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Solutions (7):
Recent article
Solutions
Abstract
Two methods for determination of imidapril hydrochloride (IMD) in the form of tablets were developed and the stability-indicative determination of IMD in solid state formulations by means of the proposed methods was investigated. IMD is not a pharmacopeial raw material, therefore there is no official...
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PMID: 21928708
PDF is available here.
PDF is available here.
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Abstract
We show that studying biomolecular structures in nano-confinements improves the accuracy of cryostructures and provides better insight into the relationship between hydration water and biomolecules. Synthetic prion protein peptides are studied in two experimental conditions: (i) in confined nanochan...
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PMID: 21844377
PDF is available here.
PDF is available here.
Abstract
We observe-at a fixed spin magnetic moment-the subsequent transition of both spin sub-systems from the Fermi liquid to the Wigner crystal state. A dramatic signature of Wigner crystallization is that the persistent current drops sharply with increasing r(S). We observe simultaneously the emergence o...
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PMID: 21811009
PDF is available here.
PDF is available here.
Abstract
In the present study single-crystalline ZnO samples grown from the vapor phase, the melt, and a high-temperature aqueous solution (hydrothermal growth) are investigated before and after hydrogen plasma treatments, by means of deep level transient spectroscopy (DLTS) and high-resolution Laplace DLTS....
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PMID: 21813951
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)8 2011
Abstract
A low density and high strength alloy, Ca65Mg15Zn20 bulk metallic glass (CaMgZn BMG), was evaluated by both in vitro tests on ion release and cytotoxicity and in vivo implantation, aimed at exploring the feasibility of this new biodegradable metallic material for potential skeletal a...
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PMID: 21571105
PDF is available here.
PDF is available here.
Abstract
Abstract
The paper presents the results of viscosity determinations on aqueous solutions of different mammalian serum albumins at a wide range of concentrations and at temperatures ranging from 278 K to 318 K. On the basis of these measurements and a modified Arrhenius equation, the functiona...
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PMID: 21613666
PDF is available here.
PDF is available here.
Abstract
We recently reported that 2-methyl-4-bromopyridine is a quiescent affinity label for the nitric oxide controlling enzyme dimethylarginine dimethylaminohydrolase (DDAH) (Johnson, C. M.; Linsky, T. W.; Yoon, D. W.; Person, M. D.; Fast, W. J. Am. Chem. Soc.2011, 133, 1553-1562). Discovery of this novel...
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PMID: 21630706
PDF is available here.
PDF is available here.
Abstract
We show that (71) Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga complexes and to follow the purification steps of the Ga complex solutions. Copyright © 2011 John Wiley & Sons, Ltd.
Copyright © 2011 John Wiley & Sons, Ltd....
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PMID: 21698774
PDF is available here.
PDF is available here.
Abstract
A simple soft-core model potential is proposed to discuss the self-diffusion of biomolecules in solution. Extensive Brownian-dynamics simulations are performed to obtain the long-time self-diffusion coefficient. Then the simulation results are compared with the experimental data from...
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PMID: 21728529
PDF is available here.
PDF is available here.
Transfusion (51)5 2011
Abstract
In subsets of pediatric cardiac surgery patients, red blood cells (RBCs) are often washed to reduce extracellular potassium (K) to avoid hyperkalemia, but mechanical manipulation and time delay in issuing washed products may increase hemolysis and K. This study's purpose was to evalu...
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PMID: 21091957
PDF is available here.
PDF is available here.
Abstract
We already reported that IPF% values were highly fluctuated in stored whole blood sample with EDTA-2K at 4 degrees C day by day. In this study we investigated the stability of IPF% in blood samples obtained from 11 patients with chronic immune thrombocytopenic purpura (ITP) and 19 healthy volunteers...
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PMID: 21706858
PDF is available here.
PDF is available here.
Abstract
We report a simplified analysis for the orientation-selective DEER data which can be applied when the orientation selection of one spin in the spin pair dominates the orientation selection of the other spin. The dipolar spectra reveal a dominant distance of 3.85 nm and a dominant orientation of the...
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PMID: 21539799
PDF is available here.
PDF is available here.
Abstract
We quantified the effect of crowding by globular proteins on the equilibrium thermodynamic stability of a small globular protein. Theory has long predicted that crowding should stabilize proteins, and experiments using synthetic polymers as crowders show such stabilizing effects. We find that protei...
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PMID: 21506571
PDF is available here.
PDF is available here.
Abstract
Single-molecule free solution hydrodynamic separation (SML-FSHS) cohesively integrates cylindrical illumination confocal spectroscopy with free solution hydrodynamic separation. This technique enables single-molecule analysis of size separated DNA with 100% mass detection efficiency,...
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PMID: 21504160
PDF is available here.
PDF is available here.
Biopolymers (95)8 2011
Abstract
We consider the Porod-Debye law as a powerful tool for detecting biopolymer flexibility in SAS experiments. We show that the Porod-Debye region fundamentally describes the nature of the scattering intensity decay by capturing the information needed for distinguishing between folded and flexible part...
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PMID: 21509745
PDF is available here.
PDF is available here.
Abstract
This note concerns the evaluation of the static acoustic radiation torque exerted by an acoustic field on a scatterer immersed in a nonviscous fluid based on far-field scattering. The radiation torque is expressed as the integral of the time-averaged flux of angular momentum over a spherical surface...
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PMID: 21476624
PDF is available here.
PDF is available here.
Abstract
The development of suitable biomimetic three-dimensional scaffolds is a fundamental requirement of tissue engineering. This paper presents the first successful attempt to obtain electrospun gelatin nanofibers cross-linked with a low toxicity agent, genipin, and able to retain the ori...
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PMID: 21095244
PDF is available here.
PDF is available here.
Abstract
A simple and rapid HPLC method with UV detection was developed for the separation of ciprofloxacin, levofloxacin and moxifloxacin. Chromatography was carried out using a BDS Hypersil C18 (100 x 4.6 mm, 2.4 microm) HPLC column and an isocratic mobile phase consisting of MeOH/25 mM pho...
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PMID: 21612150
PDF is available here.
PDF is available here.
Biopolymers (95)8 2011
Abstract
We present an overview of the effect that structural diversity intrinsic to protein ensembles has on scattering data. We then demonstrate the observation of these effects in scattering from four molecular systems; myoglobin; ubiquitin; alcohol dehydrogenase; and HIV protease; and demonstrate the mod...
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PMID: 21462170
PDF is available here.
PDF is available here.
Abstract
We have considered both the trans → cis and the cis → trans processes, caused by excitation in the n → π* band (S(1) state). To bring out the solvent effects on the excited state dynamics, we have run simulations in four different environments: in vacuo, in n-hexane, in methanol, and in ethyl...
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PMID: 21401136
PDF is available here.
PDF is available here.
Abstract
Through the use of single-molecule total internal reflection fluorescence microscopy, the dynamic behavior of fibrinogen was observed at the interface between aqueous solution and various solid surfaces. Multiple populations of objects were observed, as characterized by surface residence times, inter...
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PMID: 21391676
PDF is available here.
PDF is available here.
Abstract
We monitored the deprotection reaction of acetyl protected dithiols of oligophenylene ethynylenes (OPEs) in solution using two different bases and studied the quality of the resulting SAMs on gold. We found that the optimal conditions to reproducibly form dense, high-quality monolayers are 9-15% tri...
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PMID: 21384876
PDF is available here.
PDF is available here.
Abstract
We present our findings on the formation of metal sulfide nanocrystals from sulfur-alkylamine solutions. By pulsed field gradient diffusion NMR along with the standard toolbox of 1D and 2D NMR, we determined that sulfur-amine solutions used as a sulfur precursor exist as alkylammonium polysulfides a...
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PMID: 21384888
PDF is available here.
PDF is available here.
Abstract
We present a kinetic model for flowing active suspensions and analyze the behavior of a suspension subjected to a weak steady shear. Asymptotic solutions are sought in Deborah number expansions. At the leading order, we explore the steady states and perform their stability analysis. We predict the r...
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PMID: 21517529
PDF is available here.
PDF is available here.
Abstract
We study self-avoiding random walks in an environment where sites are excluded randomly, in two and three dimensions. For a single polymer chain, we study the statistics of the time averaged monomer density and show that these are well described by multifractal statistics. This is true even far from...
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PMID: 21517516
PDF is available here.
PDF is available here.
Fogorvosi szemle (104)1 2011
Abstract
The effects of three different decontaminating solutions in clinical use for peri-implantitis therapy on the chemical structure and surface roughness of commercially pure (CP) Ti were investigated. A further aim was to survey the response of the biological environment to these changes, by examining t...
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PMID: 21789931
PDF is available here.
PDF is available here.
Abstract
2,3,9,10-Tetramethoxy-12-oxo-12-H-indolo[2,1-a]isoquinolinium chloride 1 (compound X) and 13-(3,4-dimethoxyphenyl)-2,3,8,9-tetramethoxy-6a, 12a-diazadibenzo[a,g] fluorenylium chloride 2 (compound NF) are new papaverine oxidation products. A solution of compound 1 bleaches on addition...
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PMID: 21553644
PDF is available here.
PDF is available here.
Abstract
Sulfadimethoxine was subjected to different International Conference on Harmonisation prescribed stress conditions (hydrolysis, oxidation and photolysis). A stability-indicating high-performance liquid chromatography method was developed for analysis of the drug in the presence of its major degradati...
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PMID: 21440101
PDF is available here.
PDF is available here.
Abstract
We demonstrate a new method to control nucleation with polymer microgels by tuning their microstructure to vary systematically the degree of nanoscopic confinement and its effects on nucleation. We find that the polymer microstructure has a significant impact on nucleation kinetics. Moreover, there...
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PMID: 21344857
PDF is available here.
PDF is available here.
Abstract
The lactate concentrations were significantly higher in the LR group than in the Plasmalyte group 1 h after hepatectomy [4.2 (3.2-5.7) vs. 3.3 (2.6-4.6) mmol/l; P=0.005, median (interquartile ranges)]. In addition, the nadir concentration of albumin was significantly lower and the peak total bil...
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PMID: 21342149
PDF is available here.
PDF is available here.
Abstract
A study on the phenomenon of clouding and the applications of cloud point technology has been thoroughly discussed. The phase behaviour of clouding and various methods adopted for the determination of cloud point of various surfactant systems have been elucidated. The systems containing anionic, cati...
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PMID: 21296314
PDF is available here.
PDF is available here.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] (Chapter 11) 2011
Abstract
Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented: one uses pyroglutamate aminopeptidase for N(α)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(α)-ac...
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PMID: 21400688
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (115)2 2011
Abstract
To investigate the sustained effects of sodium hyaluronate solution (HA) on tear film stability using a Tear Stability Analysis System (TSAS), a method enabling quantitative evaluation of tear film stability.
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PMID: 21400919
PDF is available here.
PDF is available here.
Abstract
The aim of the present work was to improve the dissolution characteristics of the poorly water soluble antiepileptic drug lamotrigine (LMN) by inclusion complexation using hydroxy propyl beta-cyclodextrin (HP beta-CD) by co-evaporation technique and by, solid dispersion, prepared by...
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PMID: 21434574
PDF is available here.
PDF is available here.
Biopolymers (95)4 2011
Abstract
A water soluble acidic heteropolysaccharide named WAF was isolated from Auricularia auricula-judae by extracting with 0.9% NaCl solution. By using gas chromatography, gas chromatography-mass spectrometry, and NMR, its chemical structure was determined to be composed of a backbone of α-(1→3)-linked...
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PMID: 21280017
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
Amyloid fibers in human semen known as SEVI (semen-derived enhancer of viral infection) dramatically increase the infectivity of HIV and other enveloped viruses, which appears to be linked to the promotion of bridging interactions and the neutralization of electrostatic repulsion between the host and...
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PMID: 21262195
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)4 2011
Abstract
The three dimensional structure of a 32 residue three disulfide scorpion toxin, BTK-2, from the Indian red scorpion Mesobuthus tamulus has been determined using isotope edited solution NMR methods. Samples for structural and electrophysiological studies were prepared using recombinant DNA methods. El...
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PMID: 21256986
PDF is available here.
PDF is available here.
Abstract
We examined the structures of Escherichia coli Sec intermediates in solution as visualized by negatively stained electron microscopy in order to probe the oligomeric states of SecA during this process. The symmetric interaction pattern between the SecA dimer and SecB becomes asymmetric in the presen...
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PMID: 21304597
PDF is available here.
PDF is available here.
Abstract
We have designed Met35Nle and G37p mutations in the Aβ(42) peptide (Aβ(42)Nle35p37) that appear to organize Aβ(42) into stable oligomers. 2D NMR on the Aβ(42)Nle35p37 peptide revealed the occurrence of two β-turns in the V24-N27 and V36-V39 stretches that could be the possible cause for the oli...
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PMID: 21799748
PDF is available here.
PDF is available here.
Abstract
In this study, the application of a new polydimethylsiloxane (PDMS)/dual support composite membrane was investigated by incorporating the pervaporation process into the A-B-E (acetone-butanol-ethanol) fermentation. The performance of the A-B-E fermentation using the integrated pervap...
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PMID: 21312361
PDF is available here.
PDF is available here.
Abstract
The osmotic second virial coefficients B_{2} are directly related to the solubility of protein molecules in electrolyte solutions and can be useful to narrow down the search parameter space of protein crystallization conditions. Using a residue level model of protein-protein interact...
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PMID: 21405721
PDF is available here.
PDF is available here.
Abstract
We have previously suggested, based on Small Angle X-ray Scattering data, that recombinant murine proNGF has features typical of an intrinsically unfolded protein. Using complementary biophysical techniques, we show here new evidence that clarifies and widens this hypothesis through a detailed compa...
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PMID: 21818348
PDF is available here.
PDF is available here.
Abstract
We compare materials generated from a single honeybee silk protein to materials containing all four recombinant proteins or to natural honeybee silk. We analyse solution conformation by dynamic light scattering and circular dichroism, solid state structure by Fourier Transform Infrared spectroscopy...
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PMID: 21311767
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
We describe the structural and functional properties of three-dimensional (3D) nerve guides fabricated from poly-ε-caprolactone (PCL) using the air gap electrospinning process. This process makes it possible to deposit nano-to-micron diameter fibers into linear bundles that are aligned in parallel...
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PMID: 20727992
PDF is available here.
PDF is available here.
Abstract
Xenobiotics, including therapeutic agents, can produce a variety of beneficial, as well as adverse, effects in mammals. One potential source of drug-mediated toxicity stems from metabolic activation of the parent compound, typically catalyzed by one or more members of the cytochrome P450 family of e...
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PMID: 20972760
PDF is available here.
PDF is available here.
Abstract
Self-assembled liposome gel from liposome and cholesterol-end capped polyethylene glycol, was systematically investigated by rheological method, especially in the aspect of its recovery ability upon either mechanical deformation or temperature change. The liposome gel was found to have rheological b...
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PMID: 20855187
PDF is available here.
PDF is available here.
Abstract
We present a detailed AFM study on multilayered dry lipid films prepared from aqueous vesicle suspensions. Different preparation techniques were applied in order to optimize the preparation of homogeneous lipid films of various film thicknesses. Suspensions of preformed DOPC/DPPC vesicles were adsor...
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PMID: 20832257
PDF is available here.
PDF is available here.
Abstract
We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and...
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PMID: 20850281
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
A rapid and specific HPLC method has been developed and validated for the simultaneous determination of liensinine (CAS 2586-96-1), isoliensinine (CAS 6817-41-0) and neferine (CAS 2292-16-2) in rat plasma. The sample was prepared by a liquid-liquid extraction with diethyl ether and the recovery was a...
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PMID: 21827045
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A sensitive and specific liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method was developed and validated for the identification and quantification of voriconazole (VRC, CAS 137234-62-9) in human plasma. Following liquid-liquid extraction, VRC and lorata...
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PMID: 21428249
PDF is available here.
PDF is available here.
Abstract
We observe a statistical mixture of macrocyclic complexes of Eu(2)L(x)(2), Tb(2)L(x)(2), and EuTbL(x)(2). The EuTbL(x)(2) macrocycle displays dual color emission, incorporating the characteristic f-f transitions of Eu(3+) and Tb(3+). Investigation into the time-resolved photophysical properties of E...
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PMID: 21182290
PDF is available here.
PDF is available here.
Abstract
We further investigate this phenomenon and demonstrate the use of VCD to probe the fibril formation kinetics of a short alanine-rich peptide. To elucidate the origin of the anomalous VCD intensity enhancement, we use an excitonic coupling model to simulate the VCD spectrum of stacked β-sheets conta...
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PMID: 21186804
PDF is available here.
PDF is available here.
Quadrupole central transition 17O NMR spectroscopy of biological macromolecules in aqueous solution.
Abstract
We demonstrate a general nuclear magnetic resonance (NMR) spectroscopic approach in obtaining high-resolution (17)O (spin-5/2) NMR spectra for biological macromolecules in aqueous solution. This approach, termed quadrupole central transition (QCT) NMR, is based on the multiexponential relaxation pro...
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PMID: 21175170
PDF is available here.
PDF is available here.
Abstract
We show that a simple but long-ranged anisotropy in nanoparticles' interactions can greatly enrich this scenario. In experiments with colloidal Co nanocrystals, which bear a substantial magnetic dipole, we observe assemblies quite distinct from those formed by nonmagnetic particles. Reflecting the s...
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PMID: 21158454
PDF is available here.
PDF is available here.
Abstract
To compare the efficacy and side effects profile of topical 2% lidocaine gel with injectable 2% lidocaine solution as local anaesthetics for incision and curettage of chalazion.
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PMID: 21809603
PDF is available here.
PDF is available here.
Abstract
Organically-modified hydroxyapatite materials were synthesized through the addition of oxalic, succinic, adipic and citric acids to a calcium hydroxide solution before neutralization by ammonium dihydrogenphosphate. All carboxylic acids have a significant influence on apatite crystallinity and nanop...
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PMID: 20886132
PDF is available here.
PDF is available here.
Abstract
We used scaled particle theory (SPT) to explain these experimental observations. The effective length, called Tolman's length that describes the curvature correlations to a surface area or surface tension and in turn contributes to the change in free energy, is discussed. Tolman's length is higher f...
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PMID: 20919749
PDF is available here.
PDF is available here.
Abstract
The structural and thermodynamic characters of alpha-syn12 peptide in aqueous solution at different pH and temperatures have been investigated through temperature replica exchange molecular dynamics (T-REMD) simulations with GROMOS 43A1 force field. The two independent T-REMD simulations were comple...
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PMID: 20919750
PDF is available here.
PDF is available here.
Abstract
We demonstrate that an analog of doxorubicin (a representative example of an anticancer therapeutic) conjugated to human serum albumin (HSA, a representative example of a macromolecular carrier) via this NEBI crosslinker can internalize and localize into acidic lysosomes of ovarian cancer cells. Flu...
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PMID: 20820656
PDF is available here.
PDF is available here.