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Pharmaceutical Preparations (21)
Articles on Pharmaceutical Preparations
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A rapid UHPLC method for the simultaneous determination of drugs from different therapeutic groups in surface water and wastewater.
Bull Environ Contam Toxicol 89(1):8-14 (2012) PMID 22487965
A SPE-UHPLC-UV method for the determination of 13 pharmaceuticals from different therapeutic groups in surface water and wastewater samples was proposed. The following three solid-phase-extraction (SPE) columns with polymeric sorbents were used as a pre-concentration step: the Oasis... -
Limited options to manage specialty drug spending.
pubmed 1 Apr 2012 PMID 23155549
Spending on specialty drugs--typically high-cost biologic medications to treat complex medical conditions--is growing at a high rate and represents an increasing share of U.S. pharmaceutical spending and overall health spending. Absence of generic substitutes, or even brand-name ther... -
The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population.
Expert Rev Clin Pharmacol 5(2):187-97 (2012) PMID 22390561
Although numerous initiatives and interventions have been developed to promote medication safety, medication incidents still remain an important cause of hospitalization. To avoid this, it is important for physicians to prescribe safely. To date, the Beers criteria have been the most... -
Rapid screening of drug compounds in urine using a combination of microextraction by packed sorbent and rotating micropillar array electrosp...
Rapid Commun Mass Spectrom 26(3):297-303 (2012) PMID 22223316
We found that the C(2), C(8) and C(18) sorbents in combination with 96% alkaline methanol as an eluent worked the best. All compounds were easily detected and identified by MS/MS in spiked urine samples. The whole qualitative analytical procedure was rapid as the sample treatment together with the M... -
Application of on-line nano-liquid chromatography/mass spectrometry in metabolite identification studies.
Rapid Commun Mass Spectrom 26(3):320-6 (2012) PMID 22223319
We have developed a method that utilizes a nano-LC system coupled to a high-resolution tandem mass spectrometer to identify metabolites from in vitro and in vivo samples. Using this approach, we were able to increase the sensitivity of analysis by approximately 1000-fold over HPLC/MS. In vitro sampl... -
The prevalence of drugs in injured drivers.
Forensic Sci Int 215(1-3):14-7 (2012) PMID 21377816
In mid 2009 Victoria introduced compulsory drug testing of blood taken from all injured drivers taken to hospital. Δ(9)-Tetrahydrocannabinol (THC), methylamphetamine (MA) and 3,4-methylenedioxy-methylamphetamine (MDMA) are prohibited and if drivers are positive to any amount an auto... -
Avastin doesn't blind people, people blind people.
Am J Ophthalmol 153(2):196-203.e1 (2012) PMID 22264942
To review the appropriate preparation of bevacizumab for intravitreal injection by compounding pharmacies with specific recommendations designed to prevent microbial contamination. Perspective. A review and discussion of compounding issues with support... -
Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines.
J Gerontol A Biol Sci Med Sci 67(2):175-80 (2012) PMID 21835808
Hepatic clearance plays a key role in determining the systemic exposure of drugs and metabolites, which in turn has a major effect on variability in the beneficial and adverse effects of medicines. Aging results in a number of significant changes in the human liver including reductio... -
Greece's financial crisis dries up drug supply.
Lancet 379(9813):302 (2012) PMID 22292163
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Medication shortages threaten cancer care: the oncology community and the FDA tackle ongoing drug shortage problem.
Cancer 118(2):289-91 (2012) PMID 22222939
