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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Protein Folding (0):
Recent article
Protein Folding
Abstract
We examined the conformational transitions in a multimeric and high molecular weight class II α-mannosidase from Canavalia ensiformis (Jack Bean) (Jbα-man) utilizing intrinsic fluorescence, solute quenching, hydrophobic dye binding, size exclusion chromatography and circular dichroism (CD) spectro...
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PMID: 21087596
PDF is available here.
PDF is available here.
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Abstract
We first analyzed donor specificity of UGGT, which was proven to be rather narrow. However, marginal activity was observed with UDP-galactose and UDP-glucuronic acid as well as with 3-, 4- and 6-deoxy glucose analogues to give corresponding transfer products. Intriguingly, G-II smoothly converted al...
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PMID: 21075077
PDF is available here.
PDF is available here.
Abstract
Abstract
A disruptive interaction of phosphoserine with tryptophan in peptides that autonomously fold into a β-hairpin structure in aqueous solution was explored in a positional context within the hairpin structure. All the peptides presented here have a serine or phosphoserine directly cross strand from a...
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PMID: 20856979
PDF is available here.
PDF is available here.
Abstract
We fractionated by chromatographic methods the ultrafiltrate obtained during dialysis, and examined by flow cytometry the effect of the resulting fractions on phosphatidylserine exposure in human red cells. Chromatographic procedures disclosed a homogeneous fraction able to increase erythrocyte phos...
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PMID: 21107472
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)12 2010
Abstract
This article summarizes the proceedings of a one-day international workshop held in July 2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related disorders. HLA-B27 is found in about 90% of patients with AS, with an odds ratio of about 100, but the mechanism underlyi...
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PMID: 21123333
PDF is available here.
PDF is available here.
EMBO Journal (29)23 2010
Abstract
We found that, in the rate-limiting intermediate of a chaperonin reaction, the unfolded polypeptide in the cage partly protrudes through a narrow space near the GroEL/GroES interface. Then, the entire polypeptide is released either into the cage or to the outside medium. The former adopts a native s...
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PMID: 20959808
PDF is available here.
PDF is available here.
Abstract
We report a structural and functional study of cold shock protein A from Mycobacterium tuberculosis, MTB-CspA. Structural investigations by CD and NMR reveal that MTB-CspA is less ordered than expected and is the least thermal stable cold shock protein so far characterized. However, electrophoretic...
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PMID: 20977881
PDF is available here.
PDF is available here.
Journal of Chromatography B (878)30 2010
Abstract
We described here an effective approach termed Enzymatic Digestion-Organic Solvent Extraction (eDOSE) that utilizes the enzymatic approach to disrupt the folded structures of proteins and release entrapped or adsorbed pesticide residues. In this approach, samples were first reduced, alkylated, trypt...
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PMID: 20970391
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)46 2010
Abstract
The deletion of phenylalanine 508 in the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator is directly associated with >90% of cystic fibrosis cases. This mutant protein fails to traffic out of the endoplasmic reticulum and is subsequently degraded by the pro...
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PMID: 20667826
PDF is available here.
PDF is available here.
A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice.
Abstract
We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1(+/0)) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of...
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PMID: 20920476
PDF is available here.
PDF is available here.
Abstract
Prions are an unusual form of epigenetics: Their stable inheritance and complex phenotypes come about through protein folding rather than nucleic acid-associated changes. With intimate ties to protein homeostasis and a remarkable sensitivity to stress, prions are a robust mechanism that links enviro...
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PMID: 21030648
PDF is available here.
PDF is available here.
Abstract
We found that protein conformation determined the size distribution of aggregates through its interactions with a molecular chaperone. Shifts in this range created variations in aggregate abundance among cells because of a size threshold for transmission, and this heterogeneity, along with aggregate...
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PMID: 21030659
PDF is available here.
PDF is available here.
Abstract
We review the role of the PN in managing the protein fold and function during synthesis in the ER and trafficking to the cell surface or extracellular space. We highlight the role of the proteostasis boundary to define the operation of the proteome (Annu Rev Biochem 2009;78:959). We discuss how mani...
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PMID: 21030523
PDF is available here.
PDF is available here.
Abstract
We review some of the basic workings of unfolded protein response and relate them to processes that are of potential relevance to pulmonary disease....
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PMID: 21030513
PDF is available here.
PDF is available here.
Abstract
Recent progress in understanding the production, processing, and function of the cystic fibrosis gene product, the cystic fibrosis transmembrane conductance regulator (CFTR), has revealed new therapeutic targets to repair the mutant protein. Classification of CFTR mutations and new treatment strateg...
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PMID: 20829696
PDF is available here.
PDF is available here.
Abstract
We present an automated tool, SimGlycan, for this purpose, which accepts raw/standard MS data files as input and characterizes the associated glycan structure with high accuracy using database searching and scoring techniques. Not only does it predict the glycan structure using an MS/MS database sea...
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PMID: 19882135
PDF is available here.
PDF is available here.
Circulation (122)17 2010
Abstract
Biochemical Journal (432)1 2010
Abstract
We have investigated the possible effects on hA misfolding of the chaperones HSP (heat-shock protein) 70, GRP78/BiP (glucose-regulated protein of 78 kDa/immunoglobulin heavy-chain-binding protein) and HSP40/DnaJ. We demonstrate that hA underwent spontaneous time-dependent β-sheet formation and aggr...
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PMID: 20735358
PDF is available here.
PDF is available here.
Abstract
We extend such work to flexible, multidomain proteins and one of the most widespread membrane transporter families, the major facilitator superfamily, thus showing that more complex membrane proteins can be successfully refolded to recover native substrate binding. We determine the unfolding free en...
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PMID: 20937906
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We examined the interaction of kAE1 with the quality control system responsible for the folding of membrane glycoproteins and the retention and degradation of misfolded mutants. Using small molecule inhibitors to disrupt chaperone interactions, two functional, dominant kAE1 mutants (R589H and R901st...
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PMID: 20628050
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We report the first three-dimensional structure of the mammalian selenoprotein methionine sulfoxide reductase B1 (MsrB1), determined by high resolution NMR spectroscopy. Heteronuclear multidimensional spectra yielded NMR spectral assignments for the reduced form of MsrB1 in which catalytic selenocys...
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PMID: 20605785
PDF is available here.
PDF is available here.
Abstract
We examined two fundamental processes in protein dynamics--protein folding and conformational change within the folded state--by means of extremely long all-atom MD simulations conducted on a special-purpose machine. Equilibrium simulations of a WW protein domain captured multiple folding and unfold...
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PMID: 20947758
PDF is available here.
PDF is available here.
Abstract
We provide the basis of pre-Tα-TCRβ assembly and pre-TCR dimerization. The pre-Tα chain comprised a single immunoglobulin-like domain that is structurally distinct from the constant (C) domain of the TCR α-chain; nevertheless, the mode of association between pre-Tα and TCRβ mirrored that media...
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PMID: 20944746
PDF is available here.
PDF is available here.
Abstract
We investigate the folding, stability and dynamics of three small protein substrates in the antechamber by methyl transverse-relaxation-optimized NMR spectroscopy. We show that these substrates interact actively with the antechamber walls and have drastically altered kinetic and equilibrium properti...
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PMID: 20944750
PDF is available here.
PDF is available here.