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Pharmaceutic Aids (4):
Recent article
Pharmaceutic Aids
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (60)1 2011
Abstract
The paper emphasizes the need of the introduction of the subject Chemistry of Pharmaceutical Auxiliaries into the Pharmacy study programme at more colleges in the Czech and Slovak Republics. It also introduces and discusses some topics for possible extension of the content of the courses of the subje...
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PMID: 21650013
PDF is available here.
PDF is available here.
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Abstract
The aim of the present study was the evaluation of basic fibroblast growth factor (bFGF, FGF-2) release in vitro from four types of polymer bases (carriers), fibrin, microcrystalline chitosan (MCCh), fibrin and MCCh, as well as MCCh and methylcellulose (MC) in the presence or absence of ketoprofen (...
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PMID: 21155388
PDF is available here.
PDF is available here.
Abstract
Significant improvement of solubilization kinetics of poorly soluble vinpocetine was obtained through a mechanochemical activation process in presence of micronized crospovidone. Drug-to-polymer weight ratio and milling time variables resulted to have statistically significant impacts on the activati...
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PMID: 20839363
PDF is available here.
PDF is available here.
Abstract
The current formulation of paclitaxel causes significant side effects, so there is a need to develop a safer delivery system. In this study, novel semi-solid lipid nanoparticles (PEG-PE-SSLN) were prepared, and evaluated as delivery vehicles for paclitaxel. The PEG-PE-SSLN are approximately 213 nm i...
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PMID: 20662317
PDF is available here.
PDF is available here.
Abstract
The purpose of the present study was to prepare multivesicular liposomes (MVL) with a high drug loading capacity for intramuscular sustained release and to investigate their potential applicability towards tramadol, and to improve the stability of liposomes by coating PEG. The basic physiochemical p...
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PMID: 20662312
PDF is available here.
PDF is available here.
Abstract
Monodisperse magnetic iron oxide nanoparticles (MNPs), coated with PEG at different molecular weight, were prepared via self-assembly method. The particle diameters were measured by dynamic light scattering and transmission electron microscope. Increasing the molecular weight of PEG in the coating p...
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PMID: 20662315
PDF is available here.
PDF is available here.
Abstract
CTP provided a significant (p = 0.01) antiplaque effect versus CRT. The results are consistent with previously reported data for CTT. All three examiners demonstrated a strong correlation for this clinical study utilizing the MGMPI methodology. CONCLUSION: This clinical investigation examined the ef...
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PMID: 20527504
PDF is available here.
PDF is available here.
Abstract
The free fraction of naproxen increased significantly after the infusion of albumin (P<0.05). The increase was concurrent with the appearance of N-acetyl-dl-tryptophan and caprylate in serum. The free fraction of naproxen declined rapidly after the albumin infusion was completed. N-acetyl-dl-tryptop...
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PMID: 19878101
PDF is available here.
PDF is available here.
Abstract
The aim of the present study was to investigate the influence of Eudragit E PO on the drug release mechanism of Eudragit L 100-55 film coatings applied to theophylline tablets by a dry powder coating technique. The process was entirely liquid-free. Calculation of the Flory-Huggins interaction parame...
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PMID: 19883252
PDF is available here.
PDF is available here.
Abstract
Paclitaxel (PTX) is a potent anticancer agent whose clinical usefulness is marred by a delivery problem that is caused by its unfavorable pharmacokinetic and physical properties. Paclitaxel is currently formulated in a mixture of Cremophor EL and ethanol, which is diluted 5-20 times with normal sali...
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PMID: 20001890
PDF is available here.
PDF is available here.
Abstract
Topical microemulsion of capsaicin without surfactant was developed in this study. In these systems, the oil phase was benzyl alcohol, and the cosurfactant was propylene glycol and ethanol. The drop-size of the systems was measured by dynamic light scattering method in order to distinguish true solu...
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PMID: 19043219
PDF is available here.
PDF is available here.
Abstract
During the last few decades microporous and mesoporous materials have been considered for medical use due to biological properties and stability in biological environment. Zeolites have been investigated as drug carriers, and as adjuvants in anticancer therapy, dietetic supplements or antimicrobial...
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PMID: 18991756
PDF is available here.
PDF is available here.
Abstract
Physical stability studies of valdecoxib (VLB) and its solid dispersions with PVP (1, 2, 5, 10, 15 and 20% w/w) were carried out by Differential Scanning Calorimetry (DSC). Change in specific heat with time was measured to determine the degree of crystallinity of amorphous drug and its binary disper...
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PMID: 19069241
PDF is available here.
PDF is available here.
Abstract
A simple high-performance liquid chromatography (HPLC) method to determine the content of betulinic acid (BA) in rat plasma collected at different times (0-8 h) after oral administration of Orthosiphon stamineus leaf extract was developed. The features of the assay include protein precipitation usin...
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PMID: 19069237
PDF is available here.
PDF is available here.
Abstract
The above formulation is reasonable and the disintegration time is suitable, so it can provide theoretic support for industrialization....
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PMID: 19230415
PDF is available here.
PDF is available here.
Abstract
A carbon paste electrode modified with poly(vinylpyrrolidone) (PVP) was developed for the determination of rutin. PVP enhances the adsorption of rutin on the electrode surface due to the presence of hydrogen bonding between the imide group in PVP and the hydroxyl group in rutin. The current response...
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PMID: 18472380
PDF is available here.
PDF is available here.
Abstract
Abstract
15,7 % of the drug pairs differed in dosage, in one quarter each colour or shape was significantly different, and in roughly 3 % the size of the substituted drug differed by more than 50 %. In 9,43 % splitting characteristics of solid oral doses differed and in 1,87 % the substituted drug contained...
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PMID: 18592450
PDF is available here.
PDF is available here.
Abstract
The drug substance SAG/ZK has a short biological half-life and because of its weakly basic nature a strong pH-dependent solubility was observed. The aim of this study was to develop a controlled release (cr) multiple unit pellet formulation for SAG/ZK with pH-independent drug release. Pellets with a...
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PMID: 18226884
PDF is available here.
PDF is available here.
Abstract
We report on the solvency of alkyl imidazolium salts (PF(6)(-)Br(-)Cl(-)) for poorly water-soluble model drugs, albendazole and danazol, indicating their potential application as pharmaceutical solvents/cosolvents. The solubility of albendazole, for example, is increased by more than 10,000 times by...
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PMID: 18291630
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (57)2 2008
Abstract
The field of drug technology widely ulilizes gel systems of high-molecular substances, which have a number of advantages, such as low toxicity, availability, unique physical properties, biocompatibility, mucoadhesivity, and others. Gel systems are used in the field of local as well as general therap...
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PMID: 18578415
PDF is available here.
PDF is available here.
Abstract
We developed an aqueous solution of hypericin non-covalently bound to polyvinylpyrrolidone (PVP). PVP is a poly-N-vinylamide of various degrees of polymerization and forms of intermolecular crosslinks suitable for diagnostic and therapeutic applications. We used PVP (molecular weights of PVP between...
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PMID: 18468384
PDF is available here.
PDF is available here.
Abstract
We also found that the cumulative amount of scutellarin over a period of 12 h of scutellarin was inversely related to the molecular weight of organic amines (r = 0.9134), as well as the logarithm of scutellarin permeability coefficient inversely related to the partition coefficient of organic amines...
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PMID: 18380914
PDF is available here.
PDF is available here.
Abstract
In order to improve the dissolution properties of poorly water-soluble drugs, some drugs were subjected to micronization or prepared as composite particles using supercritical fluid (SCF) technology with carbon dioxide (CO(2)). Solubility in CO(2) is the key when using this method. Solubility affect...
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PMID: 18068261
PDF is available here.
PDF is available here.
Abstract
The mucoadhesive layer, exhibiting a diameter of 2.5mm and a weight of 5mg, comprised polycarbophil-cysteine conjugate (49%), bovine insulin (26%), gluthatione (5%) and mannitol (20%). 74.8+/-4.8% of insulin was released from the delivery system over 6h. Six hours after administration of the patch s...
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PMID: 17706903
PDF is available here.
PDF is available here.
Abstract
Pharmacokinetic profiles of probucol were evaluated after oral administration of the various nanosuspensions in rats. Probucol nanoparticles were prepared by co-grinding with various molecular weights of polyvinylpyrrolidone (PVP K12, PVP K17 and PVP K30) and sodium dodecyl sulfate (SDS). The averag...
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PMID: 18239296
PDF is available here.
PDF is available here.
Abstract
We developed a GLP-1 entrapped microspheres to achieve sustained release GLP-1 for 4-week. GLP-1 was stabilized by GLP-1-zinc complexation with zinc carbonate and encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) with S/O/O solvent extraction to obtain GLP-1 loaded PLGA microspheres (MS). The...
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PMID: 18239299
PDF is available here.
PDF is available here.
Abstract
We used IL-2 mutein as a model protein and evaluated the effect of Tween 80, a non-ionic surfactant. In summary, we found that the dual effects of Tween 80 on the stability of IL-2SA, such as that shaking-induced aggregation of IL-2 mutein was significantly inhibited in the presence of Tween 80. How...
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PMID: 17692480
PDF is available here.
PDF is available here.
Abstract
We discuss case reports of SSO allergy and a recent case series of 12 of 112 dermatitis patients (10.7%) patch-tested during a 6-month period who showed contact allergy to SSO. We provide a list of key corticosteroids and products that can contain SSO, sorbitol, or sorbitol derivatives....
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PMID: 19134439
PDF is available here.
PDF is available here.
Abstract
Pediatricians in this study did not perceive the correct relationship between the presence of acidity in medicines and dental erosion; however, most of them presented a reasonable awareness about the relationship between sugared pediatric medicines and dental caries. Besides, they were unaware about...
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PMID: 18389679
PDF is available here.
PDF is available here.
Abstract
This observation was in line with the clinical findings that anaphylaxis had not developed despite the long use of PVP-I solution, but developed only when he received PVP-I solution treatment where basophils could contact PVP-I in the presence of serum, which was probably due to a broken skin and ve...
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PMID: 18204285
PDF is available here.
PDF is available here.
Abstract
The purpose of the research was to prepare metoclopramide HCl mouth/orally dissolving tablets (MDTs) using glycine, carboxy methyl cellulose and sodium alginate with sufficient mechanical integrity and disintegration time comparable to superdisintegrants. Application of Plackett-Burman design reveal...
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PMID: 18484492
PDF is available here.
PDF is available here.
Abstract
The physical stability, dissolution rate, and solubility enhancement of indomethacin amorphized by co-grinding with 6 pharmaceutical silicates were investigated. Mixtures of indomethacin and silicates were co-ground to amorphous states at room temperature and 75% relative humidity (RH) in a rolling...
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PMID: 18484494
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (57)1 2008
Abstract
The paper deals with the study of the strength and disintegration time of tablets made of directly compressible maltose Advantose 100. It studies the differences of the effects of two types of lubricants, magnesium stearate and sodium stearylfumarate, on the above-mentioned properties, and it also t...
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PMID: 18383920
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to investigate the transdermal iontophoretic delivery of methotrexate, alone or in combination with microneedles, in-vitro and in-vivo using intracutaneous microdialysis in the hairless rat. The average depth of the microdialysis probe in the skin was found to be 0.54 mm. M...
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PMID: 18088502
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (56)6 2007
Abstract
The paper evaluates the differences between the properties of tablets from two coprocessed dry binders based on alpha-lactose monohydrate and cellulose, MicroceLac 100 and Cellactose 80. The substances differ in the type of contained cellulose; MicroceLac 100 contains 25% of microcrystalline cellulo...
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PMID: 18257417
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (56)6 2007
Abstract
The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates--oxycellulose. This substance, prepared by oxidation of cellulose, in contrast to cellulose esters and ethers, has not been not employed in practice in a wide extent yet. However,...
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PMID: 18257415
PDF is available here.
PDF is available here.
Abstract
The effects of roller compaction process parameters, morphological forms of calcium carbonate and particle size of sorbitol on flow, compaction and compression properties were investigated. The morphology of the calcium carbonate and the sorbitol particle size were more influential on the compaction...
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PMID: 17582712
PDF is available here.
PDF is available here.
Drug Delivery (14)6 2007
Abstract
The major indication for testosterone (T) treatment is male hypogonadism that is characterized by low serum T concentrations. Although a recently developed hydroalcoholic gel, Androgel, containing 1% T addresses many of the problems associated with the more conventional formulations, the bioavailabi...
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PMID: 17701528
PDF is available here.
PDF is available here.
Vox Sanguinis (93)2 2007
Abstract
In contrast to a non-balanced 130 kDa, MS 0.4 HES (NB-HES), a 130 kDa, MS 0.42 HES preparation dissolved in a physiologically balanced electrolyte solution (B-HES) does not affect APTT, F VIII:C and vWF in vitro. Both types of HES do not affect platelet aggregation induced by ADP, collagen or TRAP....
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PMID: 17683357
PDF is available here.
PDF is available here.
Abstract
Topical treatment of acne rosacea, a chronic condition characterized by recurrent course for many years, is primarily based on metronidazole preparations. The aim of this study was to evaluate the effect of various acrylic acid polymers, in composition with methylcellulose on metronidazole release r...
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PMID: 17666834
PDF is available here.
PDF is available here.
Archives of Dermatological Research (299)5-6 2007
Abstract
We evaluated effects of a water-soluble polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (named "Radical Radical Sponge" because of its anti-oxidant ability) on melanogenesis, which was promoted by UVA-irradiation to human melanocytes and skin tissues. Radical Sponge markedly scavenged UVA-in...
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PMID: 17333222
PDF is available here.
PDF is available here.
Abstract
Tooth hypersensitivity has long been, and continues to be, the most commonly reported adverse effect of vital tooth whitening with peroxide gels. The complex etiology of whitening-induced tooth hypersensitivity has been a major obstacle in developing a definitive strategy for its prevention. This ar...
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PMID: 17915592
PDF is available here.
PDF is available here.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (56)4 2007
Abstract
The paper deals with the evaluation of tablets from the mixtures of directly compressible starch Starch 1500 and directly compressible lactitol Lacty-Tab in a ratio of 3:1 and 1:1. The examination included the tensile strength and disintegration time of tablets in dependence on compression force, ad...
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PMID: 17969317
PDF is available here.
PDF is available here.
Acta Pharmaceutica (57)2 2007
Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties.
Abstract
Celecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic stud...
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PMID: 17507314
PDF is available here.
PDF is available here.
Abstract
Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmac...
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PMID: 17395893
PDF is available here.
PDF is available here.
Abstract
Spectral peak area analysis has in this study been shown to be a viable method in near-infrared spectroscopy (NIRS) moisture assays. The study also shows that the required number of calibration samples can be minimized, and the method is, therefore, especially suitable for moisture assays in early f...
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PMID: 17391888
PDF is available here.
PDF is available here.
Abstract
Supportive Care Cancer (15)4 2007
Abstract
No significant difference was found between the Gelclair and standard therapy arms in terms of general pain (F = 1.512, df = 1, 17, ns). There did appear to be a trend towards pain improvement initially after the use of Gelclair, but this did not last for the full 24-h assessment period. There was n...
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PMID: 17131132
PDF is available here.
PDF is available here.
Abstract
These results show clearly that dissolution of povidone in melted polyethylene glycol is a prerequisite in order to prevent recrystallization....
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PMID: 17055711
PDF is available here.
PDF is available here.
Abstract
We evaluated the effect of sodium metabisulfite, a preservative commonly added to intravenously administered pharmaceuticals as an antioxidant and previously used as a catheter lock solution, on planktonic and biofilm staphylococci at clinically encountered concentrations. Sodium metabisulfite exhib...
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PMID: 17188446
PDF is available here.
PDF is available here.
Pharmaceutical Research (24)1 2007
Abstract
The observed melts are characteristic of crystalline substances and suggest that the sorbitol crystallizes over time. During freezing, the excipient must remain in the same phase as the protein to ensure protein stability. By crystallizing, the sorbitol is phase-separated from the protein, which lea...
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PMID: 17109212
PDF is available here.
PDF is available here.
Pharmaceutical Research (24)1 2007
Abstract
As exemplified by sorbitol, some common excipients have unexpected effect on bioavailability/bioequivalence, depending on the pharmacokinetic characteristics of the drug, as well as the type and amount of the excipient present in the formulation. More research is warranted to examine other 'common'...
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PMID: 17048115
PDF is available here.
PDF is available here.
Lakartidningen (104)17 2007
Abstract
Acta Pharmaceutica (56)4 2006
Abstract
The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical pr...
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PMID: 19839137
PDF is available here.
PDF is available here.
Contact Dermatitis (55)5 2006
Abstract
We report a case of allergic contact dermatitis to polyvinylpyrrolidone (PVP)/hexadecene copolymer in a purple-colored lipstick and review the literature on allergic contact dermatitis to 7 copolymers: PVP/hexadecene, PVP/eicosene, PVP/1-triacontene, methoxy polyethyleneglycol (PEG)-22/dodecyl glyco...
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PMID: 17026690
PDF is available here.
PDF is available here.
Abstract
Although nicotine replacement therapy (NRT) has shown efficacy in randomized controlled trials, population effectiveness has appeared to diminish after it became available over the counter. The present study examined the population effectiveness of bupropion. It also examined whether...
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PMID: 17008193
PDF is available here.
PDF is available here.
Pharmaceutical Research (23)10 2006
Abstract
To test the hypothesis that the molecular motions associated with chemical degradation in glassy amorphous systems are governed by the molecular motions associated with structural relaxation. The extent to which a chemical process is linked to the motions associated with structural relaxation will d...
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PMID: 16941232
PDF is available here.
PDF is available here.
Pharmaceutical Research (23)10 2006
Abstract
The properties of the metastable form alone did not explain the greater propensity for nifedipine crystallization. When considering the physical stability of amorphous systems, it is important to also consider the properties of the crystalline counterpart....
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PMID: 16927182
PDF is available here.
PDF is available here.
Pharmaceutical Research (23)10 2006
Abstract
When reactive intermediates are involved, differences in degradant profiles and other characteristics (e.g., rate constants, apparent reaction order) in the amorphous-state may simply reflect altered rates for individual reaction steps due to glass-induced changes in relative reactant mobilities rat...
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PMID: 16951993
PDF is available here.
PDF is available here.