Abstract
Infrared radiation temperature and characteristics of infrared spectrum of meridians and acupoints are summarized in this article. The infrared radiant track along the running course of meridians might be a ubiquitous phenomenon of the vital activity. The high temperature bands below the meridian li...
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PMID: 21058481
PDF is available here.
Abstract
We developed an approach that utilizes physiologically based pharmacokinetic (PBPK) modeling coupled with Monte Carlo simulation to generate a virtual population, complete with associated patient characteristics and PK data, for population PK analysis. For this work, we used a previously published P...
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PMID: 20803616
PDF is available here.
José Raúl García-Lozano,
Cristina Abad,
Ana Escalera,
Belén Torres,
Olga Fernández,
Alicia García,
Julio Sánchez-Román,
José-Mario Sabio,
Norberto Ortego-Centeno,
Enrique Raya-Alvarez,
Antonio Núñez-Roldán,
Javier Martín and
María Francisca González-Escribano
Abstract
We defined four major haplotypes in our population: the two major haplotypes (named haplotypes A and B) bear both the 5383_5397del variant and the two most common SNP sets found in the CEU population. Quantification analysis revealed that genotype B/B had the highest median of mRNA expression levels...
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PMID: 20549518
PDF is available here.
Abstract
We would like to distinguish and investigate their diffusion in former and current psychological approaches, especially when dealing with the analysis and follow-up of a moving process. We will present some illustrations, in the field of the phenomeno-structural method, which, after having dedicated...
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PMID: 20653185
PDF is available here.
Abstract
The classic anatomo-clinic paradigm based on clinical syndromes is fraught with problems. Nevertheless, for multiple reasons, clinicians are reluctant to embrace a more pathophysiological approach, even though this is the prevalent paradigm under "which basic sciences work. In recent decades, nonlin...
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PMID: 21037411
PDF is available here.
Abstract
The following was an invited pre-dinner commentary to the standing group waiting for supper, light heartedly suggesting several still unsettled physiologic problems in need of study.
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PMID: 20204765
PDF is available here.
Abstract
Phosphodiesterases (PDEs) form a family of enzymes involved in the hydrolysis of cyclic adenosine and guanosine monophosphate (cAMP and cGMP). PDE10A is a member of this family that is almost exclusively expressed in the striatum. Increasing cAMP/cGMP levels via inhibition of PDE10A is under conside...
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PMID: 20407482
PDF is available here.
Abstract
Genomics has brought with it a true biological revolution and can be applied to all areas of life sciences. The advent of genomics is thus linked to the development of high-throughput techniques which allows the genome of organisms as a whole to be studied. The first high-throughput techniques to be...
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PMID: 19996478
PDF is available here.
Abstract
In addition to psychological measures, nurse researchers have been working hard to integrate biological measures into their research in order to gain a comprehensive understanding of client health status. However, the fluctuating and interactive nature of biological systems makes biological measurem...
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PMID: 19760578
PDF is available here.
Abstract
I describe the unacknowledged contributions of Pavlov and Barcroft. Then I consider the possible reasons why Cannon ignored them....
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PMID: 18675307
PDF is available here.
Abstract
Roots of current conceptions of the regulation of states of the body through negative feedback mechanisms are traced back to Bernard's ideas on active stabilisation of bodily states against disturbances from the outside, revived by Henderson and Haldane, and crystallised in Cannon's concept of homeo...
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PMID: 18634840
PDF is available here.
Abstract
We compared the effects of different types of free-time activity on subjective and objective indices of sleep, recovery and well-being in an experimental field study. Twelve participants spent four consecutive evenings after work in each of three conditions: pursuing quiet leisure activities at home...
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PMID: 18249361
PDF is available here.
Abstract
We show how, by combining a range of theoretical approaches with the statistical analysis of individually structured databases, accurate prediction of life history decisions is possible in natural density-regulated populations undergoing large fluctuations in demographic rates from year to year. Our...
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PMID: 18641119
PDF is available here.
Abstract
We must first understand the complex entanglement of physiological and endocrine interrelationships that change after exposure to yolk androgens. Here, we take a comparative approach towards a discussion of how yolk androgens can simultaneously affect multiple body systems within developing birds, u...
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PMID: 18550405
PDF is available here.
Abstract
We show how macrophysiology--the investigation of variation in physiological traits over large geographical, temporal and phylogenetic scales--can contribute significantly to answering these questions. We do so by demonstrating, for each of the MA drivers, how a macrophysiological approach can or ha...
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PMID: 18397867
PDF is available here.
Abstract
Physiomics is that branch of omics that uses large scale databases and experimental databases along with computer algorithms to study the physiological phenotypes of genes, proteins and their relationships. It deals with studying the physiome, the total integration of genome, proteome and metabolome...
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PMID: 18336232
PDF is available here.
Abstract
We have developed a prototypical environment that simulates a common agricultural setting that provides the potential for acute injuries. We report on an exploratory study to evaluate the efficacy of our design to illicit a sense of realism and subsequently evoke a physiological response of anxiety...
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PMID: 18391354
PDF is available here.
Abstract
A brief overview is given in this article on the main design philosophies and the resulting description concepts used for components which undergo monotonic and cyclic loading. Emphasis is put on a mechanistic approach avoiding a plain reproduction of empirical laws. After a short consideration of f...
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PMID: 18376013
PDF is available here.
Abstract
We analyzed publications in Journal of Evolutionary Biochemistry and Physiology, one of the leading specialized periodicals on this problem. Analysis of works published for 4 decades has shown that the majority of papers deals with study of evolution of function of the nervous system (40-60 papers p...
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PMID: 19198168
PDF is available here.
Abstract
Bed rest studies of the past 20 years are reviewed. Head-down bed rest (HDBR) has proved its usefulness as a reliable simulation model for the most physiological effects of spaceflight. As well as continuing to search for better understanding of the physiological changes induced, these studies focus...
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PMID: 17661073
PDF is available here.
Abstract
We highlight some factors that should be considered when embarking along this path. Using a carp cDNA microarray, we have undertaken a broad, system-wide gene expression screen to investigate the physiological mechanisms underlying cold and hypoxia acclimation. This dataset provides a starting point...
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PMID: 17449823
PDF is available here.
Abstract
We have used them to gain new insights into osmotic stress signaling in animal cells....
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PMID: 17449828
PDF is available here.
Abstract
We can exploit even a small proportion of the rich and varied experimental data currently available, significant insights into clinically important aspects of human physiology will follow. To achieve this requires the integration of data from disparate sources into a common framework. Extrapolation...
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PMID: 17449822
PDF is available here.
Abstract
We study the generation of EEG rhythms by means of realistically coupled neural mass models. Previous neural mass models were used to model cortical voxels and the thalamus. Interactions between voxels of the same and other cortical areas and with the thalamus were taken into account. Voxels within...
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PMID: 17206872
PDF is available here.
Abstract
In a mass casualty incident, injured and at-risk patients will pass through a continuum of care from many different providers acting as a team in a clinical environment. As presented at MMVR 14 [Kaufman, et al 2006], formative evaluations have shown that simulation practice is nearly as good as, and...
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PMID: 17377279
PDF is available here.
Abstract
Preexercise ingestion of a high-sodium beverage increased plasma volume before exercise and involved less thermoregulatory and perceived strain during exercise and increased exercise capacity in warm conditions....
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PMID: 17218894
PDF is available here.
Abstract
We can now appreciate is how stochastic fluctuations inherent in biochemical processes contribute to cellular and organismal phenotypes. Advancements in techniques for empirically measuring single cells and in corresponding theoretical methods have enabled the rigorous design and interpretation of e...
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PMID: 17179490
PDF is available here.
Abstract
We discuss the possible reasons of population regression and the absence of population recovery....
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PMID: 16678237
PDF is available here.
Abstract
A moderate dose of caffeine (5 mg.kg) does not affect metabolism (VO2 or RER) in young children at low-moderate intensities of exercise. However, CAF causes a significantly lower HR (bpm) and higher BP (mm Hg) in both young boys and girls....
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PMID: 16540840
PDF is available here.
Abstract
The intrauterine conditions in which the mammalian fetus develops have an important role in regulating the function of its physiological systems later in life. Changes in the intrauterine availability of nutrients, oxygen, and hormones program tissue development and lead to abnormalities in adult ca...
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PMID: 16443820
PDF is available here.
Abstract
This work explores the use of the scientific literature to establish potential relationships among cellular processes. To this end we have used a document based similarity method to compute pair-wise similarities of the biological processes described in the Gene Ontology (GO). The method has been ap...
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PMID: 16872502
PDF is available here.
Abstract
We quantified obstacle avoidance performance characteristics carried out open loop (without vision) but with different initial visual sampling conditions and compared it to the full vision condition. The initial visual sampling conditions included: static vision (SV), vision during forward walking f...
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PMID: 16413969
PDF is available here.
Abstract
We measured saccharin clearance time (SCT), frequency of blinking, heart rate (HR), blood pressure, hydration state of skin, transepidermal water loss (TEWL), recovery sebum level and skin temperature as physiological responses. We asked subjects to judge thermal, dryness and comfort sensations as s...
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PMID: 16617203
PDF is available here.
Abstract
Efforts to understand the role of platelets in hemostasis and thrombosis have largely focused on the earliest events of platelet activation, those that lead to aggregation. Although much remains to be learned about those early events, this Review examines a later series of events: the interactions b...
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PMID: 16322784
PDF is available here.
Abstract
The evidence base informing terminal care is largely descriptive, retrospective, or extrapolated. While home deaths and hospice use are increasing, medical care near death is becoming more aggressive and hospice lengths of stay remain short. Though the prediction of impending death remains imprecise...
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PMID: 16238518
PDF is available here.
Abstract
We propose formulae for constructing such a system and describe some of its benefits. The arguments are general enough to be of interest to all the life sciences....
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PMID: 16329005
PDF is available here.
G Joshi-Tope,
M Gillespie,
I Vastrik,
P D'Eustachio,
E Schmidt,
B de Bono,
B Jassal,
G R Gopinath,
G R Wu,
L Matthews,
S Lewis,
E Birney and
L Stein
Abstract
We regularly create electronic projections of human pathways onto other organisms via putative orthologs, thus making Reactome relevant to model organism research communities. The database is publicly available under open source terms, which allows both its content and its software infrastructure to...
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PMID: 15608231
PDF is available here.
Abstract
We provide two examples of how this may be done. In the first, we use the method of linear chains to treat mortality that is the result of multiple physiological processes, some of which may have delays. In the second, we assume that mortality is the result of damage associated with growth and metab...
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PMID: 15136010
PDF is available here.
Abstract
It is suggested that the cold induced decrease in neutrophil count is caused by an activation and increased adhesion of the neutrophils to the endothelial wall. This finding is supported by the cold exposure-induced increases in IL-8 and Thromboxane B2 in LPS-stimulated blood, and an increase in the...
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PMID: 15253478
PDF is available here.
Abstract
I describe a scenario whereby the capacity for directional modification of an otherwise bilateral body plan can be viewed as an adaptive innovation rather closely connected with vertebrate origins, enabling optimal 'design' for very active lifestyles. But an alternative scenario, while retaining the...
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PMID: 15057939
PDF is available here.
Abstract
We suggest that ontogenetic trajectories can be used as the generative functions that build morphospaces, and propose approaches to build theoretical models for the establishment of left-right asymmetries during vertebrate heart embryogenesis.
Copyright 2004 Wiley Periodicals, Inc....
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PMID: 15057938
PDF is available here.
Abstract
Three widely used xenobiotics pentachlorophenol (PCP), 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-chloro-2,6-diethyl-N-(butoxymethyl) acetanilide (Butachlor) are evaluated for acute toxicity and stress behavior on freshwater fish (Heteropneustes fossilis, Clarias batrachus, Channa punctatus) and m...
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PMID: 14761696
PDF is available here.
Abstract
Analytical chemistry contributes significantly to the life sciences through developing measurement techniques that provide quantitative chemical information. Developments in biological research present new challenges for analytical chemistry and call for revolutionary methods and new thinking. Dana...
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PMID: 14752548
PDF is available here.
Abstract
We provide two typical examples to demonstrate that the developed technique may be a powerful tool to characterize in vivo the heterogeneity of butterfly eyes and to study the dynamic control of the light flux by the pupil mechanism....
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PMID: 14659839
PDF is available here.
Abstract
Autonomic dysreflexia is a life-threatening medical condition that affects people with spinal cord injuries above T6. Caused by the division of the autonomic nervous system, it can result in disastrous hypertension. Although complicated in nature, AD can be quickly treated and reversed by prehospita...
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PMID: 14699347
PDF is available here.
Abstract
We set out to investigate whether differences in morphology, sensory or motor behaviours exist using five age-matched strains of laboratory rats. Personal observations of morphological differences between different strains of rats led us to hypothesize that Fischer rats were dissimilar to the other...
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PMID: 12946605
PDF is available here.
Abstract
High-content information experiments in the post-genomic era hold the promise of deciphering age-old questions in biology and new ones in the biomedical arena. In response, researchers are devising computationally intensive and novel strategies to extract answers from multidimensional data sets.
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PMID: 14522048
PDF is available here.