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Bridged Compounds (2):
Recent article
Bridged Compounds
Abstract
The primary objective of this study was to determine the rate of pathological response after preoperative celecoxib and concurrent taxane-based chemotherapy in patients with cancer of the esophagus and gastroesophageal junction.
Thirty-nine patients were enrolled in t...
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PMID: 21532508
PDF is available here.
PDF is available here.
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Abstract
Capecitabine may have a higher acquisition cost compared with other select chemotherapy agents; however, its use is not associated with many of the costs typically encountered with intravenous chemotherapy, such as costs incurred through administration procedures and the management of subsequent tol...
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PMID: 20051811
PDF is available here.
PDF is available here.
Abstract
Breast cancer consists of a heterogeneous group of diseases, with a number of tumor-specific and patient-specific factors, which influence response to therapy and survival. Ixabepilone is a member of a novel class of antineoplastic agents, the epothilones, that has demonstrated activity in a number...
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PMID: 20051810
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
Treatment of a variety of tetracyclines (tigecycline, minocycline, tetracycline and doxycycline) with Ag(2)CO(3)/EDTA or Hg(OAc)(2) cleanly gave the 4,11a-bridged derivatives in high yields. The reactions proceeded through a novel, intramolecular Mannich cyclization of an iminium species generated b...
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PMID: 20978515
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A rapid, sensitive and selective liquid chromatography/tandem mass spectrometry method (LC-MS/MS) was developed and validated for simultaneous determination of albiflorin and paeoniflorin in rat plasma using geniposide as an internal standard. Plasma samples were extracted by solid-phase extraction....
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PMID: 21077251
PDF is available here.
PDF is available here.
Abstract
We succeeded in the synthesis of triplex-forming oligonucleotides (TFOs) that contain a deoxyribonucleotide (Py) bearing a 2-pyridine nucleobase or the 2',4'-BNA congener (Py(B)). By UV melting experiments, it was found that 2-pyridine was a very promising nucleobase for the sequence-selective recog...
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PMID: 20648389
PDF is available here.
PDF is available here.
Abstract
Using the method of reverse transcription-polymerase chain reaction (RT-PCR) to detect the related gene expression,with a view to clarify the principal mechanism that the neuroprotection of paeoniflorin (PF).
At the seventh day, after the pretreatment of PF (0.5, 2, 10 micromol x L(-1)), with 30 min...
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PMID: 21141500
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Rapid profiling and target analysis of principal components in Fuling Decoctions by UFLC-DAD-ESI-MS.
Abstract
The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatogr...
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PMID: 20362035
PDF is available here.
PDF is available here.
Abstract
Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer...
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PMID: 20577942
PDF is available here.
PDF is available here.
Abstract
Guest-host complex between cryptophane C, possessing two non-equivalent caps, and chloroform is investigated by NMR spectroscopy. The kinetics of the chloroform exchange between the bound and free sites is determined by (1)H exchange spectroscopy. Moreover, the preferential orientation of chloroform...
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PMID: 20589729
PDF is available here.
PDF is available here.
Abstract
Twenty-one patients received 146 cycles with a median of 5 cycles (range 1-13 cycles) per patients. Fourteen patients (66.7%) had partial response, 5 patients (23.8%) had stable disease, and 2 patients (9.5%) had progressive disease. Median time to progression and duration of response were 6.2 and 6...
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PMID: 20490795
PDF is available here.
PDF is available here.
Abstract
Hemoperfusion treatment is effective for acute tetramine poisoning in children....
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PMID: 20637151
PDF is available here.
PDF is available here.
Abstract
We present a review of salient developments over the past decade that have helped shape the adjuvant systemic therapy of today....
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PMID: 20497918
PDF is available here.
PDF is available here.
Neurobiology of Aging (31)6 2010
Abstract
Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace e...
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PMID: 18950900
PDF is available here.
PDF is available here.
Abstract
We tested the antioxidant effects of PF and its ability to prevent lipopolysaccharide (LPS)-induced oxidative stress. We intraperitoneally administered PF (2.5, 5, or 10 mg/kg) to rats for 20 days. On day 21, we injected the rats with LPS 4 h before sacrifice and measured serum levels of glutamate o...
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PMID: 20607502
PDF is available here.
PDF is available here.
Lancet Oncology (11)6 2010
Abstract
Abstract
In this study, a number of 2',4'-BNA- and 2',4'-BNA(NC)-modified siRNAs were designed and synthesized. Their thermal stability, nuclease resistance and gene silencing properties against cultured mammalian cells were evaluated and compared with those of natural siRNAs. The 2',4'-BNA- and 2',4'-BNA(NC...
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PMID: 20427190
PDF is available here.
PDF is available here.
Abstract
From three basidiomycetes, Xeromphalina sp., Stereum sp., and Pleurocybella porrigens, six triquinane sesquiterpenes with unprecendented modifications and a rearranged sesquiterpene related to coriolin C have been isolated. Their isolation, structure elucidation, and biological evaluation are descri...
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PMID: 20345148
PDF is available here.
PDF is available here.
Abstract
A family of heterocyclic thiosemicarbazone dyes (1-9) linked to different furan, thiazole, (bi)thiophene, and arylthiophene pi-conjugated bridges were synthesized in good yields, and their response toward anions was studied. Acetonitrile solutions of 1-9 show bands in the 326-407 region that are mod...
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PMID: 20373768
PDF is available here.
PDF is available here.
Abstract
Cucurbit[n]urils (CB[n]) are potential stabilizing, solubilizing, activating, and delivering agents for drugs. The toxicity of the macrocyclic host molecules cucurbit[7]uril (CB[7]), the most water-soluble homologue, as well as cucurbit[8]uril (CB[8]) has been evaluated. In vitro studies on cell cul...
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PMID: 20401379
PDF is available here.
PDF is available here.
Gynecologic Oncology (117)2 2010
Abstract
In patients with platinum-sensitive EOC, detection of asymptomatic recurrences by routine surveillance testing was associated with a high likelihood of optimal SCRS in operative candidates and extended overall survival.
Copyright (c) 2010. Published by Elsevier Inc....
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PMID: 20153027
PDF is available here.
PDF is available here.
Abstract
Cisplatin has become one of the most commonly used compounds for the treatment of a wide spectrum of human malignancies. Unfortunately, cisplatin has several major drawbacks. Driven by the impressive impact of cisplatin on cancer chemotherapy, great efforts have been made to develop...
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PMID: 20184553
PDF is available here.
PDF is available here.
Abstract
Quantum chemical calculations on carbocation intermediates encountered during the conversion of ent-copalyl diphosphate to the diterpenes beyerene, kaurene, trachylobane, and atiserene are described. Based on the results of these computations, it is suggested that previously proposed secondary carbo...
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PMID: 20353180
PDF is available here.
PDF is available here.
Abstract
In patients who underwent both AC and taxane follow-up, the mean percentage of change from the individual's baseline density was -10% (95% confidence interval: -12.8%, -7.2%) after AC and -12.7% (95% confidence interval: -16%, -9.4%) after AC and taxane. In patients who underwent both follow-up stud...
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PMID: 20308443
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To investigate the microbiological transformation of paeoniflorin and albiflorin. METHOD: The bacteria strains able to transform paeoniflorin and albiflorin were screened from 18 strains of microorganisms. The products were isolated by chromatography method and their structures were eluci...
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PMID: 20575389
PDF is available here.
PDF is available here.
Abstract
Simultaneous determination method of four marker components, paeoniflorin, loganin, 5-hydroxymethyl-2-furaldehyde and paeonol in traditional herbal medicine, Yukmijihwang tang, was developed to achieve rapidly and systematic quality control by high performance liquid chromatography coupled with diod...
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PMID: 20422372
PDF is available here.
PDF is available here.
Chemical Communications (46)13 2010
Abstract
New functionalized ethano-bridged Tröger bases are readily prepared using a simple alkylation/rearrangement sequence which affords configurationally stable derivatives as single stereoisomers (de > 96%).
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PMID: 20234907
PDF is available here.
PDF is available here.
Abstract
We report the synthesis of two-faced inhibitors 1-5 that contain both enzyme inhibitor and cucurbit[n]uril binding domains. The enzyme binding domains of 1-5 bind to the active sites of bovine carbonic anhydrase (BCA) or acetylcholinesterase (AChE) and inhibit their catalytic activities. Addition of...
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PMID: 20210325
PDF is available here.
PDF is available here.
Abstract
The host-guest chemistry between a series of 1-alkyl-3-methyl-imidazolium bromide ([C(n)mim]Br) guests and the macrocyclic host molecule cucurbit[6]uril (CB[6]) in an aqueous system is systematically studied in neutral aqueous media. Both 1D and 2D NMR experiments in conjunction with...
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PMID: 20143372
PDF is available here.
PDF is available here.
Abstract
The host-guest chemistry between a series of 1-alkyl-3-methyl-imidazolium bromide ([C(n)mim]Br) guests and the macrocyclic host molecule cucurbit[6]uril (CB[6]) in an aqueous system is systematically studied in neutral aqueous media. Both 1D and 2D NMR experiments in conjunction with...
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PMID: 20143372
PDF is available here.
PDF is available here.
Abstract
Defined anticancer drugs are able to induce severe local damages in cases of accidental extravasation. The underlying pathomechanisms differ from each other, e.g. vincristine and conventional doxorubicin, when the corresponding intervention needs hyaluronidase and dexrazoxane, respectively. Whether...
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PMID: 20355670
PDF is available here.
PDF is available here.
Abstract
Abstract
S-013420 (EDP-420) is a novel bicyclolide (bridged bicyclic macrolide) antibacterial currently under development for the treatment of respiratory tract infections. The objective of the present study was to determine the plasma and intrapulmonary pharmacokinetic parameters of orally administered S-01...
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PMID: 19933801
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)1 2010
Abstract
We evaluated pathologic complete response (pCR) rate and cardiac safety of preoperative doxorubicin and cyclophosphamide followed by a taxane with or without trastuzumab.
We reviewed pCR rate and change in left ventricular ejection fraction in women with operable HER2+ breast cancer...
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PMID: 20133257
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)2 2010
Abstract
Our analysis suggests that curcumin alone has a therapeutic value in HRPC. In combination with a taxane agent, this compound may enhance cytotoxicity and retard PC cell resistance to taxane. As a consequence, a rationale is provided for considering the possible benefits of curcumin regimen in combin...
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PMID: 20099188
PDF is available here.
PDF is available here.
Abstract
We established an animal model of cerebral infarct by occluding both the common carotid arteries and the right middle cerebral artery for 90 min, followed by reperfusion of 24 hours. The ratios of cerebral infarction area to total brain area, and neuro-deficit score were used as an index to observe...
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PMID: 20128044
PDF is available here.
PDF is available here.
Abstract
In work the review of some clinik-morphological and pharmacological researches devoted to a temporal epilepsy and its experimental models is resulted. On the basis of the analysis of existing problems in working out antiepileptic drugs and in studying of mechanisms epilepsy necessity of development...
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PMID: 20469603
PDF is available here.
PDF is available here.
Abstract
Primary mediastinal non-seminomatous germ cell tumors (NSCGTs) have a poor prognosis in the International Germ Cell Cancer Collaborative Group (IGCCCG) classification. There is no clear standard of treatment at relapse. Between 1995 and 2005, 13 patients experienced progression or relapse, and 1 pat...
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PMID: 20215805
PDF is available here.
PDF is available here.
Abstract
Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer's disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Br...
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PMID: 20737911
PDF is available here.
PDF is available here.
Xenobiotica (39)12 2009
Abstract
Taxanes exhibit a high tendency to epimerize at C-7 under physiological conditions. This study aimed to investigate the composite effect of C-7 configuration and other substructural elements on the metabolic properties of taxanes. Cephalomannine, 7-epi-cephalomannine, 10-deacetyl-paclitaxel, and 7-e...
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PMID: 19795923
PDF is available here.
PDF is available here.
Abstract
We examined the intracellular signaling pathway of IL-1beta-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expre...
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PMID: 19561397
PDF is available here.
PDF is available here.
Fa yi xue za zhi (25)5 2009
Abstract
At 45 degrees C and 25 degrees C, the concentration of tetramine changed without distinctly in first 3 days and declined significantly from 4 days to 12 days. Thereafter it declined more slowly. At 4 degrees C, the concentration of tetramine changed without distinctly in 12 days and declined signifi...
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PMID: 20000046
PDF is available here.
PDF is available here.
Abstract
Abstract
An investigation was conducted into the clinical symptoms and causative agent associated with a whelk poisoning incident that occurred in March 2005 in Korea. The whelk consumed in the poisoning incident was identified as Neptunea intersculpta. All of the 17 patients suffered from eyeball pain, head...
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PMID: 19777897
PDF is available here.
PDF is available here.
Abstract
We set out to determine the efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting including carboplatin for lung cancer. Indisetron hydrochloride was given orally to 32 patients (indisetron group), and intravenous 5-HT3 receptor antagonists were given to...
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PMID: 19755818
PDF is available here.
PDF is available here.
Abstract
We show that alongside the two classical covalent and ionic bond families, there exists a class of charge-shift (CS) bonds wherein the electron-pair fluctuation has the dominant role. Charge-shift bonding shows large covalent-ionic resonance interaction energy, and depleted charge densities, and fea...
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PMID: 21378912
PDF is available here.
PDF is available here.
Abstract
The applicable technological conditions of purification for TPG by D101 macroporous resin were as follows: the concentrations of albiflorin and paeoniflorin in original solution were 0.12 mg/mL, 2.58 mg/mL with a flow rate of 3.6 BV/h, and the adsorption capacity were 0.71 mg/mL, 15.43 mg/mL, respec...
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PMID: 19960954
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (124)2 2009
Abstract
ETHNOPHARMACOLOGY RELEVANCE: Peony, the processed root of Paeonia lactiflora Pall. (Ranunculaceae), is a component herb of many traditional formulae for the treatment of depression-like disorders.
The present study aimed to investigate whether the total glycosides of peony (TGP) could prevent depres...
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PMID: 19375493
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: The aim of this study is to develop a simple and rapid HPLC method and investigate the effect of glycyrrhizin on pharmacokinetic fate of paeoniflorin after intravenous administration. METHOD: Paeoniflorin and glycyrrhizin was administrated to rat via vena caudalis, and paeoniflorin in rat...
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PMID: 19873790
PDF is available here.
PDF is available here.
Abstract
These results implicate ceramide in the pathogenesis of spinal cord injury, providing the rationale for development of candidates for its therapeutic inhibition....
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PMID: 18838947
PDF is available here.
PDF is available here.
Abstract
Cucurbit[7]uril (CB[7]) forms very stable complexes with the alpha-axial 5,6-dimethylbenzimidazole (alpha-DMB) nucleotide base when dissociated from the Co(III) center in vitamin B(12) (CNCbl, K(CB[7]) = (7.5 +/- 0.5) x 10(4) dm(3) mol(-1)) and coenzyme B(12) (AdoCbl, K(CB[7]) = (3.02 +/- 0.35) x 10...
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PMID: 19381421
PDF is available here.
PDF is available here.
Abstract
Anthracycline, taxane or trastuzumab play a central role in systemic chemotherapy for breast cancer. The standard of subsequent treatment is capecitabine, S-1, vinorelbine, irinotecan or gemcitabine. Ixabepilone or nanoparticle paclitaxel is effective for taxane-resistant breast cancer. Lapatinib pr...
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PMID: 19461171
PDF is available here.
PDF is available here.
Abstract
PS and primary DFI are useful predictors of the response to third-line chemotherapy in women with recurrent ovarian, fallopian tube, and primary peritoneal cancer. In this setting, however, both of these variables are subject to several well-established potential biases and limitations; further pros...
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PMID: 18830625
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the effects of four trace elements Mn, Fe, Zn and Cu on growth of the 2nd- and the 3rd-years Paeonia lactiflora. METHOD: The experiment was designed as randomized blocks. The data of physiological parameters such as fresh weight of root, numbers of bud and root division, length a...
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PMID: 19639775
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To research the intestinal absorption characteristics of paeoniflorin in extractive Radix Paeoniae Alba in the different intestinal segment, and the interaction with P-glycoprotein. METHOD: Paeoniflorin, a representative component in extractive Radix Paeoniae Alba, on the intestinal absor...
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PMID: 19623988
PDF is available here.
PDF is available here.
Abstract
The characteristics of host-guest complexation between cucurbit [7] uril (CB7) and methylene blue (MB) were investigated by fluorescence spectrometry in acetate buffer solution at room temperature. It was found that the fluorescence intensity of methylene blue regularly increased upon the addition o...
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PMID: 19626899
PDF is available here.
PDF is available here.
Abstract
The gold(I)-catalyzed cycloisomerization of 1,5-enynes and 1,4-allylallenes to tetracyclododecane and tetracyclotridecane derivatives, respectively, is reported. Complexation of the cationic gold(I) complex to either the alkyne or allene moiety induces an intramolecular addition of the alkene, leadi...
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PMID: 19206518
PDF is available here.
PDF is available here.
Journal of Fluorescence (19)2 2009
Abstract
Polypropylene supports were functionalized by plasma-deposition of polymeric allylamine layers. The surface amino groups generated were wet-chemically reacted with xanthene dyes resulting in fluorescent polymer films. The effect of polymer-attachment of the dyes on their emission features was studie...
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PMID: 18758927
PDF is available here.
PDF is available here.
Abstract
We conclude that, for tumors between 2 and 4 cm, preoperative chemotherapy is associated with a significantly decreased rate of re-excision following lumpectomy. This not only results in fewer mastectomies, but also avoids the morbidity and inferior cosmetic results associated with a re-excision lum...
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PMID: 19132447
PDF is available here.
PDF is available here.
Abstract
Three supramolecular compounds constructed from decamethylcucurbit[5]uril (Me(10)Q(5)) and decavanadate [H(2)V(10)O(28)](4-) were synthesized and characterized.
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PMID: 19322478
PDF is available here.
PDF is available here.