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Articles on Drugs, Chinese Herbal
[Protective effect of Qihuang Mingmu capsule on retina of diabetic mice and its impact on VEGF expression].
To investigate the protective effect of Qihuang Mingmu capsule (QHMM) on retina of diabetic mice and its impact on VEGF expression. Forty KK/Upj-Ay mice were randomly divided into the model group and high, middle and low dose QHMM (8.32, 4.16, 2.08 g x kg(-1)) groups....
Lignans from Kadsura angustifolia and Kadsura coccinea.
Further phytochemical investigation of Kadsura angustifolia and Kadsura coccinea led to the isolation of six lignans and one flavonoid, including two new lignans named kadangustin L(1) and kadcoccilignan (2). The structures and stereochemistry of 1 and 2 were elucidated by analysis o...
A new inositol derivative from Prenanthes macrophylla.
A new chiro-inositol ester, 4-hydroxyphenylacetyl-3-d-chiro-inositol ester (1), was isolated from the whole plants of Prenanthes macrophylla Franch., along with 10 known compounds, 4-hydroxyphenylacetic acid (2), trans-ethyl caffeate (3), cis-ethyl caffeate (4), protocatechualdehyde...
Smilasides M and N, two new phenylpropanoid glycosides from Smilax riparia.
Two new phenylpropanoid glycosides, smilasides M and N, together with the known compound 2',6'-diacetyl-3,6-diferuloylsucrose, were isolated and characterized from the roots and rhizomes of Smilax riparia A. DC. The structures of the new compounds were elucidated as 2',6'-diacetyl-3-...
Simultaneous identification of multiple celangulins from the root bark of Celastrus angulatus using high-performance liquid chromatography-d...
Celangulins are a small family of β-dihydroagarofuran sesquiterpenoids endowed with diverse polyoxygenated polyol esters and various biological properties. Since our research focuses on celangulins, the development of rapid and sensitive online analytical methods to analyse and char...
Efficacy of ghrelin in cancer cachexia: clinical trials and a novel treatment by rikkunshito.
Cachexia is characterized by decreased food intake, increased energy expenditure, and muscle wasting. It is observed in 80% of patients with advanced-stage cancer and is a major source of decreased quality of life and increased morbidity and mortality in cancer patients. Ghrelin play...
Two methyl-migrated 16,17-seco-dammarane triterpenoid saponins from the seeds of Hovenia acerba.
Two new methyl-migrated 16,17-seco-dammarane triterpenoid saponins, named acerboside A (1) and acerboside B (2), were isolated from the seeds of Hovenia acerba. Their structures were elucidated on the basis of spectroscopic analysis and hydrolysis.
New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis.
Two new ursane-type triterpenes, named as 3β, 19α, 23, 24-tetrahydroxyurs-12-en-28-oic acid (1) and 2β, 3β, 19α, 24-tetrahydroxyurs-12-en-28-oic acid (2), together with two known triterpenoids, 3-oxo-urs-12-ene-27, 28-dioic acid (3) and quinovic acid-3-β-rhamnopyranoside...
Two new compounds from Dictamnus dasycarpus.
Two new compounds, one new pyrrolidine alkaloid and one new eudesmane-type sesquiterpene derivative, named, respectively, as dictamnaindiol and dictamnadiol, were isolated from the EtOAc soluble fraction of the ethanolic extract from the root barks of Dictamnus dasycarpus. Their stru...
Two new lignans from Celastrus flagellaris Rupr.
Two new lignans (R-biar)-12-angeloyloxy-6,7,8,9-tetrahydro-1,2,3,13,14-pentamethoxy-7,8-dimethyl-7-dibenzo[a,c]cyclooctenol (1) and (R-biar)-12-benzoyloxy-6,7,8,9-tetrahydro-1,2,3,13,14-pentamethoxy-7,8-dimethyl-7-dibenzo[a,c]cyclooctenol (2) were isolated from the stems of Celastrus...