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Articles on Catechols
In situ electrogeneration of o-benzoquinone and high yield reaction with benzenethiols in a microflow system.
We have successfully demonstrated that a microflow reactor is extremely useful in controlling reactions involving an unstable o-benzoquinone. The key features of the method are an effective o-benzoquinone generation and its rapid use for the following reaction without decomposition in a microflow sy...
A chemical proteomic probe for detecting dehydrogenases: catechol rhodanine.
We describe such a fluorescent probe, based on a catechol rhodanine acetic acid (CRAA) ligand that binds to dehydrogenases. The CRAA ligand is fluorescent and binds to dehydrogenases at pH > 7, and hence can be used effectively to stain dehydrogenases in native gels to identify what subset of protei...
Salicylic acid mediates the reduced growth of lignin down-regulated plants.
Our data place SA as a central component in growth signaling pathways that either sense flux into the monolignol pathway or respond to secondary cell-wall integrity, and indicate that it is possible to engineer plants with highly reduced cell-wall recalcitrance without negatively impacting growth....
A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans.
We identified a candidate dihydrocaffeic acid receptor (DCAR), DCAR-1. DCAR-1 is a novel seven-transmembrane protein that is expressed in the ASH avoidance sensory neurons of C. elegans. dcar-1 mutant animals are defective in avoidance response to DHCA, and cell-specific expression of dcar-1 in the...
6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice.
To investigate the hepatoprotective efficacy of 6-gingerol against acetaminophen-induced hepatotoxicity in mice. Mice were injected with a single dose of acetaminophen (900 mg/kg) to induce hepatotoxicity, while 6-gingerol (30 mg/kg) or the standard drug silymarin (25...
Pharmacokinetics of phenolic compounds of Danshen extract in rat blood and brain by microdialysis sampling.
To evaluate the pharmacokinetics of phenolic compounds after oral administration of Danshen extract in rat brain. Blood and brain microdialysis probes were inserted into jugular vein and cerebral cortex of rat under anesthesia and perfused with ringer's solution at th...
[Investigation on simultaneous determination of dihydroxybenzene isomers in water samples using multi-walled carbon nanotube modified screen...
These results indicate MWCNT/SPE can be applied to rapid in-situ determination of dihydroxybenzenes-polluted water samples....
Inhibitors of catechol-O-methyltransferase sensitize mice to pain.
We have assessed the effects of acute and repeated administrations of COMT inhibitors on mechanical, thermal and carrageenan-induced nociception in male mice. We used single and repeated administration of a peripherally restricted, short-acting (nitecapone) and also a centrally actin...
Selective catechol-triggered supramolecular gel disassembly.
Supramolecular gels formed by an isonicotinic acid derivative in toluene are selectively disassembled in the presence of catechol. The results represent a unique example of molecular recognition associated to gel rupture which is of interest, for example, in controlled drug release applications.
Substrate binding mechanism of a type I extradiol dioxygenase.
I extradiol dioxygenase, and the enzyme substrate (3-methylcatechol) complex revealed the substrate binding process of extradiol dioxygenase. AkbC is composed of an N-domain and an active C-domain, which contains iron coordinated by a 2-His-1-carboxylate facial triad motif. The C-domain includes a ...