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Membrane Fluidity (0):
Recent article
Membrane Fluidity
Fungal Biology (115)10 2011
Abstract
Our aim was to investigate the response of selected yeasts and yeast-like fungi from extreme environments to various temperatures at the level of their plasma membranes, in order to elucidate the connections between their plasma-membrane fluidity (measured by electron paramagnetic resonance spectro...
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PMID: 21944207
PDF is available here.
PDF is available here.
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Abstract
Two experiments were performed in the present study that demonstrated that boar spermatozoa are capable of surviving rapid cooling rates within a range of 15-5 °C before freezing. Boar ejaculates diluted in Beltsville thawing solution (BTS) (1:1, v/v) were held at 17-20 °C and shipped over a 24-h t...
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PMID: 21635817
PDF is available here.
PDF is available here.
Abstract
We show that the entropic contribution enhances the curvature-mediated repulsion between the two cylinders. This is contrary to the usual attractive Casimir force in the absence of curvature-mediated interactions. For a large distance between the cylinders, we retrieve the renormalization of the sur...
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PMID: 21728585
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)8 2011
Abstract
We provide a comprehensive discussion on the possible explanations for the observed mechanics and dynamics in the TOPOPC system and on their potential cellular implications....
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PMID: 21545789
PDF is available here.
PDF is available here.
Abstract
We find that at some concentration ratios the bilayers separate spatially into regions of higher and lower chain order coinciding with areas enriched with PSM and POPC, respectively. To examine the effect of the asymmetric chain structure of POPC on bilayer lateral inhomogeneity, we consider POPC-li...
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PMID: 21517541
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
It has been recently shown that mitochondrial creatine kinase (mtCK) organizes mitochondrial model membrane by modulating the state and fluidity of lipids and by promoting the formation of protein-cardiolipin clusters. This report shows, using Brewster angle microscopy, that such clustering is largel...
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PMID: 21256109
PDF is available here.
PDF is available here.
Abstract
We have previously shown that besides its interaction with anionic lipids, the cyt c is also able to cross neutral lipid membranes. In this work, with the help of AFM and punch-through experiments, we have measured the force required to penetrate the membrane in the fluid and in the gel phases with...
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PMID: 20832261
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Our present study also showed that supplementation of the synbiotic reduced the concentration of saturated fatty acids (SFA), increased unsaturated fatty acids (UFA), and increased the ratio of UFA:SFA over 12 wk, whereas the control showed inconspicuous changes. The alteration of RBC membrane was a...
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PMID: 20854987
PDF is available here.
PDF is available here.
Abstract
We have proposed a possibility of another important sphingolipid function associated with cold acclimation. In animal cells, it has been known that the plasma membrane contains microdomains due to the chanracteristics of sphingolipids and sterols, and the sphingolipid- and sterol-enriched microdomai...
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PMID: 20818179
PDF is available here.
PDF is available here.
Abstract
We observed changes in cell morphology under stress conditions. Surprisingly, in the cell, Hsp12 exists both as a soluble cytosolic protein and associated to the plasma membrane. The in vitro analysis revealed that Hsp12, unlike all other Hsps studied so far, is completely unfolded; however, in the...
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PMID: 20797624
PDF is available here.
PDF is available here.
Abstract
We showed that ezrin and RhoGDI1 are expressed in human testes. Thus, we sought to determine whether the ezrin-RhoGDI1-actin-membrane protein network has a role in human sperm capacitation. Our results by Western blot indicate that ezrin is activated by phosphorylation of the threonine567 residue du...
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PMID: 20711218
PDF is available here.
PDF is available here.
Abstract
Penetration of the liposome membranes formed in the gel phase from DPPC (DPPC liposomes) and in the liquid-crystalline phase from egg yolk lecithin (EYL liposomes) by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) and 16 DOXYL (2-ethyl-2-(15-methoxy-oxopentadecyl)-4,4-dimethyl-3-oxazolidinyloxy) s...
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PMID: 19857052
PDF is available here.
PDF is available here.
Abstract
Liposomal locked-in dendrimers (LLDs), the combination of liposomes and dendrimers in one formulation, represents a relatively new term in the drug carrier technology. LLDs undergone appropriate physicochemical investigation can merge the benefits of liposomal and dendrimeric nanocar...
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PMID: 20564386
PDF is available here.
PDF is available here.
Abstract
Cardiac arrhythmias are a leading cause of morbidity and mortality in the Western world. Ventricular arrhythmias are reportedly responsible for the majority of sudden cardiac deaths and atrial fibrillation is responsible for 15% of all strokes in the USA. Recent evidence suggests a role for choleste...
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PMID: 20602558
PDF is available here.
PDF is available here.
Abstract
Sperm membrane fluidity is one of the causes of male infertility, and it is thought to be related with temperature, reactive oxygen species, oxygen free radicals, anti-sperm antibodies, stilbestrol, and fenvalerate. A deeper insight into the influencing factors of sperm membrane fluidity is of vital...
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PMID: 20608360
PDF is available here.
PDF is available here.
Abstract
We characterized the influence of three different detachment procedures: cell scraping by rubber policeman, trypsinization and a citrate buffer treatment on V-79 cells in the plateau phase of growth (arrested in G1). We have measured cell viability by a dye-exclusion test; nitroxide reduction kineti...
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PMID: 20337597
PDF is available here.
PDF is available here.
Abstract
We previously reported the presence of Pgp pumps in eggshells and cuticles of the nematode Haemonchus contortus. Eggshells and cuticles are different from cell membranes, in particular they include a chitin layer. Nevertheless these structures present some common biological features with cell membra...
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PMID: 20555388
PDF is available here.
PDF is available here.
Abstract
Haemolysis must be limited during perioperative blood salvage in order to prevent exposure to oxidative stress and improve the efficiency of autotransfusion....
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PMID: 20158444
PDF is available here.
PDF is available here.
Chemistry and Physics of Lipids (163)4-5 2010
Abstract
We have studied the membrane interaction of E(2) using a combination of solid-state NMR methods. (2)H NMR results indicate that E(2) does not cause a condensation effect of the surrounding phospholipids, which is contrary to the effects of cholesterol, and only very modest E(2) induced alterations o...
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PMID: 20153306
PDF is available here.
PDF is available here.
Abstract
We have shown in oxidative-stress-resistant cell lines, HT22(H2O2) and HT22(Glu), derived from the neuronal cell line HT22 by chronic exposure to sublethal concentrations of H(2)O(2) and glutamate, that, in addition to the known antioxidant defense mechanisms, e.g., activation of antioxidant enzymes...
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PMID: 20156550
PDF is available here.
PDF is available here.
Abstract
We demonstrate the effects of type III secretory phospholipase A(2) (sPLA(2)-III) on sAPP(alpha) secretion. Exposing differentiated neuronal cells (SH-SY5Y cells and primary rat neurons) to sPLA(2)-III for 24 h increased sAPP(alpha) secretion and decreased levels of Abeta(1-42) in SH-SY5Y cells, and...
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PMID: 19805624
PDF is available here.
PDF is available here.
Journal of Membrane Biology (235)1 2010
Abstract
SIMtoEXP is a software package designed to facilitate the comparison of biomembrane simulations with experimental X-ray and neutron scattering data. It has the following features: (1) Accepts number density profiles from simulations in a standard but flexible format. (2) Calculates the electron dens...
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PMID: 20407764
PDF is available here.
PDF is available here.
Journal of Membrane Biology (235)1 2010
Abstract
We examined the thermodynamic and structural changes that occur as a phosphatidylcholine lipid bilayer stack is dehydrated. The simulated system represents a micropatch of lipid multilayer systems that are studied experimentally using surface force apparatus, atomic force microscopy and osmotic pres...
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PMID: 20387061
PDF is available here.
PDF is available here.
Abstract
Lipid bilayer model membranes that contain a single lipid species can undergo transitions between ordered and disordered phases, and membranes that contain a mixture of lipid species can undergo phase separations. Studies of these transformations are of interest for what they can tell us about the i...
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PMID: 20192775
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (88)4 2010
Abstract
We used electron paramagnetic resonance (EPR) spectroscopy and fatty acid spin probes (5-DS and 12-DS) where EPR spectra were dependent on fluidity. The results showed that genistein significantly (p < 0.05) decreased erythrocyte membrane fluidity near the hydrophilic surface, while daidzein signifi...
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PMID: 20555419
PDF is available here.
PDF is available here.
Physical Review Letters (104)11 2010
Abstract
We demonstrate that the combination of the spatial correlation and temporal fluctuation spectra of the lipid domains can be employed to unambiguously differentiate between the existing theoretical scenarios. Furthermore, the differentiation of the raft formation mechanisms using this methodology can...
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PMID: 20366502
PDF is available here.
PDF is available here.
Physical Review E (81)3 Pt 1 2010
Abstract
We show that, as the rate of supply of chemical energy is increased above a certain threshold, this uniform state becomes unstable and stationary or traveling waves spontaneously develop in the system. Such waves are accompanied by periodic spatial variations of the membrane curvature and the inclus...
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PMID: 20365764
PDF is available here.
PDF is available here.
Abstract
We measured the membrane fluidity (a reciprocal value of membrane microviscosity) of red blood cells (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin-labeling method. Membrane fluidity of RBCs was decreased in hypertensive men compared with normotensive men...
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PMID: 20379046
PDF is available here.
PDF is available here.
Abstract
To explore the effects of glucose concentration fluctuation on function of cultured bovine arterial endothelial cells and underlying mechanism.
The thoracic aorta of newborn calf was used for primary endothelial cells culture. Cells were divided into 3 groups and cultured for 48 h: control group (C,...
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PMID: 20450571
PDF is available here.
PDF is available here.
Abstract
Pilots, in spite of their oxidative stress, are better protected than controls, probably as a result of their physical training and proper diet. Our results confirm that erythrocytes, with their 120-day life span, are a useful model for investigating physiopathological conditions, and glycohydrolase...
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PMID: 20001851
PDF is available here.
PDF is available here.
Abstract
The effects of tri- and monoglycerides on phospholipid (POPC) membranes were studied using spectroscopical methods. Triolein was found to form two types of POPC-rich membranes, both with POPC or as a three-component system with monopalmitin. These two membrane types were determined as co-existing ph...
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PMID: 19962372
PDF is available here.
PDF is available here.
Abstract
Anaerobic bacteria such as the solventogenic clostridia can ferment a wide range of carbon sources (e.g., glucose, galactose, cellobiose, mannose, xylose, and arabinose) to produce carboxylic acids (acetic and butyric) and solvents such as acetone, butanol, and ethanol (ABE). The fer...
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PMID: 20033401
PDF is available here.
PDF is available here.
Abstract
We previously showed that lymphocytes and erythrocytes of HIV-1-infected patients, prior to antiretroviral therapy, presented significant changes in intracellular calcium concentration ([Ca(2+)](int)) and membrane fluidity. The present study evaluates the same parameters after response to highly act...
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PMID: 20191248
PDF is available here.
PDF is available here.
Abstract
Methods of wide-field fluorescence microscopy for measuring membrane dynamics of living cells are described, including spectral imaging as well as anisotropy imaging of the membrane marker 6-dodecanoyl-2-dimethylamino naphthalene (laurdan). Plasma membranes are selected by illumination with an evane...
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PMID: 20799819
PDF is available here.
PDF is available here.
Abstract
These results suggest that TCDD-mediated oxidative stress was not responsible for changes in mitochondrial respiration or membrane fluidity. Furthermore, although TCDD produced a large increase in mitochondrial oxygen consumption, this was not associated with the poor gain in weight produced by TCDD...
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PMID: 19926830
PDF is available here.
PDF is available here.
Cellular and Molecular Biology (56 Suppl) 2010
Abstract
We determined the production of NO and the expression of endothelial NO synthase mRNAs. Na,K-ATPase activity was strongly decreased by 7-ketocholesterol. This decrease, not related to lipoperoxidation, was correlated with a decreased expression of the Na,K-ATPase α1-subunit messengers and with rigi...
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PMID: 21062577
PDF is available here.
PDF is available here.
Abstract
Novel markers for ischemic heart disease are under investigation by the scientific community at international level.This work focuses on a specific platelet membrane fatty acid condition of viscosity which is linked to molecular aspects such as serotonin and G proteins, factors involved in vascular...
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PMID: 20825633
PDF is available here.
PDF is available here.
Respiratory Research (11)1 2010
Abstract
We conclude that PFC effects can be explained by modest, unspecific interactions with the plasma membrane rather than by specific interactions with intracellular targets....
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PMID: 20459693
PDF is available here.
PDF is available here.
Abstract
In the present study it was shown that resveratrol (3,4,5-trihydroxystilbene), an efficient light-absorbing molecule, during its transition from trans to cis configuration under UV light, transfers its energy of excitation to triplet oxygen to produce singlet oxygen ((1)O(2)). This transition is pre...
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PMID: 20133975
PDF is available here.
PDF is available here.
Biochemical Journal (427)3 2010
Abstract
We show that proteolytic processing of NTL6 is regulated by cold-induced remodelling of membrane fluidity. NTL6 processing was stimulated rapidly by cold. The protein stability of NTL6 was also enhanced by cold. The effects of cold on NTL6 processing and protein stability were significantly reduced...
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PMID: 20156199
PDF is available here.
PDF is available here.
Journal of Cell Science (123)Pt 1 2010
Abstract
We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12 Delta. Cells carrying the temperature-sensitive brr6-1 allele have been shown to have defects in nucleoporin localization, mRNA metabolism and nuclear transport. Electron microscopy...
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PMID: 20016074
PDF is available here.
PDF is available here.
Methods in Molecular Biology (606)606 2009
Abstract
Electron paramagnetic resonance (EPR) spin-labeling methods provide a unique opportunity to determine the lateral organization of lipid bilayer membranes by discrimination of coexisting membrane domains or coexisting membrane phases. In some cases, coexisting membrane domains can be characterized wi...
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PMID: 20013402
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (87)12 2009
Abstract
Our results indicate that the amplification of calcium transients in the diabetic heart is associated with an increase in their amplitude. Moreover, the signals transferred by calcium transients also regulated ETP formation in nondiabetic myocardium. Evidence for the indispensable role of calcium in...
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PMID: 20029545
PDF is available here.
PDF is available here.
Abstract
We suggest a schematic model with which this kinetic feature can be interpreted in terms of a self-assembly pathway in a three-component phase diagram for a phospholipid, organic solvent, and water....
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PMID: 20364985
PDF is available here.
PDF is available here.
Abstract
We discuss the mechanism of these trends by considering the elastic free energy of the membrane....
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PMID: 20365020
PDF is available here.
PDF is available here.
Abstract
Purpose: To address the links between calcium, peroxidation, cell damage and death and the response of the enzymes involved in free radical metabolism, in splenocytes of mice irradiated with gamma-rays.
Materials and methods: Splenocytes of Swiss albino mice were irradiated... | PMID: 14703946
PDF is available here.
Materials and methods: Splenocytes of Swiss albino mice were irradiated... | PMID: 14703946
PDF is available here.
Biochemistry (Washington) (48)36 2009
Abstract
We demonstrated that fluconazole administration decreased the rigidity of the plasma membrane of Saccharomyces cerevisiae, leading to a dramatic reduction in the order parameter (S) from 0.965 to 0.907 and a 5-fold acceleration of the rotational lipid motion. This suggests that the altered sterol ha...
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PMID: 19670905
PDF is available here.
PDF is available here.
Abstract
A system for studying biological effect of radio frequency electromagnetic field was developed. The system can form an area where electromagnetic wave with large frequency range is well distributed. The strength of electromagnetic wave was measured easily. Electromagnetic wave in the system did not...
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PMID: 19798972
PDF is available here.
PDF is available here.
Nutrition and Cancer (61)3 2009
Abstract
Many data support the beneficial effect of n-3 polyunsaturated fatty acids (PUFAs) as chemopreventive and chemotherapeutic agents in the treatment of several chronic pathologies including cancer. Different molecular mechanisms have been proposed to explain their effects, including alterations in arac...
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PMID: 19373602
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1788)7 2009
Abstract
We performed computational analyses of model liposomes with palmitate, oleate, and linoleate. The computational results indicate that the unsaturated fatty acid chain serves as a membrane stabilizer by preventing changes to the membrane fluidity. Based on a Voronoi tessellation analysis, unsaturated...
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PMID: 19371719
PDF is available here.
PDF is available here.
Biophysical Journal (96)9 2009
Abstract
In this study, the center-of-mass diffusion and shape fluctuations of large unilamellar 1-palmitoyl-2-oleyl-sn-glycero-phosphatidylcholine vesicles prepared by extrusion are studied by means of neutron spin echo in combination with dynamic light scattering. The intermediate scattering functions were...
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PMID: 19413968
PDF is available here.
PDF is available here.
Biophysical Journal (96)9 2009
Abstract
We review the main trends in the development of fluorescence probes to obtain information about the structure, dynamics, and interactions in biomembranes. These probes are efficient for studying the microscopic analogs of viscosity, polarity, and hydration, as well as the molecular order, environmen...
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PMID: 19413953
PDF is available here.
PDF is available here.
médecine/sciences (25)5 2009
Abstract
We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif. Since a membrane is not solely defined by its shape but also by its lipids composition, we will show how others proteins are adapted to...
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PMID: 19480829
PDF is available here.
PDF is available here.
Abstract
We successfully form a two-phase (gel-fluid) lipid bilayer supported by nanoporous silica xerogel. Surface topology, lateral diffusion coefficient, and lipid density in comparison to mica-supported lipid bilayers were characterized by atomic force microscopy, fluorescence recovery after photobleachi...
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PMID: 19708250
PDF is available here.
PDF is available here.
Abstract
We have fabricated these hybrid liposomes by directly hybridizing metal nanoparticles with lipid bilayers solely consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC). For this, we have used the dehydration and rehydration method. Characterizing their morphology and micro-fluidity, i...
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PMID: 19162452
PDF is available here.
PDF is available here.
Abstract
These findings suggest that a short treatment with atorvastatin is disadvantageous to subjects with the CC genotype for the T-786C polymorphism compared to those with TT genotype, at least in terms of the hemorheological properties of erythrocytes....
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PMID: 19104789
PDF is available here.
PDF is available here.
Physical Review Letters (102)13 2009
Abstract
We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surroun...
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PMID: 19392406
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that ethanol adaptation in C. thermocellum involves lipid modification by comparing the fatty acid composition and membrane anisotropy of wild-type and ethanol-adapted strains. Derivatization to fatty acid methyl esters provided quantitative lipid analysis. Compared to wild-...
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PMID: 19221734
PDF is available here.
PDF is available here.
Abstract
We study the effect of temperature and membrane composition on the structural and dynamical properties of a liposomal membrane in the limit of high curvature (liposomal diameter of 15-20 nm), using coarse grained molecular dynamics simulations. Both pure dipalmitoyl phosphatidylcholine (DPPC) liposo...
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PMID: 19280016
PDF is available here.
PDF is available here.
Biophysical Journal (96)6 2009
Abstract
We used a hydrodynamic membrane tube extrusion technique to characterize the mechanical interaction between the plasma membrane and the underlying cortical cytoskeleton. Cells were anchored on 4.5 microm beads coated with polylysine (PL) to obtain nonspecific cell adhesion or with an antibody agains...
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PMID: 19289070
PDF is available here.
PDF is available here.