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Dose-Response Relationship, Drug (0):
Recent article
Dose-Response Relationship, Drug
Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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Nature Medicine (17)12 2011
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We hypothesized that, with hypertension, localized iNOS inhibition would restore vasodilation in response to NO-dependent stimuli, and iNOS expression would be increased and phosphorylated vasodilator-stimulated phosphoprotein would be decreased. For, in vivo protocols, 4 intradermal microdialysis f...
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PMID: 21931069
PDF is available here.
PDF is available here.
Abstract
We discovered in this study that rat BLINaC (rBLINaC) and mouse BLINaC are inhibited by micromolar concentrations of diarylamidines and nafamostat, similar to acid-sensing ion channels. Inhibition was voltage-dependent, suggesting pore block as the mechanism of inhibition. Furthermore, we identified...
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PMID: 21828194
PDF is available here.
PDF is available here.
Abstract
We have modified the original apparatus for organ bioassay in order to minimize foaming and to increase analytical performance. By using this modified bioassay we investigated the vasodilatory potency of various endogenous RSNOs in the presence of physiologically relevant concentrations of albumin a...
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PMID: 21827780
PDF is available here.
PDF is available here.
Abstract
We examined whether perinatal PBDE exposure could impact these functions during physiological activation. Rats were perinatally dosed with a commercial PBDE mixture, DE-71. Dams were given 0 (corn oil control), 1.7 (low dose) or 30.6 mg/kg/day (high dose) in corn oil from gestational day (GD) 6 thro...
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PMID: 21821059
PDF is available here.
PDF is available here.
Abstract
Military personnel deployed in the Middle East have emphasized concerns regarding high levels of dust generated from blowing desert sand and the movement of troops and equipment. Airborne particulate matter levels (PM(10); PM < 10 μm) in the region may exceed 1500 μg/m(3), signific...
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PMID: 21899408
PDF is available here.
PDF is available here.
Abstract
Objective To identify the common serotypes and antimicrobial resistance patterns of Salmonella spp. associated with diarrhoea in Australian dairy calves under the age of 6 weeks. Design Cross-sectional study. Methods Faecal samples were collected from outbreaks of diarrhoea in dairy and dair...
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PMID: 21933168
PDF is available here.
PDF is available here.
Abstract
We measured the effect of variations in scaffold stiffness on the expression of extracellular matrix molecules specific to the NP (proteoglycans and collagen) by native NP cells. We prepared sample discs of different concentrations of alginate (1%-6%) by two different methods, diffusion and in situ...
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PMID: 21783128
PDF is available here.
PDF is available here.
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
PDF is available here.
Abstract
Curcumin is the active ingredient of commonly used spice Curuma longa Linn. In the present study, the antidepressant like activity of curcumin and its combination with fluoxetine and imipramine was studied in acute model (three doses 24, 5 and 1 h before test) of forced swimming test (FST) in glass j...
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PMID: 21928724
PDF is available here.
PDF is available here.
Abstract
We conducted an open-label study of BoNTA in men with BPH-related LUTS who were unsuitable for surgery as well as investigation of the effect of the toxin on in vitro growth of fibroblasts. In the clinical part, 5 patients aged from 75 to 88, suffering from BPH and UR were treated. Patients were pre...
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PMID: 21928723
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (124)11 Suppl 2011
Abstract
Stress (exposure to hyperkalemic cardioplegia, metabolic inhibition, or osmotic) results in significant myocyte swelling and reduced contractility. In contrast to wild-type mice, these detrimental consequences are not observed in mice lacking the Kir6.2 subunit of the sarcolemmal ATP-sensitive potass...
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PMID: 21911821
PDF is available here.
PDF is available here.
Abstract
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokin...
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PMID: 21807507
PDF is available here.
PDF is available here.
Abstract
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokin...
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PMID: 21807507
PDF is available here.
PDF is available here.
Veterinary Record (169)10 2011
Abstract
The clinical and antibacterial efficacy of two shampoos used as a sole antibacterial treatment in dogs with superficial pyoderma were investigated and compared. In a randomised, partially blinded study, a 3 per cent chlorhexidine gluconate shampoo (Chlorhex 3; Leo Animal Health) was compared against...
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PMID: 21831997
PDF is available here.
PDF is available here.
Abstract
These results suggest that the parent hormone, progesterone, and triazolam have discordant neuropharmacological mechanisms of action. Additional research is necessary to determine the degree to which neurosteroids influence sex differences in benzodiazepine use and abuse....
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PMID: 21808190
PDF is available here.
PDF is available here.
Abstract
Drug discrimination has been an important technique in behavioural pharmacology for at least 40 years. The characteristics of drug-produced discriminative stimuli are influenced by behavioural and pharmacological variables, including the doses used to establish discriminations. This review covers stu...
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PMID: 21808191
PDF is available here.
PDF is available here.
Abstract
We suggest that low doses of WAY 100635 potentiated the (+)-amphetamine cue by blockade of 5-HT1A receptors, but stimulation of the dopamine D4 receptor by higher doses of WAY 100635 may be responsible for potentiation of amphetamine-induced behavioral sensitization. The high percentage of behaviora...
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PMID: 21814134
PDF is available here.
PDF is available here.
Abstract
This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-...
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PMID: 21836460
PDF is available here.
PDF is available here.
Abstract
We examined four different cannabinergic aminoalkylindole ligands, including one drug (AM678=JWH018) found in herbal 'Spice' concoctions, for their ability to substitute for Δ-tetrahydrocannabinol (THC), and the ability of the cannabinoid receptor 1-selective antagonist/inverse agonist rimonabant to...
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PMID: 21836461
PDF is available here.
PDF is available here.
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These results suggest that blockade of the NMDA receptor augments the interoceptive stimulus properties of methamphetamine....
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PMID: 21836462
PDF is available here.
PDF is available here.
Abstract
To study prospectively the impact of initiating insulin glargine in suboptimally controlled insulin-naïve patients with Type 2 diabetes on health-related quality of life in relation to glycaemic control.
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PMID: 21843305
PDF is available here.
PDF is available here.
Abstract
Pharmacodynamic studies reported an amplified on-clopidogrel platelet inhibition in smokers potentially caused by an increased metabolic drug activation via induction of cytochrome P450 1A2. The aims of this analysis were to evaluate the impact of smoking on the antiplatelet effect o...
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PMID: 21884870
PDF is available here.
PDF is available here.
Abstract
We realized a substudy of the COPPS trial to assess the efficacy and safety of colchicine for the prevention of postoperative pericardial and pleural effusions.
The COPPS is a multicenter, double-blind, randomized trial, where 360 consecutive patients (mean age 65.7 ± 12.3 years, 66...
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PMID: 21884871
PDF is available here.
PDF is available here.
Abstract
We have utilized d-cAMP-induced terminally differentiated NB2a cells in culture as an experimental model to study the effects of statins. The cell survival and proliferation were studied by MTT. Measurement of neurite outgrowth was done by neurotoxicity screening test. NB2a cell differentiation was...
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PMID: 22013720
PDF is available here.
PDF is available here.
Abstract
Cadmium (Cd) is ubiquitous in the environment and exposure through food and water as well as occupational sources can contribute to a well-defined spectrum of disease. The present study was undertaken to evaluate the role of hesperetin (Hp) in alleviating the Cd induced biochemical c...
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PMID: 22013721
PDF is available here.
PDF is available here.
Abstract
To determine the larvicidal and repellent activities of Coccinia (C) indica Wight and Arnold (Family:Cucurbitaceae) extract against Culex (Cx.) quinquefasciatus, Aedes (Ae.) aegypti and Anopheles (An.) stephensi.
The ovicidal activity was determined against three mosq...
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PMID: 22013723
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that TAM increases the risk for EC, at least in part, by enhancing the local estrogen biosynthesis and directing estrogen metabolism towards the formation of genotoxic and hormonally active estrogen metabolites. In addition, the differential effects of TAM and RAL in EC risk...
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PMID: 21600284
PDF is available here.
PDF is available here.
Abstract
50 patients were studied in 2 groups and the demographic characteristics were similar. Addition of pethidine resulted in block height greater than T6 and longer duration of analgesia (256.9 ± 112.2 min.) compared with the saline group (160.5 ± 65.0 min; p = 0.0005). Maternal hypotension occurred m...
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PMID: 21909151
PDF is available here.
PDF is available here.
Abstract
Androst-5-ene-3β,7β,17β-triol (βAET) is an anti-inflammatory metabolite of DHEA that is found naturally in humans, but in rodents only after exogenous DHEA administration. Unlike DHEA, C-7-oxidized DHEA metabolites cannot be metabolized into potent androgens or estrogens, and are not peroxisome p...
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PMID: 21570467
PDF is available here.
PDF is available here.
Poultry Science (90)9 2011
Abstract
A meta-analysis was carried out to study the association of mycotoxins with performance, productive indices, and organ weights in broilers. Ninety-eight papers published between 1980 and 2009 were used, totaling 1,401 diets and 37,371 animals. Meta-analysis followed 3 sequential analyses: graphical,...
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PMID: 21844257
PDF is available here.
PDF is available here.
Poultry Science (90)9 2011
Abstract
Central composite design (CCD; 5 levels and 4 factors), response surface methodology (RSM), and artificial neural network-genetic algorithm (ANN-GA) were used to evaluate the response of broiler chicks [ADG and feed conversion ratio (FCR)] to dietary standardized ileal digestible protein (dP), lysine...
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PMID: 21844277
PDF is available here.
PDF is available here.
Poultry Science (90)9 2011
Abstract
An experiment was conducted to study the effects of xylanase and citric acid on the performance, nutrient retention, jejunal viscosity, and size and pH of the gastrointestinal tract of broilers fed a low-P wheat-based diet. The experiment was conducted as a 2 × 3 factorial arrangement with 2 levels...
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PMID: 21844263
PDF is available here.
PDF is available here.
Abstract
Objectives and design This study describes a randomized controlled trial which aimed to evaluate whether 16 sessions of psychotherapy combined with pharmacotherapy is more effective in relieving depression and improving social functioning than 8 sessions of psychotherapy combined with pharmacothera...
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PMID: 21810106
PDF is available here.
PDF is available here.