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Middle Aged (0):
Recent article
Middle Aged
Abstract
Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI). These guidelines are based on small studies that associated low potassium levels with ventricular arrhythmias in the pre-β-blocker...
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PMID: 22235086
PDF is available here.
PDF is available here.
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Abstract
Marijuana smoke contains many of the same constituents as tobacco smoke, but whether it has similar adverse effects on pulmonary function is unclear.
To analyze associations between marijuana (both current and lifetime exposure) and pulmonary function....
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PMID: 22235088
PDF is available here.
PDF is available here.
Abstract
Links are well established between both family history of diabetes and reduced birthweight and increased risk of diabetes in adulthood.
1) To investigate the influence of parental history of type 2 diabetes (T2DM) on offspring birthweight and adult offspring glucose t...
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PMID: 21916855
PDF is available here.
PDF is available here.
Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
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PMID: 21812099
PDF is available here.
PDF is available here.
Abstract
We experienced a case of a peritoneal dialysis patient with chronic hepatitis C who was successfully treated with PEG-IFN monotherapy. A 50-year old man was undergoing peritoneal dialysis because of diabetic nephropathy. Considering that his HCV genotype was 2, we decided to treat him with PEG-IFN a...
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PMID: 21873827
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Abstract
We describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-γ) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall...
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PMID: 21917970
PDF is available here.
PDF is available here.
Abstract
We hypothesized that, with hypertension, localized iNOS inhibition would restore vasodilation in response to NO-dependent stimuli, and iNOS expression would be increased and phosphorylated vasodilator-stimulated phosphoprotein would be decreased. For, in vivo protocols, 4 intradermal microdialysis f...
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PMID: 21931069
PDF is available here.
PDF is available here.
Abstract
We established a new limited sampling strategy to assess CYP3A activity and evaluated the time course of reversible (voriconazole) and irreversible (ritonavir) CYP3A inhibition. In this randomized trial, two groups, each with eight healthy participants, received CYP3A inhibitors voriconazole or riton...
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PMID: 21937987
PDF is available here.
PDF is available here.
Abstract
Although extensive evidence support the key role of adipokines in cartilage homeostasis, contradictory data have been found for their expression and their effects in chondrocytes. This study was then undertaken to determine whether a phenotypic modulation may affect the expression of adipokines and t...
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PMID: 21935928
PDF is available here.
PDF is available here.
Abstract
Although feeling bothered by the sexual unresponsiveness of an intimate partner was significantly associated with both women's and men's depressive symptoms, the moderating effect of the partner's supportiveness was significant only for women. Discussion. The results suggest that gender is a key d...
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PMID: 21918124
PDF is available here.
PDF is available here.
Abstract
Comparison of surgical results on obese patients undergoing hysterectomy by robot-assisted laparoscopy or laparotomy.
University hospital.
All women (n=114) with a BMI ≥30 kg/m(2) who underwent a simple hysterectomy as the main surgical procedure bet...
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PMID: 21854364
PDF is available here.
PDF is available here.
Abstract
We analyzed the ability of each management strategy to control anemia and neutropenia and the percentage of subjects who achieved a successful treatment outcome according to the different management strategies.
During treatment, 43 subjects developed anemia (human erythropoietin, n =...
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PMID: 21876446
PDF is available here.
PDF is available here.
Abstract
We present the adaptation of the Behavioral Activation for Depression Scale (BADS), developed by Kanter, Mulick, Busch, Berlin, and Martell (2007), in a Spanish sample. The psychometric properties were tested in a sample of 263 participants (124 clinical and 139 non-clinical). The results show that,...
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PMID: 22059343
PDF is available here.
PDF is available here.
Abstract
Research has demonstrated impairments in executive functions in Bipolar Mood Disorder patients. Evidence shows that this impairment is present in both periods of active symptoms of the disorder, as well as euthymic stages, and is compounded by mood episodes, especially manic phases....
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PMID: 22059331
PDF is available here.
PDF is available here.
Abstract
This study was designed to develop a computerized test to assess gender roles. This test is presented as a decision-making task to mask its purpose. Each item displays a picture representing an activity and a brief sentence that describes it. Participants have to choose the most suit...
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PMID: 22059334
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine the factorial validity of the Job Expectations Questionnaire (Cuestionario de Expectativas Laborales CEL) in a sample of Mexican workers. Following a cross validation approach, two samples were used in the study. The first sample consisted of 380...
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PMID: 22059344
PDF is available here.
PDF is available here.
Abstract
The present study tests the relationships between the three frequently used personality models evaluated by the Temperament Character Inventory-Revised (TCI-R), Neuroticism Extraversion Openness Five Factor Inventory - Revised (NEO-FFI-R) and Zuckerman-Kuhlman Personality Questionnai...
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PMID: 22059312
PDF is available here.
PDF is available here.
Abstract
General Factor of Personality (GFP) research is an emergent field in personality research. This paper uses a theoretical mathematical model to predict the short-term effects of a dose of a stimulant drug on GFP and reports the results of an experiment showing how caffeine achieves th...
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PMID: 22059314
PDF is available here.
PDF is available here.
Abstract
We formed a sample of professionals who took on the role of negotiator when we provoked an organizational conflict between a superior and subordinate that escalates due to the intervention of research confederates. Trained judges analyzed the negotiators' behaviors that most effectively mitigated th...
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PMID: 22059324
PDF is available here.
PDF is available here.
Abstract
The impact of personality and job characteristics on parental rearing styles was compared in 353 employees. Hypotheses concerning the relationships between personality and job variables were formulated in accordance with findings in past research and the Belsky's model (1984). Struct...
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PMID: 22059313
PDF is available here.
PDF is available here.
Abstract
Spain is one of the EU countries that receive most immigrants, especially from Latin America. The process of migration implies a high level of stress what may have repercussions for the mental health of immigrants. The purposes of this study were: (a) to determine whether the degree...
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PMID: 22059329
PDF is available here.
PDF is available here.
Abstract
We describe three patients from one Spanish family affected by this disease. All three cases underwent comprehensive clinical and neuropsychological examination, and were monitored for seven years. The results obtained in this study describe a) a significant loss of the intelligence quotient (IQ) an...
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PMID: 22059337
PDF is available here.
PDF is available here.
Abstract
We have explored the psychometric properties and construct validity of the Turkish adaptation of the Mathematics Teacher Efficacy Belief Instrument developed by Enochs, Smith, & Huinker (2000) for in-service mathematics teachers. The instrument distinguishes between two dimensions of efficacy belief...
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PMID: 22059339
PDF is available here.
PDF is available here.
Abstract
We the adaptation and testing of the psychometric properties of the Running Addiction Scale (RAS) in Spanish. To this end, we conducted two independent studies. The aim of the first was to present the first preliminary psychometric data (pilot sample of 174 marathon runners). Explained the process o...
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PMID: 22059340
PDF is available here.
PDF is available here.
Abstract
These results provided empirical evidence in favour of the reliability and validity of the Parenting Stress Index-Short Form in Spanish fathers, and can be useful to elucidate the mechanisms through which stress impacts parenting and permitting to develop more targeted interventions for infants and...
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PMID: 22059342
PDF is available here.
PDF is available here.
Abstract
A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematologic malignancies who are older or have comorbid conditions.
To describe outcomes of patients 60 years or older afte...
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PMID: 22045765
PDF is available here.
PDF is available here.
Abstract
Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology.
To d...
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PMID: 22045767
PDF is available here.
PDF is available here.
Abstract
Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitia...
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PMID: 21849225
PDF is available here.
PDF is available here.
Abstract
Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitia...
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PMID: 21849225
PDF is available here.
PDF is available here.
Transplantation (92)8 2011
Abstract
We examined 10 stable kidney transplant patients (mean estimated glomerular filtration rate 51±10 mL/min/1.73 m(2)) who received cinacalcet daily for persistent hyperparathyroidism. Urine specimens were collected at baseline and every 2 hr for a total study period of 6 hr after ingestion of 30 mg c...
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PMID: 21876476
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)45 2011
Abstract
Incidence of the JAK2 mutation in their patients with chronic myeloproliferative neoplasia subgroups mainly corresponds to the literary data. Thrombosis ensued both in JAK positive polycythemia vera and essential thrombocythemia cases occurred nearly in the same number, but the incidence of thrombos...
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PMID: 22011365
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)45 2011
Abstract
The results suggest that the prevalence of HPV in this study population exceeds the international data. The results attracts the attention the peak prevalence of the high risk types in the youngest age-group, and the higher risk of cervical abnormality in case of presence of two or more HPV types. T...
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PMID: 22011366
PDF is available here.
PDF is available here.
Abstract
Smoking is a major risk factor for both cancer and chronic obstructive pulmonary disease (COPD). Computed tomography (CT)-based lung cancer screening may provide an opportunity to detect additional individuals with COPD at an early stage.
To determine whether low-dose...
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PMID: 22028353
PDF is available here.
PDF is available here.
Abstract
We have modified the original apparatus for organ bioassay in order to minimize foaming and to increase analytical performance. By using this modified bioassay we investigated the vasodilatory potency of various endogenous RSNOs in the presence of physiologically relevant concentrations of albumin a...
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PMID: 21827780
PDF is available here.
PDF is available here.
Abstract
We find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited win...
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PMID: 21964341
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)41 2011
Abstract
MMW Fortschritte der Medizin (153)41 2011
Abstract
Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
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PMID: 21976613
PDF is available here.
PDF is available here.
Abstract
Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.
To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free...
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PMID: 21990299
PDF is available here.
PDF is available here.
Abstract
We evaluated the incidence of positive lymph nodes in the presacral and retroperitoneal regions in patients who underwent radical cystectomy and extended pelvic lymph node dissection for urothelial bladder cancer.
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PMID: 21849181
PDF is available here.
PDF is available here.
Abstract
We examined the growth of tissue proven renal oncocytoma on serial imaging to improve our understanding of its natural history.
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PMID: 21849182
PDF is available here.
PDF is available here.
Abstract
A novel platform was developed that fuses pre-biopsy magnetic resonance imaging with real-time transrectal ultrasound imaging to identify and biopsy lesions suspicious for prostate cancer. The cancer detection rates for the first 101 patients are reported.
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PMID: 21849184
PDF is available here.
PDF is available here.
Abstract
Men at risk for prostate cancer may concurrently experience chronic prostatitis or pelvic pain. We evaluated the effect of dutasteride on prostatitis-like symptoms in the REDUCE study population.
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PMID: 21849186
PDF is available here.
PDF is available here.
Abstract
We investigated whether the exercise response varied by the prior duration of exposure to androgen suppression therapy, that is acute-less than 6 months vs later-6 months or greater....
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PMID: 21849187
PDF is available here.
PDF is available here.
Abstract
We investigated whether serum amino acid profiles are a potentially useful biomarker in patients with renal cell carcinoma....
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PMID: 21849193
PDF is available here.
PDF is available here.
Abstract
We hypothesized that HLA-DR(+) CD38(+) (DR(+) 38(+)) CD4(+) T cells produce the majority of HIV-1 due to elevated expression of CCR5 and CXCR4. In phytohemagglutinin (PHA)-stimulated CD8-depleted peripheral blood mononuclear cells (PBMC) infected with HIV-1 green fluorescent protein (GFP) reporter v...
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PMID: 21813616
PDF is available here.
PDF is available here.
Abstract
Serum C-reactive protein has been shown to have prognostic value in localized and metastatic renal cell carcinoma. However, the prognostic value of intratumor C-reactive protein remains unknown.
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PMID: 21849188
PDF is available here.
PDF is available here.
Abstract
From the perspective of oncological and functional outcomes partial nephrectomy is considered standard surgery for small renal tumors 4 cm or less. However, radical nephrectomy is commonly done for small tumors. It is important to predict postoperative renal function in patients to choose the most op...
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PMID: 21849191
PDF is available here.
PDF is available here.