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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Half-Life (0):
Recent article
Half-Life
Abstract
A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high p...
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PMID: 21068517
PDF is available here.
PDF is available here.
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Hämostaseologie (30 Suppl 1) 2010
Abstract
We report on a boy with severe haemophilia A and intron 22 inversion of the FVIII gene who was diagnosed at ten months of age. After 16 exposure days to FVIII (81 days after initial exposure) he developed a FVIII inhibitor (maximum: 9.76 BU/ml). Therapy: We started immune tolerance induction (ITI) a...
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PMID: 21042665
PDF is available here.
PDF is available here.
Abstract
The pharmacokinetics of procaterol, a selective beta2-adrenergic agonist with a high intrinsic efficacy in man, could not be determined in humans when the drug was launched because of the low therapeutic dose and the low sensitivity of the analytical methods available at the time. However, a recentl...
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PMID: 20979933
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of PRB co-administered with mizoribine (MZR) on the pharmacokinetics (PK) of MZR in 12 patients with nephrotic syndrome. The elimination rate constant (kel) was used as an indicator of changes in the PK of MZR when the secretion of MZR was inhibited by co-administration of P...
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PMID: 20979934
PDF is available here.
PDF is available here.
Abstract
Controlled-release levodopa/carbidopa (CR-LC) is often used to provide prolonged control of night-time motor symptoms in patients with Parkinson's disease (PD). Levodopa/carbidopa/entacapone (LCE) provides higher bioavailability of levodopa compared with levodopa/carbidopa formulations and has been...
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PMID: 20979935
PDF is available here.
PDF is available here.
Abstract
To investigate potential differences in zibotentan pharmacokinetics between Japanese and Caucasian patients with hormone-resistant prostate cancer (HRPC) following single and multiple dosing.
In the Japanese study, 18 patients received a single dose of zibotentan 5, 10 or 15 mg followed by 72 h wash...
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PMID: 20979929
PDF is available here.
PDF is available here.
Health Physics (99)5 2010
Abstract
The Standard Model of Particle Physics is reviewed with an emphasis on its relationship to the physics supporting the health physics profession. Concepts important to health physics are emphasized and specific applications are presented. The capability of the Standard Model to provide health physics...
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PMID: 20938231
PDF is available here.
PDF is available here.
Marine Pollution Bulletin (60)11 2010
Abstract
The occurrence of three endocrine disrupting compounds, 4-n-nonylphenol, triclosan and bisphenol A, was investigated in different bivalves originating from the Aegean Sea (Greece). The bioconcentration potential of these compounds was studied using the Mediterranean mussel (Mytilus galloprovincialis...
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PMID: 20850845
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)5 2010
Abstract
Current Eye Research (35)11 2010
Abstract
I and group II and each group received a single drop (30 µl) of either 1% or 0.1% VZ formulation. Aqueous humor was collected at designated time intervals. For multidose kinetics, a single drop of 1% VZ was instilled 5 times either hourly or every 2 hr. The aqueous humor was tested for VZ at the 5t...
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PMID: 20958183
PDF is available here.
PDF is available here.
Abstract
To investigate the pharmacokinetics behaviour of tetramethylpyrazine (TMP) by intravenous administration in rats.
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PMID: 21355200
PDF is available here.
PDF is available here.
Abstract
Thienorphine-loaded microspheres composed of poly(D,L-lactide-co-glycolide) were prepared by an O/W emulsion solvent evaporation method. HPLC was used to determine the drug loading and drug release, while a LC-MS-MS system was employed to analyze the plasma drug concentration. Results indicated that...
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PMID: 21105573
PDF is available here.
PDF is available here.
Abstract
In a previous study it has been demonstrated that a dissolution/permeation (D/P) system can discriminate between different immediate release fenofibrate formulations. The fractions permeated were correlated with fenofibrate's in vivo exposure in rats following p.o. administration. In the present stu...
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PMID: 21105572
PDF is available here.
PDF is available here.
Abstract
Midazolam in an autoinjector was evaluated in an open-label dose escalation study involving 39 healthy participants. Safety and pharmacokinetic parameters were determined for doses ranging from 5 to 30 mg. No serious adverse events were noted during the study. Two participants (30 mg) experienced ch...
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PMID: 20466872
PDF is available here.
PDF is available here.
Abstract
No adverse effects were observed in any of the mares after minocycline administration. The mean+/-SD elimination half-life was 7.70+/-1.91 hours. The total body clearance was 0.16+/-0.04 L/h/kg, and the volume of distribution at steady state was 1.53+/-0.09 L/kg. The percentage of plasma protein bin...
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PMID: 20807146
PDF is available here.
PDF is available here.
Abstract
Captive Asian elephants (Elephas maximus) are susceptible to lameness resulting from foot and joint pain, including chronic arthritis. In the past, opioid analgesics, such as butorphanol, have been used clinically for pain management. However, dosages used in treating elephants were often extrapolat...
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PMID: 20945638
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
We determined the mRNA and protein expression of DNMT1 in Jurkat T-leukemia cells, after incubation with Lfcin B, by real-time quantitative reverse transcription PCR and Western blot analysis. The results of real-time quantitative reverse transcription PCR showed that DNMT1 expression in Jurkat T-le...
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PMID: 20723665
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)3 2010
Abstract
Because of large arteriovenous differences in M6G plasma, concentration biases in pharmacodynamic model parameters will occur when linking venous concentration to effect, using a traditional effect-compartment model....
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PMID: 20547824
PDF is available here.
PDF is available here.
Abstract
Oral sunitinib 37.5 mg/day on Schedule 2/1 with docetaxel 75 mg/m(2) IV q21d is a clinically feasible regimen with a manageable safety profile, no pharmacokinetic drug-drug interactions, and shows antitumor activity in patients with advanced solid tumors....
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PMID: 20043166
PDF is available here.
PDF is available here.
Abstract
We examine current evidence on the relevance of FcRn in maintaining high autoantibody levels and discuss FcRn-targeted therapeutic approaches. Further investigation of the FcRn-IgG interaction will not only provide mechanistic insights into the receptor function, but should also greatly facilitate t...
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PMID: 20217455
PDF is available here.
PDF is available here.
Abstract
Optimal biotin concentration was 0.04 pg of biotin/RBC, and the optimal streptavidin-PE ratio was 1.2 microg of streptavidin-PE/1 x 10(6) RBCs. Posttransfusion lifespan of autologous RBCs was 99, 89, 66, and 59 days after storage for 0, 1, 14, and 28 days, respectively. Storage did not result in sig...
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PMID: 20673097
PDF is available here.
PDF is available here.
Abstract
A simple, specific and sensitive RP-HPLC method with UV detection for the determination of hopantenic acid in human blood plasma has been developed. The pharmacokinetics of drug pantocalcin upon single peroral administration was investigated on 18 healthy volunteers. The peak of hopantenic acid in b...
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PMID: 20919560
PDF is available here.
PDF is available here.
Abstract
These studies demonstrated that Danshen aqueous extract affected the metabolism of CYP1A2 substrates through competitive inhibition and altered their clearance....
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PMID: 20663043
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)2 2010
Abstract
Clearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of the gamma-carboxy glutamic acid (Gla) domain and the sialic acid content of the protein on rFVIIa clearance...
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PMID: 20508904
PDF is available here.
PDF is available here.
Abstract
Gimatecan appears to have high plasma disposition. The drug was present in plasma almost completely as the intact lactone form and showed substantial activity in all tumor models. Prolonged daily treatment with low doses of gimatecan produced significant tumor regression in all tumor xenografts. CON...
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PMID: 20091168
PDF is available here.
PDF is available here.