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Tablets (1):
Recent article
Tablets
Abstract
Two methods for determination of imidapril hydrochloride (IMD) in the form of tablets were developed and the stability-indicative determination of IMD in solid state formulations by means of the proposed methods was investigated. IMD is not a pharmacopeial raw material, therefore there is no official...
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PMID: 21928708
PDF is available here.
PDF is available here.
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Abstract
The present investigation concerns with the development and optimization of a bipolymeric delivery device for the treatment of colonic diseases. Prednisolone - a popular glucorticoid was used a model drug. The formulations were designed with an objective to deliver the drug to the large bowel with a...
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PMID: 21928719
PDF is available here.
PDF is available here.
Abstract
The purpose of this research was to develop oro-dispersible tablets of metformin by direct compression method using super disintegrants approach, effervescent approach and sublimation approach. Powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausne...
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PMID: 21928717
PDF is available here.
PDF is available here.
Abstract
Quinolones have a broad spectrum of activity against bacteria and are a class of synthetic antimicrobial modeled after nalidixic acid.
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PMID: 21913534
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)37 2011
Abstract
Nearly 90% of the diabetic patients are suffering of type 2 diabetes while approximately 60-65% of patients with type 2 diabetes are treated with oral antidiabetic drugs. In the last couple of years a new treatment option, namely incretin-based therapy, became available. The dipeptid...
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PMID: 21893477
PDF is available here.
PDF is available here.
Abstract
The administration of dose-adjusted controlled-release hydralazine according to the acetylation status of cancer patients yields similar levels of hydralazine....
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PMID: 21781652
PDF is available here.
PDF is available here.
Abstract
The geometric means, Cmax, of the reference and the test formulations were 696.42 and 734.06 ng/ml. The mean values of the AUC0-t and AUC0-inf of the test formulation were 2,073.03 and 2,237.37 ng × h/ml, while those of the reference formulation were 1,950.26 and 2,078.06 ng × h/ml. The geometric...
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PMID: 21781653
PDF is available here.
PDF is available here.
Abstract
Ae((0 - 24 h)) increased by 42% (uncorrected, p = 0.0001) and 30% (creatinine-corrected, p = 0.0001), after intake, compared with the placebo; serum calcium exposure (AUC((0 - 6 h))) was also, statistically, significantly greater. PTH, in serum, decreased by 28% (AUC((0 - 6 h)), p = 0.0001) and 14%...
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PMID: 21635154
PDF is available here.
PDF is available here.
Abstract
The main aim of present investigation was to develop sustained release matrix tablets of Gliclazide using fruit mucilage from the plant Ficus glomerata. Varying ratios of drug and polymer viz. 1:0.25, 1:0.5, 1:0.75, 1:1.0 and 1:1.25 were selected for the study. The flow properties of powdered mucilag...
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PMID: 21715275
PDF is available here.
PDF is available here.
Abstract
The 90% confidence intervals for Test/Reference ratios of the pharmacokinetic parameters (Cmax, AUC0-t and AUC0-∞) of both risperidone and its active metabolite (9-hydroxyrisperidone) fell within the acceptable bioequivalence range (80 - 125%) according to ASEAN guideline. Conclusion: The two risp...
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PMID: 21612749
PDF is available here.
PDF is available here.
Abstract
Abstract
The roles of magnesium oxide (MgO) release from solid dispersions (SDs) in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and water were investigated to elucidate the enhanced dissolution and reduced intestinal damages of telmisartan as a model drug. The polyethylene glycol 6000 (PEG...
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PMID: 21656360
PDF is available here.
PDF is available here.
Abstract
The present work was aimed at designing microsponge based colon specific drug delivery system containing paracetamol. Eudragit S-100 based microsponges containing drug in varying amounts were prepared using quasi-emulsion solvent diffusion method. The microsponges were prepared by optimizing various...
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PMID: 21656358
PDF is available here.
PDF is available here.
Abstract
Oral transmucosal fentanyl citrate lozenges (lollipops) are indicated for the oral management of breakthrough cancer pain. When abused, these sucrose-containing lozenges can cause rampant dental caries.
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PMID: 21454846
PDF is available here.
PDF is available here.
Abstract
Enalapril maleate, one of the Angiotensin converting enzyme (ACE) inhibitor is effective in the treatment of hypertension. Enalapril maleate is selected for the present study. The aim of this study was to develop a new formulation of Enalapril maleate tablet and its comparative evalu...
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PMID: 21454172
PDF is available here.
PDF is available here.
Abstract
The objective of the study was to formulate and evaluate controlled release polymeric tablets of Diclofenac Potassium for the release rate, release patterns and the mechanism involved in the release process of the drug. Formulations with different types and grades of Ethyl Cellulose...
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PMID: 21454168
PDF is available here.
PDF is available here.
Abstract
Nanonization, which involves formulating the drug powder as nanometer-sized particles, is a known method to improve drug absorption and allow the intravenous administration of insoluble drugs. This study investigated a novel femtosecond (fs) laser technique for the fabrication of nanocrystals in aque...
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PMID: 20809524
PDF is available here.
PDF is available here.
Abstract
I studies and later were updated with data from a phase IIb study. The population pharmacokinetic model described differences between the liquid-filled capsule used in phase I and phase IIb and the hot-melt extruded (HME) tablet formulation introduced in phase III, allowing for bridging of the two f...
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PMID: 21347617
PDF is available here.
PDF is available here.
Abstract
To compare the efficacy and tolerability of oral hyoscine butylbromide tablets and capsules in Chinese patients with recurrent episodes of self-reported gastric or intestinal spasm-like pain and to show non-inferiority of both formulations.
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PMID: 21329622
PDF is available here.
PDF is available here.
Abstract
It were established and validated the conditions of voltammetric determination of copper in pharmaceutical preparations. The three selected preparations: Zincuprim (A), Wapń, cynk, miedź z wit. C (B), Vigor complete (V) contained different salts and different quantity of copper (II) and increasing...
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PMID: 21485290
PDF is available here.
PDF is available here.
Abstract
Meloxicam is a cyclooxygenase-2, preferential inhibitor non-steroidal anti-inflammatory drug (NSAID) and belongs to an enolic acid (oxicam) class used for the treatment of osteoarthritis and rheumatoid arthritis. The purpose of this single dose randomized cross-over study was to assess bioequivalence...
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PMID: 21485709
PDF is available here.
PDF is available here.
Abstract
The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of...
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PMID: 21485300
PDF is available here.
PDF is available here.
Abstract
A new, simple, sensitive luminescence methods for the determination of carvedilol have been developed and validated. Carvedilol was remarkably quenching the luminescence intensity of the Tb(III) ion in the new terbium complex with 1-butyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid-(4-meth...
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PMID: 21648186
PDF is available here.
PDF is available here.
Abstract
The objective of the present work was to optimize the formulation of fast disintegrating tablets (FDTs) of ondansetron HCl containing novel superdisintegrants, possessing sufficient mechanical strength and disintegration time comparable to those containing crospovidone or croscarmellose sodium. The F...
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PMID: 21796940
PDF is available here.
PDF is available here.
Abstract
In the present study, the possible interactions between celecoxib and some excipients (colloidal silicon dioxide (Aerosil), microcrystalline cellulose (Avicel PH 102), lactose anhydrous, magnesium stearate, cross-povidone and talc) were evaluated by examining the pure drug or drug-excipient powder mi...
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PMID: 21648198
PDF is available here.
PDF is available here.
Abstract
We measured 3-yr changes in cortical BMD (CtBMD), cortical thickness (CtThk), periosteal circumference (PC), endosteal circumference (EC), and strength-strain index (SSI) at 1/3 midshaft femur (N=171), and trabecular BMD (TbBMD), PC, and SSI at 4% distal tibia (N=162). We found no treatment effect o...
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PMID: 21295742
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
Prasugrel (CAS 150322-43-3), an inhibitor of platelet activation and aggregation, is indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome. If a proton pump inhibitor is co-administered with prasugrel, a pH dependent salt-to-base conversion rate of...
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PMID: 21650084
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
The present study was performed to compare the bioavailability of two perindopril erbumine (CAS 107133-36-8) 4 mg tablet formulations (test formulation and reference formulation). This study was a randomized, single-blind, two-period, two-sequence cross-over study which included 20 healthy adult male...
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PMID: 21650082
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)4 2011
Abstract
A randomised, double blind, parallel groups, placebo controlled clinical trial was conducted to assess the efficacy and safety profile of 250 mg ascorbic acid (Vit. C, Vagi C) in women with bacterial vaginosis (BV). Overall, 277 out-patients with at least three of the following signs (white discharge...
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PMID: 21650086
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A randomized, two-treatment and two-way crossover study on twelve healthy Indian male subjects was conducted to assess the bioequivalence of two tablet formulations containing 20 mg of rimonabant (CAS 158681-13-1). Both of the formulations were administered orally as a single dose wi...
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PMID: 21428241
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)50 2010
Abstract
We wanted to test whether we, by using data on thousands of prescriptions, could answer a prosaic yet very timely question: Which penicillin is most widely accepted?
By use of the Odense PharmacoEpidemiological Database (OPED) we extracted data on all penicillin prescriptions issued to children in t...
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PMID: 21156107
PDF is available here.
PDF is available here.
Abstract
Placebo granules consisting of lactose monohydrate, corn starch, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration, and pressure data obtained over the course of dry...
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PMID: 21061102
PDF is available here.
PDF is available here.
Abstract
Tamsulosin, an alpha1 adrenoceptor blocking agent, exhibits selectivity for alpha1 receptors in human prostate. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of benign pro...
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PMID: 21084043
PDF is available here.
PDF is available here.
Abstract
We report iron-sulfate-induced mucosal injury of the hypopharynx in a patient receiving therapeutic oral iron supplementation. The patient presented with dysphagia when swallowing pills, but not when eating or drinking. Imaging studies and clinical examination revealed an ulcerated and protuberant h...
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PMID: 20975344
PDF is available here.
PDF is available here.
Abstract
The main objective of the present study was to develop an orally disintegrating tablet formulation of domperidone and to study the functionality differences of superdisintegrants each obtained from two different sources on the tablet properties.
Domperidone tablets were formulated with different sup...
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PMID: 21155386
PDF is available here.
PDF is available here.
Abstract
Abstract
We report the experimental protocols developed for in situ MRI studies and the effect that the operating conditions and tablet orientation have on the hydrodynamics inside commercial flow cells. It was found that the flow field inside the dissolution cells was, at most operating conditions, heteroge...
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PMID: 20949631
PDF is available here.
PDF is available here.
Abstract
Abstract
Our findings show that both preparations exhibit sustained release characteristics; also the structure of the device considerably affects the drug release and the release rate. Furthermore erosion and swelling greatly influence the overall behavior, function and performance of the systems. Finally k...
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PMID: 20695845
PDF is available here.
PDF is available here.
Abstract
We find that the rate of water ingress has no direct influence on release kinetics, which also renders air in the tablets a secondary factor. On the other hand, drug release is directly correlated with the polymer mobilization kinetics. Water diffusion into the originally dry polymer grains determin...
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PMID: 20561585
PDF is available here.
PDF is available here.
Abstract
We evaluated the relative bioavailability, safety, and therapeutic adequacy of a novel chewable pediatric FDC tablet of stavudine (7 mg), lamivudine (30 mg), and nevirapine (50 mg), referred to as GPO-VIR S7, and compared it with the individual original brand-name liquid formulations in human immuno...
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PMID: 20453709
PDF is available here.
PDF is available here.
Abstract
In a previous study it has been demonstrated that a dissolution/permeation (D/P) system can discriminate between different immediate release fenofibrate formulations. The fractions permeated were correlated with fenofibrate's in vivo exposure in rats following p.o. administration. In the present stu...
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PMID: 21105572
PDF is available here.
PDF is available here.
Abstract
Near-infrared spectroscopy offers tremendous advantages for pharmaceutical manufacturing as a fast and nondestructive method of quantitative and qualitative analysis. Content uniformity (end-product analytics) and process analytics are two important applications of the method. Diffuse reflection (DR)...
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PMID: 20862671
PDF is available here.
PDF is available here.
Abstract
To observe the pharmacological effects of Heart tablets on cardiac function and its mechanism, the effects on cardiac hemodynamics and myocardial oxygen consumption in anesthetized dogs were observed.
Observe the effect of Heart tablets on coronary blood flow, cardiac output, myocardial oxygen consu...
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PMID: 21141505
PDF is available here.
PDF is available here.
Abstract
A simple, rapid, and precise method is developed for the quantitative simultaneous estimation of amlodipine (AM) and olmesartan (OL) in combined pharmaceutical dosage form. A chromatographic separation of the two drugs was achieved with an ACE 5 C(18) 25-cm analytical column using buffer-acetonitril...
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PMID: 20819287
PDF is available here.
PDF is available here.
Abstract
In this study, the fluid uptake (swelling) kinetics and disintegrant properties of gellan gum in metronidazole tablets were evaluated in both simulated gastric and intestinal fluids (SGF and SIF respectively) without enzymes. The mechanical properties as well as the disintegration and dissolution pr...
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PMID: 20471410
PDF is available here.
PDF is available here.
Abstract
Abstract
The limit of quantification for escitalopram was 0.2 ng x ml(-1). The geometric mean with corresponding 90% confidence interval (CI) for Test/Reference percent ratios were 97.35% (90% CI = 90.28-104.96%) for C(max), 99.60% (90% CI = 92.93-106.74%) for AUC(last) and 99.92% (90% CI = 93.34-106.97%) fo...
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PMID: 20650049
PDF is available here.
PDF is available here.
Abstract
The purpose of this investigation was to introduce a new concept of admixing coated pellets with excipients to obtain a segregation-free combination of pellet-containing granules and cushioning granules during mixing and compression.
Acrylic polymeric-coated pellets were granulated by centrifugal gr...
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PMID: 20433923
PDF is available here.
PDF is available here.
Abstract
For the first time quantitative Rapid Acquisition with Relaxation Enhancement (RARE) based ultra-fast two-dimensional magnetic resonance imaging has been used to follow the dissolution of hydroxypropylmethyl cellulose (HPMC) in water. Quantitative maps of absolute water concentration...
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PMID: 20229597
PDF is available here.
PDF is available here.
Abstract
We demonstrate that size enlargement is an important mechanism for over-granulation in HSWG. A higher granulation water level results in larger granules and lower tabletability. With increasing water, granules enlarge sharply when water level is higher than 65%. Granule tabletability deteriorates wi...
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PMID: 20232456
PDF is available here.
PDF is available here.
Abstract
We conclude that the method presented herein is useful for the quantification of naratriptan in pharmaceutical drugs and that this method requires no separations or extractions. Finally, this voltammetric method was successfully applied to determine the quantity and the content uniformity of naratri...
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PMID: 20602972
PDF is available here.
PDF is available here.
Abstract
Tricalcium phosphate and calcium carbonate appear to be approximately equally effective in supporting bone building with a potent anabolic agent; phosphate salt may be preferable in patients with restricted phosphorus intakes. This trial was registered at clinicaltrials.gov as NCT00074711....
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PMID: 20484446
PDF is available here.
PDF is available here.
Abstract
To investigate the colon specificity of novel natural polymer khaya gum and compare with guar gum. Release profile of tablets was carried out in presence and absence of rat cecal contents. The fast disintegrating core tablets of budesonide, were initially prepared by direct compression technique. La...
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PMID: 20566437
PDF is available here.
PDF is available here.
Abstract
The mean +/- SD of pharmacokinetic parameters of generic product and the innovator's product were 0.82 +/- 0.52 vs. 1.02 +/- 1.50 hr of Tmax, 796.51 +/- 155.19 vs. 723.48 +/- 134.69 ng/ml of Cmax, 3.94 +/- 0.80 vs. 3.87 +/- 0.77 hr of T1/2, 4,308.43 +/- 1,006.28 vs. 4,135.66 +/- 1,061.96 ng x hr/ml...
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PMID: 20572378
PDF is available here.
PDF is available here.
Abstract
To study the preparation of fufangxiaoyepipa dispersible tablets and evaluate its quality.
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PMID: 21049626
PDF is available here.
PDF is available here.
Abstract
During the introduction of a new once-daily nifedipine 60 mg osmotic delivery tablet to Canada in 2009, several patients previously maintained at target blood pressure on regimens that included nifedipine 60 mg daily were observed to have > 10 mmHg rises in their systolic pressure during follow-up....
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PMID: 20497748
PDF is available here.
PDF is available here.
Abstract
Abstract
The adsorption mechanism of the poorly water-soluble drug carbamazepine onto crosslinked polyvinylpyrrolidone (crospovidone) was investigated by adsorption isotherms in different solvents and Fourier-transformation infrared spectroscopy (FTIR). The drug adsorption was a result of hydrogen bonds betw...
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PMID: 20214967
PDF is available here.
PDF is available here.
Abstract
The use of a light induced fluorescence (LIF) instrument to estimate the total content of fluorescent active pharmaceutical ingredient in a tablet from surface sampling was demonstrated. Different LIF sampling strategies were compared to a total tablet ultraviolet (UV) absorbance test for each table...
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PMID: 20156535
PDF is available here.
PDF is available here.