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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Xenobiotics (0):
Recent article
Xenobiotics
Abstract
We found evidence of fibrin deposition in livers of patients with cholestasis. Key components of the fibrinolytic pathway modulate cholestatic liver injury by regulating activation of hepatocyte growth factor. However, the exact role of hepatic fibrin deposition in chronic cholestasis is not known....
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PMID: 21356363
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Xenobiotics, including therapeutic agents, can produce a variety of beneficial, as well as adverse, effects in mammals. One potential source of drug-mediated toxicity stems from metabolic activation of the parent compound, typically catalyzed by one or more members of the cytochrome P450 family of e...
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PMID: 20972760
PDF is available here.
PDF is available here.
Abstract
We have utilized a model protein, cytochrome c, to guide us in identifying 1,4-BQ- and 1,4-BQ-thioether derived site-specific protein modifications. LC-MS/MS analyses reveals that these modifications occur selectively on lysine and glutamic acid residues of the target protein, and that these modific...
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PMID: 20972762
PDF is available here.
PDF is available here.
Abstract
We have developed a new approach called cellular metabolomics. This approach, developed in vitro, provides a panoramic view not only of the pathways involved in the metabolism of physiologic substrates of any normal or pathologic human or animal cell but also of the beneficial and adverse effects of...
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PMID: 20972755
PDF is available here.
PDF is available here.
Abstract
The rodent whole embryo culture (WEC) system is a well-established model for characterizing developmental toxicity of test compounds and conducting mechanistic studies. Laboratories have taken various approaches in describing type and severity of developmental findings of organogenes...
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PMID: 21058394
PDF is available here.
PDF is available here.
Abstract
The identification of xenobiotic metabolizing enzymes (i.e., CYP) and transporters (i.e., ABC transporters) (XMET) in the human brain, including the BBB, raises the question whether these transporters and enzymes have specific functions in brain physiology, neuropharmacology and toxicology.
Relevant...
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PMID: 20843279
PDF is available here.
PDF is available here.
Abstract
Humans are unavoidably exposed to a variety of environmental toxicants and combinations thereof, resulting in an increased risk for a number of diseases. The emerging field of toxicoproteomics has been boosted by quantitative and qualitative proteomic technologies and its increasing...
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PMID: 20175663
PDF is available here.
PDF is available here.
Abstract
High-throughput omics strategies delineate the molecular mechanism of toxicity, predict the toxicity of newer drugs and chemicals, and identify individuals at high risks on the basis of expression patterns of messenger ribonucleic acids, genes, and proteins, and detection of intermed...
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PMID: 20082572
PDF is available here.
PDF is available here.
Abstract
We summarize the possible role of cytochrome P450 (CYP) enzymes in drug-induced interstitial lung disease.
The CYP enzyme family plays an important role in the metabolism of all sorts of ingested, injected or inhaled xenobiotic substances. Although the liver is considered to be the major metabolism...
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PMID: 20592596
PDF is available here.
PDF is available here.
Reproductive Toxicology (30)2 2010
Abstract
Abstract
We recently demonstrated aryl hydrocarbon receptor (AHR)-dependent induction of FMO mRNAs in mouse liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Celius et al., Drug Metab Dispos 36:2499, 2008). We now evaluated FMO induction by other AHR ligands and xenobiotic chemicals in vivo and in mouse H...
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PMID: 20570689
PDF is available here.
PDF is available here.
Abstract
Our present results, including seasonality, slightly differ from former observations (Solé et al., 2009a) and reveal a more significant role of the ecological variables in controlling biomarkers expression in fish from the shelf....
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PMID: 20494437
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
The Kashmir Valley has an elevated incidence rate of esophageal cancer (EC). Several environmental and genetic factors have been suspected for development of EC. A case-control study was performed in 135 EC patients and 195 healthy controls to analyze association of polymorphisms in glutathione S-tr...
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PMID: 20661821
PDF is available here.
PDF is available here.
Drug Metabolism Reviews (42 Suppl 1) 2010
Abstract
Abstract
We reviewed evidence on the impact of environmental chemicals on lung development and key signaling events in lung morphogenesis, and the relevance of potential outcomes to public health and regulatory science .
We evaluated the peer-reviewed literature on developmental lung biology and toxicology,...
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PMID: 20444669
PDF is available here.
PDF is available here.
Abstract
We have generated an extrahepatic-CL (xh-CL) mouse for testing of the functions of CPR-dependent enzymes in all extrahepatic tissues. The xh-CL mice, generated by mating of r-CL mice with albumin-Cre mice, had normal CPR expression in hepatocytes but down-regulated CPR expression elsewhere. They wer...
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PMID: 20375200
PDF is available here.
PDF is available here.
FEBS Letters (584)13 2010
Abstract
In humans, about 50 ABC proteins play physiologically important roles. Many ABC proteins are involved in lipid outward translocation and lipid homeostasis in the body, and defects in their functions cause various diseases. However, the precise mechanisms of substrate transport remain unclear. In bac...
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PMID: 20412807
PDF is available here.
PDF is available here.
Abstract
Spices and herbal remedies have been used since ancient times to treat a variety of disorders. It has been experimentally demonstrated that spices, herbs, and their extracts possess antimicrobial, anti-inflammatory, antirheumatic, lipid-lowering, hepatoprotective, nephroprotective, antimutagenic and...
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PMID: 20533590
PDF is available here.
PDF is available here.
Abstract
We investigated the role of five basic residues within or near transmembrane (TM) 2 of BCRP in transport activity. Lys(452), Lys(453), His(457), Arg(465), and Lys(473) were replaced with Ala or Asp. K452A, K453D, H457A, R465A, and K473A were stably expressed in human embryonic kidney (HEK) cells, an...
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PMID: 20203106
PDF is available here.
PDF is available here.
Abstract
We have developed a coculture system which in parallel indicates the sensitizing and irritative potential of xenobiotics. The assay is named loose-fit coculture-based sensitization assay (LCSA) and may be performed within 5 days. The system is composed of human monocytes that differentiate to a kind...
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PMID: 20219181
PDF is available here.
PDF is available here.
Biomedical Papers (154)2 2010
Abstract
Phase II biotransformation reactions (also 'conjugation reactions') generally serve as a detoxifying step in drug metabolism. Phase II drug metabolising enzymes are mainly transferases. This review covers the major phase II enzymes: UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferas...
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PMID: 20668491
PDF is available here.
PDF is available here.
Abstract
Abstract
The induction of hepatic cytochrome P450 (CYP) enzymes, conjugating enzymes, and drug transporters involved in the phase I-III metabolism of xenobiotics is frequently encountered in pre-clinical drug safety studies. As xenobiotics, new drug entities can serve as ligands to three major nuclear recept...
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PMID: 20218941
PDF is available here.
PDF is available here.
Abstract
Liver is the major body reservoir for enzymes involved in the metabolism of endogenous and xenobiotic compounds. Recently, it has been shown that hepatocytes release exosome-like vesicles to the extracellular medium, and the proteomic characterization of these hepatocyte-secreted exosomes has reveal...
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PMID: 20192903
PDF is available here.
PDF is available here.
Lab Animal (39)5 2010
Abstract
To assess a drug's toxic or carcinogenic effects on neonatal and adult mice and rats, researchers often carry out oral gavage studies. Whether dosed singly or in various combinations, provided as soluble solutions or as colloidal suspensions, the drug must be delivered in accurate and precise doses....
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PMID: 20410899
PDF is available here.
PDF is available here.
Abstract
Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and p...
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PMID: 20347140
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of these agents on PP13 and beta-hCG levels using choriocarcinoma cell lines as surrogates for primary villous trophoblast. Five different cell lines were triggered with forskolin and cultured for 48 h. Amongst the five tested cell lines BeWo cells showed the strongest inc...
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PMID: 20347141
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
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PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
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PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
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PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We have begun to address the structural requirements for their actions through membrane estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes tha...
|
PMID: 19955490
PDF is available here.
PDF is available here.