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All › Organic Chemicals › Amides › Polyunsaturated Alkamides › Capsaicin

Capsaicin (0)

      Articles on Capsaicin

      1. A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal se...
        David B DB Clifford, David M DM Simpson, ...

        J Acquir Immune Defic Syndr 59(2):126-33 (2012) PMID 22067661

        Effective treatment of HIV-associated distal sensory polyneuropathy remains a significant unmet therapeutic need. In this randomized, double-blind, controlled study, patients with pain due to HIV-associated distal sensory polyneuropathy received a single 30-minute or...
      2. Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions.
        A A Brenchat, D D Zamanillo, ... J M JM Vela

        Eur J Pain 16(1):72-81 (2012) PMID 21843960

        Several studies have suggested that 5-HT(7) receptors are involved in nociceptive processing but the exact contribution of peripheral versus central 5-HT(7) receptors still needs to be elucidated. In the present study, the respective roles of peripheral and spinal 5-HT(7) receptors i...
      3. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.
        P P Anand and K K Bley

        Br J Anaesth 107(4):490-502 (2011) PMID 21852280 PMCID PMC3169333

        Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza...
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      4. Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
        Hélène H Beaudry, Dave D Dubois, and Louis L Gendron

        J Neurosci 31(37):13068-77 (2011) PMID 21917790

        We have previously seen that expression of MOPR is essential for morphine and inflammation to potentiate the analgesic properties of selective DOPR agonists. In vivo, it is not clear whether MOPRs and DOPRs are expressed in the same neurons. Indeed, it was recently proposed that these receptors are...
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      5. The role of decongestants, cromolyn, guafenesin, saline washes, capsaicin, leukotriene antagonists, and other treatments on rhinitis.
        Nataliya M NM Kushnir

        Immunol Allergy Clin North Am 31(3):601-17 (2011) PMID 21737044

        Clinical symptoms of allergic and nonallergic rhinitis are similar despite the significant difference in underlying mechanisms. Over-the-counter (OTC) treatments can be used as effective and affordable therapeutic modalities when recommended by a physician. Adjunct treatments, such a...
      6. Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation a...
        Sung-E SE Choi, Tae Ho TH Kim, ... Kwan-Woo KW Lee

        Nutr Res 31(6):468-78 (2011) PMID 21745629

        We tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages. To...
      7. Nanoparticle formulation for controlled release of capsaicin.
        Seon S Kim, Jong Chul JC Kim, ... Giyoong G Tae

        J Nanosci Nanotechnol 11(5):4586-91 (2011) PMID 21780502

        Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water s...
      8. TRPV1, NK1 receptor and substance P immunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after system...
        Yujing J Heng, Cassandra I M Saunders, ... Dominic P Geraghty

        Regul Pept 167(2-3):250-8 (2011) PMID 21329730

        Transient receptor potential vanilloid 1 (TRPV1), neurokinin 1 (NK1) receptor and substance P (SP) immunoreactivity (-ir) and mRNA in the rat lumbosacral spinal cord and urinary bladder were measured 24h after s.c. injection of the vanilloids, capsaicin (50mg/kg) and resiniferatoxin...
      9. c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats.
        Ying Han, Ning Yuan, ... Guo-Qing Zhu

        Pflugers Arch 461(4):437-46 (2011) PMID 21340460

        These results indicate that c-Src in the PVN is involved in the enhanced CSAR and sympathetic activation in renovascular hypertension, and mediates the excitatory effects of Ang II in the PVN on the CSAR and sympathetic activity via NAD(P)H oxidase-derived generation of superoxide anions....
      10. Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
        Ji-Hye Kang, Goto Tsuyoshi, ... Rina Yu

        J Med Food 14(3):310-5 (2011) PMID 21332406

        We assessed whether dietary capsaicin attenuated the metabolic dysregulation in genetically obese diabetic KKAy mice, which have severe diabetic phenotypes. Male KKAy mice fed a high-fat diet for 2 weeks received a 0.015% capsaicin supplement for a further 3 weeks and were compared with nonsupplemen...