Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
Abstract
We will describe some results of theses studies and propose some practical recommendations in use of the anti-TNF alpha therapy....
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PMID: 21309182
PDF is available here.
Mario Cottone,
Anna Kohn,
Marco Daperno,
Alessandro Armuzzi,
Luisa Guidi,
Renata D'Inca,
Fabrizio Bossa,
Erika Angelucci,
Livia Biancone,
Paolo Gionchetti,
Sandro Ardizzone,
Claudio Papi,
Walter Fries,
Silvio Danese,
Gabriele Riegler,
Maria Cappello,
Fabiana Castiglione,
Vito Annese and
Ambrogio Orlando
Abstract
We evaluated the risk and benefits of therapy with tumor necrosis factor (TNF) inhibitors in these patients.
We collected data from patients with IBD treated with infliximab (n = 2475) and adalimumab (n = 604) from 2000 to 2009 at 16 tertiary centers. Ninety-five patients (3%) were m...
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PMID: 20951835
PDF is available here.
Ambrogio Orlando,
Alessandro Armuzzi,
Claudio Papi,
Vito Annese,
Sandro Ardizzone,
Livia Biancone,
Aurora Bortoli,
Fabiana Castiglione,
Renata D'Incà,
Paolo Gionchetti,
Anna Kohn,
Gilberto Poggioli,
Fernando Rizzello,
Maurizio Vecchi,
Mario Cottone,
Italian Society of Gastroenterology and
Italian Group for the study of Inflammatory Bowel Disease
Abstract
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's an...
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PMID: 20843756
PDF is available here.
Abstract
Anti-TNF-α antibodies are widely used. The indications for their usage are still increasing. With their emerging use, their infectious complications are seen more often. We describe the first case of a pneumonia with Legionella pneumophila in a pregnant women with Crohn's disease, d...
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PMID: 21122583
PDF is available here.
Abstract
We report 2 cases of fatal Pneumocystis jirovecii pneumonia in patients with severe ulcerative colitis receiving combination immunosuppression including tacrolimus. We discuss the necessity of a P. jirovecii prophylaxis especially in elderly patients according to the European evidence-based consensu...
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PMID: 21122569
PDF is available here.
Abstract
Pneumocystis jirovecii pneumonia is an opportunistic infection affecting not only HIV patient but also patients with others causes of immunosuppression. The reference method for the diagnostic is the direct visualization of the pathogen in induced sputum or in bronchoalveolar lavage...
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PMID: 21089559
PDF is available here.
Abstract
Hematopoietic stem-cell transplantation is a potentially curative therapy for many high-risk hematologic malignancies and other life-threatening disorders. Advances in transplantation over the last four decades have resulted in an increasing number of long-term survivors who may be at risk for devel...
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PMID: 21140762
PDF is available here.
Abstract
Histopathological examination of the pulmonary parenchyma and spinal cord revealed loose aggregates of Gram-positive, partially acid-fast, fine, beaded, filamentous bacteria, most consistent with Nocardia spp.
A presumptive diagnosis was made of disseminated nocardiosis of the spinal cord and lungs....
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PMID: 20927178
PDF is available here.
Abstract
Distinguishing between an infective and malignant process provides a diagnostic challenge for clinicians. This case highlights an example of an acute spinal cord compression that could fall into either of these two categories. The diagnosis in this case of disseminated Nocardiosis is an extremely ra...
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PMID: 20646828
PDF is available here.
W Miehsler,
G Novacek,
H Wenzl,
H Vogelsang,
P Knoflach,
A Kaser,
C Dejaco,
W Petritsch,
M Kapitan,
H Maier,
W Graninger,
H Tilg,
W Reinisch and
Austrian Society of Gastroenterology and Hepatology
Abstract
Infliximab (IFX) has tremendously enriched the therapy of inflammatory bowel diseases (IBD) and other immune mediated diseases. Although the efficacy of IFX was undoubtedly proven during the last decade numerous publications have also caused various safety concerns. To summarize the...
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PMID: 21122513
PDF is available here.
Abstract
Known for a century, Toxoplasma gondii has been studied in Serbia half this time, ever since the introduction of the Sabin-Feldman test at the Institute for Medical Research (IMR) in 1959. However, despite 50 years of continuous efforts, exact data on the frequency of acute clinical disease, acute i...
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PMID: 21073140
PDF is available here.
Abstract
We report the first published case of bacterial laryngitis caused by MRSA....
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PMID: 21033025
PDF is available here.
Abstract
We found that age and prophylaxis, but not the type of catheter, were associated with a significantly reduced risk of bacteremia.
Children with ALL receiving SMX-TMP prophylaxis during induction therapy experienced fewer febrile episodes, fewer days with fever demanding intravenous a...
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PMID: 20583218
PDF is available here.
Abstract
We prospectively assessed all data from RA patients who underwent in-patient treatment for septic complications in the 3-year period from 01.01.2006 to 31.12.2009. All disease- and infection-specific data were gathered and analysed.
Of the 36 cases in total, infection was localized in the rheumatoid...
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PMID: 20632179
PDF is available here.
Abstract
Lung infections with Nocardia and Aspergillus spp in lung transplant recipients (LTRs) create diagnostic and therapeutic challenges. The present case illustrates the difficulties in identifying these pathogens in LTRs. A high degree of clinical suspicion and aggressive early management are required...
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PMID: 20541440
PDF is available here.
Abstract
Pathogens were isolated from 44% of all patients. MM patients more frequently had multiple pathogens in blood cultures (38% versus 25%). Transplantation related mortality was similar between the groups. CONCLUSION: The frequency of isolated pathogens, positive blood cultures, and the diversity of pa...
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PMID: 20670481
PDF is available here.
Abstract
Working age adults with asthma are at increased risk of IPI. In this population, approximately 5% of disease burden could be attributed to asthma. These findings support adding medicated asthma in adults to the list of indications for pneumococcal vaccination....
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PMID: 20685743
PDF is available here.
Abstract
Invasive aspergillosis (IA) is a serious opportunistic infection in immunocompromised patients. Transplant recipients and patients with cancer represent the highest risk group. The antifungal treatment involves prolonged hospitalization and high economic resources. Objective: to estimate costs repre...
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PMID: 21046712
PDF is available here.
Abstract
Cavitary pneumonia caused by Rhodococcus equi may occur in patients with defective cell-mediated immunity. Prolonged CD4 lymphopenia may develop in patients with chronic lymphocytic leukemia who receive fludarabine. The authors report the first case of a patient with chronic lymphocytic leukemia who...
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PMID: 20463575
PDF is available here.
Abstract
We report the case of a human immunodeficiency virus-1-infected patient who had several relapses of visceral leishmaniasis after treatment with standard therapies and responded to a combined therapy....
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PMID: 20595469
PDF is available here.
Abstract
We present here the first case of osteomyelitis of the distal femur caused by Salmonella typhimurium in a patient with Crohn's disease. The infection was successfully treated with a combination of antibiotics and surgical treatment....
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PMID: 20623256
PDF is available here.
Abstract
We report here a case of post-transplant acute limbic encephalitis (PALE) syndrome that was possibly related to EBV infection. Six weeks after hematopoietic stem-cell transplantation, the patient developed confusion and anterograde amnesia. Brain magnetic resonance imaging (MRI) was performed and re...
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PMID: 19959232
PDF is available here.
M Mosca,
C Tani,
M Aringer,
S Bombardieri,
D Boumpas,
R Brey,
R Cervera,
A Doria,
D Jayne,
M A Khamashta,
A Kuhn,
C Gordon,
M Petri,
O P Rekvig,
M Schneider,
Y Sherer,
Y Shoenfeld,
J S Smolen,
R Talarico,
A Tincani,
R F van Vollenhoven,
M M Ward,
V P Werth and
L Carmona
Abstract
A set of recommendations for monitoring patients with SLE in routine clinical practice has been developed. The use of a standardised core set to monitor patients with SLE should facilitate clinical practice, as well as the quality control of care for patients with SLE, and the collection and compari...
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PMID: 19892750
PDF is available here.
Abstract
Our aim was to evaluate the occurrence and antimicrobial resistance of P. aeruginosa in the water of swimming pools in northern Greece. Water samples were obtained from hydrotherapy pools, jacuzzis/spas and swimming pools. A total of 16.6% (45/271) of the samples were positive for P. aeruginosa. Of...
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PMID: 20799537
PDF is available here.
Abstract
The estimated PAF of diabetes for pulmonary tuberculosis is highest for Asian men (19.6%, 95% CI 10.9% to 33.1%) and women (14.2%, 95% CI 7.1% to 26.5%). The PAF for all ages is similar in white and black men (6.9%, 95% CI 3.1% to 12.4% and 7.4%, 95% CI 4.6% to 12.9%, respectively) and women (8.2%,...
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PMID: 20421330
PDF is available here.
Abstract
We report on a patient with Pneumocystis jirovecii pneumonia who developed fever, rash, eosinophilia and hepatitis 10 days after initiation of a therapy with sulfamethoxazole and trimethoprim. A DRESS syndrome was diagnosed and the therapy was changed successfully to pyrimethamine and dapsone. We de...
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PMID: 20571998
PDF is available here.
Abstract
We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation....
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PMID: 20455691
PDF is available here.
Abstract
We present two new cases of K. ohmeri fungemia. We investigated the nature and treatment of K. ohmeri infections using minimum inhibitory concentrations of antifungal agents and by comparing the two cases with those described in the literature.
From March 1998 to December 2008, a tot...
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PMID: 21291847
PDF is available here.
Abstract
The greatest threat to patients with AAV in the first year of therapy is from adverse events rather than active vasculitis. The accumulation of adverse events, monitored using this scoring method, should prompt increased awareness that the patient is at high risk of death....
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PMID: 19574233
PDF is available here.
Abstract
There is good evidence for the efficacy of biological agents in patients with RA. Safety data confirm an increased risk of bacterial infection and TB with TNFi compared with conventional DMARDs....
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PMID: 20447957
PDF is available here.
Abstract
We investigated the relationship between the time from obtaining the blood specimen to the detection of positive culture tests as well as the significance of the pathogen detected. Twenty-three inpatients demonstrated CNS-positive blood culture tests. It was judged that six patients (26%) had contam...
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PMID: 20622485
PDF is available here.
Abstract
We conducted this study to analyze the frequency of these complications, before and after the use of daclizumab induction therapy. We reviewed all neurologic complications in our HT cohort, comparing infectious with non-infectious complications over 2 periods of time in which different induction the...
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PMID: 20453603
PDF is available here.
Abstract
Urosepsis is one of the most frequent sepsis entities. Mortality from urosepsis is nowadays mostly lower than from other entities. Sepsis syndrome is pathophysiologically characterized by a generalized infection and immune dysregulation. Exogenous microbiological and active or passive endogenous fac...
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PMID: 20414763
PDF is available here.
Abstract
We report 2 cases of gallstone associated with portal cavernoma in 2 girls. The first one suffered from Evans syndrome associated with congenital immune deficiency. The portal cavernoma was discovered with gallstone after splenectomy indicated because of high steroid dependence. In the second case,...
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PMID: 20303244
PDF is available here.
Abstract
We prospectively investigated the pharmacokinetics and promotion of treatment adherence in patients taking oral ITCZ solution mixed with a beverage. Compared with the responses of patients taking oral ITCZ solution with water, the taste of the agent was improved significantly when mixed with orange...
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PMID: 20534951
PDF is available here.
Abstract
We present the cases of 2 patients with rheumatoid arthritis and one patient with ankylopoietic spondylitis on treatment with adalimumab, who developed pulmonary and disseminated tuberculosis despite following the screening and prophylaxis measures recommended in guidelines. We also review the assoc...
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PMID: 19896259
PDF is available here.
Abstract
Our study indicates that the prevalence of opportunistic infections in the Lupus under treatment in a high-risk area for infectious diseases was low. This finding suggests that the risk of infectious complications secondary to corticosteroid therapy in sub-Saharan zone is acceptable provided that su...
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PMID: 20486367
PDF is available here.
Abstract
All marketed TNF inhibitors for compared to control RA appear to increase the risk of serious and nonserious infections compared with DMARDs. Although suggestive, data for abatacept and rituximab are less definitive and longer periods of patient exposure to these agents are needed before an assessme...
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PMID: 19117595
PDF is available here.
Abstract
Invasive fungal infection (IFI) is a serious and common complication in hematological patients. The risk is highest among acute leukemia patients undergoing induction chemotherapy and patients undergoing allogeneic hematopoietic stem-cell transplantation. Owing to the difficulty in diagnosing IFIs a...
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PMID: 20377335
PDF is available here.
Abstract
We report a 39-year-old man hospitalized with newly diagnosed acute myelocytic leukemia who developed disseminated Fusarium infection originating from toenail paronychia in the setting of neutropenia. Pathologic diagnosis of Fusarium is difficult because the septate hyphae of Fusarium are difficult...
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PMID: 20486458
PDF is available here.
Abstract
In 2009 lung transplantation is a valuable therapeutic option for a number of patients suffering from end-stage pulmonary diseases. Lung transplantation frequently offers a major improvement in quality of life; however, long-term survival is often limited by the development of the bronchiolitis obli...
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PMID: 20403546
PDF is available here.
Abstract
We describe an unusual granulomatous reaction to gram-positive cocci in the skin of a 52-year-old man undergoing salvage chemotherapy for acute myeloid leukemia. The patient presented with a papular eruption on the arms, trunk, and face and fever; concomitant blood cultures were positive for Rothia...
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PMID: 19940746
PDF is available here.
Abstract
Rhinocerebral mucormycosis is a rare angioinvasive fungal infection that has a strong predilection for patients with poorly controlled diabetes and immunosuppression. Initial presenting symptoms are nonspecific and frequently are attributed to more mundane sinonasal and orbital patho...
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PMID: 19942703
PDF is available here.