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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Physiological Processes (11):
Recent article
Physiological Processes
Abstract
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Abstract
We generated PAC1 conditional knockout mice. PAC1-null mice exhibited early embryonic lethality, demonstrating that PAC1 is essential for mammalian development, especially for explosive cell proliferation. In quiescent adult hepatocytes, PAC1 is responsible for producing the majority of the 20S prot...
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PMID: 20498273
PDF is available here.
PDF is available here.
Abstract
We show that the statistics of the gaps can be analyzed in a novel way, borrowed from the study of quantum disordered systems in statistical mechanics. It turns out that due to a phenomenon similar to Anderson localization, exponentially small gaps appear close to the end of the adiabatic algorithm...
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PMID: 20616043
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We report on three Drosophila Ly6-like proteins essential for septate junction (SJ) formation. SJs provide a paracellular diffusion barrier and appear molecularly and structurally similar to vertebrate paranodal septate junctions. We show that Crooked (Crok), a small GPI-anchored Ly6-like protein, i...
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PMID: 20570942
PDF is available here.
PDF is available here.
Reproductive Toxicology (29)3 2010
Abstract
Spontaneous ejaculation has been reported in a variety of mammalian species and may occur either as a result of pharmacological treatment or as a component of the daily behavior of normal, untreated animals. Infrequently, increased numbers of spontaneous ejaculatory plugs have been reported among th...
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PMID: 20184952
PDF is available here.
PDF is available here.
Abstract
We report the results of a study of healthy humans demonstrating that plasma concentrations of the endocannabinoid, N-arachidonylethanolamine (anandamide), exhibit a circadian rhythm. Concentrations of anandamide are threefold higher at wakening than immediately before sleep, a relationship that is...
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PMID: 20590563
PDF is available here.
PDF is available here.
Development (137)12 2010
Abstract
The Company of Biologists recently launched a new series of workshops aimed at bringing together scientists with different backgrounds to discuss cutting edge research in emerging and cross-disciplinary areas of biology. The first workshop was held at Wilton Park, Sussex, UK, and the chosen theme wa...
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PMID: 20501588
PDF is available here.
PDF is available here.
Abstract
We have developed a rabbit ocular exposure model system. In this paper, we report molecular, histological, ultrastructural, and clinical consequences of rabbit ocular SM injury, which can be used to assess Tbeta4 efficacy, including timepoints at which Tbeta4 will be assessed for therapeutic utility...
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PMID: 20536452
PDF is available here.
PDF is available here.
Kidney International (77)8 2010
Abstract
Most kidney diseases that ultimately lead to end-stage renal failure originate within the glomerulus and are associated with proteinuria. Treatment options are unspecific and offer partial cures at best because available therapies do not primarily treat glomerular cells but rather ac...
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PMID: 20130528
PDF is available here.
PDF is available here.
Abstract
In powder technology, it is often important to directly measure real powder flow rate from a small amount of powder. For example, in pharmaceutical industry, a frequent problem is to determine powder flow properties of new active pharmaceutical ingredient (API) in an early stage of the development w...
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PMID: 20238189
PDF is available here.
PDF is available here.
Abstract
Characteristics of fructification and seed ripening of Panax stipuleanatus were studied in this paper with a view to better understand the species' biological characteristics and promote cultivation. Dynamic of fructification and types of fruits were observed in a period of 80 days. The seeds' biolo...
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PMID: 20545184
PDF is available here.
PDF is available here.
Abstract
Accurate plantar pressure measurements are mandatory in both clinical and research contexts. Differences in accuracy, precision, reliability of pressure measurement devices (PMDs) prevented so far the onset of standardization processes and of reliable reference datasets. The Italian National Institu...
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PMID: 20567067
PDF is available here.
PDF is available here.
Abstract
Semagacestat treatment lowers plasma, cerebrospinal fluid and brain A beta in a dose-dependent manner in animals and plasma and cerebrospinal fluid A beta in humans, compared with placebo-treated patients. On the basis of extant data, semagacestat seems to be well tolerated, with most adverse events...
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PMID: 19527190
PDF is available here.
PDF is available here.
Abstract
1) By using DGGE analysis, there were 5 dominant bands A, B, C, D and E in all tobacco leaves samples of the three varieties; In further studies, five dominant DGGE bands were isolated, cloned and sequenced. From them we screened a dominant microorganism. 2) The content of most aroma components in t...
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PMID: 19637570
PDF is available here.
PDF is available here.
Abstract
These results suggest that alexithymia in AN patients is associated with a deficit in the cognitive evaluation of negative emotions concerning body image. Alexithymia might play a crucial role in the emotional processing impairments that are often observed in AN patients, and this trait might ultima...
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PMID: 19400551
PDF is available here.
PDF is available here.
Critical Care Medicine (37)3 2009
Abstract
Abstract
We analyze a minimal, reciprocally connected circuit of three spiking units and explore all possible dynamical regimes and transitions between them. We show that the SHC arises due to a Neimark-Sacker bifurcation of an unstable cycle....
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PMID: 19335011
PDF is available here.
PDF is available here.
Hereditas (Beijing) (31)2 2009
Abstract
One hundred and eighty-three recombinant inbred lines from the cross between GH06 and P174 were used for genetic analysis of seed germination rate and physiological trait analysis of Brassica napus L. Composite interval mapping (CIM) was applied to identify QTL associated with seed germination rate...
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PMID: 19273430
PDF is available here.
PDF is available here.
Abstract
We provide an exhaustive review of the many faces of semaphorins both during developmental, regulatory and pathological processes. Indeed, because of their crucial fundamental roles, the semaphorins and their receptors represent important targets for the development of drugs directed at a variety of...
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PMID: 18953684
PDF is available here.
PDF is available here.
Nucleic Acids Research (37)Database issue 2009
Abstract
Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level p...
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PMID: 18981052
PDF is available here.
PDF is available here.
Journal of Bacteriology (191)1 2009
Abstract
We focus on the contribution of SMC proteins to sporulation-associated chromosome segregation in S. coelicolor. Deletion of the smc gene causes aberrant DNA condensation and missegregation of chromosomes (7.5% anucleate spores). In vegetative mycelium, immunostained SMC proteins were observed sporad...
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PMID: 18931116
PDF is available here.
PDF is available here.
ChemBioChem (9)18 2008
Abstract
The fungal phylum zygomycota uses trisporic acids (TSAs), a family of apocarotenoids, during sexual reproduction to synchronize and control activity between the mycelial hyphae of opposite mating types. Separate as well as mixed cultures of Blakeslea trispora were systematically supplemented with pu...
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PMID: 19035372
PDF is available here.
PDF is available here.
Abstract
We will show successful approaches that have been used recently and will illustrate some of the results that have contributed to elucidate important structural aspects of amyloid formation in vivo....
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PMID: 18952166
PDF is available here.
PDF is available here.
Abstract
We give equations, adapted from the work of Kimura on random genetic drift, for the full mtDNA heteroplasmy distribution. We describe how to use the Kimura distribution in mitochondrial genetics, and we test the Kimura distribution against human, mouse, and Drosophila data sets....
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PMID: 18976726
PDF is available here.
PDF is available here.
Microcirculation (15)8 2008
Abstract
The Physiome projects comprise a loosely knit worldwide effort to define the Physiome through databases and theoretical models, with the goal of better understanding the integrative functions of cells, organs, and organisms. The projects involve developing and archiving models, providing centralized...
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PMID: 19051119
PDF is available here.
PDF is available here.
Abstract
Recent revelations in the human reproductive process have fuelled much interest in this field of study. In particular, the once prevailing view of large numbers of ejaculated sperms racing towards the egg has been refuted recently. This is opposed to the current views derived from numerous clinical...
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PMID: 18652708
PDF is available here.
PDF is available here.
Abstract
A comparative proteomic analysis was performed to explore the mechanism of cell elongation in developing cotton fibers. The temporal changes of global proteomes at five representative development stages (5-25 days post-anthesis [dpa]) were examined using 2-D electrophoresis. Among ap...
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PMID: 18823139
PDF is available here.
PDF is available here.
Abstract
We propose that the function of Wnts depend upon a skeletogenic cell's state of differentiation. In this review we summarize recent data with a focus on the roles of Wnt signaling in mesenchymal stem cell fate, osteoprogenitor cell differentiation, chondrocyte maturation, bone remodeling, and bone r...
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PMID: 18824114
PDF is available here.
PDF is available here.
Abstract
microRNA (miRNA) is a class of small, noncoding, regulatory RNAs. The approximately 21 nt mature miRNA is processed from larger precursor molecules following a coordinated series of events. In theory, miRNA processing may be regulated at any of these steps. A growing body of evidence...
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PMID: 18752632
PDF is available here.
PDF is available here.
Abstract
Heliogeophysical situation during prenatal development of humans is essential for blood rheology, hemostasis, and spectral and frequency parameters of the blood. The relationship between these parameters and natural physical factors is determined by the intensity of solar activity and geomagnetic in...
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PMID: 19145363
PDF is available here.
PDF is available here.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques (11)2 2008
Abstract
We have also attempted to highlight the efforts that are being made in the development of new molecules based on thiolactomycin as lead compound, including studies from this laboratory....
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PMID: 19203471
PDF is available here.
PDF is available here.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques (11)4 2008
Abstract
Purpose - This paper looks into the functional food and nutraceutical registration processes in Japan and China. The Japanese have developed the Foods for Specified Health Use (FOSHU) registration process whereas the Chinese have put into place the Health Food (HF) registration process. The aim of t...
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PMID: 19183509
PDF is available here.
PDF is available here.
Abstract
The sequencing of the human genome has already had an enormous impact on medicine, particularly with single-gene changes that predispose to a serious disease such as cystic fibrosis or the overexpression of Her2 in about one-third of breast cancers. Genetic technology has led to some very important...
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PMID: 17851575
PDF is available here.
PDF is available here.
Abstract
I have warned not to split off the Medical Faculty as a separate Medical University "... since such a separation of a part of a University corresponds to an amputation." In spite of this and of other warnings the decision was made by a federal law to permit this separation. The irrevocable and defin...
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PMID: 17853779
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
This study assessed prenatal influenza exposure in relation to pregnancy complications and delivery complications. Participants of this study consisted of a community sample of all mothers of 1,795 children who were a birth cohort recruited at age 3 in a prospective longitudinal project in Mauritius...
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PMID: 19241651
PDF is available here.
PDF is available here.
Abstract
Physical Review Letters (97)11 2006
Abstract
We confirm the 1/f scaling of global variables for selected frequency bands, but show that neuronal activity is not consistent with critical states. We propose a model of 1/f scaling which does not rely on critical states, and which is testable experimentally....
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PMID: 17025932
PDF is available here.
PDF is available here.
Biophysical Journal (90)3 2006
Abstract
We reformulate our model of the NF-kappaB regulatory module to analyze a single cell regulation. Ordinary differential equations, used for description of fast reaction channels of processes involving a large number of molecules, are combined with a stochastic switch to account for the activity of th...
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PMID: 16284261
PDF is available here.
PDF is available here.
Fiziologiia cheloveka (32)2 2006
Abstract
Chronobiology International (23)1-2 2006
Abstract
We measured sleep EEG characteristics (i.e., SWA, sleep spindles) in healthy older volunteers in response to high (sleep deprivation protocol) and low sleep pressure (nap protocol) conditions. Despite the fact that the older volunteers had impaired sleep consolidation and reduced SWA levels, their r...
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PMID: 16687319
PDF is available here.
PDF is available here.
Abstract
Seventy-nine acupuncture clinical trials were identified. Twenty-six studies (33%) offered no physiologic rationale. Fifty-three studies (67%) posited a physiologic basis for acupuncture: 33 (62% of 53) proposed neurochemical mechanisms, 2 (4%) segmental nervous system effects, 6 (11%) autonomic ner...
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PMID: 16824230
PDF is available here.
PDF is available here.
Abstract
During color, colored Kanji characters and Stroop task of the visual stimuli, the P300 component of the event-related brain potential (ERPs) was used in conjunction with response time to identify sex differences in perceptual processing. Participants were instructed to respond to the display colors...
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PMID: 16287630
PDF is available here.
PDF is available here.
Abstract
We hypothesised that after a short bout of intense exercise GH may increase lipolysis during recovery. In 7 moderately trained young male subjects (21.8 +/- 0.5 years) and 7 moderately trained older male subjects (56.0 +/- 1.0 years) [(2)H(5)] glycerol was infused for 370min to measure glycerol prod...
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PMID: 16213174
PDF is available here.
PDF is available here.
Abstract
We studied the content of hemopoietic precursor cells in the bone marrow, production of IL-1, IL-3, and colony-stimulating and erythropoietic activities by bone marrow cells under conditions of chronic stress. It was shown that in mice subjected to 15-h immobilization no hyperplasia of the bone marr...
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PMID: 16758639
PDF is available here.
PDF is available here.
Abstract
We summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression....
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PMID: 16179466
PDF is available here.
PDF is available here.
Journal of Experimental Biology (208)Pt 17 2005
Abstract
We have made relatively few attempts to understand it. Inherently complex systems are more difficult to study and less predictable. However, a deeper understanding of physiological systems can be achieved by modifying experimental design and analysis to account for complexity. We begin this essay wi...
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PMID: 16109885
PDF is available here.
PDF is available here.
Abstract
Diabetes Care (28)7 2005
Abstract
Reduced exercise capacity in patients with type 2 diabetes is associated with diabetes control, subclinical LV dysfunction, and impaired HRR....
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PMID: 15983314
PDF is available here.
PDF is available here.
Biophysical Journal (88)4 2005
Abstract
We develop a biophysical theory of ligand accumulation in cell-culture assays. Our theory predicts the ligand concentration as a function of time and measurable parameters of autocrine cells and cell-culture experiments. The key step of our analysis is the derivation of the survival probability of a...
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PMID: 15653719
PDF is available here.
PDF is available here.
Abstract
Abstract
The aim of this paper is to show that biological kinds can be causally homogeneous, although all biological causes are identical with configurations of physical causes. The paper considers two different strategies to establish that result: the first one relies on two different manners of classificat...
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PMID: 16898210
PDF is available here.
PDF is available here.
Medical Hypotheses (65)4 2005
Abstract
A great number of papers have shown that free radicals as well as bioactive molecules can play a role of mediator in a wide spectrum of biological processes, but the biological actions and chemical reactivity of the free radicals are quite different from that of the bioactive molecules, and that a w...
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PMID: 15961255
PDF is available here.
PDF is available here.
Abstract
Breathing route during sleep has been studied very little, however, it has potential importance in the pathophysiology of sleep disordered breathing. Using overnight polysomnography, with separate nasal and oral thermocouple probes, data were obtained from 41 subjects (snorers and nonsnorers; 25 mal...
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PMID: 15293607
PDF is available here.
PDF is available here.
New England Journal of Medicine (347)11 2002
Abstract
Abstract
Advanced technologies and biology have extremely different physical implementations, but they are far more alike in systems-level organization than is widely appreciated. Convergent evolution in both domains produces modular architectures that are composed of elaborate hierarchies of protocols and l...
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PMID: 11872830
PDF is available here.
PDF is available here.
Abstract
We must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicin...
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PMID: 11872829
PDF is available here.
PDF is available here.
Bio/Technology (13)2 1995
Abstract
Abstract
Until recently, the mouse has been the animal of choice for transgenic studies. This is because the scientists who pioneered transgenic technologies emerged from the fields of mouse genetics and embryology. The mouse will continue to be the most convenient mammalian model for asking...
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PMID: 21390666
PDF is available here.
PDF is available here.