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Metabolic Clearance Rate (0)
Articles on Metabolic Clearance Rate
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A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of rem...
Anesth Analg 115(2):274-83 (2012) PMID 22190555
We report on the safety and efficacy of the first human study. A phase I, single-center, double-blind, placebo- and active-controlled, randomized, single-dose escalation study was conducted. Up to 10 cohorts of healthy subjects were scheduled to receive a single 1-minute IV infusion... -
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of rem...
Anesth Analg 115(2):274-83 (2012) PMID 22190555
We report on the safety and efficacy of the first human study. A phase I, single-center, double-blind, placebo- and active-controlled, randomized, single-dose escalation study was conducted. Up to 10 cohorts of healthy subjects were scheduled to receive a single 1-minute IV infusion... -
PET with 64Cu-histidine for noninvasive diagnosis of biliary copper excretion in Long-Evans cinnamon rat model of Wilson disease.
pubmed 53(6):961-8 1 Jun 2012 PMID 22577234
We hypothesized that a radiocopper-histidine complex would be effective for diagnosing Wilson disease by molecular imaging and tested this hypothesis in the Long-Evans cinnamon (LEC) rat model with Atp7b deficiency.... -
Bringing physiology into PET of the liver.
pubmed 53(3):425-33 1 Mar 2012 PMID 22323781
Several physiologic features make interpretation of PET studies of liver physiology an exciting challenge. As with other organs, hepatic tracer kinetics using PET is quantified by dynamic recording of the liver after the administration of a radioactive tracer, with measurements of time-activity curve... -
Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.
Cancer Chemother Pharmacol 69(2):397-405 (2012) PMID 21789689
To evaluate the ability of a physiology-based pharmacokinetic (PBPK) model to predict the systemic drug exposure of high- and low-dose etoposide in children from a model developed with adult data. Simulations were performed with PK-Sim(®) (Bayer Technology Services).... -
Dose adaptation of capecitabine based on individual prediction of limiting toxicity grade: evaluation by clinical trial simulation.
Cancer Chemother Pharmacol 69(2):447-55 (2012) PMID 21809035
These results indicate that individual prediction-based dose adaptation based on ordinal data may be feasible and beneficial.... -
The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coad...
Eur J Clin Pharmacol 68(1):29-37 (2012) PMID 21739267 PMCID PMC3249179
To investigate the effects of coadministration of paroxetine or fluvoxamine on the pharmacokinetics of aripiprazole in healthy adult Japanese with different CYP2D6 genotypes. Fourteen CYP2D6 extensive metabolizer (EM) and 14 CYP2D6 intermediate metabolizer (IM) subjec... -
Radiation dosimetry estimates of [18F]-fluoroacetate based on biodistribution data of rats.
Appl Radiat Isot 70(1):332-5 (2012) PMID 22019094
We estimated the dosimetry of [(18)F]fluoroacetate (FAC) with the method established by MIRD based on biodistribution data of rats. We selected some important organs and computed their residence time, their absorbed doses and effective dose with the (%ID(Organ)) (human) data using OLINDA/EXM 1.1 pro... -
Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters.
Nanomedicine (Lond) 7(1):95-110 (2012) PMID 22191779
Characterize different sized ceria-engineered nanomaterial (ENM) distribution in, and clearance from, blood (compared to the cerium ion) following intravenous infusion. Cerium (Ce) was quantified in whole blood, serum and clot (the formed elements) up to 720 h.... -
Nanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stage.
Nanomedicine (Lond) 7(1):111-20 (2012) PMID 22191780
We report on these recent advances regarding therapeutic efficacy, targeting and safety issues related to the application of mesoporous silica nanoparticles in cancer therapy....
