Abstract
The results showed that MOTHMO is capable of replicating the seat belt-to-shoulder complex interaction, pelvis impacts, head displacement, neck and shoulder belt loading from inboard mounted belts, and impacts from multiple directions. Overall, the model performed better than Thor-NT and at least as...
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PMID: 21972862
PDF is available here.
Abstract
The objective of this research is to determine the best location to place a conventional mobile computer supported by a commercially available mount in a light truck cab.
U.S. and Canadian electric utility companies are in the process of integrating mobile computers i...
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PMID: 22046721
PDF is available here.
Abstract
We were able to successfully identify the RCOF in a significantly large number of strikes across 40 participants. In a portion of the strikes, the transverse shear force increased the RCOF significantly. In a significant portion of the strikes, the RCOF2 occurred much earlier than RCOF1....
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PMID: 22046720
PDF is available here.
Abstract
Mechanical signals can play a key role in regulating the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure could be used to improve the functional properties of carti...
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PMID: 21783134
PDF is available here.
Abstract
Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling....
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PMID: 21813957
PDF is available here.
Abstract
We aim to design new biocompatible materials to overcome this. In this paper we investigate the use of photoelastomers for artificial vascular constructs since they may be precisely structured by means of additive manufacturing technologies. Hence, 3D computer aided design and manufacturing technolo...
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PMID: 21849722
PDF is available here.
Abstract
In this study, a two-part bone tissue engineering scaffold was investigated. The scaffold consists of a solid poly(propylene fumarate) (PPF) intramedullary rod for mechanical support surrounded by a porous PPF sleeve for osseointegration and delivery of poly(dl-lactic-co-glycolic aci...
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PMID: 21757034
PDF is available here.
Abstract
The aim of this study was to evaluate the effects of newly formulated topical cream of Calendula officinalis extract on the mechanical parameters of the skin by using the cutometer. The Cutometer 580 MPA is a device that is designed to measure the mechanical properties of the skin in response to the...
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PMID: 21928714
PDF is available here.
Abstract
The purpose of this study was to examine knee valgus in drop landings during three different footwear conditions and to examine the ground reaction forces exhibited during the drop landing in the three different footwear conditions.
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PMID: 21977709
PDF is available here.
Abstract
Many sport and exercise activities require powerful movements of the upper body. Despite their importance, there is a paucity of research examining stretch-shortening cycle (SSC) activities occurring in the upper limbs. The purpose of this study was to examine the effect of fatigue on throwing perfor...
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PMID: 21936288
PDF is available here.
Abstract
Tkachev on uneven bars is a release and re-grasp skill performed using variations of preparatory longswing techniques; the reasons why different techniques are chosen remains unclear. This study examined kinematic and key release parameters specific to three distinct techniques with the aim of unders...
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PMID: 21936286
PDF is available here.
Abstract
A deterministic model is a modeling paradigm that determines the relationships between a movement outcome measure and the biomechanical factors that produce such a measure. This review provides an overview of the use of deterministic models in biomechanics research, a historical summary of this resea...
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PMID: 21936290
PDF is available here.
Abstract
When cycling on level ground at a speed greater than 14 m/s, aerodynamic drag is the most important resistive force. About 90% of the total mechanical power output is necessary to overcome it. Aerodynamic drag is mainly affected by the effective frontal area which is the product of the projected fron...
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PMID: 21936289
PDF is available here.
Abstract
The Paralympic Games are the pinnacle of sport for many athletes with a disability. The overall purpose of this paper is to highlight the role that the field of sports biomechanics specifically (and sports science in general) may play in improving performance in various summer Paralympic sports throu...
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PMID: 21936291
PDF is available here.
Abstract
Most total knee arthroplasty prostheses have modular tibial components with metal-backed tibial baseplates. Biomechanical studies have demonstrated mechanical advantages to a metal-backed tibial component in terms of tibial load transfer. In addition, tibial component modularity provides intraoperati...
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PMID: 21885698
PDF is available here.
Abstract
An efficient and selective four-electron plus four-proton (4e(-)/4H(+)) reduction of O(2) to water by decamethylferrocene and trifluoroacetic acid can be catalyzed by a synthetic analog of the heme a(3)/Cu(B) site in cytochrome c oxidase ((6)LFeCu) or its Cu-free version ((6)LFe) in acetone. A detail...
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PMID: 21808032
PDF is available here.
Abstract
We have used single-molecule force spectroscopy in combination with molecular dynamics simulations to characterize the mechanics of the myomesin dimer comprising immunoglobulin domains My12-My13. We find that at forces of approximately 30 pN the α-helical linker reversibly elongates allowing the m...
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PMID: 21825161
PDF is available here.
Abstract
We created two mutant constructs with extended neck-linkers and measured their properties using single-molecule optical trapping and ensemble fluorescence techniques. Owing to a reduction in the inter-head tension, the constructs access an otherwise rarely populated conformational state in which bot...
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PMID: 21841789
PDF is available here.
Abstract
We present the evaluation of a living, tissue-engineered IVD composed of a gelatinous nucleus pulposus surrounded by an aligned collagenous annulus fibrosus in the caudal spine of athymic rats for up to 6 mo. When implanted into the rat caudal spine, tissue-engineered IVD maintained disc space heigh...
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PMID: 21808048
PDF is available here.
Abstract
Finite-element analysis was used to investigate the extent of bias in the ichnological fossil record attributable to body mass. Virtual tracks were simulated for four dinosaur taxa of different sizes (Struthiomimus, Tyrannosaurus, Brachiosaurus and Edmontosaurus), in a range of subst...
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PMID: 21233145
PDF is available here.
Abstract
To describe the determinants of the severity of the head kinematics of a pedestrian when struck by common sport utility vehicles (SUV) and work utility vehicles (WUVs) to assess how effective assessment protocols are in assessing injury risk for SUVs and work utilities.
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PMID: 21823947
PDF is available here.
Abstract
To study the potential of active, passive, and integrated (combined active and passive) safety systems in reducing pedestrian upper body loading in typical impact configurations.
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PMID: 21823948
PDF is available here.
Abstract
The objective was to quantify dynamic responses of 50th percentile females in rear impacts and compare to those from similar tests with males. The results will serve as a basis for future work with models, criteria, and safety systems.
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PMID: 21823943
PDF is available here.
Abstract
The goal of the present study was to identify rib-level differences in fracture characteristics for individual ribs subjected to anterior-posterior loading.
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PMID: 21823946
PDF is available here.
Abstract
We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen (CTX-I), total osteocalcin (total OC), procollagen type I N propeptide (PINP) and bone alkaline phosphatase (bone ALP). We investigated bone morphogenetic protein-2 (BMP-2) in the proximal...
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PMID: 21901984
PDF is available here.
Abstract
These results indicate that cells isolated from umbilical cord can be used to produce vascular constructs. Arterial constructs possessed superior mechanical properties when compared with venous constructs produced using cells isolated from the same human donor. This study highlights the fact that sm...
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PMID: 21457095
PDF is available here.
Abstract
Our results also show that this replacement may change the strain energy distribution within the bone. Based on a semi-mechanistic bone remodeling theory, it is speculated that this alteration in strain energy distribution in artificial bone can destabilize normal bone remodeling process, and theref...
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PMID: 21870458
PDF is available here.
Abstract
The conformational analysis of the DNA structural unit--the nucleotide with thymine base and electroneutral phosphate group at 5'-position-has been carried out with the applied quantum mechanics methods at the MP2/6-311++G(d,p) // B3LYP/6-31G(d,p) theory level. As many as 660 conformations with relat...
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PMID: 21805865
PDF is available here.
Abstract
We analyzed the response of a stenotic trachea after a stent implantation. An endotracheal stent is the common treatment for tracheal diseases such as stenosis, chronic cough, or dispnoea episodes. Medical treatment and surgical techniques are still challenging due to the difficulties in overcoming...
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PMID: 21823742
PDF is available here.
Abstract
The facet joint contributes to the normal biomechanical function of the spine by transmitting loads and limiting motions via articular contact. However, little is known about the contact pressure response for this joint. Such information can provide a quantitative measure of the facet joint's local e...
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PMID: 21823743
PDF is available here.
Abstract
Our hypothesis is that the experimental protocols influence the mechanical properties of both annulus fibrosus and nucleus pulposus. IVD extracted from bovine tails were tested in unconfined compression stress-relaxation experiments according to six different protocols, where for each protocol, the...
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PMID: 21823745
PDF is available here.
Abstract
We conclude that histology sections yield a more consistent measurement of the unloaded dimensions and that there are no significant changes in the mechanical behavior of mouse carotid artery with storage up to 28 days....
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PMID: 21823746
PDF is available here.
Abstract
The incidence of anterior cruciate ligament (ACL) injury remains high, and there is a need for simple, cost effective methods to identify athletes at a higher risk for ACL injury. Wearable measurement systems offer potential methods to assess the risk of ACL injury during jumping tasks. The objective...
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PMID: 21823747
PDF is available here.
Abstract
We present a computer simulation of the epithelial tissue in which the global interfacial energy between cells is minimized. Experimental data for both normal cells and mutant cells either lacking or misexpressing the adhesion protein N-cadherin can be explained by a simple model incorporating salie...
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PMID: 21814505
PDF is available here.
Abstract
We hypothesized that the placement of one femoral head/neck fixation device in the PFNA would improve positioning of the implant in the femoral head compared with the PFN and reduce the number of reoperations in both short and long term....
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PMID: 21818023
PDF is available here.
Abstract
We investigated the hypothesis that aortic valve biomechanics participate in the regulation of both 5HTR expression and interrelated extracellular matrix remodeling events....
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PMID: 21718840
PDF is available here.
Abstract
Differences in the location and incidence of lower extremity injuries have been reported between high and low arched individuals. These differences might be related to functional differences between the two foot types. In particular, the characteristics of the medial longitudinal arch may influence f...
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PMID: 21972767
PDF is available here.
Abstract
This paper presents a mathematical model to describe the growth of tissue into a rapid-prototyped porous scaffold when it is implanted onto the chorioallantoic membrane (CAM). The scaffold was designed to study the effects of the size and shape of pores on tissue growth into conventi...
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PMID: 20922556
PDF is available here.
Abstract
We investigated fracture forces and implant subsidence rates in embalmed human femurs undergoing impaction grafting. The study consisted of two arms, the first examining the force at which femoral fracture occurs in the embalmed human femur, and the second examining whether significant graft implant...
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PMID: 21689068
PDF is available here.
Abstract
This paper examines the usefulness of psychophysiological measurements in a biocooperative feedback loop that adjusts the difficulty of an upper extremity rehabilitation task. Psychophysiological measurements (heart rate, skin conductance, respiration and skin temperature) were used...
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PMID: 21708507
PDF is available here.
Abstract
A ground reaction based method is proposed to evaluate the hypothesis that a stabilization phase occurs in transitions towards erect posture, following the macroscopic movement and preceding the quiet final erect posture, whose aim is to control and dissipate the residual inertial un...
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PMID: 21708508
PDF is available here.
Abstract
We aimed to systematically study the effect of prosthetic foot mechanics on gait, to gain insight into fundamental prosthetic design principles. We varied a single parameter in isolation, the energy-storing spring in a prototype prosthetic foot, the Controlled Energy Storage and Return (CESR) foot,...
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PMID: 21708509
PDF is available here.
Michael S MS Samuel,
Jose I JI Lopez,
Ewan J EJ McGhee,
Daniel R DR Croft,
David D Strachan,
Paul P Timpson,
June J Munro,
Ewald E Schröder,
Jing J Zhou,
Valerie G VG Brunton,
Nick N Barker,
Hans H Clevers,
Owen J OJ Sansom,
Kurt I KI Anderson,
Valerie M VM Weaver and
Michael F MF Olson
Abstract
We expressed conditionally active ROCK2 in mouse skin. ROCK activation elevated tissue stiffness via increased collagen. β-catenin, a key element of mechanotranscription pathways, was stabilized by ROCK activation leading to nuclear accumulation, transcriptional activation, and consequent hyperprol...
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PMID: 21665151
PDF is available here.
Abstract
Currently, biomedical engineering is rapidly expanding, especially in the areas of drug delivery, gene transfer, tissue engineering, and regenerative medicine. A prerequisite for further development is the design and synthesis of novel multifunctional biomaterials that are biocompati...
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PMID: 21469742
PDF is available here.
Abstract
We have designed and produced a modular, recombinant resilin-like polypeptide bearing both mechanically active and biologically active domains to create novel biomaterial microenvironments for engineering mechanically active tissues such as blood vessels, cardiovascular tissues, and vocal folds. Pre...
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PMID: 21553895
PDF is available here.
Abstract
We discuss the use of AFM to characterize the dramatic shape changes of mitotic cells. AFM-based mechanical assays can be applied to measure the considerable rounding force and hydrostatic pressure generated by mitotic cells. A complementary AFM technique, single-molecule force spectroscopy, is able...
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PMID: 21646023
PDF is available here.
Abstract
The median segmentation time was <1 hour (mean 39.2 minutes, range 25-48) for datasets from the AAA patients; for the healthy individuals, segmentation times were considerably shorter (median 8.7 minutes, range 4-15). Intraobserver reproducibility was high, as represented by a CV <3% for the diam...
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PMID: 21679063
PDF is available here.
Abstract
The numerical predictions showed a good overall agreement between the calculated displacements of the motion measures from MRA images. The average position error comparing the calculated vs. actual displacements of the femoropopliteal intersection measured on the MRA was 8±4 mm. Two of the 8 subje...
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PMID: 21679081
PDF is available here.
Abstract
Understanding how the human speech production system is related to the human auditory system has been a perennial subject of inquiry. To investigate the production-perception link, in this paper, a computational analysis has been performed using the articulatory movement data obtaine...
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PMID: 21682422
PDF is available here.
Abstract
We determined the reliability of the hip-to-ankle radiograph using the Bland-Altman analysis. Two consecutive hip-to-ankle radiographs were obtained in 52 patients (52 knees) after total knee arthroplasty. There was an excellent agreement between mechanical axis angles, tibiofemoral angles, and femo...
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PMID: 21846000
PDF is available here.
Abstract
This paper presents a formulation for the three-dimensional numerical simulation of mechanically regulated bone adaptation. Attention is focussed on a phenomenologically-based approach to bone remodelling that can be used as a computationally efficient tool to provide insight into th...
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PMID: 21616467
PDF is available here.
Abstract
We present results where ten typically-developing toddlers are trained to drive a robot within an obstacle course. We also report a case study with a toddler with spina-bifida who cannot independently walk. Using algorithms based on artificial potential fields to avoid obstacles, we create force fie...
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PMID: 21324787
PDF is available here.
Abstract
Objective-To determine solar load-bearing structures in the feet of feral horses and investigate morphological characteristics of the sole in feral horses and domestic Thoroughbreds. Sample-Forelimbs from cadavers of 70 feral horses and 20 domestic Thoroughbreds in Australia. Procedures-Left forefeet...
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PMID: 21627516
PDF is available here.
Abstract
Objective-To determine the accuracy of pressure plate kinetic asymmetry indices (ASIs) for diagnosis of unilateral hind limb lameness in dogs and their correlation with visual gait assessment (VGA) scores. Animals-9 healthy dogs and 16 dogs with previously diagnosed unilateral rupture of the cranial...
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PMID: 21627529
PDF is available here.
Abstract
The aim of this study was to evaluate the reliability of two long jump tasks and their ability to predict 10 m sprint performance in elite adolescent female athletes. Eight junior national-level female track and field athletes completed three standing (SLJ) and reactive long jumps (RLJ) on portable f...
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PMID: 21834392
PDF is available here.
Abstract
By understanding the normal humeral and scapular kinematics during the kayak stroke, inferences about the relationship of kayaking technique and shoulder injury may be established. The purpose of this study was to describe scapular and humeral kinematics and to compare dominant versus nondominant sym...
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PMID: 21834394
PDF is available here.