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Polycyclic Compounds (4):
Recent article
Polycyclic Compounds
Abstract
Funding injections by British Petroleum this summer are fueling studies in the Gulf Coast, raising hopes that the Deepwater Horizon oil spill might provide answers to long-standing questions on the nature of cellular toxicity. Rebecca Alvania investigates.
Copyright ...
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PMID: 21816268
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PDF is available here.
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Abstract
The objective of this study was to investigate the enzymatic generation of the Mn(3+) -malonate complex and its application to the process of oxidizing several organic compounds. The experimental set-up consisted of an enzymatic reactor coupled to an ultrafiltration membrane, providi...
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PMID: 21509948
PDF is available here.
PDF is available here.
Abstract
We examined whether STA-21, a small Stat3 inhibitor, could be useful in ameliorating the skin lesions not only in the model mouse but also in human psoriasis. Treatment with STA-21 markedly inhibited the cytokine-dependent nuclear translocation of Stat3 in normal human keratinocytes in vitro. Kerati...
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PMID: 20811392
PDF is available here.
PDF is available here.
Abstract
Despite 7-epi-nemorosone and plukenetione A sharing some structural core elements, the mechanism of action involved in their antiretroviral activity seems to be different. We propose that 7-epi-nemorosone inhibits the viral replication by interrupting the Akt/PKB signaling cascade, as was demonstrat...
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PMID: 20875373
PDF is available here.
PDF is available here.
Abstract
We show that monochloramine also leads to disturbances in intracellular free zinc concentration ([Zn(2+)](i)) in the gastric gland of the rabbit and that the increased Zn(2+) within the cell causes an independent decrease in cell viability. Changes in [Zn(2+)](i) were measured by using the fluoresce...
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PMID: 20430873
PDF is available here.
PDF is available here.
Abstract
We developed an efficient chemical synthesis of the ABCDEFG segment 3 of maitotoxin. (13)C NMR chemical shift comparisons of synthetic 3 with the corresponding values for the same carbons of maitotoxin revealed a close match, providing compelling evidence for the correctness of the originally assign...
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PMID: 20415445
PDF is available here.
PDF is available here.
Abstract
A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs(2)CO(3) in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15-24 min, which makes workup convenient. Four...
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PMID: 20356095
PDF is available here.
PDF is available here.
Brain research (1330) 2010
Abstract
These results suggest that P2X3 receptors in the lPAG play an inhibitory role in pain modulation and EA exerts a marked therapeutic effect in relieving neuropathic pain in CCI rats, which may be related to its regulative effect on the expression of P2X3 receptors in the lPAG. In conclusion, P2X3 rec...
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PMID: 20302849
PDF is available here.
PDF is available here.
Chemosphere (79)8 2010
Abstract
A highly chlorinated flame retardant, Dechlorane Plus (DP), was measured in five fish species collected in 2008 from 22 river sites across South Korea. The sites consisted of 15 urban-industrial areas, three rural-industrial areas, and four rural rivers. Both syn- and anti-DP isomer were consistentl...
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PMID: 20303139
PDF is available here.
PDF is available here.
Abstract
Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that...
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PMID: 20232845
PDF is available here.
PDF is available here.
Organic Letters (12)7 2010
Abstract
A new and efficient method for the synthesis of aza-fused polycyclic quinolines (e.g., benzimidazo[1,2-a]quinolines) is described. This protocol includes an intermolecular condensation followed by a copper-catalyzed intramolecular C-N coupling reaction. The method is applied to a wid...
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PMID: 20196570
PDF is available here.
PDF is available here.
Abstract
Highly potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors, including 9-hydroxy-1,2-dihydro-4H-thiopyrano[3,4-c]quinolin-5(6H)-one derivatives with a non-aromatic A-ring, were synthesized. Among the derivatives, 12a showed low nanomolar enzyme and cellular activity (IC(50) = 42 nM, ED(50) = 220...
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PMID: 20189385
PDF is available here.
PDF is available here.
Abstract
We conclude that the inhibition of CYP3A activity in rat liver microsomes by schisandrin A and schisandrin B is mostly attributed to a mixed noncompetitive and complete inhibition.
Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved....
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PMID: 20448858
PDF is available here.
PDF is available here.
Abstract
Polycyclic aromatic hydrocarbons (PAHs) in coastal surface sediments from Rizhao offshore area were analyzed by gas chromatography-mass spectrometry. A chemical mass balance (CMB) model developed by the U.S. Environmental Protection Agency (EPA), CMB8.2, was used to apportion sources of PAHs. Seven...
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PMID: 19280357
PDF is available here.
PDF is available here.
Abstract
Abstract
Deoxyschisandrin could markedly increase the blood level of Tac in this liver transplant patient. Monitoring the trough levels of Tac frequently is recommended when deoxyschisandrin is co-administered....
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PMID: 19656076
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the sediment from most commercial ponds, and a few residential and golf course ponds, were moderately contaminated with PAHs. PAH levels in these contaminated ponds exceeded between 42% and 75% of the ecological screening values for individual PAH analytes established...
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PMID: 19229645
PDF is available here.
PDF is available here.
Abstract
We compared the pro-apoptotic effect of two dibenzocyclooctadiene lignans, gomisin A and gomisin N, isolated from Schizandra chinensis Baill, in U937 human promyelocytic leukemia cells in vitro. Gomisin N, but not gomisin A, inhibited cell growth in a dose-dependent manner, which was associated with...
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PMID: 20034537
PDF is available here.
PDF is available here.
Abstract
We investigated whether the nine major compounds of Schiandra chinensis could be applied to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Among the nine lignans, three, gomisin J, gomisin N, and schisandrin C, were found to reduce nitric ox...
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PMID: 20139628
PDF is available here.
PDF is available here.
Journal of Chromatography A (1217)7 2010
Abstract
The enantiomeric separation of four chiral polycyclic musks (Galaxolide, Tonalide, Traseolide and Phantolide) using CE was achieved for the first time in this work. Two chiral methodologies were developed by CD-MEKC using SDS as surfactant in a CHES buffer (pH 9.0). One methodology enabled the fast...
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PMID: 20031145
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the liposoluble ingredients of Quchiling (LQ), which enter the blood and the brain,and to confirm the active ingredients of LQ in vivo. METHOD: Serum pharmacochemistry and gas chromatography mass spectroscopy were used to analyze ingredients of LQ entering the blood and the brain...
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PMID: 20349718
PDF is available here.
PDF is available here.
Abstract
To investigate the involvement of reactive oxidant species (ROS), presumably arising from cytochrome P-450 (CYP)-catalyzed metabolism of schisandrin B (Sch B), in triggering glutathione antioxidant response, Sch B induced reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent and CYP-...
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PMID: 20460761
PDF is available here.
PDF is available here.
Abstract
An improved synthesis of 5-amino-1,2-dihydrofuro[2,3-c]isoquinoline has been achieved using a slight modification of reaction conditions for the Truce-Smiles rearrangement. Acid treatment of the obtained 5-amino-1,2-dihydrofuro[2,3-c]isoquinolines gave unexpected ring-opened spiro ring compounds. Th...
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PMID: 20190442
PDF is available here.
PDF is available here.
Abstract
The reactions of N-(5,6,7,8-tetrahydroquinazolin-4-yl)amidines and their amide oximes with hydroxylamine hydrochloride gave abnormal cyclization products via a ring cleavage of pyrimidine component accompanied with a ring closure of 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)cyclohexen-1-y...
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PMID: 20190443
PDF is available here.
PDF is available here.
Abstract
Reaction of fused 2,3-dihydrofuro[2,3-b]pyridines with various nucleophiles (N and O) gave dihydrofuran ring cleaved products. The scope of this reaction was investigated in detail.
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PMID: 20460811
PDF is available here.
PDF is available here.
Abstract
Reaction of 1-(3-cyanopropoxy)-3,4-dihydronaphthalene-2-carbonitriles with potassium tert-butoxide gave 5-amino-1,2,6,7-tetrahydrobenzo[f]furo[2,3-c]isoquinolines via a Truce-Smiles rearrangement. The 5-amino group was transformed to the bromo derivatives which were allowed to react with aliphatic c...
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PMID: 20460797
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To determine lignan content in the vine stem of Schisandra chinensis during 12 months and provide the scientific basis for the development and utilization of the resources. METHOD: Analysis was carried out on an Eclipse XDB C18 column eluted with a mixture of methanol-acetonitrile-water (...
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PMID: 20353009
PDF is available here.
PDF is available here.
Abstract
The reaction of 3-(2-cyanophenyl)quinazolin-4(3H)-one with various primary alkylamines gave 3-alkylquinazolin-4(3H)-ones via an addition of the nucleophile, ring opening, and ring closure (ANRORC) mechanism. This type of reaction required hydroxy group functionality in either the solvent or reagent....
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PMID: 19881286
PDF is available here.
PDF is available here.
Abstract
Based on the concentrations of polycyclic aromatic hydrocarbons (PAHs) in 12 surface sediment samples from Yellow sea, the relative risk of 9 PAHs was investigated using joint risk probability distribution curves and overlapping area, which were generated based on the distributions of exposure and a...
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PMID: 19771383
PDF is available here.
PDF is available here.
Abstract
Seasonal and offshore concentration variations for selected sixteen priority pollutant polycyclic aromatic hydrocarbons (PAHs) in surface sediments and water of Car Wash and Kisat areas of Winam Gulf, Lake Victoria, have been investigated. PAHs concentrations in sediments and water range from 0.4 to...
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PMID: 19629366
PDF is available here.
PDF is available here.
Abstract
Mean concentrations of selected USEPA priority polycyclic aromatic hydrocarbons (PAHs) in surface sediments and water samples from Car Wash and Kisat areas of Winam Gulf, Lake Victoria in Kenya have been determined using GC-FID and GC-MS. Sampling was done during the rainy season in April 2006. The...
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PMID: 19768360
PDF is available here.
PDF is available here.
Abstract
We analyzed atmospheric particulate polycyclic aromatic hydrocarbons (PAHs) in Ho Chi Minh City, Vietnam, for 19 months. The average concentrations of total PAHs at dry and rainy seasons were 4.28 +/- 2.83 and 15.71 +/- 8.21 ng m(-3), respectively. The use of motorcycles without catalytic converters...
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PMID: 19471847
PDF is available here.
PDF is available here.
Abstract
Polycyclic aromatic hydrocarbons (PAHs) were investigated in the surface soils from Dashiwei and Datuo Karst tiankengs, Guangxi Province, South China. Concentrations of total PAHs ranged from 16.93 ng g(-1) to 190 ng g(-1) with a mean of 58.29 ng g(-1). In Dashiwei more PAHs were concentrated than i...
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PMID: 19565171
PDF is available here.
PDF is available here.
Abstract
The enantiomerically pure and readily available metabolites 10-12 have been converted over four simple steps into the epoxyquinol derivatives 22-24, respectively. Compounds 23 and 24 or their immediate precursors have been exploited in efficient total syntheses of (-)-bromoxone (ent-1), (-)-epiepofo...
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PMID: 19743818
PDF is available here.
PDF is available here.
Abstract
We isolated two phytochemical lignans, schisandrin and schisandrin C, from Schizandra chinensis Baill and investigated their anti-cancer effects in human leukemia U937 cells. Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the c...
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PMID: 19724890
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
The functionalized, enantiomerically pure [7]helicene 1 derived from bis(benzodithiophene) functionalized with four heptyl groups is prepared from 1,8-dibromo-4,5-diheptylbenzo[1,2-b:4,3-b']dithiophene building block 2. Such [7]helicene structure, functionalized with bromines at the terminal positio...
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PMID: 19739665
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
We present the synthesis and characterization of a bis(IBF), 2,7-di(tert-butyl)pyreno[4,5-c:9,10-c']difuran. Reaction with bis(maleimide) dienophiles gives pyrenophanes. The solid-state structures of the bis(IBF) and two cyclophanes are discussed....
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PMID: 19715283
PDF is available here.
PDF is available here.
Optics Express (17)20 2009
Abstract
A novel method is proposed to generate slow and fast lights at arbitrary signal wavelength in benzocyclobutene (BCB) polymer, which eliminates the requirement on the optical nonlinearity or the resonant effect at the signal wavelength with the help of the thermo-optic nonlinear effect induced by a c...
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PMID: 19907620
PDF is available here.
PDF is available here.
Abstract
Interest in stable nucleophilic carbenes has grown rapidly since the isolation of the first "bottle-able" example in 1991. Not only has the structural variation of this class of compounds seen an incredible expansion from laboratories around the world, but the chemical reactivity of these compounds...
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PMID: 20449128
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (168)2-3 2009
Abstract
Artificially contaminated soil with four different polynuclear aromatic hydrocarbons (acenaphthene, phenathrene, anthracene and fluoranthene) has been separately treated by two different processes: (A) concentrated hydrogen peroxide at mild conditions of temperature (343-393 K) and pressure (0.5 MPa...
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PMID: 19356845
PDF is available here.
PDF is available here.
Inorganic Chemistry (48)17 2009
Molecular Oxygen and Sulfur Reactivity of a Cyclotriveratrylene Derived Trinuclear Copper(I) Complex
Abstract
Our continuing efforts into developing copper coordination chemistry relevant to dioxygen-processing copper proteins has led us to design and synthesize a cyclotriveratrylene (CTV)-based trinucleating ligand, CTV-TMPA, which employs tetradentate tris(2-pyridylmethyl)-amine chelates (TMPA) for their...
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PMID: 19663454
PDF is available here.
PDF is available here.
Anticancer Research (29)9 2009
Abstract
The air pollution index correlated with respiratory, digestive tract, urogenital, female, blood and skin cancer. Air pollution was estimated to account for 5% of male cancer deaths and 3% of female cancer deaths between 1970-1994. Solar UVB was inversely correlated with all these types of cancer exc...
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PMID: 19667146
PDF is available here.
PDF is available here.
Abstract
We have discovered a highly efficient oxidative C-N bond forming reaction that relies on the union of a nitrogen anion and a carbon anion. Empirical evidence amassed during our synthetic studies suggests that the mechanism of the C-N bond forming process encompasses polar as well as radical processe...
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PMID: 19591469
PDF is available here.
PDF is available here.
Abstract
Alternaria sonchi is a fungal pathogen isolated from Sonchus arvensis and proposed as a biocontrol agent of this noxious perennial weed. Different phytotoxic metabolites were isolated from solid culture of the fungus. Two new polycyclic ethanones, named alternethanoxins A and B, were characterized u...
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PMID: 19594161
PDF is available here.
PDF is available here.
Abstract
We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism by which Ni induces MT expression is unclear. We hypothesized that the ability of Ni to mobilize zinc (Zn) may contribute to such regulation...
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PMID: 19097988
PDF is available here.
PDF is available here.
Abstract
Eight compounds were isolated and identified as wuweizisu C (I), ganwuweizic acid(II), beta-sitosterol(III), gomisin A(IV), schizandrin(V), daucosterol(VI), wuweizisu A(VII), gamma-schizandrin (VIII). CONCLUSION: Compounds I - VIII are isolated from the fruit handles of Schizandra chinensis for the...
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PMID: 19873730
PDF is available here.
PDF is available here.
Abstract
We investigated the neuroprotective effects of schisandrin B on amyloid-beta1-42-induced toxicity and its potential mechanisms in rat cortical neuron cells. Amyloid beta1-42 significantly reduced cell viability and increased apoptosis. Pretreatment with schisandrin B prior to amyloid-beta1-42 exposu...
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PMID: 19694182
PDF is available here.
PDF is available here.
Abstract
It is demonstrated that even unsubstituted cationic ligands, namely the known diazoniadibenzochrysenes (, ) and the so far unreported tetraazoniapentaphenopentaphene (), stabilize quadruplex DNA upon association; the ligand exhibits essentially the same affinity towards the quadruplex as does 5,10,1...
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PMID: 19240889
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (162)2-3 2009
Abstract
PAH are particularly monitored because of their carcinogenic properties and their ubiquity in the environment. Their presence in municipal sewage sludge is a major problem due to the environmental risks associated with the sludge spreading on agricultural soils. The objective of this work was to ass...
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PMID: 18649997
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (162)2-3 2009
Abstract
A survey of polycyclic aromatic hydrocarbons (PAHs) in residential air in Hangzhou, China, was carried out. Air samples were collected from indoor and outdoor environments during both summer and winter and analyzed for the level of 16 PAHs. The results showed total PAH contents ranging from 0.425 to...
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PMID: 18640778
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (162)2-3 2009
Abstract
The supercritical CO(2) extraction of four PAHs (acenaphthene, phenanthrene, anthracene and fluoranthene) from an artificially contaminated soil has been investigated. The effect of temperature (40-60 degrees C), pressure (300-500 bar) and extraction time (90-150 min) has been assessed by conducting...
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PMID: 18602215
PDF is available here.
PDF is available here.
Abstract
A water-soluble triacetic acid cryptophane-A derivative (TAAC) was synthesized and determined by isothermal titration calorimetry and fluorescence quenching assay to have a xenon association constant of 33,000 M(-1) at 293 K, which is the largest value measured for any host molecule to date. Fluores...
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PMID: 19239271
PDF is available here.
PDF is available here.
Abstract
Stormwater runoff from three highway sites in Los Angeles, California, was monitored, during the 2000 to 2003 wet seasons. Correlations among heavy metals, polycyclic aromatic hydrocarbons (PAHs), and storm characteristics were performed using datasets collected for 62 storm events. Statistical corr...
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PMID: 19378660
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)5 2009
Abstract
We show that Pi limits the extracellular zinc concentration by inducing metal precipitation. We present data suggesting that amino acids like histidine may counteract the Pi-induced zinc precipitation by the formation of soluble zinc complexes. We propose that the interplay between Pi and amino acid...
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PMID: 19183267
PDF is available here.
PDF is available here.
Analytical Sciences (25)3 2009
Abstract
A new C(3)-functionalized cyclotriveratrylene (CTV) bearing three fluorogenic quinolinyl groups was synthesized and studied as a fluorescent probe. The CTV derivative exhibited a selective response of fluorescence enhancement toward Cu(2+). The fluorescence intensity in CH(3)CN was increased until t...
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PMID: 19276606
PDF is available here.
PDF is available here.
Abstract
Tetraphenyl[5]cumulene (tetraphenylhexapentaene) underwent cyclotrimerization in refluxing toluene for 10-15 min to give a tricyclodecadiene derivative in 68% yield.
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PMID: 19283295
PDF is available here.
PDF is available here.
Abstract
These results suggest the importance of copepods in the biogeochemical cycles of hydrophobic organic contaminants in estuarine ecosystems....
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PMID: 18937527
PDF is available here.
PDF is available here.
Abstract
Nine locations in Shantou coastal waters were chosen for the study on contamination and ecotoxicology risks posed by polycyclic aromatic hydrocarbons (PAHs). Sediment samples were collected to investigate PAH distribution behaviour, sources and understand their origin, which is fundamental in predic...
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PMID: 18773133
PDF is available here.
PDF is available here.
Abstract
Our results showed that increasing NaCl concentration in soil had decreasing effect on total crude oil and PAHs reduction. The biodegradation of total crude oil was higher in 0% NaCl (41%) while higher total PAHs reduction was observed in 1% NaCl (35%). The lower total crude oil and PAHs reduction w...
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PMID: 18777147
PDF is available here.
PDF is available here.
Abstract
A study of particulate laden polyaromatic hydrocarbon was conducted at 13 selected locations in a 10 km radial distance of a proposed site for a grass root level industry. Suspended particulate matter samples were continuously monitored for 24 h over a period of 3 months. The Polyaromatic Hydrocarbo...
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PMID: 18974916
PDF is available here.
PDF is available here.