Abstract
Average life expectancy has increased over the past century resulting in a shift in world population demographics. There are more elderly people alive now than throughout all of human history. The burden of comorbid disease and dependency rises with age and has been shown to independently predict nee...
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PMID: 21925408
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Abstract
Most of patients with hematological malignancies are elderly (more than 60 years). Allogeneic stem cell transplantation is an important and effective treatment for most of these diseases. However, the toxicity and the supposed frailty of elderly patients, have limited the applicability of allogene...
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PMID: 21835732
PDF is available here.
Abstract
Although the number of frail elderly individuals has rapidly increased with global aging, few studies have assessed the main medical conditions that are covered by Long-Term Care Insurance (LTCI) systems.
To improve preventive care strategies, the author researched da...
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PMID: 21879591
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Abstract
High Quality Care for All (Department of Health (DH), 2008) emphasised the centrality of quality within NHS provision based upon a service that is 'fair, personalized, effective and safe'. The challenge of meeting this aspiration is even greater today amid resource constraints and the imperative of t...
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PMID: 21642932
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Abstract
We compared the discrimination calibration of SHERPA vs SHERPA+, a logistic regression model including SHERPA and selected biomarkers.
Three months after discharge, functional decline had occurred in 46 patients. IL-6 and IGF-1 were selected, since their levels were significantly dif...
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PMID: 20448452
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Abstract
We evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) g...
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PMID: 21449785
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Abstract
in NH residents, MDRD and CKD-EPI formulas yield highly concordant GFR values, but CG behaves differently in up to one-third of patients. Such findings have important implications in dosing drugs cleared by the kidney. Setting should be taken into consideration in studies for validation of GFR equat...
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PMID: 21398293
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Abstract
Patients with ESRD have extensive and unique end-of-life care considerations and needs. Despite substantial advancements in renal palliative care over the past decade, much research is still required. Identifying CKD patients whose illness trajectory has shifted and would likely benefit from a pallia...
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PMID: 21510132
PDF is available here.
Abstract
Whole cereal grain foods are rich in phytate, a Ca chelator, and could increase the risk of hip fracture. The objective of the present study was to investigate the association between baseline whole grain intake and incident hip fracture. In the present study, 29 192 women who at baseline in 1986 we...
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PMID: 20569526
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Abstract
The FIM(TM) score decreased by 3.41 (standard deviation 6.7) points in intervention group and 4.35 (standard deviation 8.0) in control group (p = 0.0987). The decrease in the 15D was equal in both groups. The mean incremental cost of adding rehabilitation to standard care was 3111 euros per person....
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PMID: 21031292
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Abstract
DEMMI admission scores were normally distributed (mean 30.2, standard deviation 16.7) and other activity limitation instruments had either a floor or a ceiling effect. Evidence of convergent, discriminant and known groups validity for the DEMMI were obtained. The minimal detectable change with 90% c...
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PMID: 21031293
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Abstract
The primary aim of this study was to explore the impact of falling for frail community-dwelling older persons with and without cognitive impairments who have experienced a recent fall and their primary family caregivers. The secondary aim was to define components for a future fall prevention program...
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PMID: 20635232
PDF is available here.
Abstract
Our estimates of the incidence of depressive symptoms were considerably higher than those previously found in elderly populations living in the community. A vulnerable health status is associated with a high risk of depressive symptoms....
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PMID: 20658371
PDF is available here.
Abstract
Objective In the People's Republic of China (China), caregivers carry a large burden because of the rapid aging of the population, the one-child policy and the uncertainty of the social security system. The situation is further complicated by the fact of 56 ethnic groups in the country. Few studies...
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PMID: 21061560
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Abstract
Altogether 433 residents were on PPIs. The factors associated with regular PPI use in univariate analyses included poor functional status, higher number of comorbidities, higher number of medications and lactose intolerance. The users had suffered from a prior ventricular or duodenal ulcer, cancer a...
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PMID: 20586539
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Abstract
Control-group patients were more likely to be readmitted than intervention-group patients (52% v 40%; p = 0.03). In the intervention group, the proportions of patients who used prescribed medication of which the GP was unaware (48% vs. 34%; p = 0.02) and who did not take the medication prescribed by...
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PMID: 20429738
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Abstract
This rapidly expanding cancer patient group benefits of specialist care. The use of frailty assessment tools is mandatory in clinical practice and in medical reporting. A fair risk-benefits balance should be kept in mind at all times; patients' requests and expectations should be prioritised. Aggres...
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PMID: 20591605
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Abstract
Despite a wide distribution, little is known about the relationship between subscriber satisfaction and the extent of use or non-use of personal emergency response systems (PERS).
To examine the degree of satisfaction with PERS, the wearing time and its use in case of a fall.
Telephone and face-to-f...
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PMID: 20814795
PDF is available here.
Abstract
We evaluated the association between low serum 25-hydroxyvitamin D concentration and frailty, defined according to a set of criteria derived from a definition previously described and validated.
Nationally representative survey of noninstitutionalized US residents collected between 1...
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PMID: 20528970
PDF is available here.
Abstract
This population-based study does not support the hypothesis that interindividual differences in (CAG)n can account for a lack of association between circulating androgens and the frailty phenotype. Longitudinal analyses are needed to confirm these conclusions....
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PMID: 20410235
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Abstract
Drugs have been widely associated with the development of delirium in the elderly and represent the most common reversible cause of this condition. This is of importance since successful treatment depends on identifying the reversible contributing factors. Medications with anticholinergic properties...
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PMID: 20640925
PDF is available here.
Abstract
Oral anticoagulant therapy has been shown to be of benefit also in elderly patients in various therapeutic and prophylactic indications. Despite strong evidence in literature, doctors still refuse to prescribe oral anticoagulants to geriatric patients in daily routine. Main reason for this decision...
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PMID: 20640923
PDF is available here.
Abstract
Frailty independently predicts postoperative complications, length of stay, and discharge to a skilled or assisted-living facility in older surgical patients and enhances conventional risk models. Assessing frailty using a standardized definition can help patients and physicians make more informed d...
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PMID: 20510798
PDF is available here.
Abstract
Understanding the distinctions between the management of clinical problems in nursing homes compared with the community setting helps improve the overall care of nursing home residents. Liberalizing diets helps avoid unintentional weight loss in nursing home residents, although the use of feeding tu...
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PMID: 20507047
PDF is available here.
Abstract
Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocompetent adults. The authors conducted a prospective observational cohort study (1992...
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PMID: 20400465
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Abstract
Epidemiological studies find that elderly, susceptible, and previously impaired individuals are more sensitive to transient air pollution exposures than healthy persons. However, any associated changes in life expectancy remain largely unresolved. Murray and Nelson published a model of daily mortali...
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PMID: 20480861
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Abstract
Heart failure is a major and growing public health problem that affects close to 10 million European and 5 million North Americans. Substitutive hospital-at-home care, defined as"a service that provides active treatment by health care professionals, in the patient's home, of a condition that otherwi...
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PMID: 20540398
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Abstract
We aimed to compare the validity of two frailty measures in participants of the Conselice Study of Brain Aging.
Prospective population-based study with 4 year follow up.
1,016 subjects aged 65 and over in a rural Italian population.
For each participant, a Frailty Index (FI) and a Conselice Study of...
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PMID: 20305994
PDF is available here.
Abstract
Synergistic interactions between specific inflammatory diseases may heighten the risk of frailty. These findings suggest that a common etiologic pathway may exist among co-occurring inflammatory diseases and that their improved comanagement may be an approach to reducing frailty....
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PMID: 19933749
PDF is available here.
Abstract
The prevalence of underweight was 15.4%. Low BMI values were more frequent in women than men (18.8 vs. 13.1%) and more frequent in persons needing professional nursing care at the time of death (28.9%). Underweight increased for the age range 70-79 from about 15% to over 38% for those 90 years and o...
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PMID: 19806291
PDF is available here.
Abstract
We should explore the appropriate approach to modify fall direction, defensive reaction, local shock absorption, which are closely related to fall-related fracture risk....
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PMID: 20354322
PDF is available here.
Abstract
Nephrologists care for an increasing number of elderly patients on hemodialysis. As such, an understanding of the overlap among complications of hemodialysis and geriatric syndromes is crucial. This article reviews hemodialysis management issues including vascular access, hypertension, anemia and bo...
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PMID: 20424572
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Abstract
To describe the informal care network of US veterans referred to home and community-based services (Homemaker Home Health services, H/HHA, or Home-Based Primary Care, HBPC) at the Durham Veterans Affairs Medical Center (VAMC), including: quantity and types of tasks provided and desir...
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PMID: 20308351
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Abstract
The experience of the next of kin could be understood as being a devoted companion during the transition toward the inevitable end, embracing the categories of living in the shadow of death; focusing on the needs of the dying person, making adjustments to everyday life; feeling the major responsibil...
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PMID: 20163756
PDF is available here.
Abstract
There was consensus among the experts on the inclusion of the following components in the operational definition of frailty: strength, balance, nutrition, endurance, mobility, physical activity and cognition. Some respondents indicated that they would wish to add components from the psychological or...
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PMID: 20191249
PDF is available here.
Abstract
This paper reviews the characteristics of sleep disorders found in people at a greater risk of dementia: the elderly adult, patients with mild cognitive impairment (MCI) and those with neurodegenerative diseases. The frequency of sleep architecture modifications and circadian rhythm sleep disturbanc...
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PMID: 20191256
PDF is available here.
Abstract
Each physiological system had a direct relationship with EC, which was lower in frail compared with nonfrail. The relationship between FVC and EC was positive and increased with increasing QS in nonfrail subjects. The effect of QS on EC was positive and increased with increasing FVC regardless of fr...
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PMID: 19822621
PDF is available here.
Abstract
Quality improvement efforts that provide access to focused and timely clinical information, facilitate change, and promote staff working together in multidisciplinary teams impacted clinical outcomes. Prevention of PrUs showed a trend of improvement in facilities that fully integrated tools to ident...
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PMID: 20177165
PDF is available here.
Abstract
Increased longevity raises the proportion of elderly individuals in a population, and thereby, the number of individuals suffering from frailty. Frailty is associated with loss of skeletal muscle mass and function (sarcopenia), which stems from an imbalance between muscle protein synthesis and degra...
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PMID: 20549924
PDF is available here.
Abstract
Frailty and malnutrition are both highly prevalent in the older population and have therefore become principle topics in geriatric research. Frailty is of multifactorial origin and is regarded as a fundamental risk factor for deteriorating health status and disability in older people. It is estimate...
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PMID: 20518190
PDF is available here.