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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Vaginal Creams, Foams, and Jellies (0):
Recent article
Vaginal Creams, Foams, and Jellies
Abstract
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Arzneimittel-Forschung (61)4 2011
Abstract
A randomised, double blind, parallel groups, placebo controlled clinical trial was conducted to assess the efficacy and safety profile of 250 mg ascorbic acid (Vit. C, Vagi C) in women with bacterial vaginosis (BV). Overall, 277 out-patients with at least three of the following signs (white discharge...
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PMID: 21650086
PDF is available here.
PDF is available here.
Dermatologic Clinics (28)4 2010
Abstract
The concept of vaginitis is widely accepted. Most physicians assume that vaginitis represents an infection, with nearly all vaginal complaints diagnosed as Candidiasis, bacterial vaginosis, or trichomonas. However, like the mouth, the vagina is covered with squamous epithelium, and therefore affecte...
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PMID: 20883916
PDF is available here.
PDF is available here.
Dermatologic Clinics (28)4 2010
Abstract
The diagnosis and management of chronic vulvovaginal disease requires attention to several issues. Psychological factors are usually important, because women worry about malignancy, impaired sexuality and self-image, fertility, and sexually transmitted diseases. Multifactorial processes are common d...
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PMID: 20883909
PDF is available here.
PDF is available here.
Abstract
Abstract
Although menopause is a normal, physiological process in the lives of women, many report uncomfortable urogenital symptoms as they transition through this stage. Such symptoms include urinary frequency, increased urinary tract infections, vaginal dryness and irritation, and painful intercourse, amon...
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PMID: 20608584
PDF is available here.
PDF is available here.
Abstract
Currently in clinical trials, vaginal microbicides are proposed as a female-initiated method of sexually transmitted infection prevention. Much of microbicide acceptability research has been conducted outside of the United States and frequently without consideration of the social interaction between...
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PMID: 19224355
PDF is available here.
PDF is available here.
Abstract
We explored the intersection of sexual pleasure and vaginal lubrication to understand whether and under what circumstances women would use a microbicide gel covertly with primary partners. This study question emerged from acceptability research in diverse settings showing that even though future mic...
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PMID: 19636696
PDF is available here.
PDF is available here.
Abstract
Both concentrations of PRO 2000 gel were found to be safe and well tolerated. These data justified testing the gels in large-scale effectiveness trials....
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PMID: 20444744
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to evaluate cervical changes and delivery at term during pregnancy in rats after various progestin treatments.
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PMID: 20452487
PDF is available here.
PDF is available here.
Abstract
A Lipschütz ulcer or 'ulcus vulvae acutum' is an acute simple ulceration of the vulva or vagina of non-venereal origin which can be associated with lymphadenopathy. Three cases are described with accompanying clinical photographs. Two cases refer to adolescents, one an infant, all without any histo...
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PMID: 20498113
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the effects of glycerol monolaurate (GML) on Lactobacillus, Candida, and Gardnerella vaginalis human vaginal microflora. Our previous work demonstrated that 6 months of GML treatment vaginally does not alter lactobacillus counts in monkeys. Candida and G. vaginalis are commonly assoc...
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PMID: 20008774
PDF is available here.
PDF is available here.
Abstract
SPL7013 Gel applied vaginally once daily for 7 days at concentrations of 0.5% to 3% was safe and well tolerated in healthy, sexually abstinent women, with no evidence of systemic toxicity or absorption....
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PMID: 19823111
PDF is available here.
PDF is available here.
The Journal of reproductive medicine (55)9-10 2010
Abstract
To evaluate patient satisfaction of cervical ripening using dinoprostone (PGE2) by either intravaginal gel or pessary.
A group of 173 nulliparous women requiring cervical ripening were recruited in the study and randomized to receive either intravaginal gel (Prepidil, Upjohn, Milan, Italy [group A])...
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PMID: 21043369
PDF is available here.
PDF is available here.
Abstract
We conclude that administration of UniPron into baboon vagina did not cause any detectable toxicity....
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PMID: 20690277
PDF is available here.
PDF is available here.
Abstract
Bacterial vaginosis is the most common cause of vaginal complaints. Bacterial vaginosis is further associated with a sizeable burden of infectious complications. Diagnosis relies on standardized clinical criteria or on scoring bacterial cell morphotypes on a Gram-stained vaginal smear. A few point-o...
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PMID: 19883331
PDF is available here.
PDF is available here.
Abstract
One course of Praneem treatment resulted in elimination of HPV in 6 out of 10 (60%) cases. A repeat treatment of four patients with persisting HPV infection resulted in clearance of HPV in two additional cases resulting in an overall 80% clearance of HPV 16 as against a spontaneous clearance of 10%...
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PMID: 19526249
PDF is available here.
PDF is available here.
Abstract
To investigate the safety and efficacy of promestriene capsule used in the treatment of postmenopausal atrophic vaginitis.
Fifty-three women at age of 45 - 75 years (more than one year history of menopause) diagnosed with postmenopausal atrophic vaginitis were enrolled in self-control study. They al...
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PMID: 20003787
PDF is available here.
PDF is available here.
Abstract
Qualitative research was conducted to explore the social context of sexual-risk behaviour among women working in recreational occupations, during a feasibility study in preparation for the Phase III clinical trial of vaginal microbicides in Mwanza, Tanzania. Participant observation was conducted in...
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PMID: 19444689
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (13 Suppl 1) 2009
Abstract
This study aimed to determine changes in fertility intentions of HIV-1 infected and uninfected reproductive age women in Blantyre, Malawi. Participants were asked about their fertility intentions at baseline and at 3-month visits for 1 year. Time-to-event statistical models were used to determine fa...
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PMID: 19308718
PDF is available here.
PDF is available here.
Abstract
Abstract
Gel-diaphragm users had better adherence than gel-only users, and predictors of adherence differed between groups. Addressing modifiable factors during counseling sessions may improve adherence....
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PMID: 19265745
PDF is available here.
PDF is available here.
Abstract
HIV microbicides are topical, self-administered products aimed at preventing or reducing HIV infection in women and may represent the most promising strategy for combating the HIV/AIDS epidemic at the present time. Although a safe and effective microbicide has yet to be identified, all products test...
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PMID: 19374141
PDF is available here.
PDF is available here.
Abstract
A low dose (1 g = 0.625 mg) of SCE-A vaginal cream administered twice weekly was shown to be effective compared with placebo in treating VVA in postmenopausal women for the three coprimary efficacy measures of maturation index, pH, and severity of the MBS....
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PMID: 19252451
PDF is available here.
PDF is available here.
Abstract
Daily and twice-weekly use of low-dose CE cream was equally effective in relieving symptoms of vulvovaginal atrophy. Both regimens showed endometrial safety and sustained efficacy during 1 year of therapy....
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PMID: 19436223
PDF is available here.
PDF is available here.
Abstract
Most of the sustained release vaginal formulations are in the form of bioadhesive gels and tablets. Though proved efficient, their presence in the vagina for a longer time as a bulk produces discomfort and interference with body functioning including sexual activities. Hence, they lack complete pati...
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PMID: 18802845
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to determine the effectiveness of Lactobacillus-containing vaginal tablets in the treatment of bacterial vaginosis (BV) and in the restoration of a healthy vaginal flora. Thirty-nine women with BV were enrolled in a double-blind, placebo-controlled clinical trial. Patie...
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PMID: 19046169
PDF is available here.
PDF is available here.
Abstract
Aims
To investigate whether vaginal estrogen cream combined with tolterodine is more effective than tolterodine alone in the treatment of postmenopausal women with overactive bladder (OAB).
Materials and Methods
This is an unblinded study without placebo. A preliminary study consisted of tolterodine...
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PMID: 19089890
PDF is available here.
PDF is available here.
Abstract
Glycerol monolaurate (GML) is a fatty acid monoester that inhibits growth and exotoxin production of vaginal pathogens and cytokine production by vaginal epithelial cells. Because of these activities, and because of the importance of cytokine-mediated immune activation in human immunodeficiency viru...
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PMID: 18838587
PDF is available here.
PDF is available here.
Sexual Health (5)4 2008
Abstract
Microbicide acceptability for youth in sub-Saharan Africa may be bolstered by desperation for new methods to stop the spread of HIV, yet hindered by misgivings about experimental HIV prevention methods for youth. Understanding and addressing the microbicide's perceived benefits and shortcomings, as...
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PMID: 19061553
PDF is available here.
PDF is available here.
The Lancet (372)9654 2008
Abstract
The Lancet (372)9654 2008
Abstract
For the primary outcome (time to HIV seroconversion) we analysed 3011 women in the Carraguard group and 2994 in the placebo group. HIV incidence was 3.3 per 100 woman-years (95% CI 2.8-3.9) in the Carraguard group (134 events) and 3.8 per 100 woman-years (95% CI 3.2-4.4) in the placebo group (151 ev...
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PMID: 19059048
PDF is available here.
PDF is available here.
Abstract
Caprine herpesvirus 1 (CpHV-1) infection in goats induces genital vesicular-ulcerative lesions that strictly resemble those produced by human herpesvirus 2 in humans. In previous studies, the potent inhibition of CpHV-1 by cidofovir was demonstrated. Cidofovir antiherpetic activity was evaluated in...
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PMID: 18765685
PDF is available here.
PDF is available here.
Abstract
I and II/IIb safety studies, and phase III efficacy studies. Whereas most phase I and phase II clinical trials have found microbicide compounds to be safe and well tolerated, phase III trials completed to date have not demonstrated efficacy in preventing HIV transmission. Topical microbicides are gr...
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PMID: 18992405
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (112)5 2008
Abstract
We found no differences in the following outcomes: HPV prevalence at the time of the first postenrollment HPV test (intention-to-treat analysis, relative risk [RR] 1.02, 95% confidence interval [CI] 0.90-1.16); HPV incidence at 12 months among women HPV-negative at baseline (RR 0.95, 95% CI 0.80-1.1...
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PMID: 18978097
PDF is available here.
PDF is available here.
Abstract
New mucoadhesive formulations were designed and studied in order to improve local vaginal therapy by increasing formulation retention prolonging thus drug-mucosa contact time. Some gels were prepared using hydroxyethylcellulose (HEC) alone or mixed with chitosan (CS) or its derivative 5-methyl-pyrro...
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PMID: 18621512
PDF is available here.
PDF is available here.
Abstract
The epidemic of HIV has catalyzed the need for safe and effective prevention methods, particularly for women. Vaginal microbicides have been targeted because these methods can be controlled by women themselves. Microbicides have focused on preventing HIV as well as other sexually transmitted infecti...
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PMID: 18936885
PDF is available here.
PDF is available here.
Abstract
Participants in both treatment groups contributed 601 person-months of follow-up and 95% of the participants completed the last follow-up. Although transient genital discomfort was the main reported adverse experience, none of the study participants discontinued product use. Most of the adverse even...
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PMID: 18426844
PDF is available here.
PDF is available here.
Abstract
The potential success of a microbicide candidate in resource-poor countries will depend to a large extent on its availability and cost. Chloroquine is an inexpensive antimalarial drug that also exerts anti-HIV activity. The purpose of this study was to develop and characterize a vaginal formulation...
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PMID: 18606432
PDF is available here.
PDF is available here.
Abstract
Sequential exogenous oestradiol and progesterone are often used to prepare the endometrium in frozen embryo transfer (FET) cycles. This open-label, randomized study compared the efficacy and acceptability of self-administered once daily vaginal progesterone gel and vaginal micronized progesterone ta...
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PMID: 18765001
PDF is available here.
PDF is available here.
Abstract
A polyherbal cream (Basant) has been formulated using diferuloylmethane (curcumin), purified extracts of Emblica officinalis (Amla), purified saponins from Sapindus mukorossi, Aloe vera and rose water along with pharmacopoeially approved excipients and preservatives. Basant inhibits the growth of WH...
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PMID: 18571386
PDF is available here.
PDF is available here.
Abstract
These results indicate that female perceptions of male partner acceptability and actual male partner acceptability need to be considered when addressing female-controlled product acceptability and use....
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PMID: 18608053
PDF is available here.
PDF is available here.
Abstract
We combine relationship-based theories with anthropological work conducted with women and men using a placebo gel. We explore communication and decision-making in gel and condom use, including constructions of risk and trust. During the MDP301 Phase III pilot study, in-depth interviews were conducte...
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PMID: 18576176
PDF is available here.
PDF is available here.
Journal of Virology (82)13 2008
Abstract
These results highlight the unpredictability of antiviral compounds as topical microbicides and suggest that repeated exposures to candidate treatments should be considered for in vivo evaluation....
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PMID: 18434406
PDF is available here.
PDF is available here.
Abstract
The purpose of this work was to develop an in vitro mucoadhesion testing method for vaginal semisolid formulations. The proposed method was based on the measurement of the force (detachment force, Fdt) and the work (work of adhesion, Wad) needed to detach a sample of cow vaginal mucosa from a semiso...
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PMID: 18248972
PDF is available here.
PDF is available here.
Contraception (77)6 2008
Abstract
Immediately after gel application, the PVA distributed the gel throughout the vaginal/cervical mucosae, while the CA delivered the gel only to the cervical area. During simulated intercourse, the phallus further pushed the gel delivered with the CA into the fornix, whereas it spread the gel delivere...
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PMID: 18477496
PDF is available here.
PDF is available here.
Abstract
In nulliparous women no significant differences were found between the gel and insert groups in the rate of vaginal delivery (85.6% vs. 80.7%) delivery < or =12 (36.8% vs. 32.9%) and < or =24h (85.3% vs. 93.4%) regardless of the preinduction Bishop score. Nulliparous with Bishop score < or =4 treate...
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PMID: 17889983
PDF is available here.
PDF is available here.
Abstract
Sixty-five pregnant women with missed abortion were included and assigned to the three study groups (n=22 for group 1, n=22 for group 2, n=21 for group 3). Misoprostol vaginal gel and Dilapan-S were significantly more effective than ISMN vaginal gel in cervical dilation reached with priming (p<0.005...
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PMID: 17980952
PDF is available here.
PDF is available here.
Abstract
Abstract
Commonly used personal lubricants show a full range of mucosal irritation potential, which is related to product osmolality....
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PMID: 18356773
PDF is available here.
PDF is available here.
Abstract
Topical vaginal microbicides are being developed to reduce HIV infection in women for whom correct and consistent condom use is impossible or undesirable. Although microbicides have been heralded as a "women-initiated" method that requires no action of the male partner, gender norms for sexual relat...
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PMID: 18433322
PDF is available here.
PDF is available here.
Abstract
We compared data from one U.S. study and two South African studies that explored these issues. Frontline providers in South Africa were enthusiastic about any method that would have the potential to slow the HIV/AIDS epidemic, whereas providers in New York City and policy makers in South Africa bala...
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PMID: 18433323
PDF is available here.
PDF is available here.
Abstract
We report on 2 women with vulva EMPD who achieved biopsy-confirmed resolution of their disease after topical application of imiquimod 5% cream....
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PMID: 18369301
PDF is available here.
PDF is available here.
The AIDS reader (18)4 2008
Abstract
The AIDS reader (18)4 2008
Abstract
Nature Medicine (14)4 2008
Abstract
Abstract
The vagina provides a local and a systemic route for delivering hormones for systemic effects and uterine targeting. Due to the 'uterine first-pass effect', hormones concentrate in the uterus and nearby tissues with low systemic exposure. Vaginal oestrogens, progesterone/progestins and danazol are c...
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PMID: 17981510
PDF is available here.
PDF is available here.
Abstract
The mean induction-abortion interval in group 1 (20.9+/-12.3 h) was not significantly different from that in group 2 (17.7+/-10.2 h). The mean total dose of misoprostol was also not significantly different between the two groups (group 1, 1556.9 microg; group 2, 1350.9 microg), but the adverse effec...
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PMID: 18412782
PDF is available here.
PDF is available here.
Minerva ginecologica (60)2 2008
Abstract
The results obtained showed that 27 women completely recovered, 5 showed a good improvement and only 2 women were still suffering from vulvovaginitis at the end of treatment. CONCLUSION: From the data of our study, a cream containing lactoferrin seems to be clinically effective in the treatment of a...
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PMID: 18487962
PDF is available here.
PDF is available here.