Abstract
Recombinant factor VIIa (rFVIIa) is approved for treatment of bleeding in patients who have hemophilia with inhibitors but has been applied to a wide range of off-label indications.
To estimate patterns of off-label rFVIIa use in U.S. hospitals.
Retros...
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PMID: 21502649
PDF is available here.
Veronica Yank,
C Vaughan Tuohy,
Aaron C Logan,
Dena M Bravata,
Kristan Staudenmayer,
Robin Eisenhut,
Vandana Sundaram,
Donal McMahon,
Ingram Olkin,
Kathryn M McDonald,
Douglas K Owens and
Randall S Stafford
Abstract
Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia, is increasingly used for off-label indications.
To evaluate the benefits and harms of rFVIIa use for 5 off-label, in-hospital indications: intracranial hemorrhage, cardiac surgery, trauma, l...
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PMID: 21502651
PDF is available here.
Takayuki T Motoki,
Yoshio Y Naomoto,
Junji J Hoshiba,
Yasuhiro Y Shirakawa,
Tomoki T Yamatsuji,
Junji J Matsuoka,
Munenori M Takaoka,
Yasuko Y Tomono,
Yasuhiro Y Fujiwara,
Hiroshi H Tsuchita,
Mehmet M Gunduz,
Hitoshi H Nagatsuka,
Noriaki N Tanaka and
Toshiyoshi T Fujiwara
Abstract
To investigate the possible biological outcome and effect of glutamine depletion in neonatal mice and rodent intestinal epithelial cells.
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PMID: 21390141
PDF is available here.
Abstract
We discuss the pharmacology of new parenteral anticoagulants, the results of clinical studies, the newly planned or ongoing clinical trials with these compounds, and their potential advantages and drawbacks over existing therapies....
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PMID: 21045018
PDF is available here.
Abstract
To observe the clinical efficacy of pricking bleeding of 3 points of the thumb tip, and 3 points of the auricular helix for treatment of vocal cord submucosal bleeding (VCSB), so as to provide a better therapy for it.
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PMID: 21585061
PDF is available here.
Abstract
U46619 (2.5 μM and 10 μM)-induced platelet aggregation was remarkably impaired in the proband and her father. Immunoblots showed that TXA(2) R expression levels in their platelets were approximately 50% of controls, and nucleotide sequence analysis revealed that they were heterozygous for a nove...
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PMID: 21342433
PDF is available here.
Abstract
156 radiosynovectomies (RS) were performed in 104 joints of 78 haemophiliacs diagnosed with chronic synovitis. Mean patient age was 18 years. The RS was carried out with either yttrium-90 or rhenium-186 (1-3 injections with a 3-6-month interval between them). RS resulted in significa...
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PMID: 21352468
PDF is available here.
Abstract
We hypothesized that an effective windlass tourniquet could be removed after application of a hemostatic dressing in a swine model of peripheral vascular injury. A tourniquet was placed proximally in 50 forelimb-injured swine after 30 seconds of hemorrhage with cessation of hemorrhage in all cases....
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PMID: 21337872
PDF is available here.
Abstract
Most retrospective studies evaluating fresh-frozen plasma:packed red blood cell ratios in trauma patients requiring massive transfusion (MT) are limited by survival bias. As prospective resource-intensive studies are being designed to better evaluate resuscitation strategies, it is i...
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PMID: 21337871
PDF is available here.
Abstract
We have generated a zebrafish line carrying a stop mutation in the kinase domain of the Tie-2 receptor. Mutant embryos lack Tie-2 protein, but do not display any defect in heart and vessel development. Simultaneous loss of Tie-1 and Tie-2, however, leads to a cardiac phenotype. Our study shows that...
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PMID: 21045210
PDF is available here.
Abstract
Patients with predominantly squamous non-small cell lung cancer (NSCLC) have been generally excluded from studies of bevacizumab treatment, because squamous histology was identified as a possible risk factor for severe (grade ≥3) pulmonary hemorrhage (PH) in a phase II study. BRIDG...
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PMID: 21107290
PDF is available here.
Abstract
The use of low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes is recommended by existing guidelines, but definitive evidence supporting its efficacy is lacking. The authors undertook a meta-analysis of published trials to determine the effect of low-dose aspir...
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PMID: 21191260
PDF is available here.
Abstract
We hypothesized that initial studies suffer from survival bias because they do not consider early deaths secondary to uncontrolled exsanguinating hemorrhage. To help resolve this controversy, we evaluated the temporal relationship between blood product administration and mortality in civilian trauma...
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PMID: 21217487
PDF is available here.
Abstract
We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5).
FFP from 30 single donors were thawed at 37°C and kept at 1°C to 6°C for 5 days. HP was evaluated at day 0 and 5 by measuring kinetics of thrombin generation (TG), kinetic...
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PMID: 21217484
PDF is available here.
Abstract
We report the use of a new P2Y12 point-of-care assay (VerifyNow; Accumetrics, San Diego, CA) to determine the magnitude of platelet inhibition in trauma patients using clopidogrel.
Trauma patients in 2009 were queried for clopidogrel use by prehospital personnel and the trauma team. Blood was obtain...
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PMID: 21217483
PDF is available here.
Abstract
Benefits of high ratios of fresh frozen plasma (FFP) to packed red blood cells (pRBC) in massively transfused trauma patients have been reported previously. This study aimed to assess the effect of higher FFP:pRBC ratios on outcome in patients receiving less than massive transfusion during acute tra...
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PMID: 21217485
PDF is available here.
Abstract
We report preliminary findings on the effects of different FFP:PRBC ratios on coagulation.
This is a prospective observational cohort study of trauma patients requiring >4 U of PRBCs. Blood was drawn before and after each 4-U PRBC interval for prothrombin time and analysis by rotational thromboelast...
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PMID: 21217486
PDF is available here.
Abstract
Agmatine (CAS 2482-00-0), an amine formed by decarboxylation of L-arginine, interacts with several targets like alpha2-adrenergic, imidazoline and N-methyl-D-aspartic acid (NMDA) receptors and besides it is involved in the nitric oxide mediated effects. It has also been proposed that it possesses vas...
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PMID: 21650081
PDF is available here.
Abstract
To investigate the association between adverse events recorded during critical care and mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia.
Prospective, observational, registry-based study.
Twenty-two hospitals in Europe and the United States.
Between October 2...
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PMID: 20959789
PDF is available here.
Abstract
This review focuses on vasculitides with prominent pulmonary manifestations and discusses key contributions from the recent literature. Pulmonary vasculitis should be considered when clinical findings include alveolar hemorrhage, nodular and cavitary lung disease, airway stenosis, pulmonary artery a...
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PMID: 20882372
PDF is available here.
Abstract
We conducted a PubMed search during June 2009 using the search terms antidepressants and SSRIs (including the names of individual SSRIs: fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, and escitalopram) in association with bleeding, platelets, hemostasis, nonsteroidal anti-inflammatory...
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PMID: 21190637
PDF is available here.
Abstract
Native kidney biopsy is still performed primarily with hospital inpatient observation period. Experience with outpatient Computed Tomographic (CT)-guided renal biopsy at Yale New Haven Medical Center was studied to assess efficacy and safety. A total of 146 outpatient native kidney biopsies were ide...
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PMID: 21084047
PDF is available here.
Abstract
Delayed splenic hemorrhage after proximal splenic artery embolotherapy (SAE) in patients with blunt splenic injury is a well-known outcome. The hemorrhage is thought to be due to rupture of a splenic parenchymal pseudoaneurysm. This study attempts to explain at least part of the mechanism involved i...
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PMID: 20571451
PDF is available here.
Abstract
We present our study using emergent bilateral ligation of the internal iliac arteries (BLIA) and pelvic packing as a damage control adjunct.
We reviewed our experience during 22 months (May 2006 to March 2008) with damage control management of massive retroperitoneal hemorrhage caused by blunt pelvi...
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PMID: 20495490
PDF is available here.
Abstract
We propose to analyze whether human AM combined with human AMBP-1 provides benefit in a model of THI in the rat.
Male adult rats were subjected to trauma hemorrhage by resection of ∼50% of total liver tissues and allowed bleeding for 15 minutes. Immediately thereafter, human AM (48 μg/kg birth we...
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PMID: 21057332
PDF is available here.
Author(s) unavailable
Abstract
The FDA has approved the oral direct thrombin inhibitor dabigatran (da big' a tran) etexilate (Pradaxa--Boehringer Ingelheim) for prevention of thromboembolic stroke in patients with non-valvular atrial fibrillation.It has been available in Canada (Pradax) since 2008 for prevention of thromboembolis...
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PMID: 21068702
PDF is available here.
Abstract
Inserting a transjugular intrahepatic portosystemic shunt by means of interventional radiology has become the procedure of choice for decompression of portal hypertension. The indications and criteria for patient selection have been expanded and refined accordingly.
To review our experience with TIP...
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PMID: 21243870
PDF is available here.
Abstract
Emergency department physicians, along with hospitalists and interventional cardiologists, provide first-line care for patients experiencing symptoms potentially associated with acute coronary syndromes (ACS). Because these health care providers encounter and manage patients with varying degrees of...
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PMID: 21068524
PDF is available here.
Abstract
Many acutely ill medical patients are at significant risk for developing venous thromboembolism (VTE) during hospitalization. Venous thromboembolism risk arises from both the presenting clinical condition as well as predisposing risk factors, such as advanced age. Thromboprophylaxis is underprescrib...
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PMID: 21068523
PDF is available here.
Abstract
The addition of glycoprotein IIb/IIIa inhibitors (GPIs) to heparin in percutaneous coronary intervention (PCI) procedures has been demonstrated to reduce ischemic complications; however, GPI use is known to increase the risk of bleeding events, which are linked to increased mortality, longer hospita...
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PMID: 21068538
PDF is available here.
Abstract
Blood aspiration may be fatal, even when caused by a minor hemorrhage, and then it is important to localize and identify the source of bleeding in order to determine its origin as traumatic, spontaneous or iatrogenic. The present case deals with the clinically unexpected sudden death of a 73-year-ol...
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PMID: 20729125
PDF is available here.
Abstract
Based on the documentation from patients with severe haemophilia B (FIX:C <1%) in home treatment the positive effect of continuous prophylaxis compared to on demand treatment was investigated over one year in a retrospective study from a single treatment centre (Centre for Haemostaseology Muenster)....
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PMID: 21042666
PDF is available here.
Abstract
95% of the patients experienced their first bleeding episode at the age of less than one year. On average, the first non-joint bleed occurred at the age of 0.85 years, whereas the first joint bleed developed approximately a half year later at the age of 1.49 years. Compared to the previous investiga...
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PMID: 21042674
PDF is available here.
Abstract
In a retrospective study 118 haemophilia A patients from two treatment centres (Berlin and Muenster) were evaluated with respect to safety, i. e. inhibitor development, and efficacy of bleeding control of recombinant FVIII products. During approx. 57 thousand injections with more than 87 million I.U...
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PMID: 21042673
PDF is available here.
Abstract
111/181 patients with HA had the severe form and 12/34 patients severe HB. 4/12 patients with severe HB had a history of intracerebral bleeding in comparison to 5/111 patients with severe HA. 2/8 adult patients with severe HB used a prophylactic treatment with factor concentrates (mean consumption 1...
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PMID: 21042678
PDF is available here.
Abstract
Shock index (SI) is recognized to be a more reliable early indicator of hemorrhage than traditional vital signs. Acute traumatic brain injury (TBI) can be associated with autonomic uncoupling and may therefore alter the reliability of SI in patients with combined TBI and peripheral hemorrhage. The a...
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PMID: 20571456
PDF is available here.
Abstract
Previous studies identified WoundStat (WS, smectite) and Combat Gauze (CG, kaolin-coated gauze) as the most effective available agents for controlling arterial bleeding with potential utility in casualty care. Tissue sealant properties of WS suggested its potential advantage over clot-promoting CG f...
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PMID: 21068612
PDF is available here.
Abstract
We evaluated vascular patency and tissue responses to WS in a swine femoral artery injury model with survival up to 5 weeks.
Anesthetized swine received a standardized femoral artery injury with free hemorrhage for 45 seconds followed by WS application. One hour after application, the WS was removed...
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PMID: 20068476
PDF is available here.
Abstract
Visually estimated amount of blood loss may influence decision making in the prehospital setting. The purpose of this study was to determine the ability and accuracy of paramedics and emergency physicians to visually estimate a volume of external blood loss and the influence of different vital signs...
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PMID: 20130487
PDF is available here.
Abstract
Colloid plasma expanders are used to maintain blood pressure and ensure tissue perfusion during hypovolemia, e.g., caused by traumatic bleeding. Although colloids stabilize the cardiovascular system, they can also potentially cause coagulopathy. Consequently, bleeding tendency may increase, as well...
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PMID: 20032791
PDF is available here.
Abstract
We randomly assigned 2922 patients who were taking warfarin because of mechanical heart valves or atrial fibrillation and who were competent in the use of point-of-care INR devices to either weekly self-testing at home or monthly high-quality testing in a clinic. The primary end point was the time t...
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PMID: 20961244
PDF is available here.
Abstract
To report a case of cephalosporin-induced factor V inhibitor development, an uncommon but potentially fatal condition characterized by severe hemorrhage.
A 71-year-old Chinese man presented with factor V inhibitors after a 7-day cephradine course for a urinary tract infection, characterized by abnor...
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PMID: 20807866
PDF is available here.
Abstract
We compared the 3-month incidence of fatal PE and fatal bleeding in patients in whom the VTE had developed while in hospital for another medical condition (inpatients) with those who presented to the emergency ward because of VTE (outpatients).
Up to April 2008, 22,133 patients with acute VTE were e...
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PMID: 20816588
PDF is available here.
Abstract
We studied 46 hemostatic parameters in 566 participants: 280 patients with mucocutaneous bleeding and 286 controls. The F12 -4T allele, associated with reduced levels of FXII (P < 0.001), also significantly delayed the activated partial thromboplastin time (aPTT) expressed as aPTTr (ratio sample pla...
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PMID: 20814302
PDF is available here.
Abstract
We evaluated 980 consecutive patients undergoing urgent PCI for UA/NSTEMI who were treated with either bivalirudin or UFH plus GP IIb/IIIa inhibitor. We excluded patients who were on chronic clopidogrel therapy or received clopidogrel pretreatment prior to angiography. All patients received a clopid...
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PMID: 20882655
PDF is available here.
Abstract
Management of battlefield casualties in Iraq and Afghanistan has seen considerable development in damage control resuscitation, which aims to address the risk of haemorrhage, initially due to mechanical damage; and thereafter due to the development of life-threatening coagulopathy. Damage control re...
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PMID: 20869663
PDF is available here.