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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Chimera (1):
Recent article
Chimera
Abstract
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. A low dose (approxima...
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PMID: 21830940
PDF is available here.
PDF is available here.
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Abstract
Stem Cell Research (7)1 2011
Abstract
Unequivocal evidence for pluripotency in which embryonic stem cells contribute to chimeric offspring has yet to be demonstrated in human or nonhuman primates (NHPs). Here, rhesus and baboons ESCs were investigated in interspecific mouse chimera generated by aggregation or blastocyst...
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PMID: 21543277
PDF is available here.
PDF is available here.
Abstract
We demonstrate hematopoietic defects reminiscent of premature HSC aging, including anemia, lymphopenia, and myeloid lineage skewing. However, in contrast to physiological stem cell aging, rapidly accumulating mitochondrial DNA mutations had little functional effect on the hematopoietic stem cell poo...
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PMID: 21549326
PDF is available here.
PDF is available here.
Abstract
The Fas death receptor (CD95) is expressed on macrophages, smooth muscle cells, and T cells within atherosclerotic lesions. Given the dual roles of Fas in both apoptotic and nonapoptotic signaling, the aim of the present study was to test the effect of hematopoietic Fas deficiency on experimental ath...
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PMID: 21550016
PDF is available here.
PDF is available here.
Abstract
We show that both mouse iPS and parental ES cells exhibited highly similar in vitro capacity to undergo directed differentiation into DE progenitors. With few exceptions, both cell types displayed similar surges in gene expression of specific master transcriptional regulators and global transcriptom...
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PMID: 21537085
PDF is available here.
PDF is available here.
Folia morphologica (70)2 2011
Abstract
This study was conducted to assess the effect of melatonin on the structure of testis and spermatogenesis dynamics in neonate vitrified testis grafts. Neonate vitrified testes, candidates for transplantation heterotopically to experiment or control groups, were warmed in thawing media which had or di...
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PMID: 21630230
PDF is available here.
PDF is available here.
Folia morphologica (70)1 2011
Abstract
This study evaluates the effect of melatonin on follicular dynamics in neonate vitrified ovarian grafts. Vitrified ovaries from neonate F1 hybrid mice, candidates for transplantation to treated or non-treated groups, were thawed under standard conditions with or without the addition of 100 μM melato...
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PMID: 21604248
PDF is available here.
PDF is available here.
Innate Immunity (17)3 2011
Abstract
Dendritic cells (DCs) serve as a link between the innate and adaptive immune systems. The activation state of DCs is crucial in this role. However, when DCs are isolated from lymphoid tissues, purified and placed in culture they undergo 'spontaneous' activation. The basis of this was...
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PMID: 20501515
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (18)6 2010
Abstract
Immune reconstitution is crucially relevant for patients receiving hematopoietic stem cell transplantation (HSCT). This study was purposed to investigate the ability of α-GalCer (α-galactosylceramide), a well-known activator of natural killer T cells (NK-T), to enhance immune and hematological reco...
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PMID: 21176367
PDF is available here.
PDF is available here.
Abstract
The biological factors of leukemia cells are associated with treatment outcomes in childhood ALL. Multiplex RT-PCR assay is an efficient and sensitive diagnostic tool that may improve the ability to accurately and rapidly risk-stratify children with ALL....
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PMID: 20930648
PDF is available here.
PDF is available here.
Abstract
We asked whether FMc and MMc are impacted by the addition of new grafts as evaluated by increasing parity. Mc was identified by quantitative PCR for a nonshared polymorphism unique to the Mc source. Despite increasing sources of Mc, FMc did not increase with increasing parity. MMc concentration was...
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PMID: 20628146
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
Chromosomal novelties and the level of meiotic and mitotic abnormalities were studied in a hybrid zone between two chromosomally differentiated Spalax cytotypes of 2n = 58 and 2n = 52. These cytotypes differ by five Rb fusions, four centromeric shifts accompanied by heterochromatin deletion, one par...
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PMID: 21250542
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
Interaction of transcription factor CTCF with the minimal promoter of Xist gene was investigated in intraspecific hybrids ofcommon voles. CTCF was shown to bind with the minimal promoter region in vivo. However, the experiments of the delay in gel resulted in the absence of interaction between the C...
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PMID: 21254564
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
The results of long-term studies on the transmission of the mode of asexual reproduction through seeds to maize from gamagrass, a closely related wild plant, performed in the Laboratory of Plant Cytology and Apomixis are summarized. The first apomictic hybrids between Zea mays and Tripsacum dactyloi...
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PMID: 21061615
PDF is available here.
PDF is available here.
Abstract
We have also introduced Penelope into Drosophila melanogaster, which are otherwise naive to the element. We have taken advantage of these natural and experimentally induced colonization processes to probe the evolution of small RNA pathways in response to transposon challenge. In both species, Penel...
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PMID: 20581131
PDF is available here.
PDF is available here.
Abstract
Long term, BMDCs could repopulate recipient's intestinal epithelium even without any special treatment, which suggests a novel insight into the maintenance of the intestinal epithelial constitution....
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PMID: 19856101
PDF is available here.
PDF is available here.
Abstract
Subseries Turnera comprises a polyploid complex with ploidy levels ranging from diploid (2n = 2x = 10) to octoploid (2n = 8x = 40). The use of fluorescent in situ hybridization greatly improved the knowledge of the karyotypes of Turnera species by detecting and mapping rDNA sites. Interspecific vari...
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PMID: 20725146
PDF is available here.
PDF is available here.
Abstract
We have tested Brassica carinata, a possible target for oil modification, to establish whether it can cross with other Brassica species and related genera, and we have developed molecular DNA assays to confirm hybridization....
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PMID: 20725152
PDF is available here.
PDF is available here.
Transgenic Research (19)4 2010
Abstract
We up- and down-regulated a Populus tomentosa Delta-12 fatty acid desaturase gene (PtFAD2) in the hybrid poplar (P. alba x P. glandulosa) clone 84 K. Real-time PCR results demonstrated that compared to untransformed control lines, the transcriptional level of PtFAD2 increased by up to 90% in over-ex...
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PMID: 20012191
PDF is available here.
PDF is available here.
Abstract
The supramolecular salt [H(2)pip](3)[Ge(hedp)(2)].14H(2)O (1) [H(2)pip(2+)=piperazine cation C(4)H(12)N(2)(2+); hedp(5-)=deprotonated form of etidronic acid, C(2)H(3)P(2)O(7)(5-)) is reported. This consists of an organic-inorganic hybrid hydrogen-bonded nanoporous framework, the inte...
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PMID: 20544749
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
Our results indicate that Syk is critically involved in the development of all clinically relevant aspects of autoantibody-mediated K/BxN serum-transfer arthritis in experimental mice. These results provide the first in vivo genetic evidence of the role of Syk in the development of autoimmune arthri...
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PMID: 20201079
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 7 2010
Abstract
A small-animal model for hepatitis C virus (HCV) infection was developed using severe combined immunodeficiency (SCID) mice encoding homozygous urokinase-type plasminogen activator (uPA) transplanted with human hepatocytes. Currently, limited information is available concerning the H...
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PMID: 20164258
PDF is available here.
PDF is available here.
Gene Therapy (17)7 2010
Abstract
We show that the adenoviral-associated humoral and innate cytokine immune responses are significantly reduced when HAdV-5 vector carrying human bovine chimeric fibers (HAdV-5-F2/BAdV-4) is intravenously injected into mice. Fiber pseudotyping modified its interaction with blood coagulation factors, a...
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PMID: 20393506
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We investigate whether EG cell self-renewal and derivation are supported by 2i. We report that mouse EG cells can be established with high efficiency using 2i in combination with the cytokine leukaemia inhibitory factor (LIF). Furthermore, addition of fibroblast growth factor or stem cell factor is...
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PMID: 20519324
PDF is available here.
PDF is available here.
Abstract
We describe the chimeric gene Quetzalcoatl (Qtzl; CG31864), which formed in the recent past and swept to fixation in D. melanogaster. Qtzl arose through a duplication on chromosome 2L that united a portion of the mitochondrially targeted peptide CG12264 with a segment of the polycomb gene escl. The...
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PMID: 20534482
PDF is available here.
PDF is available here.
Abstract
We characterize the expression of a KLK4 cis sense-antisense chimeric transcript, and show other examples in prostate cancer. Using non-protein-coding microarray analyses, we initially identified an androgen-regulated antisense transcript within the 3' untranslated region of the KLK4 gene in LNCaP c...
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PMID: 20406994
PDF is available here.
PDF is available here.
Abstract
We have developed a complementary approach in which viral and synthetic components are combined to form hybrid nanoparticulate vectors. In particular, we complexed non-infectious retrovirus-like particles lacking a viral envelope protein, from Moloney murine leukemia virus (M-VLP) or human immunodef...
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PMID: 20117154
PDF is available here.
PDF is available here.
Abstract
Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment (27)5 2010
Abstract
Fusarium ear rot, caused by Fusarium verticillioides, is one of the most common diseases of maize, causing yield and quality reductions and contamination of grain by fumonisins and other mycotoxins. Drought stress and various insects have been implicated as factors affecting disease...
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PMID: 20127546
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)5 2010
Abstract
Common voles of the Microtus arvalis group distributed over the territory of European Russia are represented by three karyotypic categories, i.e., sympatric sibling species with 2n = 46 and 54, and two allopatric karyoforms in one of them, 2n = 46. For each category, molecular markers were found. Fo...
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PMID: 20583603
PDF is available here.
PDF is available here.
Abstract
We review the different forms of meiotic drive and their possible roles in speciation. We discuss the recent empirical evidence for a link between drive and hybrid male sterility, also suggesting a possible mechanistic explanation for this link in the context of chromatin remodelling. Finally, we re...
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PMID: 20308102
PDF is available here.
PDF is available here.
Abstract
Distant hybridization makes it possible to transfer the genome of one species to another, which results in changes in phenotypes and genotypes of the progenies. This study shows that distant hybridization or the combination of this method with gynogenesis or androgenesis lead to different ploidy fis...
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PMID: 20596907
PDF is available here.
PDF is available here.
Abstract
We show in the fish medaka (Oryzias latipes) that the host accessibility to ES cell contribution exhibits dramatic differences. Specifically, of three albino host strains tested (i (1) , i (3) and af), only strain i (1) generated pigmented chimeras. Strikingly, this accessibility is completely lost...
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PMID: 20238480
PDF is available here.
PDF is available here.
Abstract
We thus investigated whether mixed chimerism and tolerance could be realized without the need for cytoreductive treatment by combining Treg therapy with BM transplantation (BMT). Polyclonal recipient Tregs were cotransplanted with a moderate dose of fully mismatched allogeneic donor BM into recipien...
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PMID: 20148810
PDF is available here.
PDF is available here.
Toxicological Sciences (114)2 2010
Abstract
We describe the Nrf2 modulation of innate and adaptive immune responses in an acute autoimmune model of MS, experimental autoimmune encephalomyelitis (EAE). Wild-type (WT) mice and Nrf2 knockout mice were immunized with myelin oligodendrocyte glycoprotein (MOG 35-55) and monitored daily for clinical...
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PMID: 19910389
PDF is available here.
PDF is available here.
Abstract
Indeterminate fibrohistiocytic lesions of the skin share histological and immunohistochemical features of both benign fibrous histiocytoma/dermatofibroma and dermatofibrosarcoma protuberans (DFSP). Unlike dermatofibroma, DFSP harbors recurrent genetic aberrations resulting in the fusion of COL1A1 on...
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PMID: 19940748
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)4 2010
Abstract
Analysis of nucleotide sequences of the mitochondrial DNA (mtDNA) control region (495 bp) of sables (Martes zibellina) and martens (M. martes) from allopatric parts of the species ranges has shown a considerable interspecific genetic distance (3%). In sympatric populations of these species in the no...
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PMID: 20536027
PDF is available here.
PDF is available here.
Abstract
We report here that the E protein HEB was uniquely required at the CD4(+)CD8(+) double-positive (DP) stage of T cell development. Thymocytes lacking HEB showed impaired survival, failed to make rearrangements of variable-alpha (V(alpha)) segments to distal joining-alpha (J(alpha)) segments in the ge...
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PMID: 20154672
PDF is available here.
PDF is available here.
Nature Neuroscience (13)3 2010
Abstract
We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant to cuprizone-induced demyelination and that circulating CXCR2-positive neutrophils were important for cuprizone-induced demyelination. Our findings support a two-hit process of cuprizone-induced demyelinat...
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PMID: 20154684
PDF is available here.
PDF is available here.
Journal of UOEH (32)1 2010
Abstract
We had previously reported [1]. Comparative analysis of the Artemia trehalase gene with other animal trehalase genes revealed the existence of conserved exon/intron boundaries among different phyla. Comparison of the 5' UTR region of trehalase mRNA obtained by the 5' RACE method with the trehalase g...
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PMID: 20232644
PDF is available here.
PDF is available here.
Abstract
We term OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts. These cells are thought to resemble embryonic stem cells (ESCs) on the basis of global gene expression analyses; however, few studies have tested the ability and efficiency of iPS cells to con...
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PMID: 20139965
PDF is available here.
PDF is available here.
Abstract
We have generated a dual affinity tagged Rb1 allele in the mouse. The tagged allele functions as wild type and the encoded protein can be purified by tandem affinity chromatography. This allele will facilitate identification and characterization of native pRb molecular interactions in any tissue acc...
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PMID: 20027616
PDF is available here.
PDF is available here.
Abstract
In this paper, a novel hybrid Artificial Bee Colony (ABC) and Quantum Evolutionary Algorithm (QEA) is proposed for solving continuous optimization problems. ABC is adopted to increase the local search capacity as well as the randomness of the populations. In this way, the improved QEA can jump out o...
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PMID: 20180252
PDF is available here.
PDF is available here.
Annals of Surgery (251)2 2010
Abstract
We hypothesize that the pathogen-free NIKS human keratinocyte progenitor cell line cultured in a chimeric fashion with patient's primary keratinocytes would produce a fully stratified engineered skin substitute tissue and serve to deliver autologous keratinocytes to a cutaneous wound.
Chimeric autol...
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PMID: 20010085
PDF is available here.
PDF is available here.
Abstract
With the dye and medicinal plant Isatis indigotica (2n = 14) as pollen parent, intertribal sexual hybrids with Brassica napus (2n = 38, AACC) were obtained and characterized. Among a lot of F1 plants produced, only five hybrids (H1-H5) were distinguished morphologically from female B. napus parents...
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PMID: 20140033
PDF is available here.
PDF is available here.
Abstract
We used a modified Boyden chemotaxis system to examine monocyte recruitment to recombinant human (rhu) IL-18 in vitro. Monocyte recruitment to rhuIL-18 was then tested in vivo by using an RA synovial tissue (ST) severe combined immunodeficient (SCID) mouse chimera. We defined monocyte-specific signa...
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PMID: 20565717
PDF is available here.
PDF is available here.
Abstract
Our results document the possible impact of loss of one Odf2 allele on sperm tail structure and function, resulting in a novel sperm tail phenotype....
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PMID: 20550699
PDF is available here.
PDF is available here.
Abstract
We demonstrate a protocol to generate chimeric retinas and brains in zebrafish embryos and to perform live imaging of the donor cells. The protocol covers the preparation of transplantation needles, the transplantation of GFP-expressing donor blastomeres to GFP-negative hosts, and the examination of...
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PMID: 20689504
PDF is available here.
PDF is available here.
Abstract
Four randomized groups of male mice F1 (C57Black/CBA) were investigated: a) UV-irraidated (UV-A, 15 min daily during 9 months, dose 5.6 + 1.2 W/m2), b) gamma-rays irradiated (2 Gy), single, c) influence for combination of UV- and gamma-rays treatment, d) aging. The lens opacities were measured on 7t...
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PMID: 20734799
PDF is available here.
PDF is available here.
Abstract
From dual-color genomic in situ hybridization (GISH) analysis of three trigenomic hybrids, Brassica maurorum (MM, 2n = 16) x B. juncea (AABB, 2n = 36) (M.AB), B. maurorum x B. carinata (BBCC, 2n = 34) (M.BC), and B. carinata x B. maurorum (BC.M), the three genomes of each hybrid were distinguished a...
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PMID: 20130745
PDF is available here.
PDF is available here.
Abstract
A previous paper reported the development of disomic addition lines (2H, 3H, 4H, and 1HS isochromosomic) from hybrids between the winter wheat 'Martonvásári 9 kr1' and the two-rowed winter barley cultivar 'Igri'. The present paper describes the isolation of two new additions, the 7H disomic and 6H...
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PMID: 20130747
PDF is available here.
PDF is available here.
Methods in Enzymology (476) 2010
Abstract
We will describe the currently most cost efficient and simple method; the aggregation of pluripotent stem cells with diploid or tetraploid mouse embryos. Since most of the large knockout projects are using the C57BL/6 background, we will pay special attention to cell lines derived from this inbred s...
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PMID: 20691864
PDF is available here.
PDF is available here.
Methods in Enzymology (476) 2010
Abstract
We developed the VelociMouse method, in which injection of genetically modified ES cells into eight-cell embryos followed by maturation to the blastocyst stage and transfer to a surrogate mother produces F0 generation mice that are fully derived from the injected ES cells and exhibit a 100% GLT effi...
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PMID: 20691872
PDF is available here.
PDF is available here.
Abstract
The controversy over the creation of admixed human-nonhuman embryos, and specifically of what have been termed "cybrids," involves a range of ethical and political issues. It is not reducible to a single question. This paper focuses on one question raised by that controversy, whether...
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PMID: 21644432
PDF is available here.
PDF is available here.
Abstract
The donor-acceptor relation (DAR) in a plant under cold exposure to frost was studied in the plants of winter wheat (Triticum aestivum L.) Mironovskaya 808 cultivar and its allocytoplasmatic hybrid containing alien cytoplasm of goat grass (Aegilops ovata L.) and grown in a water culture until phenop...
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PMID: 20387387
PDF is available here.
PDF is available here.
Abstract
Abstract
We analyzed the fertilization and embryonic development of the hybrid between spotted females and barred males of sorubim specimens by light microscopy and by scanning (SEM) and transmission electron microscopy (TEM) after induced spawning. Samples were collected at pre-established moments up to lar...
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PMID: 19876824
PDF is available here.
PDF is available here.
Folia Biologica (Krakow) (58)3-4 2010
Abstract
The goal of our study was to evaluate whether private alleles can be defined in microsatellite markers for the breeds under investigation; to evaluate if these private alleles distinguish chicken chimera when using different tissues; to trace them back to the donor: Green-Legged Partridgelike and re...
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PMID: 20968194
PDF is available here.
PDF is available here.
Tsitologiia (52)2 2010
Abstract
We were able to detect the parental origin for each chromosome in hybrid cells. Based on parental chromosome ratio, all 20 hybrid clones were separated in some different groups: from the group containing practically tetraploid M. musculus genome with single M. caroli chromosomes to hybrids with domi...
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PMID: 20352696
PDF is available here.
PDF is available here.