDF is available here.
Abstract
Alterations in hepatic transsulfuration reactions were determined in rats treated with a glutathione-depleting agent. A dose of l-buthionine-(S,R)-sulfoximine decreased hepatic methionine, cysteine, S-adenosylmethionine, and glutathione levels rapidly. Methionine adenosyltransferase and gamma-glutam...
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PMID: 18275846
PDF is available here.
PDF is available here.
Abstract
We provide here an overview of the roles of amino acids as regulators of protein metabolism, by focusing particularly on sulfur amino acids. The potential importance of methionine as a "nutrient signal" is discussed in the light of recent findings. Emphasis is also placed on mechanisms controlling o...
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PMID: 17707628
PDF is available here.
PDF is available here.
Abstract
The main objective of this research was to test the hypothesis that bioavailable protein and, more specifically, the sulfur-containing amino acids within the protein, can be degraded by proteolytic enzymes to produce odor-causing compounds--mainly volatile sulfur compounds (VSCs)--during biosolids s...
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PMID: 18330222
PDF is available here.
PDF is available here.
Abstract
Two N balance experiments were conducted to study the individual response of growing pigs to limiting amino acid (AA) intake. Series of fifteen diets with increasing concentration of sulphur amino acids (SAA, Expt 1) or methionine in the presence of excess cystine (Expt 2) were fed sequentially to n...
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PMID: 18184376
PDF is available here.
PDF is available here.
Abstract
Acta Biochimica Polonica (55)4 2008
Abstract
A new methodology for prenylation of thiol compounds has been developed. The approach is based on the use of prenyl sulfates as new reagents for S-prenylation of benzenethiol and cysteamine in aqueous systems. The C(10)-prenols geraniol and nerol that differ in the configuration (E or Z, correspondi...
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PMID: 19081845
PDF is available here.
PDF is available here.
Abstract
During the processing of feedstuffs and foods, methionine can be oxidized to methionine sulfoxide and methionine sulfone, and cysteine can be oxidized to cysteic acid. Methionine sulfone and cysteic acid are nutritionally unavailable, but methionine sulfoxide can be utilized, at least to some degree...
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PMID: 18727553
PDF is available here.
PDF is available here.
Poultry Science (86)11 2007
Abstract
Three bioassays were conducted to elucidate the effects of dietary cystine on the efficacy of L-Met and DL-Met fed to chicks. In assay 1, a purified diet markedly deficient in Met (0.12%) and cyst(e)ine (0.05%) was used to compare the relative effectiveness of L-Met and DL-Met in the presence of gra...
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PMID: 17954587
PDF is available here.
PDF is available here.
Journal of Child Neurology (22)10 2007
Abstract
Isolated sulfite oxidase deficiency is a rare genetic neurometabolic disease. The first symptoms of this disorder (similar to symptoms of ischemic events) may lead to misdiagnosis and to subsequent birth of affected children in these families. This study characterizes the magnetic resonance (MR) ima...
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PMID: 17940249
PDF is available here.
PDF is available here.
Journal of Hypertension (25)10 2007
Abstract
H2S inhibited the activity of ACE in HUVEC protein extracts in a dose-dependent manner, and only Zn but not Cd, Ca or Mg could counteract the inhibitory effect. Cell-surface ACE activity was inhibited by H2S on HUVEC monolayers and in ex-vivo umbilical veins. No influence of H2S on ACE mRNA expressi...
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PMID: 17885553
PDF is available here.
PDF is available here.
Abstract
Five feedstuffs were oxidized using performic acid, and these, along with their unoxidized counterparts, were acid hydrolyzed for multiple times (0-144 h) in degassed and vacuum-sealed glass tubes. The methionine sulfone, cysteic acid, methionine, and cysteine contents were determined for each hydro...
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PMID: 17715935
PDF is available here.
PDF is available here.
Abstract
We studied the effects of SCAA restriction in culture medium. Reduction of methionine by 90%, cysteine by 50%, and total elimination of cystine resulted in dramatically lower intracellular pools of these amino acids and their metabolite, taurine, but the intracellular pools of the non-SCAA were all...
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PMID: 17567720
PDF is available here.
PDF is available here.
Abstract
We report a 6-month-old Indian infant who is compound heterozygous for both alleles and who has hawkinsinuria but not tyrosinemia type III based on biochemical investigations. The HPD gene was directly sequenced in the proband and both parents. The mechanistic model of the enzymatic function was bui...
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PMID: 17560158
PDF is available here.
PDF is available here.
Orthopedics (30)8 2007
Abstract
Abstract
A deficiency of dietary protein or amino acids has long been known to impair immune function and increase the susceptibility of animals and humans to infectious disease. However, only in the past 15 years have the underlying cellular and molecular mechanisms begun to unfold. Protein malnutrition red...
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PMID: 17403271
PDF is available here.
PDF is available here.
Journal of Nutrition (137)8 2007
Abstract
Our objective was to determine the metabolic availability (MA) of sulfur amino acids in dietary proteins using the indicator amino acid oxidation (IAAO) technique. Five to seven men received graded levels (20, 40, 60, and 70%) of the mean total sulfur amino acid (TSAA) requirement of 13 mg x kg(-1)...
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PMID: 17634258
PDF is available here.
PDF is available here.
Abstract
Journal of Hepatology (46)5 2007
Abstract
The SAA(+) diet preserves GSSG/GSH ratios, and prevents PKCzeta and p47(phox) phosphorylations, Yes activation, Fas-tyrosine phosphorylation, mitochondrial permeabilization, and hepatic apoptosis after Fas stimulation. GSH monoethyl ester is also protective, suggesting possible clinical applications...
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PMID: 17275124
PDF is available here.
PDF is available here.
Journal of Nutrition (137)5 2007
Abstract
Our objectives were to determine whether the oxidation of an indicator amino acid would decline with the addition of amino acids that were limiting in the diets of TPN-fed piglets, and to use this technique to identify limiting amino acids in a new amino acid profile. Piglets (n = 26) were randomize...
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PMID: 17449589
PDF is available here.
PDF is available here.
Journal of Nutrition (137)5 2007
Abstract
Diet-induced (taurine deficiency) dilated cardiomyopathy is reported more in large than small dogs possibly because taurine biosynthesis rate (TBR) is lower in large than small dogs. The TBR in 6 mongrels (37.9 +/- 2.1 kg) and 6 beagles (12.8 +/- 0.4 kg) was determined from the fractional dilution r...
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PMID: 17449577
PDF is available here.
PDF is available here.
Abstract
In was demonstrated using the method of organotypic culture that arginine and its metabolites: cutrulline, ornitine and especially urea, in ultralow doses stimulated the myocardium proliferation in mature rats. Only nitric oxide (NO) possessed the antiproliferative effect. The cytrulline effect was...
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PMID: 17654861
PDF is available here.
PDF is available here.
Abstract
Volatile and nonvolatile compounds, which could contribute to flavor, were analyzed in salmon. One hundred twenty-three volatile compounds were identified in the headspace of two different samples of cooked salmon, including lipid-derived volatiles, Maillard-derived volatiles, sulfur volatiles, Stre...
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PMID: 17253713
PDF is available here.
PDF is available here.
Poultry Science (86)2 2007
Abstract
Four experiments (Exp.) were conducted with Cobb 500 chicks to evaluate variations in the estimated digestible sulfur amino acid (DSAA) requirement of broilers due to rearing environment, sex, or growth performance during the starter period (7 to 19 d), and live performance response and carcass yiel...
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PMID: 17234846
PDF is available here.
PDF is available here.
Abstract
Studies indicate that the gastrointestinal tract metabolizes 20% of dietary methionine and that its main metabolic fate is transmethylation to homocysteine and transsulfuration to cysteine. The gastrointestinal tract accounts for approximately 25% of whole-body transmethylation and transsulfuration...
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PMID: 17143057
PDF is available here.
PDF is available here.
Abstract
We present the complete genome sequence of the human clinical isolate, A. butzleri strain RM4018.
Arcobacter butzleri is a member of the Campylobacteraceae, but the majority of its proteome is most similar to those of Sulfuromonas denitrificans and Wolinella succinogenes, both member...
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PMID: 18159241
PDF is available here.
PDF is available here.
Abstract
We summarize the biology of these microaerophilic parasites, their clinical manifestation and epidemiology of disease, chemotherapeutics, the modes of action of representative drugs, and problems related to these drugs, including drug resistance. We further discuss our approach to exploit unique sul...
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PMID: 17223627
PDF is available here.
PDF is available here.
Abstract
The intraperitoneal injection of taurine--zinc sulfate composition (400 mg/kg body weight) led to a considerable increase in the plasma taurine levels, activated the hepatic uptake of free amino acids, and modulated the metabolism of sulfur-containing amino acids.
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PMID: 18074803
PDF is available here.
PDF is available here.
Abstract
We investigate the suitability of this method to predict the isotopic distribution in an environment which enriches for peptides carrying sulphur. More specifically, we focus on mass spectra obtained by a COmbined FRActional DIagonal Chromatography (COFRADIC) approach, developed by Gevaert et al. (N...
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PMID: 17891751
PDF is available here.
PDF is available here.
Clinica Chimica Acta (375)1-2 2007
Abstract
Prolinase activity against prolylglycine in normal and prolidase-deficient erythrocyte lysates was inhibited by L-methionine, NAc-L-methionine and D,L-methionine in a concentration-dependent manner, but D-methionine enhanced the activity in low concentrations (0-20 mmol/l). D,L-Homocysteine inhibite...
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PMID: 16899234
PDF is available here.
PDF is available here.
Abstract
In clinical phase 1, cysteine production and its release from protein breakdown were slower in both groups of children than were the values in the recovered state. These kinetic variables were significantly slower, however, in the children with edematous SCU than in those with nonedematous SCU. De n...
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PMID: 17158422
PDF is available here.
PDF is available here.
Abstract
At clinical phase 1, children with edematous SCU had rates of total methionine flux, flux from protein breakdown, and flux to protein synthesis that were slower than the rates of the nonedematous group. There were no significant differences in homocysteine remethylation or methionine transsulfuratio...
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PMID: 17158423
PDF is available here.
PDF is available here.
Chemistry & Biology (13)12 2006
Abstract
Drug resistance in lymphoblastic and myeloblastic leukemia cells is poorly understood, with several lines of evidence suggesting that resistance can be correlated with upregulation of human asparagine synthetase (hASNS) expression, although this hypothesis is controversial. New tools are needed to i...
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PMID: 17185229
PDF is available here.
PDF is available here.
Poultry Science (85)12 2006
Abstract
I was 20 to 43 wk of age with 18.9, 17.0, and 14.4 g of protein/hen per day and 0.97, 0.85, and 0.82 TSAA:Lys, whereas phase II was 44 to 63 wk of age with 16.3, 14.6, and 13.8 g of protein/hen per day and 0.92, 0.82, and 0.72 TSAA:Lys. Egg production and feed consumption decreased from 83.7 to 82.2...
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PMID: 17135677
PDF is available here.
PDF is available here.
Poultry Science (85)11 2006
Abstract
dl-Methionine or its corresponding hydroxy analogue, DL-2-hydroxy-(4-methylthio) butanoic acid (DLHMB), are commonly added to commercial animal diets to satisfy the TSAA requirement. The utilization of DLHMB as a supplementary source of Met begins with its conversion to L-Met via a 2-step mediated p...
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PMID: 17032826
PDF is available here.
PDF is available here.
Abstract
Three experiments were conducted to determine the true ileal digestible (TID) Lys and sulfur AA (SAA) requirement and to compare the bioefficacy of 2-hydroxy-4-(methylthio)butanoic acid (HMTBA) and dl-MET as Met sources in nursery pigs. Experiment 1 included 2 studies: 1 was 662 nursery pigs (Triump...
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PMID: 16775054
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
We know of human subjects with isolated defects in all of the reactions of the combined pathway with only one exception: betaine homocysteine methyltransferase. Studies of these inborn errors have contributed significantly to our knowledge of human methionine metabolism and to the clinical consequen...
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PMID: 16702350
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
Journal of Nutrition (136)6 Suppl 2006
Abstract
The intimate relation between amino acids and protein and nitrogen requirements is well recognized. Nutrition research has focused on the capacity of food to meet the need for nitrogen and indispensable amino acids (IAA) and led to the conclusion that the quality, not just the quantity, of protein i...
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PMID: 16702339
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
We do not wish to be overly critical of the high-quality work of the ambitious and highly intelligent men and women who have conducted various studies. Our goal is to objectively review the data for the reader in a logical and comprehensive manner and propose methods that may avoid difficulties in f...
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PMID: 16702340
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
We propose RASAA as a feasible index for improvement of lipid metabolism by amino acids. Although it is not clear how SAAs influence gene expression and lipid metabolism at a molecular level, SAAs change the metabolic pathway through transcriptional stimulation and posttranslational modification of...
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PMID: 16702337
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
The adequacy range of dietary requirements of specific amino acids in disease states is difficult to determine. In health, several techniques are available allowing rather precise quantification of requirements based on growth of the organism, rises in plasma concentration, or increases in the oxida...
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PMID: 16702341
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
Methionine, cysteine, homocysteine, and taurine are the 4 common sulfur-containing amino acids, but only the first 2 are incorporated into proteins. Sulfur belongs to the same group in the periodic table as oxygen but is much less electronegative. This difference accounts for some of the distinctive...
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PMID: 16702333
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
Animal studies show that the balance of methionine relative to other amino acids in the maternal diet is critical, as fetal growth is not only retarded by diets that are deficient but also by those containing excess. Diets with an inappropriate balance of methionine can adversely affect both short-t...
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PMID: 16702342
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
Animal studies have shown that several methionine (Met) and cysteine (Cys) analogs or precursors have L-Met- and L-Cys-sparing activity. Relative oral bioavailability (RBV) values, with the L-isomer of Met and Cys set at 100% (isosulfurous basis), are near 100% for D-Met for animals but only about 3...
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PMID: 16702338
PDF is available here.
PDF is available here.
Journal of Nutrition (136)6 Suppl 2006
Abstract
No direct data exist on the influence of supranormal intakes of sulfur amino acids on immune function in humans. However 3 major products of sulfur amino acids, glutathione (GSH), homocysteine (Hcy), and taurine (Tau), influence, mainly, inflammatory aspects of the immune response in vitro and in vi...
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PMID: 16702336
PDF is available here.
PDF is available here.
Amino Acids (30)3 2006
Abstract
We outline some of the fundamental concepts for modeling sulfur amino acid metabolism and how they relate to our current understanding of mammalian sulfur amino acid metabolism....
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PMID: 16680556
PDF is available here.
PDF is available here.
Journal of Nutrition (136)5 2006
Abstract
We determined whether dietary sulfur amino acid (SAA) deficiency induces oxidative stress in vivo, as determined by redox state of major thiol/disulfide couples in plasma [Cys/cystine (CySS)] and intestinal mucosa [glutathione (GSH)/glutathione disulfide (GSSG)]. Rats were fed isocaloric, isonitroge...
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PMID: 16614411
PDF is available here.
PDF is available here.